ISSUE INFORMATION Program | Committees | Sponsors | 

https://doi.org/10.4081/jbr.2026.15502

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001 | MuMa and Siso, the sperm whale: telling the story of the sea through science, education, and environmental protection Carmelo Isgrò | MuMa Milazzo Sea Museum, MuMa Museo del Mare Milazzo, Castello di Milazzo, Milazzo, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15252

002 | Ecotoxicology in a changing planet: challenges and opportunities in the Anthropocene Paolo Pastorino¹, Antonia Concetta Elia², Monia Renzi³, Caterina Faggio^4|5, Marino Prearo¹, Damià Barceló⁶ | ¹Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; ²Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy; ³Department of Life Sciences, University of Trieste, Italy; ⁴Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ⁵Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy; ⁶Department of Chemistry and Physics, University of Almería, Carretera Sacramento, Almería, Spain.

https://doi.org/10.4081/jbr.2026.15254

003 | The Strait of Messina: a natural laboratory for studying marine ecosystem responses to environmental conditions Teresa Romeo | Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15255

004 | Oncogenic role of circBFAR in pancreatic cancer progression and chemoresistance Marilena Ardone¹, Doron Tolomeo¹, Francesca Fracasso¹, Tiago Miguel Amaral Carvalho³, Lucrezia Calamo¹, Barbara Rolando², Silvia Arpicco², Valeria Bincoletto², Stephan Joel Reshkin¹, Clelia Tiziana Storlazzi¹, Rosa Angela Cardone¹ | ¹Dept of Biosciences, Biotechnology and Environment, University of Bari “Aldo Moro”, Bari, Italy; ²Dept of Drug Science and Technology, University of Turin, ltaly; ³Molecular Mechanisms of Cancer Program, Centro de Investigación delCáncer, CSIC and Universidad de Salamanca, Spain.

https://doi.org/10.4081/jbr.2026.15256

005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16 Maria Antonella Augello¹, Giuseppa D’Amico¹, Alessandra Maria Vitale¹, Rosario Barone¹, Simona Rapposelli³, Maciej Wnuk⁴, Francesco Cappello^1|2, Celeste Caruso Bavisotto^1|2, Federica Scalia⁵ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; ³Department of Pharmacy, University of Pisa, Italy; ⁴Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; ⁵Department of Medicine and Surgery, Kore University of Enna, Italy.

https://doi.org/10.4081/jbr.2026.15257

006 | Iron-mediated mitochondrial dynamics shape ferroptosis and drug resistance in ovarian cancer cells Anna Martina Battaglia¹, Emanuele Giorgio¹, Lavinia Petriaggi¹, Giuseppe Natali¹, Cristiana Galeano¹, Sebastiano Vaccarella², Giorgia Federico³, Sandra Mota⁴, Paulo Jorge Oliveira⁴, Flavia Biamonte¹ | ¹Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Italy; ²Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; ³Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy; ⁴CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.

https://doi.org/10.4081/jbr.2026.15258

007 | Dysregulation of the trans-sulfuration-sphingosine-1-phosphate signaling axis in glioblastoma: preclinical evidence Elsa Calcaterra¹, Michela Campolo¹, Melania Correale², Rossella Basilotta¹, Maria Caffo³, Roberta D’Emmanuele Di Villa Bianca², Emma Mitidieri², Giovanna Casili¹, Emanuela Esposito¹ | ¹Department of Chemical, Biological, Pharmaceutical, Environmental Sciences, University of Messina, Italy; ²Department of Pharmacy, School of Medicine and Surgery, University of Study of Naples - Federico II, Naples, Italy; ³Unit of Neurosurgery, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15259

008 | A 3D bioprinted microfluidic Breast Cancer-on-Chip model for studying drug transport and resistance Simona Campora¹, Kimia Abedi², Alessandra Lo Cicero¹, Gabriele Lo Buglio¹, Francesco La Monica¹, Giulia Palazzo¹, Riccardo Barrile², Giulio Ghersi^1|4 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ²Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States; ³Center for Stem Cells and Organoid Medicine CuSTOM, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; ⁴Abiel Srl, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15260

009 | Metabolic adaptation to hypoxia via lipid droplet accumulation in a 3D hepatocellular carcinoma model Giorgia Cannatà¹, Caterina Faggio^1|2, Maria Giovanna Rizzo¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15261

010 | Combining a gemcitabine-derived prodrug, GEM-C18, with nanoparticles to counteract acidic ph-dependent chemoresistance of pancreatic adenocarcinoma Francesca Fracasso, Marilena Ardone, Tiago Miguel Amaral Carvalho^1|2, Barbara Rolando³, Silvia Arpicco³, Valeria Bincoletto³, Francesca Bianco⁴, Alessandra Fiorio Pla⁴, Daniela Isabel Abbrescia⁵, Ylenia Antonacci⁵, Chrysovalentinos Pousis⁵, Sharon Natasha Cox¹, Flaviana Marzano⁵, Graziano Pesole¹, Apollonia Tullo⁵, Stephan Joel Reshikn¹, Rosa Angela Cardone¹ | ¹Dept of Biosciences, Biotechnology and Environment, University of Bari, ltaly; ²CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, Covilhã, Portugal; ³Dept. of Drug Science and Technology, University of Turin, ltaly; ⁴Dept of Life Sciences and Systems Biology, University of Turin, Italy ⁵Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies – IBIOM - CNR, Bari, Italy.

https://doi.org/10.4081/jbr.2026.15262

011 | Physicochemical and biological evaluation of IgG binding to self-assembling dendrimer nanomicelles Gabriele Cavalieri, Anna Laura La Monaca, Erik Laurini, Sabrina Pricl | Molecular Biology and Nanotechnology Laboratory - MolBNL@UniTS, Department of Engineering and Architecture - DEA, University of Trieste, Italy.

https://doi.org/10.4081/jbr.2026.15263

012 | Anticancer activity of Orobanche crenata leaf extract in human colorectal cancer cell lines Floriana D’Angeli¹, Alfio Distefano², Laura Orlando², Elisa Gili³, Valentina Di Salvatore⁴, Simone Ronsisvalle⁴, Ivana Roberta Romano², Giuliana Mannino², Debora Lo Furno², Giovanni Giurdanella¹, Giovanni Li Volti², Carlo Genovese¹ | ¹Department of Medicine and Surgery, School of Medicine and Surgery, University of Enna "Kore", Enna, Italy; ²Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; ³Department of Clinical and Experimental Medicine, "Regional Referral Center for Rare Lung Diseases", University, Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Italy; ⁴Department of Health and Drug Sciences, University of Catania, Italy.

https://doi.org/10.4081/jbr.2026.15264

013 | Innovative therapeutic approaches in solid tumors Alessia Dottore¹, Rosalba Rossello², Francesco Ferraù¹ | ¹UOC Oncologia Medica, Ospedale “San Vincenzo”, Taormina [ME], Italy; ²UOS Oncologia Medica, Ospedale “Cutroni Zodda”, Barcellona Pozzo di Gotto [ME], Italy.

https://doi.org/10.4081/jbr.2026.15265

014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco¹, Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Francesco Cappello^1|2, Celeste Caruso Bavisotto^1|2 | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15266

015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina¹, Alessandro Maugeri², Michele Navarra¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15267

016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes Alice Foti¹, Fabio Allia¹, Marilena Briglia¹, Gianpiero Tamburrini², Roberta Malaguarnera¹, Francesco Cecconi^2|3, Vittoria Pagliarini^2|3, Veronica Marabitti⁴, Francesca Nazio⁴, Adriana C.E. Graziano¹ | ¹University of Enna “Kore”, Enna, Italy; ²Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; ³Università Cattolica del Sacro Cuore, Rome, Italy; ⁴University of Rome Tor Vergata, Rome, Italy.

https://doi.org/10.4081/jbr.2026.15268

017 | Targeting lipogenesis promotes the synergistic effect of the selective HDAC inhibitor ITF3756 with bortezomib in colon cancer cells Marzia Franzò¹, Giovanni Pratelli¹, Federica Affranchi², Antonietta Notaro², Michela Giuliano², Sonia Emanuele¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics, Biochemistry Building, University of Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15269

018 | BSA nanoparticles containing collagenases and doxorubicin to enhance therapeutic efficacy in 3D models of solid tumor Gabriele Lo Buglio^1|2, Alessandra Lo Cicero¹, Simona Campora¹, Paolo Cinà³Samuel Lenton², Vito Foderà², Giulio Ghersi^1|3 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ²Department of Pharmacy, University of Copenhagen, Denmark; ³Abiel srl, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15270

019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.

https://doi.org/10.4081/jbr.2026.15271

020 | A three-dimensional vascularized cancer model mimicking the tumor microenvironment for drug resistance studies Alessandra Lo Cicero¹, Gabriele Lo Buglio¹, Francesco La Monica¹, Simona Campora¹, Margot Lo Pinto², Simone Dario Scilabra², Giulio Ghersi^1|3 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Palermo, Italy; ²Proteomics Group of RiMED Foundation, Research Department IRCCS ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy; ³Abiel srl, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15272

021 | Novel para-phenylenediamine-based derivatives as receptor tyrosine kinase-like orphan receptor 1 inhibitors: an in vitro preliminary characterization Maria Rosaria Miranda¹, Gerardina Smaldone¹, Francesca Di Matteo¹, Valeria Napolitano¹, Michela Aliberti¹, Simona Musella¹, Veronica Di Sarno¹, Gianluigi Lauro¹, Giuseppe Bifulco¹, Giacomo Pepe¹, Giovanna Aquino¹, Mario Felice Tecce¹, Isabel Maria Gomez-Monterrey², Pietro Campiglia¹, Carmine Ostacolo¹, Alessia Bertamino¹, Tania Ciaglia¹, Vincenzo Vestuto¹ | ¹Department of Pharmacy, University of Salerno, Italy; ²Department of Pharmacy, University of Naples Federico II, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15273

022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15274

023 | Chaperone-associated macrophage polarization and extracellular matrix remodelling in human glioblastoma Leila Noori^1|2, Rosario Barone¹, Giuseppe Vergilio^1|2, Maria Antonella Augello¹, Giuseppa D’Amico¹, Federica Scalia³, Pierlorenzo Veiceschi², Giovanni Tringali², Francesco Cappello¹, Celeste Caruso Bavisotto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics [BiND], University of Palermo, Italy; ²Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS, Palermo, Italy; ³Department of Medicine and Surgery, Kore University of Enna, Italy.

https://doi.org/10.4081/jbr.2026.15275

024 | In vitro analysis of molecular chaperone involvement in the radiological response of triple-negative breast cancer models Giusi Alberti¹, Giuseppe Vergilio¹, Domiziana Picone¹, Denise Amico¹, Rosario Barone¹, Francesca Rappa¹, Marco Calvaruso³, Gaia Pucci³, Luigi Minafra³, Antonella Marino Gammazza² | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostic BIND, University of Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ³Institute of Bioimaging and Complex Biological Systems-National Reasearch Council IBSBC-CNR, Cefalù-Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15276

025 | Protect colorectal cancer: in vitro chemopreventive effects of bronte pistachio extracts on colorectal cancer cells Graziella Serio¹, Roberto Chiarelli¹, Giuseppe Mannino², Samuele Davì¹, Carla Gentile¹ | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ²Department of Life Sciences and Systems Biology, Innovation Centre, University of Turin, Italy.

https://doi.org/10.4081/jbr.2026.15277

026 | Graphene oxide nanosystem for antisense miRNA-21 delivery in hepatocellular carcinoma Paola Trischitta¹, Rosamaria Pennisi¹, Maria Teresa Sciortino¹, Marta Kutwin² | ¹Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Dep of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.

https://doi.org/10.4081/jbr.2026.15278

027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica¹, Laura Tomasello¹, Mattia Biondo², Giuseppe Siragusa², Giorgio Arnaldi¹, Giuseppe Pizzolanti^1|3, Valentina Guarnotta¹ | ¹Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; ²Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; ³ATeN Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15279

028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Martina Di Marco¹, Giuseppina Poppa², Pierlorenzo Maria Veiceschi³, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Paola Limoncelli², Ilaria Giusti², Vincenza Dolo², Claudia Campanella¹, Francesca Rappa¹, Rosario Barone¹, Giovanni Tringali³, Francesco Cappello¹, Celeste Caruso Bavisotto¹ | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; ³Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15280

029 | The Strait of Messina as a biodiversity hotspot for cephalopods: evidence from 17 years of stranding events Chiara Bacchiani¹, Giovanni Ammendolia², Teresa Romeo^3|4|5, Pietro Battaglia^1|5 | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, EMI Department, Messina, Italy; ²Independent researcher, Messina, Italy; ³Stazione Zoologica Anton Dohrn, Sicily Marine Centre, BEOM Department, Messina, Italy; ⁴Institute for Environmental Protection and Research, Messina, Italy; ⁵National Biodiversity Future Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15281

030 | The Piroscafo Torino shipwreck as a biodiversity hotspot in a sandy-bottom habitat (Ionian sea) Valentina Basile¹, Marcello Mezzasalma¹, Alessandra Ghelli², Mauro F. La Russa¹, Elvira Brunelli¹ | ¹Department of Biology, Ecology and Earth Science, University of Calabria, Rende [CS], Italy; ²Ministry of Culture – Regional Secretariat of the Ministry of Culture for Calabria MiC, Roccelletta di Borgia [CZ], Italy.

https://doi.org/10.4081/jbr.2026.15282

031 | Hypoxia exposure influences the oxidative status of Mytilus galloprovincialis in a time-dependent manner Alessia Caferro¹, Mariacristina Filice¹, Giorgia Giurlanda¹, Maria Assunta Iovine¹, Alfonsina Gattuso¹, Federica Impellitteri², Caterina Faggio³, Maria Carmela Cerra¹, Sandra Imbrogno¹ | ¹ Department of Biology, Ecology, and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy; ² Department of Veterinary Sciences, University of Messina, Italy; ³ Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15283

032 | Natural exposure to Lactococcus garvieae in rainbow trout: evidence of susceptibility and clinical outcomes Annalisa Cotugno¹, Sara Glorio Patrucco¹, Giorgia Zicarelli¹, Silvia Colussi^1|2, Martina Gini¹, Pier Luigi Acutis¹, Giulia Milanese¹, Giulia Stilo¹, Caterina Faggio^3|4, Giuseppe Esposito¹, Paolo Pastorino¹, Marino Prearo¹ | ¹Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy; ²Department of Animal, Nutritional and Food Sciences, Università Cattolica del Sacro Cuore, Piacenza, Italy; ³Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ⁴Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15284

033 | Innovative autonomous surface vehicles for enhanced welfare and continuous monitoring in sustainable aquaculture Alex Carnevale¹, Ayman El Qemmah², Rosario Sorbello³, Alessia Avolicino¹ | ¹DIBEST, Università della Calabria; ²DIMES, Università della Calabria; ³Dipartimento di Ingegneria Industriale e dell’Informazione, Università eCampus, Italy.

https://doi.org/10.4081/jbr.2026.15285

034 | Characterization of a ribavirin-based drug delivery system against viral nervous necrosis virus Marianna Costa^1|2, Rosamaria Pennisi¹, Paola Trischitta¹, Federica Mastrolembo Barnà^1|2, Giuseppe Nocito³, Antonino Mazzaglia³, Maria Teresa Sciortino¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy; ³CNR-ISMN URT of Messina at Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15286

035 | Shkodra lake – Drini river basin and buna in UNESCO Transboundary Biosphere Reserve: values to be protected and used in a sustainable way Aurora Dibra, Neira Medja, Irida Zmijanej, Gjergj Shegaj | University of Shkodra “Luigj Gurakuqi” Faculty of Natural Sciences, Tirana, Albania.

https://doi.org/10.4081/jbr.2026.15287

036 | Diversity and composition of microbial communities associated with deep-sea marine litter Vittoria Dias^1|2, Carmen Rizzo^1|3, Cristina Pedà¹, Pierpaolo Consoli¹, Teresa Romeo^1|3 | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ²University of Milano Bicocca, Milano, Italy; ³National Biodiversity Future Centre NBFC, Italy.

https://doi.org/10.4081/jbr.2026.15288

037 | Preliminary data on toxicological analysis in Caretta caretta eggs in Sicily, Italy Rosaria Disclafani^1|2, Paola Galluzzo¹, Giorgia Schirò¹, Gianluca Gioia¹, Oleana Olga Prato³, Salvatrice Vizzini^2|4, Chiara Lomonaco^1|5, Elisa Maria Domenica Messina⁶, Vincenzo Monteverde¹, Salvatore Dara¹ | ¹Centro di Referenza Nazionale sul Benessere, Monitoraggio, Diagnostica delle Malattie delle Tartarughe Marine CReTaM, Istituto Zooprofilattico Sperimentale della Sicilia “A Mirri”, Palermo, Italy; ²Centro di Sostenibilità e Transizione Ecologica, Università di Palermo, Italy; ³WWF Italia, Roma, Italy; ⁴Dipartimento di Scienze della Terra e del Mare, Università di Palermo, Italy; ⁵Dipartimento di scienze Veterinarie Polo Universitario dell’Annunziata Università di Messina, Italy; ⁶Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15289

038 | Piscine lactococcosis in Mediterranean fish farms involving multiple lactococcus species affecting key aquaculture species Giuseppe Esposito¹, Silvia Colussi^1|2, Fabio Bondavalli¹, Pierluigi Acutis¹, Andrea Gustinelli³, Giorgia Bignami³, Lucio Fariano⁴, Marialetizia Fioravanti³, Elena Bozzetta¹, Caterina Faggio^5|6, Paolo Pastorino¹, Marino Prearo¹ | ¹Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; ²DIANA - Dipartimento di Scienze animali, della nutrizione e degli alimenti, Università Cattolica del Sacro Cuore, Piacenza, Italy; ³Dipartimento di Scienze Mediche Veterinarie, Università degli Studi di Bologna, Italy; ⁴Azienda Agricola Canali Cavour, Regione Sagnassi, Centallo [CN], Italia; ⁵Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Italy; ⁶Dipartimento di Biotecnologie Marine Ecosostenibili Stazione Zoologica Anton Dohrn, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15290

039 | Age and growth of the mesopelagic fish Electrona risso (myctophidae) from the Strait of Messina (central Mediterranean sea) Calogero Fontana¹, Alice Vaccaro², Francesco Longo¹, Danilo Malara³, Emanuela Fanelli^2|4, Pietro Battaglia^1|4 | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ²Università Politecnica delle Marche UNIVPM, Dipartimento di Scienze della Vita e dell’Ambiente, Ancona, Italy; ³Northern Territory Government of Australia, Department of Agriculture and Fisheries, Fisheries Division, Berrimah, NT, Australia; ⁴National Biodiversity Future Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15291

040 | Comparative neurotoxicity of glyphosate and its metabolite aminomethylphosphonic acid: evidence from Cyprinus carpio Serafina Ferrara¹, Jana Blahova², Premysl Mikula², Petr Marsalek², Caterina Faggio^1|3 | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Animal Protection and Welfare and Veterinary Public Health, University of Veterinary Sciences Brno, Brno, Czech Republic; ³Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15292

041 | Longitudinal characterization of the gut microbiota of Caretta caretta under controlled in-care conditions Martina Maria Imburgia¹, Fanny Claire Capri, Vincenzo Monteverde, Giorgia Schirò, Rosaria Disclafani, Angelo Costanza, Rosa Alduina, Salvatore Dara, Paola Galluzzo | ¹Centro di Referenza Nazionale sul benessere, monitoraggio, diagnostica delle malattie delle Tartarughe Marine CRetaM, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; ²Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Università degli Studi di Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15293

042 | Functional screening of polar lake fungal isolates reveals region-specific hydrolytic signatures Aurora Lo Bue¹, Alessandro Ciro Rappazzo², Filomena De Leo¹, Angelina Lo Giudice², Maurizio Azzaro², Maria Papale² | ¹University of Messina; ²Institute of Polar Sciences, National Research Council CNR-ISP, Italy.

https://doi.org/10.4081/jbr.2026.15294

043 | Hemocyte motility integrated into a multimarker ecophysiological approach for thermal stress assessment in native and invasive bivalve species Gayatri Udayan, Claudio Calabrese¹, Daniele Arduini; Antonella Giacovelli¹, Maria Elena Giordano¹, Adriana Giangrande^1|2, Maria Giulia Lionetto^1|2 | ¹Dept Biological and Environmental Sciences and Technologies DiSTeBA, University of Salento; ²NBFC, National Biodiversity Future Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15295

044 | Thyroid response to stress in illness Caretta caretta: a preliminary study Chiara Lomonaco¹, Paola Galluzzo^2|3, Giorgia Schirò^1|3, Angelo Costanza^2|3, Rosario Adragna³, Vincenzo Monteverde^2|3, Claudia Giannetto¹, Salvatore Dara^2|3, Rosaria Disclafani^2|4 | ¹Dipartimento di Scienze Veterinarie, Polo Universitario dell’Annunziata, University of Messina, Italy; ²Centro Referenza Nazionale per il Benessere, Monitoraggio e Diagnostica delle malattie delle Tartarughe Marine CReTaM; ³Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; ⁴Centro di Sostenibilità e Transizione Ecologica, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15296

045 | From map and gap analyses to solutions for circular economy implementation in Sicilian seafood-processing sector Michelle Marchan Gonzalez^1|2|3, Alessandra Aiello^1|2|3, Concetta Maria Messina^1|2|3 | ¹Laboratory of Marine Biochemistry and Ecotoxicology, Department of Earth and Marine Sciences, DiSTeM, University of Palermo, Trapani, Italy; ²Istituto di Biologia Marina, Consorzio Universitario della Provincia di Trapani, Trapani, Italy; ³National Biodiversity Future Center NBFC, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15297

046 | First report of interspecific aggregation and behavioural mimicry between Caranx crysos and Sarpa salpa Marcello Mezzasalma, Valentina Basile, Elvira Brunelli | Department of Biology, Ecology and Earth Science, University of Calabria, Rende, Cosenza, Italy.

https://doi.org/10.4081/jbr.2026.15298

047 | Halophila stipulacea: population dynamics in the oriented nature reserve “Laghetti di Marinello”, Sicily, Italy Ilaria Nusco¹, Mattia Soppelsa¹, Fabio Mondello¹, Antonio Manghisi¹, Salvatore Giacobbe², Marina Morabito¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²CNR-IRBIM, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15299

048 | Metagenome-assembled genomes reveal spatial and seasonal variability of coastal microbial communities along the Calabrian coast Carmen Rizzo^1|2, Rosario Calogero^1|3, Erika Arcadi¹, Francesco Fabiano^1|4|6, Vittoria Dias^1|5, Angelina Lo Giudice², Teresa Romeo^6|7|8, Silvestro Greco^3|9 | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ²National Research Council, Institute of Polar Sciences, Messina, Italy; ³Calabrian Research Centre and Advanced Marine Infrastructures, CRIMAC; ⁴University of Palermo, Palermo, Italy; ⁵University of Milano Bicocca, Milano, Italy; ⁶National Biodiversity Future Centre NBFC, Italy; ⁷Zoologica Anton Dohrn, Sicily Marine Centre, Milazzo, Italy; ⁸National Institute for Environmental Protection and Research, Milazzo, Italy; ⁹Università delle Scienze Gastronomiche di Pollenzo UNISG, Cuneo, Italy.

https://doi.org/10.4081/jbr.2026.15300

049 | CMIT as an emerging contaminant: physiological and biochemical effects in Mytilus galloprovincialis Giuseppe Stracuzzi¹, Federica Impellitteri¹, Maria Giovanna Rizzo¹, Monia Perugini², Marika Cordaro³, Kateryna Yunko⁴, Oksana Stoliar⁴, Caterina Faggio^1|5 | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Feed and Food Scienxes, Teramo Univesity, Teramo, Italy; ³Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Messina, Italy; ⁴Ternopil Volodymyr Hnatiuk National Pedagogical University, Ternopil, Ukraine; ⁵Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15301

050 | Proliferative kidney disease: new insights for Piedmont region; correlation between clinical signs and proliferative kidney disease positivity in rainbow trout Giorgia Zicarelli¹, Annalisa Cotugno¹, Sara Glorio Patrucco¹, Silvia Colussi^1|2, Giulia Milanese¹, Giulia Stilo¹, Martina Gini¹, Pier Luigi Acutis¹, Caterina Faggio^3|4, Giuseppe Esposito¹, Paolo Pastorino¹, Marino Prearo¹ | ¹Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy; ²Department of Animal, Nutritional and Food Sciences, Università Cattolica del Sacro Cuore, Piacenza, Italy; ³Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ⁴Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15302

051 | Optimization of a combined spectral and imaging flow cytometry protocol integrated with AI for rapid human microbiota screening Arianna Aquilini-Mummolo^1|2, Francesca D’Ascanio^1|2|3, Giulia Colasante^1|2, Domenico De Bellis^1|2, Pasquale Simeone⁴, Sabino Porro^1|2, Tamer Esmail^1|2, Ayesha Younas^1|2, Luana D’Onofrio^1|2, Isabel Vallejo Bermúdez^5|6, Camilla Cichella², Mariagiulia Filoso^1|2, Chiara Porro⁴, Paola Lanuti^1|2. | ¹Department of Medicine and Aging Sciences, University “G d’Annunzio”, Chieti-Pescara, Chieti; ²Center for Advanced Studies and Technology CAST, University “G d’Annunzio”, Chieti-Pescara; ³Department of Humanities, Law and Economics, “Leonardo da Vinci” University, Torrevecchia Teatina, Italy; ⁴Department of Clinical and Experimental Medicine, University of Foggia, Italy; ⁵Molecular Immunology Group CTS208, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; ⁶Immunology and Allergy Group GC01, Maimonides Biomedical Research Institute of Cordoba IMIBIC, University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.

https://doi.org/10.4081/jbr.2026.15303

052 | Metabolic analysis of farm animal plasma by 1H-NMR: variation and preliminary spectral characterization Luca Cicero¹, Silvia Orecchio¹, Aldo Migliazzo¹, Valeria Vitale Badaco¹, Stefano Burgio³, Tiziana Orefice¹, Giuseppe La Corte¹, Antonino La Corte¹, Grazia Scuderi², Paolo Fagone², Giovanni Cassata¹ | ¹Istituto Zooprofilattico Sperimentale della Sicilia, Italy; ²Università degli Studi di Catania, Italy; ³Università di Enna "Kore", Italy.

https://doi.org/10.4081/jbr.2026.15304

053 | Collagen-based biomaterials for biologically relevant 3D in vitro vascular models Elena Delgrosso¹, Franca Scocozza¹, Michele Conti^1|2 | ¹Department of Civil Engineering and Architecture, University of Pavia, Italy; ²3D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, San Donato Milanese [MI], Italy.

https://doi.org/10.4081/jbr.2026.15305

054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana¹, Chiara Agliassa², Francesco Caldo¹, Moez Maghrebi¹, Valeria Contartese², Giuseppe Mannino¹, Gianpiero Vigani¹ | ¹Department of Life Sciences and Systems Biology, University of Turin, Italy; ²Green Has Italia SpA, Canale [AT], Italy.

https://doi.org/10.4081/jbr.2026.15306

055 | Investigating microgravity’s dual impact through neuronal and cyanobacterial models: mechanistic insights into spirulina bioactivity and Parkinson’s disease pathology Mohammed Amine El Faqir^1|2, Giuseppe Uras¹, Alessia Manca², Veronica Lentini², Antonella Pantaleo² | ¹Department of Clinical Neuroscience, Institute of Neurology, University college London, UK; ²Department of Biomedical Science, University of Sassari, Italy.

https://doi.org/10.4081/jbr.2026.15307

056 | Thidiazuron exposure reprograms metabolic networks with lasting effects on growth and photosynthetic efficiency in Arabidopsis thaliana Manuela Giraldo-Acosta¹, Giulia Giovanna Salerno², Marino B. Arnao¹, Cinzia Margherita Bertea³, Ada Ricci², Giuseppe Mannino³ | ¹Department of Plant Biology Plant Physiology, University of Murci, Spain; ²Department of Chemical, Life and Environmental Sustainability Sciences, University of Parma, Italy; ³Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy.

https://doi.org/10.4081/jbr.2026.15308

057 | Bioactive metabolites from antarctic sponge-associated bacteria: bioactivity and cytotoxic assessment Claudia Gravagno^1|2, Stefano Putaggio², Teresa Romeo^2|3, Annamaria Russo², Carmen Rizzo^2|4, Ester Tellone², Angelina Lo Giudice⁴ | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ²University of Messina, Italy; ³National Institute for Environmental Protection and Research, Milazzo [ME], Italy; ⁴National Research Council, Institute of Polar Sciences, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15309

058 | Interaction between cyclic peptides and lipids: spectroscopic, calorimetric and structural analysis Anna Laura La Monaca, Gabriele Cavalieri, Erik Laurini, Sabrina Pricl | Molecular Biology and Nanotechnology Laboratory MolBNL@UniTs, Department of Engineerig and Architecture DEA, University of Trieste, Italy.

https://doi.org/10.4081/jbr.2026.15310

059 | Marine cyanobacterial biomasses as biocompatible soil-wetting and water-retention agents Angela Macrì^1|2, Vincenzo Zammuto^1|2, Alice Restifo Chiavetta¹, Antonio Ficara¹, Erminia Conti³, Diego Leone³, Patrizia Trifilò¹, Maria Teresa Caccamo^2|4, Salvatore Magazù^2|4, Concetta Gugliandolo^1|2 | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²University of Messina, Research Centre for Extreme Environments and Extremophiles, Messina, Italy; ³Department of Biological, Geological and Environmental Sciences, University of Catania, Italy; ⁴Department of Mathematical and Computer Sciences, Physical and Earth Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15311

060 | Interdomain interactions and pH modulate folding intermediates in MAGI1 PDZ4 Cosmin Marian Obreja¹, Valeria Pennacchietti², Dimitrios Marinidis¹, Sara Di Matteo³, Rodolfo Ippoliti¹, Stefano Gianni², Francesca Malagrinò¹ | ¹University of L’Aquila, Italy; ²University “La Sapienza” of Rome, Italy; ³University of Chieti-Pescara, Italy.

https://doi.org/10.4081/jbr.2026.15312

061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino¹, Giovanni Perconti¹, Alessia Giannetto², Andi Alijagic³ | ¹Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; ²Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; ³Man-Technology-Environment Research Center MTM, Orebro University, Sweden.

https://doi.org/10.4081/jbr.2026.15313

062 | Enriched bioplastics with natural compounds as innovative hemocompatible biomaterials targeting red blood cells Stefano Putaggio, Annamaria Russo, Giuseppe Tancredi Patanè, Claudia Gravagno, Antonella Calderaro, Davide Barreca, Silvana Ficarra, Ester Tellone | Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15314

063 | Novel eco-friendly antifouling coatings derived from extracts of Ulva ohnoi and Asparagopsis taxiformis Lorenzo Maria Ruggeri¹, Carlo Maffei², Francesco Crea², Damiano Spagnuolo³ | ¹Centro di Sostenibilità e Transizione Ecologica, Università degli studi di Palermo, Italy; ²Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli studi di Messina, Italy; ³Maripure ApS, Hirtshals, Denmark.

https://doi.org/10.4081/jbr.2026.15315

064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica¹, Chiara Copat¹, Gea Oliveri Conti¹, Sheima Inoubli², Margherita Ferrante¹ | ¹Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; ²Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.

https://doi.org/10.4081/jbr.2026.15316

065 | Phytochemical profile, oxidative response and antimicrobial activity of Scutellaria lateriflora extract against Staphylococcus aureus Dionysia Amanatidou¹, Ioannis Tsamesidis^1|2, Stylaini Axipolitou², Nektaria Grammatika², Antonella Pantaleo³, Eleana Kontonasaki², Phaedra Eleftheriou¹ | ¹Department of Biomedical Sciences, International Hellenic University, Thessaloniki, Greece; ²Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece; ³Department of Biomedical Science, University of Sassari, Italy.

https://doi.org/10.4081/jbr.2026.15317

066 | Modulation of oxidative stress and mitochondrial alteration in IL1β-stimulated human astrocytes: effects of extracts from leaves and rhizomes of Posidonia oceanica (L) Delile Giulia Abruscato¹, Lucia Sileo², Giulia Scanavino², Manuela Mauro¹, Francesco Longo¹, Vincenzo Arizza^1|3, Mirella Vazzana^1|3, Claudio Luparello^1|3, Ada Maria Tata² | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STeBICeF, University of Palermo, Italy; ²Department of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; ³National Biodiversity Future Center NBFC, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15318

067 | Redefining amphibian innate immunity: first in vitro and in vivo evidence of phagocytic function in blood cells Valbona Aliko¹, Erion Sukaj², Cristiana Roberta Multisanti³, Federica Impelliteri⁴, Caterina Faggio⁴ | ¹University of Tirana, Faculty of Natural Sciences, Department of Biology, Tirana, Albania; ²Western Balkans University, Faculty of Medicine and Technical Medical Sciences, Tirana, Albania; ³Department of Veterinary Sciences, University of Messina, Italy; ⁴University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15319

068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15320

069 | Comparative analysis of inflammatory and redox responses in human and rat macrophages exposed to calcium-doped mesoporous silica nanoparticles Styliani Axypolitou¹, Antonietta Ligas², Ioannis Tsamesidis¹, Georgia K. Pouroutzidou¹, Pier Luigi Fiori², Antonella Pantaleo², Eleana Kontonasaki¹ | ¹Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece ²Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.

https://doi.org/10.4081/jbr.2026.15321

070 | Role of bioactive extracts obtained from marine sources and agri-food industry by-products in ETosis modulation Federica Bellistrì¹, Giulia Abruscato¹, Manuela Perlotti¹, Alessia Lo Muzzo¹, Claudio Gargano¹, Francesco Longo¹, Manuela Mauro¹, Roberto Chiarelli¹, Vincenzo Arizza^1|3, Claudio Luparello^1|3, Gianluca Sarà^2|3, Mirella Vazzana^1|3 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ²Department of Earth and Marine Sciences, Palermo, Italy; ³National Biodiversity Future Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15322

071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia¹, Alice Foti¹, Fabio Allia¹, Rosalia Battaglia¹, Giuseppe Piccione², Alessandro Attanzio³, Caterina Faggio⁴, Roberta Malaguarnera¹, Adriana Carol Eleonora Graziano¹ | ¹Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; ²Department of Veterinary Sciences, University of Messina, Messina, Italy; ³Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ⁴Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15323

072 | A standardized onion peel-derived bioactive ingredient attenuates palmitate-induced steatosis and oxidative stress in HepG2 cells Ilaria Di Gregorio^1|2, Vincenzo Migliaccio², Maria D’Elia^1|3|4, Rita Celano^1|3, Anna Lisa Piccinelli^1|3, Luca Rastrelli^1|3, Lillà Lionetti^2|3 | ¹Dept Pharmacy, University of Salerno, Salerno, Italy; ²Dept Chemistry and Biology “A Zambelli”, University of Salerno, Italy; ³National Biodiversity Future Center NBFC, Palermo, Italy; ⁴Dept Earth and Marine Sciences, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15324

073 | Modulation of NLRP3 inflammasome and macrophage polarization by quantum molecular resonance in THP-1 cells Maria Giulia Di Battista¹, Osama Elsallabi¹, Benedetta Rizza¹, Tiziano Lupi¹, Alessandro Pozzato², Paola Lanuti¹, Antonia Patruno¹ | ¹Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; ²Telea Electronic Engineering Srl, Sandrigo [VI], Italy.

https://doi.org/10.4081/jbr.2026.15325

074 | Role of macrophage gasdermins in cigarette smoke-associated mitochondrial dysfunction Chiara Finocchio^1|2, Maria Concetta Volpe¹, Maria Rita Giuffrè¹, Francesca Rappa^2|4, Alessandro Bertani³, Chiara Cipollina¹ | ¹Fondazione RiMED, Palermo, Italy; ²Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Italy; ³IRCCS ISMETT-UPMC, Palermo, Italy; ⁴Istituto di Farmacologia Traslazionale IFT-CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15326

075 | Cytotoxic effects of grape seed oils on cancer cells Daniela Ganci¹, Giulia Abruscato¹, Roberto Chiarelli¹, Manuela Mauro^1|2, Vincenzo Arizza^1|2, Mirella Vazzana^1|2, Claudio Luparello^1|2 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ²NFBC, National Biodiversity Future Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15327

076 | Iron-driven redox dysregulation fuels psoriatic signaling in CARD14 e138a mutant keratinocytes Cristiana Galeano¹, Anna Martina Battaglia¹, Emanuele Giorgio¹, Lavinia Petriaggi¹, Giuseppe Natali², Flavia Biamonte¹ | ¹Laboratory of Biochemistry and Cell Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy; ²Department of Life Science, Magna Graecia University of Catanzaro, Italy.

https://doi.org/10.4081/jbr.2026.15328

077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio¹, Alessia Bono¹, Roberto Chiarelli¹, Marta Amato¹, Mariangela Geraci¹, Adriano Trapani¹, Alessia Vermiglio¹, Lorenza La Rosa¹, Andrea Occhipinti², Gabriella Schiera¹, Antonino Lauria¹, Carla Gentile¹ | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ²Abel Nutraceuticals SRL, Turin, Italy.

https://doi.org/10.4081/jbr.2026.15329

078 | Stress-driven Dhurrin accumulation in sorghum revealed by physiological and biochemical markers Alessio Giannilivigni¹, Manuela Giraldo-Acosta², Flavia Girolami³, Stefano Giantin⁴, Luca Carisio⁴, Carlo Nebbia³, Marino Bañón Arnao², Alberico Franzin⁴, Giuseppe Mannino¹. | ¹Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy; ²Department of Plant Biology Plant Physiology, University of Murcia, Spain; ³Department of Veterinary Sciences, University of Turin, Grugliasco [TO], Italy; ⁴Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta IZSPLV, Turin, Italy; ⁵Green Has Italia Spa, Plant Physiology Unit, Canale [CN], Italy.

https://doi.org/10.4081/jbr.2026.15330

079 | Pharmacological modulation of the STING pathway as an antiviral strategy against HSV-1 Federica Mastrolembo Barnà^1|2, Paola Trischitta^1|2, Marianna Costa^1|2, Antonella Torre³, Alessia Onali³, Angela Pagliaro³, Alberto Deplano³, Elias Maccioni³, Rita Meleddu³, Simona Distinto³, Rosamaria Pennisi¹, Maria Teresa Sciortino¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Dep of chemistry, biology and biotechnology, University of Perugia, Italy; ³Department of Life and Environmental Sciences, Section of Drug Sciences, University of Cagliari, University Campus, Monserrato [CA], Italy.

https://doi.org/10.4081/jbr.2026.15331

080 | Monocytes succumb to protect head and neck cancer cells from plasma-treated water solutions cytotoxicity Giuseppe Natali¹, Anna Martina Battaglia², Emanuele Giorgio², Lavinia Petriaggi², Alessandro Antonelli³, Cristiana Galeano², Amerigo Giudice³, Eloisa Sardella⁴, Vittoria Perrotti⁵, Flavia Biamonte² | ¹Department of Health Sciences, Magna Graecia University of Catanzaro, Italy; ²Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy; ³Department of Health Science, School of Dentistry, Magna Graecia University of Catanzaro, Italy; ⁴CNR-Istituto di Nanotecnologia CNR-NANOTEC UoS Bari, c/o Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, Italy; ⁵Department of Innovative Technologies in Medicine & Dentistry, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy.

https://doi.org/10.4081/jbr.2026.15332

081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti¹, Gabriele La Monica², Federica Alamia², Alessia Bono², Antonino Lauria², Annamaria Martorana², Antonella D’Anneo¹ | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15333

082 | Supplementation with Lactobacillus fermentum reversed fiber atrophy in a myopathy model by modulating IL-6, TNFα, and hsp60 levels, thereby enhancing muscle regeneration Martina Sausa¹, Letizia Paladino², Federica Scalia³, Francesco Paolo Zummo¹, Giuseppe Vergilio¹, Francesca Rappa¹, Francesco Cappello¹, Melania Ionelia Gratie¹, Patrizia Proia⁴, Valentina Di Felice¹, Antonella Marino Gammazza,⁵, Filippo Macaluso¹, Rosario Barone¹ | ¹Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo; ²Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO]; ³Department of Medicine and Surgery, Kore University of Enna; ⁴Department of Psychology, Educational Science and Human Movement, University of Palermo; ⁵Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15334

083 | HSV-1 replication and chemokines activation in human monocytes are suppressed by Pistacia vera l. extracts Rosamaria Pennisi¹, Marianna Costa^1|2, Paola Trischitta^1|2, Giuseppina Mandalari¹, Maria Teresa Sciortino¹. | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy.

https://doi.org/10.4081/jbr.2026.15335

084 | Modulation of the autophagic process by S1P under hypoxia: dissecting the contribution of S1P1 and S1P5 receptors Beatrice Pranzo¹, Marco Greco¹, Luisa Rosato¹, Rita Paroni², Maria Rosaria Coscia³, Paola Italiani⁴, Giacomo Strapazzon⁵, Sara Ottolenghi², Federico Maria Rubino², Alessia Ametrano³, Michele Samaja², Giulia Maria Lionetto⁶, Michele Maffia¹ | ¹Department of Experimental Medicine, University of Salento, Lecce, Italy; ²Department of Health Sciences, University of Milano, Italy; ³Institute of Biochemistry and Cell Biology, National Research Council of Italy, Naples, Italy; ⁴Institute for Biomedical Research and Innovation, National Research Council of Italy, Palermo, Italy; ⁵Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy; ⁶Department of Biological and Environmental Sciences and Technologies, Lecce, Italy.

https://doi.org/10.4081/jbr.2026.15336

085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan¹, Alessandra Maria Vitale¹, Federica Scalia^1|2, Rosario Barone¹ | ¹Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; ²Department of Medicine and Surgery, Kore University of Enna, Italy.

https://doi.org/10.4081/jbr.2026.15337

086 | Kir4.1 channels at the crossroads of oxidative stress and presbycusis: redox imbalance, electrophysiological failure and quercetin-mediated rescue Sara Spinelli¹, Alessia Remigante², Angela Marino¹, Rossana Morabito¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15338

087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci¹, Marika Cordaro², Rosanna Di Paola³ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; ²Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; ³Department of Veterinary Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15339

088 | Investigating the role of Hsp60 in the pathophysiology of celiac disease Giusy Vultaggio¹, Giuseppe Vergilio^1|2, Letizia Paladino³, Rosario Barone¹, Francesca Rappa¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy; ³Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy.

https://doi.org/10.4081/jbr.2026.15340

089 | Epithelial-immune cell crosstalk in salivary gland tumors: implications for tumor progression and diagnostic assessment Martina Sausa¹, Giuseppe Vergilio¹, Rosario Barone¹, Rossana Porcasi², Prince Ofori³, Fatima Azhraa Haddad^3|4, Francesca Rappa^1|5, Francesca Levi-Schaffer,³ Angelo Leone^1|3 | ¹Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; ²Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo, Italy; ³Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel; ⁴Department of Otolaryngology Head and Neck Surgery, Hadassah Medical Center, Hebrew University of Jerusalem, Israel; ⁵Institute of Translational Pharmacology, National Research Council of Italy CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15341

090 | Activation of Sirtuin-1 by Cipollotto Nocerino leaf extract protects HepG2 cells from lipotoxicity Vincenzo Vestuto¹, Maria Rosaria Miranda¹, Giovanna Aquino², Tania Ciaglia¹, Rodolfo Maria Abbate¹, Giuseppina Amodio³, Manuela Giovanna Basilicata⁴, Mario Felice Tecce¹, Luca Rastrelli¹, Pietro Campiglia¹, Michele Manfra⁵, Giacomo Pepe¹ | ¹Department of Pharmacy, University of Salerno, Italy; ²AREA Science Park, Laboratorio di Multi-omica Area Sud LAAS, Baronissi [SA], Italy; ³Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi [SA], Italy; ⁴Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; ⁵Department of Science, University of Basilicata, Potenza, Italy.

https://doi.org/10.4081/jbr.2026.15342

091 | Increased vulnerability to experimental colitis following chronic low-dose exposure to Sicilian environmental contaminants Noemi Aloi^1|2, Paolo Colombo², Valeria Longo², Rosa Serio¹, Maria Grazia Zizzo¹ | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Università di Palermo, Italy; ²Institute for Biomedical Research and Innovation, National Research Council of Italy IRIB-CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15343

092 | Cellular and physiological responses of Mytilus galloprovincialis to the biocide octylisothiazolinone Emanuela Castronovo¹, Cristiana Roberta Multisanti², Benedetta Napoli¹, Annalisa Cotugno³, Paolo Pastorino³, Caterina Faggio^1|4 | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina; ²Department of Veterinary Sciences, University of Messina; ³Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; ⁴Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15344

093 | Beyond biodegradability: assessing the toxicological footprint of polylactic acid nanoplastics on zebrafish gastrointestinal tract development Francesca Chiara Cecala¹, Giusy Vultaggio¹, Martina Di Marco¹, Alessandra Maria Vitale¹, Rosario Barone¹, Francesca Rappa¹, Maria Denise Amico¹, Erwin Pavel Lamparelli², Giovanna Della Porta², Antonietta Santoro², Francesco Cappello^1|4, Federica Scalia³, Marta Anna Szychlinska⁵ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; ³Department of Medicine and Surgery - Kore University of Enna, Italy; ⁴Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; ⁵Department of Precision Medicine in Medical, Surgical and Critical Care MePreCC, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15345

094 | 2-octyl-2h-isothiazol-3-one and its role in zebrafish larvae neurogenesis and neuronal function Vanessa D’Altilia¹, Ludovica Sulcanese¹, Valentina Iezzi², Silvana Zugaro², Annamaria Iannetta¹, Tommaso Silvestrini^1|3, Elisabetta Benedetti², Monia Perugini¹. | ¹Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy; ²Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy; ³University of Camerino, International School of Advanced Studies, Camerino, Italy.

https://doi.org/10.4081/jbr.2026.15346

095 | Nanoplastic as modulators of human immune responses: effect on natural killer and T cells Francesca D’Ascanio^1|2|3, Isabel María Vallejo Bermúdez^4|5, Domenico De Bellis^1|2, Giulia Colasante,^1|2, Arianna Aquilini^1|2, Sabino Porro^1|2, Tamer Shibl Ali Esmail^1|2, Ayesha Younas^1|2, Mariagiulia Filoso^1|2, Luana D’Onofrio^1|2, Piero Chiacchiaretta^1|6, Melania Dovizio^1|6, Patrizia Ballerini^1|6, Piero Di Carlo^1|6, Alejandra Pera^4|5, Bruna Sinjiari⁶, Paola Lanuti^1|2. | ¹Center for Advanced Studies and Technology CAST, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; ²Department of Medicine and Aging Sciences, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; ³Department of Humanities, Law and Economics, “Leonardo da Vinci” University, Torrevecchia Teatina, Italy; ⁴Immunology and Allergy Group GC01, Instituto Maimónides de Investigación Biomédica IMIBIC, Córdoba, Spain; ⁵Molecular Immunology Group CTS208, Department of Cell Biology, Physiology and Immunology, University of Cordoba, , Spain; ⁶Department of Innovative Technologies in Medicine and Dentistry, University "G d'Annunzio" of Chieti-Pescara, Chieti, Italy.

https://doi.org/10.4081/jbr.2026.15347

096 | Hidden threats: trojan horse effects of microplastics enhance the toxicity of tire-wear chemicals in marine ecosystems Federica Davì, Roberta Fusco, Davide Di Paola | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15348

097 | Pharmaceutical pollution in aquatic environments: effects of valsartan on Mytilus galloprovincialis Giorgia Giurlanda¹, Alessia Caferro¹, Mariacristina Filice¹, Maria Assunta Iovine¹, Alfonsina Gattuso¹, Federica Impellitteri², Caterina Faggio³, Maria Carmela Cerra¹, Sandra Imbrogno¹ | ¹Department of Biology, Ecology, and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy; ²Department of Veterinary Sciences, University of Messina, Italy; ³Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15349

098 | Gill damage in zebrafish exposed to environmentally relevant concentrations of the UV filter avobenzone Antonio Paolo Maria Graziani, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Rachele Macirella, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.

https://doi.org/10.4081/jbr.2026.15350

099 | Mechanistic insights into the ecotoxicity of bisphenol analogues and their mixtures in marine mussels: oxidative stress and neuro-immune responses Antonella Iaconis¹, Marika Cordaro², Davide Di Paola¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; ²Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina,, Italy.

https://doi.org/10.4081/jbr.2026.15351

100 | Tracking polystyrene nanoplastics by raman microscopy reveals intestinal and retinal toxicity Valentina Iezzi¹, Roberta Maria Ferri¹, Annamaria Iannetta², Ludovica Sulcanese², Tommaso Silvestrini², Vanessa D’Altilia², Giovanni Angelozzi², Federico Perrella³, Carino Ferrante⁴, Giulia Fioravanti³, Monia Perugini², Elisabetta Benedetti¹ | ¹Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; ²Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy; ³Department of Physical and Chemical Sciences University of L’Aquila, Italy; ⁴CNR-SPIN, c/o department of Physical and Chemical Sciences University of L’Aquila, Italy.

https://doi.org/10.4081/jbr.2026.15352

101 | Physiological and cellular responses of the Mediterranean mussel to antifouling biocides 2-n-octyl-4-isothiazolin-3-one and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, alone and in mixture Federica Impellitteri¹, Maria Giovanna Rizzo¹, Giuseppe Piccione², Paolo Pastorino³, Cristiana Roberta Multisanti², Caterina Faggio^1|4 | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Messina, Italy; ³Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; ⁴Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15353

102 | Polylactic acid nanoparticles as metabolically active entities: a metabolomics and fluxomics perspective Martina Lombardi^1|2|3, Vera Abenante^2|3, Alessio Trotta^2|3, Erwin Pavel Lamparelli¹, Federica Montella¹, Giovanna Della Porta¹, Andrea Viggiano¹, Jacopo Troisi^1|2|3|4, Antonietta Santoro¹ | ¹Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; ²Theoreo Srl, Montecorvino Pugliano, Salerno, Italy; ³European Institute of Metabolomics - Fondazione EIM, Baronissi, Salerno, Italy; ⁴Department of Chemistry and Biology, “A Zambelli”, University of Salerno, Fisciano [SA], Italy.

https://doi.org/10.4081/jbr.2026.15354

103 | Valorization of olive mill wastewaters for the recovery of polyphenols with reducing, radical scavenging and anti-inflammatory activities Francesco Longo¹, Luisa Tesoriere¹, Claudio Luparello¹, Ignazio Restivo¹, Federica Bellistrì¹, Serena Indelicato¹, David Bongiorno¹, Rosi De Luca¹, Giulia Abruscato¹, Antonio Fabbrizio², Salvatore Terrani³, Mirella Vazzana¹, Vincenzo Arizza¹, Manuela Mauro¹ | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ²Department of Theoretical and Applied Sciences DiSTA, University e Campus, Novedrate [CIO], Italy; ³The Wave Innovation Group, Verona, Italy.

https://doi.org/10.4081/jbr.2026.15355

104 | In vitro crosstalk between perfluorooctanoic acid–induced hypertrophic adipocytes and MCF-7 breast cancer cells Maria Sofia Molonia¹, Federica Lina Salamone^1|2, Santi Trischitta¹, Antonella Saija¹, Antonio Speciale¹, Francesco Cimino¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; ²Imbesi Foundation, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15356

105 | The invasive crab Callinectes sapidus as a model for assessing sub-lethal effects of polyvinyl alcohol Alessandra Maganza^1|2, Alice Gabetti¹, Camilla Mossotto^1|2, Alessia Merialdi¹, Monia Renzi³, Francesca Provenza⁴, Serena Anselmi⁴, Antonia Concetta Elia², Giorgia Zicarelli¹, Annalisa Cotugno¹, Giuseppe Esposito¹, Caterina Faggio^5|6, Marino Prearo¹, Paolo Pastorino¹ | ¹The Veterinary Medical Research Institute for Piemonte, Liguria and Valle d’Aosta, Torino, Italy; ²Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy; ³Bioscience Research Center, Orbetello, Italy; ⁴Department of Life Sciences, University of Trieste, Trieste, Italy; ⁵Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ⁶Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15357

106 | Health effects of noise pollution on juvenile crustaceans: behavioral and molecular responses in Procambarus clarkii Maria Ceraulo^1|2, Giuseppa Buscaino¹, Clarissa De Vita¹, Aiti Vizzini^2|3|*, Mirella Vazzana^2|3, Elena Papale¹, Vincenzo Arizza^2|3, Francesco Longo³, Francesco Paolo Faraone³, Manuela Mauro^2|3 | ¹Institute for the Study of Anthropogenic impacts and Sustainability in the marine environment, National Research Council of Italy, Torretta Granitola, Campobello di Mazara [TP], Italy; ²NBFC, National Biodiversity Future Center, Palermo, Italy; ³Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15358

107 | Protective effects of hydroxytyrosol against dichlorodiphenilethylene-induced oxidative injury in liver cells Vincenzo Migliaccio¹, Ilaria Di Gregorio¹, Martina Coletta¹, Giuliana Panico², Assunta Lombardi², Lillà Lionetti¹ | ¹Dept Chemistry and Biology “Adolfo Zambelli”, University of Salerno, Italy; ²Dept Biology, University Federico II, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15359

108 | Emerging models for emerging contaminants Camilla Mossotto^1|2, Alice Gabetti¹, Alessandra Maganza^1|2, Alessia Merialdi¹, Antonia Concetta Elia², Monia Renzi³, Giuseppe Esposito¹, Marino Prearo¹, Caterina Faggio⁴, Paolo Pastorino¹ | ¹Istituto Zooprofilattico del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; ²Università di Perugia, Italy; ³Università degli Studi di Trieste, Italy; ⁴Università degli Studi di Messina, Italy.

https://doi.org/10.4081/jbr.2026.15360

109 | Novel eco-sustainable approaches to prevent and mitigate emerging contaminants-induced physiological changes in a marine model organisms Cristiana Roberta Multisanti¹, Marina Russo², Paolo Pastorino³, Giuseppe Piccione¹, Federica Impellitteri¹, Caterina Faggio^4|5 | ¹Dept of Veterinary Sciences, University of Messina, Messina, Italy; ²Dept of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Messina Institute of Technology c/o, University of Messina, Messina, Italy; ³Zooprophylactic Institute of Piedmont, Liguria and Valle d'Aosta, Turin, Italy; ⁴Dept of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ⁵Dept of Eco-sustainable Marine Biotechnology, SZN Anton Dohrn, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15361

110 | Integrative ultrastructural and molecular evidence of ferroptosis in lead-exposed zebrafish liver Ilaria Olivito, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.

https://doi.org/10.4081/jbr.2026.15362

111 | Plastic contamination in bycaught yelkouan shearwater (Puffinus yelkouan) from the Mediterranean sea Marco Parolini¹, Federico Tossani¹, Federico De Pascalis², Dimitra Christidi³, Angelos Evangelidis³, Andrea Benvenuti⁴, Sara Di Leo¹, Simona Mondellini¹, Giacomo Dell’Omo⁴, Danae Portolou³, Jacopo G. Cecere², Diego Rubolini¹ | ¹Department of Environmental Science and Policy, University of Milan, Italy; ²Area Avifauna Migratrice, Istituto Superiore per la Protezione e la Ricerca Ambientale ISPRA, Ozzano dell’Emilia, Italy; ³Hellenic Ornithological Society, Athens, Greece; ⁴Animal Tracking, TECHNOSMART EUROPE srl, Guidonia-Montecelio, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15363

112 | Environmental isolation and genetic characterization of first Italian Candida blankii strains: an emerging pathogen Gabriele Parrino¹, Alessia Billè¹, Lucilla Lo Re¹, Bianca Bauso¹, Francesco Mediati¹, Kyrylo Oleksandrovych Hnezdilov¹, Domenico Davide Anania¹, Gabriele Rigano^2|3, Letterio Giuffrè¹, Giuseppe Criseo¹, Orazio Romeo¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; ³PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.

https://doi.org/10.4081/jbr.2026.15364

113 | Ecotoxicological effects of bromuconazole in Oryzias latipes from embryos to adult endpoints Tania Russo^1|2, Ilaria Olivito¹, Iolanda Carratù², Chiara Barone², Ivan Conte², Anna Di Cosmo², Gianluca Polese², Elvira Brunelli¹ | ¹Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende [CS], Italy; ²Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.

https://doi.org/10.4081/jbr.2026.15365

114 | Mechanisms of antimony-induced intestinal injury under chronic low-dose exposure: evidence from Caco‑2 cells and protective role of cyanidin-3-o-glucoside Federica Lina Salamone^1|2, Maria Sofia Molonia¹, Santi Trischitta¹, Antonella Saija¹, Francesco Cimino¹, Antonio Speciale¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ²Imbesi Foundation, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15366

115 | Thyroid-active endocrine disruptors shape distinct neurobehavioral signatures in zebrafish larvae Tommaso Sivestrini^1|2, Annamaria Iannetta¹, Ludovica Sulcanese¹, Giovanni Angelozzi¹, Vanessa D’Altilia¹, Monica Ceci¹, Monia Perugini¹ | ¹Advanced Study “Theoretical and Applied Neuroscience”, Preclinical clinical and Translational Neuroscience, University of Camerino, Italy; ²Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy.

https://doi.org/10.4081/jbr.2026.15367

116 | Exosomes and miRNA content engagement in inflammatory processes let's take stock in the veterinary field Francesca Arfuso¹, Jessica M. Abbate², Claudia Giannetto¹, Marilena Briglia³, Elisabetta Giudice¹, Giovanni Lanteri², Giuseppe Piccione¹ | ¹Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Messina, Italy; ²Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Universitario Papardo, Messina, Italy; ³Department of Medicine and Surgery “Kore”, University of Enna, Italy.

https://doi.org/10.4081/jbr.2026.15368

117 | Modulation of DNA methylation patterns and heat shock proteins following exercise and probiotic supplementation A. Boatta^1|2, G. Messina¹, A. Pagliaro³, A. Alioto³, C. Rossi³, L. Paladino⁴, F. Rappa⁶, F. Naselli⁵, F. Cappello⁶, R. Barone⁶, P. Proia³ | ¹Department of Human Sciences and Promotion of Quality of Life, San Raffaele Roma Open University, Roma, Italy; ²Institute for Biomedical Research and Innovation, CNR, Palermo, Italy; ³Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy; ⁴Department of Theoretical and Applied Sciences DiSTA, eCampus University, Novedrate, Italy; ⁵Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy; ⁶Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15369

118 | Perinatal tissue-derived extracellular vesicles for diabetic wound healing: a translational proposal Mattia Biondo¹, Laura Tomasello², Giuseppina Biscari¹, Grazia L. Di Grado², Calogero Fiorica¹, Fabio S. Palumbo¹, Marian Mellen³, Ismael Santa-Maria³, Antonio S. Laganà², Maite Iglesias³, Giovanna Pitarresi¹, Giuseppe Pizzolanti^2|4 | ¹Dept of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ²Dept of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo, Italy; ³Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain; ⁴ATeN Center, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15370

119 | Insights into interleukin-8–dependent extracellular vesicle-mediated communication in melanoma Gaia Giannitti¹, Kinga Kamińska^2|3, Sara Marchesi¹, Riccardo Garavaglia¹, Ivan Preosto¹, Małgorzata Grzesiak², Fabrizio Fontana¹ | ¹Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Italy; ²Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland; ³Department of Animal Biotechnology, University of Agriculture in Krakow, Poland.

https://doi.org/10.4081/jbr.2026.15371

120 | Exploring CD36-dependent lipid uptake in melanoma–adipocyte communication mediated by extracellular vesicles Gaia Giannitti¹, Kinga Kamińska^2|3, Sara Marchesi¹, Riccardo Garavaglia¹, Ivan Preosto¹, Małgorzata Grzesiak², Fabrizio Fontana¹ | ¹Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Italy; ²Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland; ³Department of Animal Biotechnology, University of Agriculture in Krakow, Poland.

https://doi.org/10.4081/jbr.2026.15372

121 | Probiotics effect on brain-gut axis mediated by nanovescicles Alessandro Lo Giudice¹, Giuseppa D’Amico¹, Melania Ionelia Gratie¹, Letizia Paladino², Giusy Vultaggio¹, Adelaide Carista¹, Francesco Cappello¹, Vita Di Stefano³, Celeste Caruso Bavisotto¹ | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; ²Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy; ³Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15373

122 | Tangential flow filtration enables high-yield isolation and stable characterization of grape-derived extracellular vesicles for therapeutic application Sabino Porro^1|2, Tamer Esmail^1|2, Francesca D’Ascanio^1|2|3, Giulia Colasante^1|2, Arianna Aquilini-Mummolo,^1|2, Luana D’Onofrio^1|2, Mariagiulia Filoso^1|2, Ayesha Younas^1|2, Isabel Maria Vallejo Bermudez^4|5, Camilla Cichella^1|2, Michela Battistelli⁶, Anna Piro⁷, Serena Veschi⁷, Serena Pilato⁷, Antonella Fontana⁷, Alessandro Cama⁷, Angelo Cichelli⁸, Paola Lanuti^1|2, Federica Flamminii⁹ | ¹Department of Medicine and Aging Sciences, University “G d’Annunzio” of Chieti-Pescara, Italy; ²Center for Advanced Studies and Technology CAST; ³Molecular Immunology Group CTS208 Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy; ⁴Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; ⁵Immunology and Allergy Group GC01, Maimonides Biomedical Research Institute of Cordoba IMIBIC, University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain; ⁶Department of Biomolecular Sciences DISB University of Urbino Carlo Bo, Italy; ⁷Department of Pharmacy, University “G d’Annunzio” of Chieti-Pescara, Italy; ⁸Department of Innovative Technologies in Medicine & Dentistry, University “G d’Annunzio” of Chieti-Pescara, Italy; ⁹Department of Promotion of Human Sciences and Quality of Life, San Raffaele Telematic University, Rome, Italy.

https://doi.org/10.4081/jbr.2026.15374

123 | Characterization of extracellular vesicles from the insect Hermetia illucens, a potential source of bioactive molecules Sharon Catrin Raimondi¹, Kristian Riolo¹, Domenico Savastano², Sabrina Oliva¹, Jessica Maria Abbate¹, Antonio Leonardi¹, Alessia Irrera³, Annalisa Pinsino⁴, Alessia Giannetto¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Progetto Hermetia, Gioia Tauro, Reggio Calabria, Italy; ³CNR IMM sede di Messina, Messina, Italy; ⁴Institute of Translational Pharmacology IFT National Research Council CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15375

124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo¹, Francesco Di Pietro¹, Sabrina Oliva¹, Claudia Mosca¹, Valeria Stefanizzi¹, Giovanna Montana², Annalisa Pinsino², Alessia Giannetto¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15376

125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio¹, Giuseppina Poppa¹, Giuseppe Cammarata², Sandra D’Ascenzo¹, Vincenza Dolo¹, Simona Taverna², Ilaria Giusti¹ | ¹Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; ²Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15377

126 | Vertical stratification shapes microbial community assembly in the meromictic Lake Faro water column Erika Arcadi¹, Carmen Rizzo^2|3, Rosario Calogero¹, Marilena Sanfilippo¹, Francesco Fabiano^4|5, Vittoria Dias^2|6, Teresa Romeo^5|7|8 | ¹Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ²Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; ³Institute of Polar Sciences, National Research Council CNR-ISP, Messina, Italy; ⁴Department of Earth and Marine Sciences, University of Palermo, Italy; ⁵National Biodiversity Future Centre NBFC, Italy; ⁶Earth and Environmental Science Department, University of Milano Bicocca, Milano, Italy; ⁷Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Milazzo [ME], Italy; ⁸National Institute for Environmental Protection and Research, Milazzo [ME], Italy.

https://doi.org/10.4081/jbr.2026.15378

127 | Integrated taxonomy methodology applied to phycological herbarium samples from southern Madagascar Valerio Avola¹, Marina Morabito¹, Line Le Gall², Antonio Manghisi¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²Institut de Systématique, Évolution, Biodiversité ISYEB, Muséum National d’Histoire Naturelle, CNRS, Sorbonne Université, EPHE, Université des Antilles, Paris, France.

https://doi.org/10.4081/jbr.2026.15379

128 | Human biodiversity (anthropological, agricultural, and urban) is closely connected to experimental biology studies to understand the present and pave the way for the future Paolo Bonivento | Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15380

129 | Ochratoxin and green coffee: certified analyses to prevent the presence of toxic alien microorganisms transported by logistic carriers Lorenzo Cergol¹, Elena Ramalli¹, Paolo Bonivento² | ¹New Eco srl, Trieste, Italy; ²Istituto di Studi Europei “A De Gasperi”, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15381

130 | Behavioural taxonomy of the common octopus: a framework for understanding individual variation through complex task navigation Emanuela Cirillo^1|2, Tania Russo³, Mariangela Norcia¹, Valeria Maselli¹, Salvatore Valiante¹, Michael Kuba¹, Marco Gamba⁴, Gianluca Polese^1|2, Anna Di Cosmo^1|2 | ¹Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy; ²MNESYS - PNRR partenariato esteso; ³Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende (CS), Italy; ⁴Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Italy.

https://doi.org/10.4081/jbr.2026.15382

131 | First evidence of karyotype diversity and evolution in endemic Scincinae (squamata: scincinae) from madagascar Barbara Cirimele¹, Elvira Brunelli¹, Gaetano Odierna², Fabio M. Guarino², Valentina Basile¹, Marcello Mezzasalma¹ | ¹Department of Biology, Ecology and Earth Science, University of Calabria Rende, Cosenza, Italy; ²Department of Biology, University of Naples Federico II, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15383

132 | Environmental DNA: a preliminary characterization of invertebrate biodiversity in a Sicilian river Manuela Mauro¹, Rosi De Luca¹, Mario Lo Valvo¹, Slobodanka Radovic², Aiti Vizzini¹, Grazia Orecchio¹, Francesco Longo¹, Vinicius Queiroz³, Rosario Badalamenti¹, Claudio Gargano¹, Mirella Vazzana¹ | ¹Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Università Degli Studi di Palermo, Palermo, Italy; ²IGA Technology Services Srl, Udine, Italy; ³Department of Physiology, Institute of Biosciences, University of São Paulo, Brazil.

https://doi.org/10.4081/jbr.2026.15384

133 | Biodiversity and eco-epidemiological distribution of Rickettsia spp. in different biological matrices and vectors in Sicily Santina Di Bella, Virginia Talarico, Cristina Panteghini, Francesca Gucciardi, Giuseppa Purpari, Antonina Princiotta, Valeria Blanda, Elisa Maria Petta, Valeria Vaglica, Annalisa Guercio | Istituto Zooprofilattico Sperimentale della Sicilia “A Mirri”, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15385

134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan¹, Paolo Bonivento² | ¹Nanocoatings Research, Trieste, Italy; ²Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15386

135 | Genotype-dependent modulation of drought-induced responses in durum wheat through wheat–clover intercropping Noemi Gatti¹, Moez Maghrebi¹, Matteo Spada², Giuseppe Mannino¹, Stefania Astolfi², Gianpiero Vigani¹ | ¹University of Turin, Department of Life Sciences and Systems Biology, Turin, Italy; ²University of Tuscia, Department of Agriculture and Forest Sciences, Viterbo, Italy.

https://doi.org/10.4081/jbr.2026.15387

136 | Community structure of ixodid ticks in Mediterranean protected areas: a comparative study of four Sicilian woodlands Paola Galluzzo¹, Ettore Napoli², Sergio Migliore², Federico Cangialosi¹, Elisa Maria Petta¹, Valeria Vaglica¹, Rosario Adragna¹, Davide Pepe¹, Francesca Gucciardi¹, Vincenza Cannella¹, Caterina Elen Culoma², Annalisa Guercio¹, Valeria Blanda¹ | ¹Istituto Zooprofilattico Sperimentale della Sicilia “A Mirri”, Palermo, Italy; ²University of Messina, Department of Veterinary Sciences, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15388

137 | Bluetongue and epizootic hemorrhagic disease in wildlife with particular attention to the Sicilian scenario Francesca Gucciardi¹, Valeria Blanda¹, Paola Galluzzo¹, Sergio Migliore¹, Federico Cangialosi¹, Davide Pepe¹, Valeria Vaglica¹, Antonina Princiotta¹, Santina Di Bella¹, Josephine Muscarella¹, Jessica Pivotti¹, Antonia Raia¹, Ettore Napoli², Annalisa Guercio¹, Giuseppa Purpari¹ | ¹Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; ²Dipartimento di Scienze Veterinarie, Università degli Studi di Messina, Italy.

https://doi.org/10.4081/jbr.2026.15389

138 | Genetic studies to investigate the taxonomic issues of Vespa velutina and Vespa orientalis, expanding in Italian urban and agricultural areas Valeria Maselli¹, Mariangela Norcia¹, Alessia Illiano², Paolo Bonivento³ | ¹Dipartimento di Biologia, Università degli Studi di Napoli Federico II, Napoli, Italy; ²NEW ECO srl, Trieste, Italy; ³Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15390

139 | Municipal and agricultural waste is increasingly complex and impacts local biodiversity electronics integrated with ai systems can help Matteo Mottica¹, Paolo Bonivento² | ¹MQuadro srl, Trieste, Italy; ²Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.

https://doi.org/10.4081/jbr.2026.15391

140 | The “invisible” plastic in our seafood chain: how a simple box can Sabrina Pricl^1|2|3 | ¹Molecular Biology and Nanotechnology Laboratory MolBNL@UniTS, Department of Engineering and Architecture DEA, University of Trieste, Italy; ²Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland; ³Delegate for Friuli Venezia-Giulia Region, WWF Italia, Rome, Italy;.

https://doi.org/10.4081/jbr.2026.15392

141 | An inverted taxonomic approach unveils diversity of cladophoraceae (Chlorophyta) in two nature oriented reserves in northern Sicily (Italy) Matteo Vita¹, Vincenzo Zammuto¹, Mattia Soppelsa¹, Fabio Mondello¹, Salvatore Giacobbe², Marina Morabito¹, Antonio Manghisi¹ | ¹Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²CNR-IRBIM, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15393

142 | Drug repositioning reveals novel therapeutic candidates for spinal muscular atrophy Marina Boido¹, Daniela Maria Rasà¹, Serena Stanga¹, Ersilia Nicorvo¹, Pamela Santonicola², Nadia Mazzarella³, Antonella Camera², Roberto Iacomino², Ilenia Matino², Silvia Chasseur¹, Giuseppina Zampi², Piera Smeriglio⁴, Elia Di Schiavi², Alessandro Vercelli¹ | ¹Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy; ²Institute of Biosciences and BioResources ^IBBR, National Research Council CNR, Naples, Italy; ³Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" IGB-ABT, National Research Council CNR, Naples, Italy; ⁴Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.

https://doi.org/10.4081/jbr.2026.15394

143 | Anodal tDCS enhances decision precision during biological motion perception: a computational active inference perspective Antonio Cangelosi¹, Umberto Quartetti¹, Giulio Musotto², Dimitri Ognibene³, Giuditta Gambino¹, Giuseppe Giglia¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, Section of Human Physiology, University of Palermo, Italy; ²Bioengineering Unit, RiMED Foundation, Palermo, Italy; ³Department of Psychology, University of Milan-Bicocca, Milan, Italy.

https://doi.org/10.4081/jbr.2026.15395

144 | Effect of groove music on pain perception: evidence from a behavioural and electrophysiological study Fabrizio Di Giovanni¹, Marzia Magnanini¹, Antonio Cangelosi¹, Giuditta Gambino¹, Filippo Brighina¹, Pierangelo Sardo¹, Giuseppe Giglia^1|2 | ¹Università degli Studi di Palermo, Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15396

145 | Synergistic effects of APP and Tau on neuronal miRNA regulation Laura M. De Plano¹, Alessandra Saitta¹, Antonella Caccamo¹, Emanuele L. Sciuto¹, Sabrina Conoci², Salvatore Oddo¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Dipartimento di Chimica "Giacomo Ciamician", University of Bologna, Italy.

https://doi.org/10.4081/jbr.2026.15397

146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato¹, Nicolò Ricciardi¹, Valentina Di Liberto¹, Miriana Scordino¹, Giulia Urone¹, Danila Di Majo¹, Giuseppe Giglia^1|4, Pierangelo Sardo¹, Giuseppe Ferraro¹, Riccardo Alessandro^1|2|3, Stefania Raimondo^1|2, Giuditta Gambino¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; ²Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; ³Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; ⁴Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15398

147 | Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease Cristina Giuffré¹, Miriana Scordino¹, Giulia Urone¹, Miriam Buttacavoli¹, Alessandra Montalbano², Marilia Barreca², Roberta Bivacqua², Paola Barraja², Virginia Spano’², Giuseppa Mudo’¹, Valentina Di Liberto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15399

148 | Lysosomal and synuclein pathology in IPSC-derived dopaminergic neurons from GBA1-mutant Parkinson’s disease patients Gaia Pinna¹, Giuseppe Uras^1|2, Veronica Lentini¹, Luca Miuzzo¹, Sara Del Pozo³, Federico Fierli³, Anthony Schapira³, Antonella Pantaleo¹ | ¹Department of Biomedical Science, University of Sassari, Italy; ²Department of Haematology, UCL, London, United Kingdom; ³Department of Clinical and Movement Neurosciences, UCL, London, UK.

https://doi.org/10.4081/jbr.2026.15400

149 | Behavioral markers of epileptogenesis and pharmacoresistance in a longitudinal pilocarpine model of temporal lobe epilepsy Nicolò Ricciardi¹, Miriana Scordino¹, Giulia Urone¹, Miriam Buttacavoli¹, Giuseppa Mudò¹, Pierangelo Sardo¹, Giuseppe Giglia^1|2, Valentina Di Liberto¹, Giuditta Gambino¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Euro Mediterranean Institute of Science and Technology - IEMEST, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15401

150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino¹, Giulia Urone¹, Monica Frinchi¹, Lucia Seidita¹, Alessandra Montalbano², Marilia Barreca², Paola Barraja², Maria Valeria Raimondi², Roberta Bivacqua², Fanny Malhaire³, Cyril Goudet³, Giuseppa Mudò¹, Virginia Spanò², Valentina Di Liberto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ³IGF, Université de Montpellier, CNRS, INSERM, France.

https://doi.org/10.4081/jbr.2026.15402

151 | Dysregulation of the lung-brain axis induced by CMIT/MIT: oxidative stress and junctional protein impairment lead to α-synuclein accumulation and dopaminergic neurotoxicity Nicla Tranchida¹, Rosanna Di Paola², Marika Cordaro³ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Italy; ³Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15403

152 | Genetic and morphological factors in cortical folding: studies on the rolandic fissure Sophie Martinet, Fabrizio Pizzagalli, Alessandro Vercelli | Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy.

https://doi.org/10.4081/jbr.2026.15404

153 | α-synuclein regulation in brain and bone marrow is releted to the differential expression of GATA1 transcription factor Viola Velardi¹, Francesca Arciprete¹, Claudia Caturano,¹Rosa Alba Rana¹, Romina Mancinelli², Maria Zingariello¹, Giorgio Vivacqua¹ | ¹Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; ²Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy.

https://doi.org/10.4081/jbr.2026.15405

154 | Metabolomic reprogramming and ferroptosis protection by the indole-based compound 20 against Aβ (25–35) in SH-SY5Y cells Mariapia Vietri¹, Enza Napolitano¹, Carmen Marino¹, Tania Ciaglia¹, Rodolfo Maria Abbate¹, Pietro Campiglia¹, Alessia Bertamino¹, Michele Manfra², Anna Maria D’Ursi¹, Ornella Moltedo¹, Vincenzo Vestuto¹ | ¹Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy; ²Department of Health Science, University of Basilicata, Potenza, Italy.

https://doi.org/10.4081/jbr.2026.15406

155 | Mitochondrial dynamics and therapeutic insights in spinal muscular atrophy: effects of MFN2 boosting in motoneurons and human fibroblasts Francesco Paolo Zummo¹, Serena Stanga¹, Letizia Paladino², Maria Beltran³, Francesco Fedeli⁴, Maria Rosa Soler³, Fabio Bucchieri⁵, Marina Boido¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy; ²E-Campus University, Palermo, Italy; ³Neuronal Signaling Unit, Experimental Medicine Department, University of Lleida-IRBLleida, Lleida, Spain; ⁴University of Pavia, Italy; ⁵Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15407

156 | Thinned apple polyphenols extract improves skin wound healing by regulating oxidant, angiogenic and fibrotic markers Regina Aparo¹, Ramona D’Amico², Rosalba Siracusa¹, Giancarlo Aldini³, Daniela Impellizzeri¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Medicine and Surgery, “Kore” University of Enna, Italy; ³Department of Pharmaceutical Sciences DISFARM, Università degli Studi di Milano, Italy.

https://doi.org/10.4081/jbr.2026.15408

157 | A preliminary study on the interplay between serum neurotransmitter levels and the behavioral phenotype of Canis familiaris Federica Arrigo¹, Raffaella Cocco², Claudia Giannetto¹, Giuseppe Piccione¹, Alberto Cesarani^3|4, Giuseppe Pulina³, Sara Sechi², Francesca Arfuso¹ | ¹Department of Veterinary Sciences, University of Messina, Messina, Italy; ²Department of Veterinary Medicine, University of Sassari, Italy; ³Department of Agriculture, University of Sassari, Italy; ⁴Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

https://doi.org/10.4081/jbr.2026.15409

158 | Tick-borne pathogens in wild ungulates from Sicily (southern Italy): molecular detection and characterization Valeria Blanda¹, Valeria Vaglica¹, Sergio Migliore¹, Ilenia Giacchino¹, Elisa Maria Petta¹, Federico Cangialosi¹, Rosario Adragna¹, Santina Di Bella¹, Francesca Gucciardi¹, Silvia Scibetta¹, Francesca Grippi¹, Annalisa Guercio¹, Ettore Napoli², Paola Galluzzo¹ | ¹Istituto Zooprofilattico Sperimentale della Sicilia, Palermo, Italy; ²Department of Veterinary Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15410

159 | Innovative and sustainable strategies to recover bioactive molecules from pruning waste Giovanna Cafeo¹, Marina Russo¹, Alessia Arena², Mariosimone Zoccali³, Paola Dugo^1|2, Luigi Mondello^1|2 | ¹Messina Institute of Technology, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ³Department of Mathematical and Computer Science, Physical Sciences and Earth Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15411

160 | Short-term mild caloric restriction induces early adaptive metabolic and mitochondrial responses in the liver of healthy rats Martina Coletta¹, Vincenzo Migliaccio¹, Giuliana Panico², Ilaria Di Gregorio¹, Assunta Lombardi², Lillà Lionetti¹ | ¹Dept Chemistry and Biology "A Zambelli", University of Salerno, Italy; ²Dept Biology, University of Naples Federico II, Naples, Italy.

https://doi.org/10.4081/jbr.2026.15412

161 | Anle 138b inclusion complex with methyl-β-cylodextrin: a novel liquid formulation for administration in Parkinson disease Giuditta Colangelo¹, Adriana Trapani², Giuseppe Fracchiolla², Rosa Angela Cardone³, Anna Patrizia De Nichilo², Stefano Castellani⁴, Michele Maffia⁵, Massimo Conese¹, Rosanna Mallamaci³ | ¹Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; ²Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy; ³Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, Bari, Italy; ⁴Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J, University of Bari “Aldo Moro”, Bari, Italy; ⁵Department of Biological and Environmental Science and Technologies DiSTeBA, University of Salento, Lecce, Italy.

https://doi.org/10.4081/jbr.2026.15413

162 | Functional and health-promoting properties of EVOO from Sicilian olive cultivars: focus on oxidative stress and inflammation Mariateresa Cristani¹, Ali Mert Yetisgin², Giovanni Bartolomeo³, Nicola Cicero^3|4, Rosaria Costa³, Nicola Micale¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; ²İnönü University, Faculty of Pharmacy, Kampüs, Battalgazi/Malatya, Türkiye; ³Department of Biomedical, Dental, Morphological and Functional Images Sciences BIOMORF, University of Messina, Messina, Italy; ⁴Science4Life srl, start-up of the University of Messina, Messina, Italy.

https://doi.org/10.4081/jbr.2026.15414

163 | SIX-2G as a novel compound to attenuate airway inflammation in cystic fibrosis through modulation of molecular chaperones Giuseppa D’Amico¹, Federica Scalia², Maria Antonella Augello¹, Giusi Alberti¹, Roberta Bivacqua³, Marilia Barreca³, Rosario Barone¹, Francesco Cappello¹, Paola Barraja³, Alessandra Montalbano³, Celeste Caruso Bavisotto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Department of Medicine and Surgery, Kore University of Enna, Italy; ³Department of Biological, Chemical, Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15415

164 | Analysis of the regenerative capacity and biochemical composition of pediatric platelet rich plasma in oronasal fistulas Anna Barbara Di Stefano¹, Daniele Matta², Francesca Toia^1|2 | ¹Department of Precision Medicine in Medical, Surgical and Critical Care, Plastic and Reconstructive Surgery Section, Palermo, Italy; ²BIOPLAST-Laboratory of BIOlogy and Regenerative Medicine-PLASTic Surgery, University of Palermo, Italy; ²Department of Precision Medicine in Medical, Surgical and Critical Care, Plastic and Reconstructive Surgery Section, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15416

165 | Preliminary results of a nutritional intervention trial using selenium-biofortified strawberries Antonino Salvatore Fiore, Luigi Di Rosa, Carola Pia Giordano, Sara Baldassano, Sonya Vasto | Department of Biological, Chemical, Pharmaceutical Sciences and Technologies, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15417

166 | Attenuation of Pseudomonas aeruginosa virulence by engineered phage Domenico Franco¹, Salvatore Papasergi², Francesco Mediati¹, Salvatore P.P. Guglielmino¹, Laura Maria De Plano¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; ²Institute of Translational Pharmacology of the National Research Council; ³Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’Compensation Authority INAIL, Italy.

https://doi.org/10.4081/jbr.2026.15418

167 | The importance of personalized oxygen-ozone dosing in systemic therapy: algorithmic solutions for regenerative medicine Antonio Galoforo¹, Paolo Bonivento² | ¹Tavolo Tecnico “Salute ed Ambiente”, Intergruppo parlamentare “One Health”, Camera dei Deputati, Roma, Italy; ²RING - ODR Research Innovation Networking Generation, Organismo di Ricerca, Milano, Italy.

https://doi.org/10.4081/jbr.2026.15419

168 | GLP‑1 receptor signaling directs adipogenic repression and thermogenic activation in human adipose-derived stem cells Carola Pia Giordano, Laura Tomasello, Luigi Di Rosa, Antonino Salvatore Fiore, Sonya Vasto, Sara Baldassano | Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15420

169 | Microbiological resistance and clinical ineffectiveness: an investigation into amoxicillin and amoxicillin/clavulanate efficacy in real-world populations Pierangela Irrera¹, Gabriella Frattima¹, Fabiola De Luca¹, Anna Paola Capra¹, Michela Campolo¹, Alessio Ardizzone², Emanuela Esposito¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy.

https://doi.org/10.4081/jbr.2026.15421

170 | Seeding microvascular fragments and fibroblasts onto poly-L-lactic acid scaffolds for chronic wound healing Francesco La Monica¹, Francesco Carfì Pavia², Simona Campora¹, Alessandra Lo Cicero¹, Gabriele Lo Buglio¹, Camilla Carbone², Veronica Schiera², Gundula Schulze-Tanzil³, Giulio Ghersi^1|4 | ¹STEBICEF Department, University of Palermo, Italy; ²Engineering Department, University of Palermo, Italy; ³Paracelsus Medical University PMU, Nuremberg, Germany; ⁴ABIEL Srl, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15422

171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano¹, Massimo Biondo¹, Adelaide Carista¹, Domiziana Picone¹, Stefano Burgio^2|3, Alberto Fucarino⁴, Francesca Rappa¹, Alessandro Pitruzzella¹, Fabio Bucchieri¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; ³Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; ⁴Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.

https://doi.org/10.4081/jbr.2026.15423

172 | Genetic diversity of Candida albicans in animal hosts Lucilla Lo Re¹, Letterio Giuffrè¹, Silvia Crotti², Deborah Cruciani², Alice Ranucci², Orazio Romeo¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Experimental Zooprophylactic Institute of Umbria and Marche “Togo Rosati”, Perugia, Italy.

https://doi.org/10.4081/jbr.2026.15424

173 | Lab-on-chip (LOC) as a tool for parkinson disease diagnosis: preliminary evaluation of neuronal cell culture on LOC Rosanna Mallamaci¹, Rosangela Cardone¹, Lorenzo Guerra¹, Maria Noemi Sgobba¹, Marilena Ardone¹, Antonio Ancona², Annalisa Volpe^2a, Stefania Caragnano², Salvatore Petralia³, Adriana Trapani⁴ | ¹Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, Bari, Italy; ²Physics Department, Università degli Studi di Bari & Politecnico di Bari, Italy; ³Department of Drug and Health Sciences, University of Catania, Italy; ⁴Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy.

https://doi.org/10.4081/jbr.2026.15425

174 | Mummified lung tissue as a microbiological archive: an integrated approach to investigate past pulmonary microbial communities in 18^th-19^th century Europe Angela Mollica Nardo¹, David Harasser², Dario Piombino-Mascali^3|4 | ¹Life Sciences Center, Vilnius University, Vilnius, Lithuania; ²Institute for Mummy Studies, EURAC Research, Bolzano, Italy; ³Department of Anatomy, Histology, and Anthropology, Vilnius University, Vilnius, Lithuania; ⁴Department of Cultural Heritage, University of Salento, Lecce, Italy.

https://doi.org/10.4081/jbr.2026.15426

175 | Blue value chains: the integration of the marine domain into the International Regulatory Framework Flavia Murabito | Università della Calabria, Rende (CS), Italy.

https://doi.org/10.4081/jbr.2026.15427

176 | Preliminary observations on cannabinoid receptor activation in an in vitro steatosis model and in triple-negative breast cancer cells Roberta Oliveri¹, Gianluca Lavanco², Giovanni Pratelli¹, Diana Di Liberto¹, Fabiana Plescia³, Anna De Blasio³, Francesca Vaccaro², Stella Cascioferro³, Flavia Zingales¹, Marianna Lauricella¹, Rosaria Maria Pipitone², Stefania Grimaudo², Fulvio Plescia², Daniela Carlisi¹ | ¹Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; ²Department of Health Promotion Sciences, Maternal and Child Care, Internal Medicine and Medical Specialties “Giuseppe D'Alessandro”, University of Palermo, Italy; ³Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF - University of Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15428

177 | Efficacy of parasitic treatments in the brown dog tick (Rhipicephalus sanguineus): experimental evidence of acaricide resistance Davide Pepe, Dario Bonomo, Vincenza Cannella, Annalisa Guercio, Santina Di Bella | Istituto Zooprofilattico Sperimentale della Sicilia “A Mirri”, Palermo, Italy.

https://doi.org/10.4081/jbr.2026.15429

178 | Food-borne and environmental pathogens in wild ungulates from Sicily: implications for public health at the wildlife–livestock–human interface Elisa Maria Petta¹, Valeria Vaglica¹, Ilenia Giacchino¹, Paola Galluzzo¹, Sergio Migliore¹, Federico Cangialosi¹, Silvia Scibetta¹, Elena Lo Bue¹, Martina Imburgia¹, Giuseppina Chiarenza¹, Ettore Napoli², Annalisa Guercio¹, Francesca Grippi¹, Valeria Blanda¹ | ¹Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; ²Department of Veterinary Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15430

179 | Body fat reduction in adult women: a longitudinal study after six-month Bikram yoga Federico Zoila^1|2, Francesca Martina Filannino¹, Maria Ida De Stefano¹, Pasquale Simeone¹, Daniela Cagnetta¹, Antonia Cianciulli³, Melania Ruggiero³, Maria Antonietta Panaro³, Chiara Porro¹ | ¹Department of Clinical and Experimental Medicine, University of Foggia, Italy; ²Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy; ³Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy.

https://doi.org/10.4081/jbr.2026.15431

180 | Shared pathways in experimental projects: research, territory, and scientific communities compared the example of the initiatives of the Regional Agency for Rural Development – Ersa (Friuli Venezia Giulia, Italy) Simona Rainis | Regional Agency for the Rural Development ERSA, Gorizia, Italy.

https://doi.org/10.4081/jbr.2026.15432

181 | Exploring boron neutron capture therapy effects on healthy skin: from cells to tissues Stefania Ricci^1|2|3, Silva Bortolussi^3|4, Ricardo Luis Ramos^3|4, Ian Postuma³, Daniele Dondi^3|5, Cinzia Ferrari^3|7, Laura Cansolino^3|7, Tea Maverna², Federica Riva^2|3 | ¹Dept of Internal Medicine and Medical Therapy, University of Pavia, Italy; ²Dept of Experimental Medicine, Histology and Embryology Unit, University of Pavia, Italy; ³National Institute of Nuclear Physics INFN, Unit of Pavia, Italy; ⁴Dept of Physics, University of Pavia, Italy; ⁵Dept of Chemistry, University of Pavia, Italy; ⁶Dept of Molecular Medicine, Human Physiology Unit, University of Pavia, Italy; ⁷Laboratory of Experimental Surgery, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Italy.

https://doi.org/10.4081/jbr.2026.15433

182 | Preliminary data on clinical assessment, blood biochemistry analysis, and infrared thermography in dairy cows affected by foot diseases Maria Rizzo¹, Nicolò Parisi¹, Andrea Spadaro¹, Esterina Fazio¹, Enrico Fiore², Giorgia Taio², Giuseppe Piccione¹, Francesca Arfuso¹, Filippo Spadola¹ | ¹Department of Veterinary Sciences, University of Messina, Polo University Annunziata, Messina, Italy; ²Department of Animal Medicine, Productions and Health MAPS, University of Padua, Legnaro, Italy;.

https://doi.org/10.4081/jbr.2026.15434

183 | Pericyte-like adipose mesenchymal stem cells as a tool for blood-retinal barrier repair Ivana Roberta Romano¹, Giuliana Mannino², Alessio Canovai³, Rosario Amato³, Silvia Marracci³, Matteo Fallico⁴, Claudio Bucolo¹, Rosario Giuffrida¹, Maurizio Cammalleri³, Debora Lo Furno¹ | ¹Dept Biomedical and Biotechnological Sciences, Catania University, Catania, Italy; ²Faculty of Medicine and Surgery, Kore University, Enna, Italy; ³Department of Biology, Pisa University, Italy; ⁴Department of Ophthalmology, University of Catania, Italy.

https://doi.org/10.4081/jbr.2026.15435

184 | Phytochemicals in pruning waste and food industry by-products: biodiversity and circular economy Marina Russo¹, Giovanna Cafeo¹, Luigi Mondello^1|2, Paola Dugo^1|2 | ¹Messina Institute of Technology c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy; ²Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15436

185 | From mycelium to medicine: cytotoxic effects of Ganoderma adspersum extracts in renal cancer cells Maria Noemi Sgobba¹, Nikola Schlosserova^1|2, Biagia Musio³, Federica Mastropirro¹, Antonio Radesco⁴, Maria Favia⁵, Simona Marianna Sanzani⁴, Stefano Todisco³, Mariateresa Volpicella¹, Anna De Grassi¹, Vito Gallo³, Elena Ciani¹, Ciro Leonardo Pierri⁶, Jakub Treml⁷, Lorenzo Guerra¹ | ¹Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; ²Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Czech Republic; ³Department of Civil, Environmental, Land, Building Engineering and Chemistry DICATECh, Polytechnic University of Bari, Italy; ⁴Department of Soil, Plant and Food Sciences, University of Bari, Italy; ⁵Department of Translational Biomedicine and Neurosciences DiBraiN, University of Bari, Italy; ⁶Department of Pharmacy – Pharmaceutical Sciences, University of Bari, Italy; ⁷Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.

https://doi.org/10.4081/jbr.2026.15437

186 | Climatic conditions influence feed intake and body weight in Equus caballus Giulia Sisia, Francesca. Aragona, Francesco Fazio, Giuseppe Piccione, Elisabetta Giudice, Francesca Arfuso, Alessandro Zumbo, Claudia Giannetto | Department of Veterinary Sciences, University of Messina, Italy.

https://doi.org/10.4081/jbr.2026.15438

187 | Beyond marker genes: mitochondrial genomics as a high-resolution tool for Sporothrix schenckii molecular epidemiology Laura Taca¹, Andrea Bonomo², Gabriele Rigano^3|4, Letterio Giuffrè¹, Orazio Romeo¹, Domenico Giosa¹ | ¹Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ²Department of Mathematics, University of Pavia, Italy; ³Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; ⁴PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.

https://doi.org/10.4081/jbr.2026.15439

188 | Frontal sinus osteomas in the mummy of a poor clare nun from Fara in Sabina (17^th-18^th century) Luca Ventura¹, Federico Bruno², Veronica Forte¹, Nadia Gabriele¹, Irene Faenza³, Enrico Petrella⁴, Gianandrea Pasquinelli⁵, Mirko Traversari⁵ | ¹UOC di Anatomia Patologica, Ospedale San Salvatore, L’Aquila, Italy; ²UOC di Neuroradiologia e Radiologia Interventistica, Ospedale San Salvatore, L’Aquila, Italy; ³Dipartimento di Scienze Biomediche e Neuromotorie DIBINEM, Alma Mater Studiorum Università di Bologna, Italy; ⁴Dipartimento di Radiologia, AUSL Romagna, Ospedale Morgagni-Pierantoni, Forlì, Italy; ⁵Dipartimento di Scienze Mediche e Chirurgiche DIMEC, Alma Mater Studiorum Università di Bologna, Italy.

https://doi.org/10.4081/jbr.2026.15440

189 | Fluorescent analysis by confocal microscopy of lipid droplets as a marker of oocyte quality in Sarda sheep under different seasonal conditions Silvia Zaccardi¹, Domenica Cocciolone¹, Guido Macchiarelli¹, Sara Succu², Giovanni Giuseppe Leoni³, Maria Grazia Palmerini¹ | ¹Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; ²Department of Veterinary Medicine, University of Sassari, Italy; ³Department of Biomedical Sciences, University of Sassari, Italy.

https://doi.org/10.4081/jbr.2026.15441

190 | Surface engineering of titanium implants with vanillin-chitosan and cerium doped-nanoparticle coatings for improved osteoimmune response Ioannis Tsamesidis¹, Styliani Axypolitou¹, Georgia K. Pouroutzidou¹, Maria Bousnaki¹, Dimitrios Bikiaris¹, Evi Christodoulou¹, Antonios D. Anastasiou², Eleana Kontonasaki¹ | ¹Aristotle University of Thessaloniki, Greece ²University of Manchester, UK.

https://doi.org/10.4081/jbr.2026.15442