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017 | Targeting lipogenesis promotes the synergistic effect of the selective HDAC inhibitor ITF3756 with bortezomib in colon cancer cells
Marzia Franzò1, Giovanni Pratelli1, Federica Affranchi2, Antonietta Notaro2, Michela Giuliano2, Sonia Emanuele1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, Biochemistry Building, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15269
- 142 abstract views
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011 | Physicochemical and biological evaluation of IgG binding to self-assembling dendrimer nanomicelles
Gabriele Cavalieri, Anna Laura La Monaca, Erik Laurini, Sabrina Pricl | Molecular Biology and Nanotechnology Laboratory - MolBNL@UniTS, Department of Engineering and Architecture - DEA, University of Trieste, Italy.DOI https://doi.org/10.4081/jbr.2026.15263
- 158 abstract views
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024 | In vitro analysis of molecular chaperone involvement in the radiological response of triple-negative breast cancer models
Giusi Alberti1, Giuseppe Vergilio1, Domiziana Picone1, Denise Amico1, Rosario Barone1, Francesca Rappa1, Marco Calvaruso3, Gaia Pucci3, Luigi Minafra3, Antonella Marino Gammazza2 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic BIND, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 3Institute of Bioimaging and Complex Biological Systems-National Reasearch Council IBSBC-CNR, Cefalù-Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15276
- 151 abstract views
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005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16
Maria Antonella Augello1, Giuseppa D’Amico1, Alessandra Maria Vitale1, Rosario Barone1, Simona Rapposelli3, Maciej Wnuk4, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2, Federica Scalia5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Pharmacy, University of Pisa, Italy; 4Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; 5Department of Medicine and Surgery, Kore University of Enna, Italy.DOI https://doi.org/10.4081/jbr.2026.15257
- 180 abstract views
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018 | BSA nanoparticles containing collagenases and doxorubicin to enhance therapeutic efficacy in 3D models of solid tumor
Gabriele Lo Buglio1|2, Alessandra Lo Cicero1, Simona Campora1, Paolo Cinà3Samuel Lenton2, Vito Foderà2, Giulio Ghersi1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Pharmacy, University of Copenhagen, Denmark; 3Abiel srl, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15270
- 159 abstract views
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012 | Anticancer activity of Orobanche crenata leaf extract in human colorectal cancer cell lines
Floriana D’Angeli1, Alfio Distefano2, Laura Orlando2, Elisa Gili3, Valentina Di Salvatore4, Simone Ronsisvalle4, Ivana Roberta Romano2, Giuliana Mannino2, Debora Lo Furno2, Giovanni Giurdanella1, Giovanni Li Volti2, Carlo Genovese1 | 1Department of Medicine and Surgery, School of Medicine and Surgery, University of Enna "Kore", Enna, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Department of Clinical and Experimental Medicine, "Regional Referral Center for Rare Lung Diseases", University, Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Italy; 4Department of Health and Drug Sciences, University of Catania, Italy.DOI https://doi.org/10.4081/jbr.2026.15264
- 166 abstract views
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025 | Protect colorectal cancer: in vitro chemopreventive effects of bronte pistachio extracts on colorectal cancer cells
Graziella Serio1, Roberto Chiarelli1, Giuseppe Mannino2, Samuele Davì1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Life Sciences and Systems Biology, Innovation Centre, University of Turin, Italy.DOI https://doi.org/10.4081/jbr.2026.15277
- 159 abstract views
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006 | Iron-mediated mitochondrial dynamics shape ferroptosis and drug resistance in ovarian cancer cells
Anna Martina Battaglia1, Emanuele Giorgio1, Lavinia Petriaggi1, Giuseppe Natali1, Cristiana Galeano1, Sebastiano Vaccarella2, Giorgia Federico3, Sandra Mota4, Paulo Jorge Oliveira4, Flavia Biamonte1 | 1Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Italy; 2Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy; 4CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.DOI https://doi.org/10.4081/jbr.2026.15258
- 228 abstract views
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling
Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.DOI https://doi.org/10.4081/jbr.2026.15271
- 202 abstract views
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013 | Innovative therapeutic approaches in solid tumors
Alessia Dottore1, Rosalba Rossello2, Francesco Ferraù1 | 1UOC Oncologia Medica, Ospedale “San Vincenzo”, Taormina [ME], Italy; 2UOS Oncologia Medica, Ospedale “Cutroni Zodda”, Barcellona Pozzo di Gotto [ME], Italy.DOI https://doi.org/10.4081/jbr.2026.15265
- 163 abstract views
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026 | Graphene oxide nanosystem for antisense miRNA-21 delivery in hepatocellular carcinoma
Paola Trischitta1, Rosamaria Pennisi1, Maria Teresa Sciortino1, Marta Kutwin2 | 1Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Dep of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland.DOI https://doi.org/10.4081/jbr.2026.15278
- 147 abstract views
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007 | Dysregulation of the trans-sulfuration-sphingosine-1-phosphate signaling axis in glioblastoma: preclinical evidence
Elsa Calcaterra1, Michela Campolo1, Melania Correale2, Rossella Basilotta1, Maria Caffo3, Roberta D’Emmanuele Di Villa Bianca2, Emma Mitidieri2, Giovanna Casili1, Emanuela Esposito1 | 1Department of Chemical, Biological, Pharmaceutical, Environmental Sciences, University of Messina, Italy; 2Department of Pharmacy, School of Medicine and Surgery, University of Study of Naples - Federico II, Naples, Italy; 3Unit of Neurosurgery, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.DOI https://doi.org/10.4081/jbr.2026.15259
- 182 abstract views
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020 | A three-dimensional vascularized cancer model mimicking the tumor microenvironment for drug resistance studies
Alessandra Lo Cicero1, Gabriele Lo Buglio1, Francesco La Monica1, Simona Campora1, Margot Lo Pinto2, Simone Dario Scilabra2, Giulio Ghersi1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Palermo, Italy; 2Proteomics Group of RiMED Foundation, Research Department IRCCS ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy; 3Abiel srl, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15272
- 158 abstract views
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids
Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15266
- 166 abstract views
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027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma
Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15279
- 216 abstract views
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008 | A 3D bioprinted microfluidic Breast Cancer-on-Chip model for studying drug transport and resistance
Simona Campora1, Kimia Abedi2, Alessandra Lo Cicero1, Gabriele Lo Buglio1, Francesco La Monica1, Giulia Palazzo1, Riccardo Barrile2, Giulio Ghersi1|4 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States; 3Center for Stem Cells and Organoid Medicine CuSTOM, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; 4Abiel Srl, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15260
- 218 abstract views
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021 | Novel para-phenylenediamine-based derivatives as receptor tyrosine kinase-like orphan receptor 1 inhibitors: an in vitro preliminary characterization
Maria Rosaria Miranda1, Gerardina Smaldone1, Francesca Di Matteo1, Valeria Napolitano1, Michela Aliberti1, Simona Musella1, Veronica Di Sarno1, Gianluigi Lauro1, Giuseppe Bifulco1, Giacomo Pepe1, Giovanna Aquino1, Mario Felice Tecce1, Isabel Maria Gomez-Monterrey2, Pietro Campiglia1, Carmine Ostacolo1, Alessia Bertamino1, Tania Ciaglia1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Italy; 2Department of Pharmacy, University of Naples Federico II, Naples, Italy.DOI https://doi.org/10.4081/jbr.2026.15273
- 129 abstract views
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models
Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.DOI https://doi.org/10.4081/jbr.2026.15267
- 186 abstract views
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028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine
Alessandra Maria Vitale1, Giuseppa D’Amico1, Martina Di Marco1, Giuseppina Poppa2, Pierlorenzo Maria Veiceschi3, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Paola Limoncelli2, Ilaria Giusti2, Vincenza Dolo2, Claudia Campanella1, Francesca Rappa1, Rosario Barone1, Giovanni Tringali3, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; 3Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.DOI https://doi.org/10.4081/jbr.2026.15280
- 160 abstract views
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009 | Metabolic adaptation to hypoxia via lipid droplet accumulation in a 3D hepatocellular carcinoma model
Giorgia Cannatà1, Caterina Faggio1|2, Maria Giovanna Rizzo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.DOI https://doi.org/10.4081/jbr.2026.15261
- 179 abstract views
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9
Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.DOI https://doi.org/10.4081/jbr.2026.15274
- 158 abstract views
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016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes
Alice Foti1, Fabio Allia1, Marilena Briglia1, Gianpiero Tamburrini2, Roberta Malaguarnera1, Francesco Cecconi2|3, Vittoria Pagliarini2|3, Veronica Marabitti4, Francesca Nazio4, Adriana C.E. Graziano1 | 1University of Enna “Kore”, Enna, Italy; 2Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4University of Rome Tor Vergata, Rome, Italy.DOI https://doi.org/10.4081/jbr.2026.15268
- 165 abstract views
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010 | Combining a gemcitabine-derived prodrug, GEM-C18, with nanoparticles to counteract acidic ph-dependent chemoresistance of pancreatic adenocarcinoma
Francesca Fracasso, Marilena Ardone, Tiago Miguel Amaral Carvalho1|2, Barbara Rolando3, Silvia Arpicco3, Valeria Bincoletto3, Francesca Bianco4, Alessandra Fiorio Pla4, Daniela Isabel Abbrescia5, Ylenia Antonacci5, Chrysovalentinos Pousis5, Sharon Natasha Cox1, Flaviana Marzano5, Graziano Pesole1, Apollonia Tullo5, Stephan Joel Reshikn1, Rosa Angela Cardone1 | 1Dept of Biosciences, Biotechnology and Environment, University of Bari, ltaly; 2CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, Covilhã, Portugal; 3Dept. of Drug Science and Technology, University of Turin, ltaly; 4Dept of Life Sciences and Systems Biology, University of Turin, Italy 5Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies – IBIOM - CNR, Bari, Italy.DOI https://doi.org/10.4081/jbr.2026.15262
- 212 abstract views
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023 | Chaperone-associated macrophage polarization and extracellular matrix remodelling in human glioblastoma
Leila Noori1|2, Rosario Barone1, Giuseppe Vergilio1|2, Maria Antonella Augello1, Giuseppa D’Amico1, Federica Scalia3, Pierlorenzo Veiceschi2, Giovanni Tringali2, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics [BiND], University of Palermo, Italy; 2Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Italy.DOI https://doi.org/10.4081/jbr.2026.15275
- 152 abstract views
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004 | Oncogenic role of circBFAR in pancreatic cancer progression and chemoresistance
Marilena Ardone1, Doron Tolomeo1, Francesca Fracasso1, Tiago Miguel Amaral Carvalho3, Lucrezia Calamo1, Barbara Rolando2, Silvia Arpicco2, Valeria Bincoletto2, Stephan Joel Reshkin1, Clelia Tiziana Storlazzi1, Rosa Angela Cardone1 | 1Dept of Biosciences, Biotechnology and Environment, University of Bari “Aldo Moro”, Bari, Italy; 2Dept of Drug Science and Technology, University of Turin, ltaly; 3Molecular Mechanisms of Cancer Program, Centro de Investigación delCáncer, CSIC and Universidad de Salamanca, Spain.DOI https://doi.org/10.4081/jbr.2026.15256
- 201 abstract views
Session I - Advances in cancer research and therapeutics
25 articles