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Chemotherapy-induced muscle wasting: association with NF-κB and cancer cachexia
3671Downloads: 1744HTML: 195 -
25 | Target adipogenic progenitors to cure Duchenne muscular dystrophy Luca Sali1, B. Periou2, A. Cojocaru1, E. Giry1, G. Severa2, L. Giordani3, V. Taglietti1, E. Malfatti1|2 | 1Univ. Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France; 2Assistance Publique-Hôpitaux de Paris, Centre de Référence de Pathologie Neuromusculaire Nord-Est-Ile-de-France, Filnemus, Hôpital Henri Mondor, Créteil, France; European Reference Center for Neuromuscular Disorders, EURO-NMD, France; 3Sorbonne Université, INSERM UMRS 974, Association Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths?
1182Downloads: 725HTML: 39 -
16 | Immunoproteasome inhibition positively impacts the gut-muscle axis in Duchenne muscular dystrophy Debora Mostosi1, A. Farini2, F. Strati3, M. Molinaro2, S. Saccone2, C. Amoroso3, B. Cassani4, E. Leonetti1, F. Caprioli5, F. Facciotti3, Y. Torrente1|2 | 1Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 2Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy; 4Department of Medical Biotechnologies and Translational Medicine, University of Milan, Italy; 5Department of Pathophysiology and Transplantation, University of Milan, Unit of Gastroenterology and Endoscopy, Fondazione IRCCS Ca’ Granda, Ospedale Policlinico di Milano, Italy.
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29 | RNA-based combinatorial multi-target therapy for the treatment of Duchenne muscular dystrophy Mathieu Horeau, C. Pezzini, M. Sandri | Department of Biomedical Sciences, University of Padova, Italy.
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08 | Combination therapy targeting HDAC8 and SIRT1 improves muscle integrity in a Duchenne muscular dystrophy zebrafish model Sabrina Carbone1, A. Brix1, L. Lociuro1, O. Gjana1, L. Belleri2, M. Schiavone3, A. Marozzi1, F. Del Bene2, C. De Palma1, A. Pezzotta1, A. Pistocchi1 | 1Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy; 2Sorbonne Université, INSERM U968, CNRS UMR 7210, Institut de la Vision, Paris, France; 3Department of Molecular and translational medicine, Università degli Studi di Brescia, Brescia, Italy.
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23 | Preclinical evaluation of 3s-HMGB1 as a therapeutic strategy for Duchenne muscular dystrophy Federica Esposito1, E. Sbolli1, S. Curtarello1, E. Ruggieri1|2, M. Patrone1|2, M. Rodrigues3, V. Taglietti3, F. Relaix3, E. Vénéreau1|2 | 1Unit, Division of Genetics and Cellular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; 2University Vita-Salute San Raffaele, Milan, Italy; 3Univ Paris-Est Créteil, INSERM, U955 IMRB, Créteil, France.
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26 | Validation of a new multi-target antioxidant treatment for the therapy of Duchenne muscular dystrophy F. Fontana1|2, F. Carozzi1, G. Piccoli3, L. Nogara3, G. Romagnoli2, E. Petricci2, B. Blaauw3, M. Canton3, Libero Vitiello1, F. Galvagni2 | 1Dept. of Biology, Univ. of Padova, Italy; 2Dept. of Biotechnology, Chemistry and Pharmacy, Univ. of Siena, Italy; 3Dept. of Biomedical Sciences, Univ. of Padova, Italy.
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15 | GDF5 therapeutic potential for Duchenne muscular dystrophy C. Gentil, A. Bourguiba, A. Vergnol, B. Cadot, Z. Guesmia, L. Saillard, P. Meunier, S. Falcone, L. Giordani, France Pietri-Rouxel | Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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41 | SRT2104 improves muscle and cognitive outcomes and has the potential to enhance μDys gene therapy in Duchenne muscular dystrophy Laura Lociuro1, A. Arcari2, O. Gjana1, G. Scolari1, S.R. Casati1|2, S. Zecchini2, M. Giovarelli2, C. Perrotta2, C. De Palma1 | 1Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, Segrate (MI), Italy; 2Department of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, Italy.
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Abstract 022 | Lecture: new insights leading to improved designs of micro-dystrophins for use in adeno-associated viruses vectors David Hammers, Cora Hart, Matthew Lee, H. Lee Sweeney, and UF Animal Assessment Core | University of Florida Myology Institute, Gainesville, Florida, USA.
92Downloads: 35 -
Assessing muscle architecture with ultrasound: implications for spasticity
1669Downloads: 1040HTML: 12 -
14 | Extracellular matrix guides human neuromuscular organoid morphogenesis Beatrice Auletta1|2|3, P. Chiolerio1|2, G. Cecconi1|2, L. Sartore1|2, L. Rossi1|2, E. Maghin4, S. Angiolillo3|5, S. Calabrò1, O. Gagliano3|5, C. Laterza3|5, M. Cescon1, Y. Torrente6|7, C. Luni8, M. Piccoli4, N. Elvassore3|5, A. Urciuolo1|2 | 1Department of Molecular Medicine, University of Padova, Padova, Italy; 2Neuromuscular Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; 3Department of Industrial Engineering, University of Padova, Padova, Italy; 4Tissue Engineering lab, Istituto di Ricerca Pediatrica, Città della Speranza, Padova, Italy; 5Veneto Institute of Molecular Medicine, Padova, Italy; 6Stem Cell Laboratory, Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 7Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 8Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, Italy.
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21 | Transcriptional and metabolic analyses of cardiac mononucleated cells in dystrophic mdx mice upon treatment with a specific monoamino oxidase B inhibitor Francesca Fontana1|2, F.C. Venegas3|4, E. Baldisseri3|4, R. Sánchez-Rodríguez3|4, A. Reggio5, A. Palma6, M. Canton3|4, L. Vitiello1 | 1Department of Biology, University of Padova, Italy; 2Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy; 3Fondazione Istituto di Ricerca Pediatrica Città della Speranza, IRP, Italy; 4Department of Biomedical Sciences, University of Padova, Italy; 5Saint Camillus International University of Health Sciences, Italy; 6Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Italy.
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Abstract 027 | Investigating skeletal muscle diseases and therapeutics in a donor-derived bioengineered muscle platform Karly A. Caples 1, Yangyi Edward Luo 2, Alexa Cooney 1, Elisabeth Barton 2, Karen Hecht 3, Siobhan Malany 1 | 1Department of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, 32610; 2Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, 32611 3AstraReal, Inc Karly A. 7761 Randolph Rd. NE, Moses Lake, WA 98837.
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11 | Human immortalized myoblasts/induced pluripotent stem cell derived skeletal muscle model to investigate cystinosis myopathy Jianhao Zhang1, R. Mora De La Serna2, M. Smits2, V. Marini1, A. Wang1, M. Biglietto1, M. Campaner Socias1, L. Rinvenuto1, Z. Ge1, R. Gijsbers2|3, M. Sampaolesi1|4 | 1Translational Cardiomyology Laboratory, Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; 2Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; 3Leuven Viral Vector Core, KU Leuven, Leuven, Belgium; 4Histology and Medical Embryology Unit, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy.
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22 | Subcutaneous injection of microencapsulated Sertoli cells is more efficacious than deflazacort treatment in mdx mice Sara Chiappalupi1|2, G. Gentili1|2, L. Salvadori2|3, I. Arato1, F. Mancuso1, M. Paiella1|2, F. Riuzzi1|2, R. Calafiore1, G. Luca1, G. Sorci1|2 | 1Department of Medicine and Surgery, University of Perugia, Italy; 2Interuniversity Institute of Myology (IIM), Perugia, Italy; 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. | S. Chiappalupi and G. Sorci shared Senior authorship; S. Chiappalupi and G. Gentili contributed equally.
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