Advances in Musculoskeletal and Neuromuscular Rehabilitation Open access

A neurophysiological and genetic assessment of a case of rapidly progressive scoliosis

Authors

Published
19 December 2024
Section
Advances in Musculoskeletal and Neuromuscular Rehabilitation
DOI
10.4081/ejtm.2024.13249

Abstract

Scoliosis is a three-dimensional spinal deformity characterized by a lateral deviation of at least 10° Cobb, categorized into idiopathic and non-idiopathic forms, caused by identifiable factors like congenital abnormalities, neuromuscular conditions, or genetic syndromes. This case report discusses a 15-year-old girl with growth delay and Growth Hormone (GH) deficiency who experienced rapid scoliosis progression. Initial evaluations were normal, and Electroencephalography (EEG) showed nonspecific alterations, but further assessment revealed a MYH3 gene variant associated with scoliosis, short stature, and distinct facial features. Treatment with a Lyon ARTbrace and tailored exercises stopped curve progression. This case highlights the need for thorough evaluations in atypical AIS cases to uncover potential causes.

Keywords

References

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