Session VII: SOMMA, Mechanistic Studies of Muscle Aging in Humans

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• Abstract 061 | Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance Gaia Gherardi ¹, Anna Weiser ^2|3, Flavien Bermont ², Eugenia Migliavacca ², Benjamin Brinon ², Guillaume E. Jacot ², Aurelie Hermant ², Mattia Sturlese ⁴, Leonardo Nogara ^1|4, Filippo Vascon ⁵, Agnese De Mario ¹, Andrea Mattarei ⁴, Emma Garratt ^6|7, Mark Burton ⁶, Karen Lillycrop ^6|7|8, Keith M. Godfrey ^6|7|9, Laura Cendron ⁵, Denis Barron ², Stefano Moro ⁴, Bert Blaauw ^1|10, Rosario Rizzuto ^1|11, Jerome N. Feige ^2|12, Cristina Mammucari ^1|11, Umberto De Marchi ^2|14 | ¹Department of Biomedical Sciences, University of Padova, Padova, Italy; ²Nestlé Institute of Health Sciences, Nestlé Research, Socié té des Produit Nestlé S.A., EPFL Innovation Park, Lausanne, Switzerland; ³Molecular Nutritional Medicine, Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Freising, Germany; ⁴Molecular Modeling Section - MMS, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; ⁵Department of Biology, University of Padova, Padova, Italy; ⁶Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; ⁷NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK; ⁸Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; ⁹Medical Research Council Lifecourse Epdemiology Centre, University of Southampton, Southampton, UK; ¹⁰Venetian Institute of Molecular Medicine - VIMM, Padova, Italy; ¹¹Myology Center CIR-Myo, University of Padova, Padova, Italy; ¹²School of Life Sciences, Ecole Polytechnique Federale de Lausanne - EPFL, Lausanne, Switzerland.

  Gaia Gherardi

  https://doi.org/10.4081/ejtm.2026.15060

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  Downloads: 4

• Abstract 059 | Mitochondrial dna variation impacts cellular and physical function in older adults Gregory Tranah ^1|2 | ¹California Pacific Medical Center Research Institute, Sutter Health, San Francisco, California, USA; ²Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

  Gregory Tranah

  https://doi.org/10.4081/ejtm.2026.15058

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  Downloads: 7

• Abstract 058 | Muscle size across the lifespan: D3Cr muscle mass and MRI thigh muscle volume Peggy M. Cawthon ^1|10, Charles E. McCulloch ², Stephen B. Kritchevsky ³, Anne B. Newman ⁴, Russell T. Hepple ⁵, Paul M. Coen ⁶, Bret H. Goodpaster ⁶, Mahalakshmi Shankaran ⁷, Marc Hellerstein ⁷, William J. Evans ⁷, Frederico G.S. Toledo ⁸, Nancy E. Lane ⁹, Megan Hetherington-Rauth ¹ | ¹California Pacific Medical Center Research Institute, San Francisco, CA USA; ²Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA; ³Department of Internal Medicine: Gerontology & Geriatric Medicine and The Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA; ⁴Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA USA; ⁵Department of Physical Therapy, University of Florida, Gainesville, FL USA; ⁶Translational Research Institute, AdventHealth, Orlando, FL, USA; ⁷Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA; ⁸Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; ⁹Department of Internal Medicine, University of California, Davis, USA; ¹⁰Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA .

  Peggy M. Cawthon

  https://doi.org/10.4081/ejtm.2026.15057

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  Downloads: 5

• Abstract 060 | Muscle transcriptomics involved in mitochondrial ets activities are associated with cardiorespiratory fitness and physical performance in older adults in the study of muscle, mobility and aging (somma) Bumsoo Ahn ^1|2, Tyler A. Mansfield ³, Peggy M. Cawthon ^3|4, Paul M. Coen ⁵, Russell T. Hepple ⁶, Karyn A. Esser ⁷, Gregory J. Tranah ^3|4, Nancy W. Glynn ⁸, Daniel S. Evans ^3|4, Theresa Mau ³, Bret H. Goodpaster ⁵, Michael J. Jurczak ⁹, Anne B. Newman ⁸, Steven R. Cummings ^3|4, Stephen B. Kritchevsky ^1|2 | ¹Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; ²Sticht Center for Healthy Aging and Alzheimer’s Prevention, Wake Forest School of Medicine; Winston-Salem, NC, USA; ³San Francisco Coordinating Center, California Pacific Medical Center Research Institute, Sutter health, San Francisco, California, USA; ⁴Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA; ⁵Translational Research Institute, AdventHealth, Orlando, Florida, USA; ⁶Department of Physical Therapy, University of Florida College of Medicine, Gainesville, Florida, USA; ⁷Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL; ⁸Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA; ⁹Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

  Bumsoo Ahn

  https://doi.org/10.4081/ejtm.2026.15059

  39

  Downloads: 3

• Abstract 057 | Skeletal muscle heterogeneity index as a histological indicator of aging muscle impact Russell T. Hepple | University of Florida, Gainesville, FL, USA.

  Russell T. Hepple

  https://doi.org/10.4081/ejtm.2026.15056

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  Downloads: 9