Abstract 061 | Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance

Gaia Gherardi ¹, Anna Weiser ^2|3, Flavien Bermont ², Eugenia Migliavacca ², Benjamin Brinon ², Guillaume E. Jacot ², Aurelie Hermant ², Mattia Sturlese ⁴, Leonardo Nogara ^1|4, Filippo Vascon ⁵, Agnese De Mario ¹, Andrea Mattarei ⁴, Emma Garratt ^6|7, Mark Burton ⁶, Karen Lillycrop ^6|7|8, Keith M. Godfrey ^6|7|9, Laura Cendron ⁵, Denis Barron ², Stefano Moro ⁴, Bert Blaauw ^1|10, Rosario Rizzuto ^1|11, Jerome N. Feige ^2|12, Cristina Mammucari ^1|11, Umberto De Marchi ^2|14 | ¹Department of Biomedical Sciences, University of Padova, Padova, Italy; ²Nestlé Institute of Health Sciences, Nestlé Research, Socié té des Produit Nestlé S.A., EPFL Innovation Park, Lausanne, Switzerland; ³Molecular Nutritional Medicine, Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Freising, Germany; ⁴Molecular Modeling Section - MMS, Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; ⁵Department of Biology, University of Padova, Padova, Italy; ⁶Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; ⁷NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK; ⁸Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; ⁹Medical Research Council Lifecourse Epdemiology Centre, University of Southampton, Southampton, UK; ¹⁰Venetian Institute of Molecular Medicine - VIMM, Padova, Italy; ¹¹Myology Center CIR-Myo, University of Padova, Padova, Italy; ¹²School of Life Sciences, Ecole Polytechnique Federale de Lausanne - EPFL, Lausanne, Switzerland.

Abstract withdrawn to prevent dissemination of unpublished results.