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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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095 | Nanoplastic as modulators of human immune responses: effect on natural killer and T cells Francesca D’Ascanio1|2|3, Isabel María Vallejo Bermúdez4|5, Domenico De Bellis1|2, Giulia Colasante,1|2, Arianna Aquilini1|2, Sabino Porro1|2, Tamer Shibl Ali Esmail1|2, Ayesha Younas1|2, Mariagiulia Filoso1|2, Luana D’Onofrio1|2, Piero Chiacchiaretta1|6, Melania Dovizio1|6, Patrizia Ballerini1|6, Piero Di Carlo1|6, Alejandra Pera4|5, Bruna Sinjiari6, Paola Lanuti1|2. | 1Center for Advanced Studies and Technology CAST, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 2Department of Medicine and Aging Sciences, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 3Department of Humanities, Law and Economics, “Leonardo da Vinci” University, Torrevecchia Teatina, Italy; 4Immunology and Allergy Group GC01, Instituto Maimónides de Investigación Biomédica IMIBIC, Córdoba, Spain; 5Molecular Immunology Group CTS208, Department of Cell Biology, Physiology and Immunology, University of Cordoba, , Spain; 6Department of Innovative Technologies in Medicine and Dentistry, University "G d'Annunzio" of Chieti-Pescara, Chieti, Italy.
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MICRO- AND NANO-PLASTICS: HEALTH, DENTAL PRACTICE, AND ENVIRONMENT Giuseppina DE BENEDETTO1, Veronica FOLLIERO1, Maria Pia DI PALO1, Leonardo AULISIO1, Luca RINALDI2, Gianluigi FRANCI1, Federica DI SPIRITO1 | 1Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; 2Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
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09 | POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTINATION): ORGAN INJURIES AND UNDERLINING MOLECULAR MECHANISMS: EVIDENCE FROM IN VIVO ZEBRAFISH MODEL Marta A. Szychlinska1, Federica Scalia2, Martina Di Marco3, Giusy Vultaggio3, Maria Denise Amico3, Fabiano Capparucci4, Carmelo Iaria4, Marianna Marino5, Erwin Pavel Lamparelli5, Giovanna Della Porta5, Francesca Rappa3, Antonella Marino Gammazza3, Rosario Barone3, Antonino Testa6, Rosaria Meccariello7, Antonietta Santoro5, Francesco Cappello3 | 1Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 2Department of Medicine and Surgery - Kore University of Enna, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 4Department of Chemical, Biological, Pharmacological and Environmental Sciences, University of Messina, Italy; 5Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 6Department of Biological and Pharmaceutical Environmental Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 7Department of Movement and Wellness Sciences, Parthenope University of Naples, Italy
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTAMINATION): SIZE-DEPENDENT EFFECTS OF PLA-DERIVED NANOPLASTICS ON EARLY ZEBRAFISH DEVELOPMENT Giusy VULTAGGIO1, Martina DI MARCO1, Antonietta SANTORO2, Marianna MARINO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Francesco CAPPELLO1,3, Federica SCALIA1,4, Marta Anna SZYCHLINSKA5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery - Kore University of Enna, Enna, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Italy
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.
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086 | Kir4.1 channels at the crossroads of oxidative stress and presbycusis: redox imbalance, electrophysiological failure and quercetin-mediated rescue Sara Spinelli1, Alessia Remigante2, Angela Marino1, Rossana Morabito1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Italy.
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08 | NEURAL AND INTESTINAL IMPACT OF BIODEGRADABLE POLYLACTIC ACID NANOPLASTICS: RESULTS FROM THE PLASTAMINATION PROJECT Antonietta Santoro | Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy; Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy
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025 | Protect colorectal cancer: in vitro chemopreventive effects of bronte pistachio extracts on colorectal cancer cells Graziella Serio1, Roberto Chiarelli1, Giuseppe Mannino2, Samuele Davì1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Life Sciences and Systems Biology, Innovation Centre, University of Turin, Italy.
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121 | Probiotics effect on brain-gut axis mediated by nanovescicles Alessandro Lo Giudice1, Giuseppa D’Amico1, Melania Ionelia Gratie1, Letizia Paladino2, Giusy Vultaggio1, Adelaide Carista1, Francesco Cappello1, Vita Di Stefano3, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy; 3Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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161 | Anle 138b inclusion complex with methyl-β-cylodextrin: a novel liquid formulation for administration in Parkinson disease Giuditta Colangelo1, Adriana Trapani2, Giuseppe Fracchiolla2, Rosa Angela Cardone3, Anna Patrizia De Nichilo2, Stefano Castellani4, Michele Maffia5, Massimo Conese1, Rosanna Mallamaci3 | 1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 2Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, Bari, Italy; 4Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J, University of Bari “Aldo Moro”, Bari, Italy; 5Department of Biological and Environmental Science and Technologies DiSTeBA, University of Salento, Lecce, Italy.
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011 | Physicochemical and biological evaluation of IgG binding to self-assembling dendrimer nanomicelles Gabriele Cavalieri, Anna Laura La Monaca, Erik Laurini, Sabrina Pricl | Molecular Biology and Nanotechnology Laboratory - MolBNL@UniTS, Department of Engineering and Architecture - DEA, University of Trieste, Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy
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024 | In vitro analysis of molecular chaperone involvement in the radiological response of triple-negative breast cancer models Giusi Alberti1, Giuseppe Vergilio1, Domiziana Picone1, Denise Amico1, Rosario Barone1, Francesca Rappa1, Marco Calvaruso3, Gaia Pucci3, Luigi Minafra3, Antonella Marino Gammazza2 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic BIND, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 3Institute of Bioimaging and Complex Biological Systems-National Reasearch Council IBSBC-CNR, Cefalù-Palermo, Italy.
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062 | Enriched bioplastics with natural compounds as innovative hemocompatible biomaterials targeting red blood cells Stefano Putaggio, Annamaria Russo, Giuseppe Tancredi Patanè, Claudia Gravagno, Antonella Calderaro, Davide Barreca, Silvana Ficarra, Ester Tellone | Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy.
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MICROFLUIDIC SYNTHESIS OF PLA NANOPARTICLES: COMPARISON OF DIFFERENT SYSTEMS TO ACHIEVE HIGH SCALABILITY AND BATCH-TO-BATCH REPRODUCIBILITY Federica MONTELLA , Erwin Pavel LAMPARELLI, Giovanna DELLA PORTA | Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy
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150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France.
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075 | Cytotoxic effects of grape seed oils on cancer cells Daniela Ganci1, Giulia Abruscato1, Roberto Chiarelli1, Manuela Mauro1|2, Vincenzo Arizza1|2, Mirella Vazzana1|2, Claudio Luparello1|2 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2NFBC, National Biodiversity Future Center, Palermo, Italy.
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071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia1, Alice Foti1, Fabio Allia1, Rosalia Battaglia1, Giuseppe Piccione2, Alessandro Attanzio3, Caterina Faggio4, Roberta Malaguarnera1, Adriana Carol Eleonora Graziano1 | 1Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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103 | Valorization of olive mill wastewaters for the recovery of polyphenols with reducing, radical scavenging and anti-inflammatory activities Francesco Longo1, Luisa Tesoriere1, Claudio Luparello1, Ignazio Restivo1, Federica Bellistrì1, Serena Indelicato1, David Bongiorno1, Rosi De Luca1, Giulia Abruscato1, Antonio Fabbrizio2, Salvatore Terrani3, Mirella Vazzana1, Vincenzo Arizza1, Manuela Mauro1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Theoretical and Applied Sciences DiSTA, University e Campus, Novedrate [CIO], Italy; 3The Wave Innovation Group, Verona, Italy.
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BIODEGRADATION OF POLYETHYLENE TEREPHTHALATE MICROPLASTIC IN THE RUMEN OF CATTLE Sonia TASSONE1, Salvatore BARBERA1, Valentina BALESTRA2, Rabeb ISSAOUI1, Hatsumi KAIHARA1, Stefania PRAGLIOLA3, Vincenzo VENDITTO3, Khalil ABID1 | 1Dipartimento di Scienze Agrarie, Forestali e Alimentari – Università di Torino; 2Dipartimento di Ingegneria dell’Ambiente, del Territorio e delle Infrastrutture, Politecnico di Torino; 3Dipartimento di Chimica e Biologia – Università di Salerno, Italy
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061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino1, Giovanni Perconti1, Alessia Giannetto2, Andi Alijagic3 | 1Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 3Man-Technology-Environment Research Center MTM, Orebro University, Sweden.
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