Navigating the nexus: unraveling the impact of sustainability and the circular economy on food safety

Sustainable food production systems can be achieved through a circular economy, yet the whole system remains susceptible to various known, emerging, or even unknown/novel food safety hazards and contaminants. These upcycled foods can introduce related risks for human or animal health and ecological balance. These potential risks can be effectively mitigated by adopting integrated smart “safe-by-design” approaches. These multi-effective strategies can cascade far beyond consequences by addressing all potential food safety risks at each stage of the food supply chain, even at the post-consumption stage. Sustainability through circularity without harming food production systems can be achieved by integrating and harmonizing evidence-based risk control strategies, fostered with extensive and objective-oriented research and development, and preemptive ideological relationships with relevant stakeholders. The current review aimed at addressing the possible occurrence and risks associated with potential emerging or unknown hazards/contaminants linked to various production systems, along with relevant mitigation strategies. It also highlights the importance of implementing quality control measures and safety precautions throughout the food supply chain to prevent the occurrence and propagation of hazardous substances. Agricultural production systems can be transformed into sustainable entities by vigilant monitoring of end-product quality through the use of upcycled technologies.

Alegbeleye OO, Singleton I, Sant’Ana AS, 2018. Sources and contamination routes of microbial pathogens to fresh produce during field cultivation: a review. Food Microbiol 73:177-208.

Aro R, Eriksson U, Kärrman A, Chen F, Wang T, Yeung LW, 2021. Fluorine mass balance analysis of effluent and sludge from Nordic countries. Acs Es&T Water 1:2087-96.

Asiri F, Chu KH, 2020. A novel recirculating aquaculture system for sustainable aquaculture: Enabling wastewater reuse and conversion of waste-to-immune-stimulating fish feed. ACS Sustain Chem Eng 8:18094-105.

Banach JL, Hoek‐van den Hil EF, van der Fels‐Klerx HJ, 2020. Food safety hazards in the European seaweed chain. Compr Rev Food Sci Food Saf 19:332-64.

Barros MV, Salvador R, de Francisco AC, Piekarski CM, 2020. Mapping of research lines on circular economy practices in agriculture: from waste to energy. Renew Sustain Energ Rev 131:109958.

Berendsen BJA, Lahr J, Nibbeling C, Jansen LJM, Bongers IEA, Wipfler EL, Van de Schans MGM, 2018. The persistence of a broad range of antibiotics during calve, pig and broiler manure storage. Chemosphere 204:267-76.

Berendsen BJ, Wegh RS, Memelink J, Zuidema T, Stolker LA, 2015. The analysis of animal faeces as a tool to monitor antibiotic usage. Talanta 132:258-68.

Blum KM, Andersson PL, Ahrens L, Wiberg K, Haglund P, 2018. Persistence, mobility and bioavailability of emerging organic contaminants discharged from sewage treatment plants. Sci Total Environ 612:1532-42.

Bodar C, Spijker J, Lijzen J, Waaijers-van der Loop S, Luit R, Heugens E, Janssen M, Wassenaar P, Traas T, 2018. Risk management of hazardous substances in a circular economy. J Environ Manage 212:108-14.

Bodin N, Abarnou A, Fraisse D, Defour S, Loizeau V, Le Guellec AM, Philippon X, 2007. PCB, PCDD/F and PBDE levels and profiles in crustaceans from the coastal waters of Brittany and Normandy (France). Mar Pollut Bull 54:657-68.

Boudra H, Rouillé B, Lyan B, Morgavi DP, 2015. Presence of mycotoxins in sugar beet pulp silage collected in France. Animal Feed Sci Technol 205:131-5.

Bouma K, Kalsbeek-van Wijk DK, Sijm DTHM, 2022. Migration of formaldehyde from ‘biobased’bamboo/melamine cups: a Dutch retail survey. Chemosphere, 292:133439.

Brambilla G, Abate V, Battacone G, De Filippis SP, Esposito M, Esposito V, Miniero, R, 2016. Potential impact on food safety and food security from persistent organic pollutants in top soil improvers on Mediterranean pasture. Sci Total Environ 543:581-90.

Campanati C, Willer D, Schubert J, Aldridge DC, 2022. Sustainable intensification of aquaculture through nutrient recycling and circular economies: more fish, less waste, blue growth. Rev Fish Sci Aquacult 30:143-69.

Campos I, Valente LMP, Matos E, Marques P, Freire F, 2020. Life-cycle assessment of animal feed ingredients: poultry fat, poultry by-product meal and hydrolyzed feather meal. J Clean Prod 252:119845.

Charlton AJ, Dickinson M, Wakefield ME, Fitches E, Kenis M, Han R, Smith R, 2015. Exploring the chemical safety of fly larvae as a source of protein for animal feed. J Insects Food Feed 1:7-16.

Chitescu CL, Nicolau AI, Stolker AAM, 2013. Uptake of oxytetracycline, sulfamethoxazole and ketoconazole from fertilised soils by plants. Food Addit Contam Part A 30: 1138-46.

Conti C, Castrica M, Balzaretti CM, Tedesco DE, 2019. Edible earthworms in a food safety perspective: Preliminary data. Ital J Food Saf 8:7695.

Colovíc D, Rakita S, Banjac V, Đuragić O, Čabarkapa I, 2019. Plant food by-products as feed: Characteristics, possibilities, environmental benefits, and negative sides. Food Rev Int 35:363-89.

Colovíc R, Puvača N, Cheli F, Avantaggiato G, Greco D, Đuragić O, Pinotti L, 2019. Decontamination of mycotoxin-contaminated feedstuffs and compound feed. Toxins 11:617.

Costello MCS, Lee LS, 2020. Sources, fate, and plant uptake in agricultural systems of per-and polyfluoroalkyl substances. Curr Pollut Rep 10:799-819.

Devarajan N, McGarvey JA, Scow K, Jones MS, Lee S, Samaddar S, Schmidt R, Tran TD, Karp DS, 2021. Cascading effects of composts and cover crops on soil chemistry, bacterial communities and the survival of foodborne pathogens. J Appl Microbiol 131:1564-77.

European Parliament, Council of the European Union, 2002. Regulation (EC) No 178/2002 of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. In: Official Journal, L 31, 1/02/2002.

European Parliament, Council of the European Union, 2008. Directive 2008/98/EC of the European Parliament and of the Council of 19 November 2008 on waste and repealing certain Directives. In: Offcial Journal, L 312, 19/11/2008.

European Parliament, Council of the European Union, 2009. Regulation (EC) No 1069/2009 of the European Parliament and of the Council of 21 October 2009 laying down health rules as regards animal by-products and derived products not intended for human consumption and repealing Regulation (EC) No 1774/2002 (Animal by-products Regulation). In: Official Journal, L 300, 14/11/2009.

European Commission, 2013. Commission Regulation (EU) No 68/2013 of 16 January 2013 on the Catalogue of feed materials. In: Official Journal, L 29, 30/01/2013.

European Commission, 2021. Commission Regulation (EU) 2021/1372 of 17 August 2021 amending Annex IV to Regulation (EC) No 999/2001 of the European Parliament and of the Council as regards the prohibition to feed non-ruminant farmed animals, other than fur animals, with protein derived from animals. In: Official Journal, L 295, 18/06/2021.

EFSA, 2024. Emerging chemical risks in food and feed. EFSA Supporting Publications 21:8992E.

FAO, 2006. Food safety risk analysis: a guide for national food safety authorities. Available from: https://www.fao.org/4/a0822e/a0822e00.htm.

FAO, WHO, 2002. Principles and guidelines for incorporating microbiological risk assessment in the development of food safety standards, guidelines and related texts. Available from: https://www.who.int/publications/m/item/guidelines-for-incorporating-microbiological-risk-assessment-food-safety-standards.

FAO, 2023. The future of food safety. Available from: https://openknowledge.fao.org/server/api/core/bitstreams/e37a57ec-26fe-4c0e a7e7-4cdc691d5360/content/safe-food-for-everyone-2023/food-production consumption-technology.html.

FDA, 2022. Hazard analysis and risk-based preventive controls for food for animals, guidance for industry. Available from: https://www.fda.gov/media/110477/download.

Focker M, Van Asselt ED, Berendsen BJA, Van De Schans MGM, Van Leeuwen SPJ, Visser SM, Van der Fels-Klerx HJ, 2022. Review of food safety hazards in circular food systems in Europe. Food Res Int 158:111505.

Gale P, 2004. Risks to farm animals from pathogens in composted catering waste containing meat. Vet Rec 155:77-82.

Garrett RD, Ryschawy J, Bell LW, Cortner O, Ferreira J, Garik AV, Gil JDB, Klerkx L, Moraine M, Peterson CA, Dos Reis JC, Valentim JF, 2020. Drivers of decoupling and recoupling of crop and livestock systems at farm and territorial scales. Ecol Soc 25:24.

Geueke B, Groh K, Muncke J, 2018. Food packaging in the circular economy: overview of chemical safety aspects for commonly used materials. J Clean Prod 193:491-505.

Godenau D, Caceres-Hernandez JJ, Martin-Rodriguez G, Gonzalez-Gomez JI, 2020. A consumption-oriented approach to measuring regional food self-sufficiency. Food Sec 12:1049-63.

Gooding CH, Meeker DL, 2016. Comparison of 3 alternatives for large-scale processing of animal carcasses and meat by-products. The Professional Animal Scientist 32:259-70.

Gullon P, Gullon B, Astray G, Carpena M, Fraga-Corral M, Prieto MA, Simal-Gandara J, 2020. Valorization of by-products from olive oil industry and added-value applications for innovative functional foods. Food Res Int 137:109683.

Gustavsson M, Molander S, Backhaus T, Kristiansson E, 2022. Estimating the release of chemical substances from consumer products, textiles and pharmaceuticals to wastewater. Chemosphere 287:131854.

Gworek B, Kijeńska M, Wrzosek J, Graniewska M, 2021. Pharmaceuticals in the soil and plant environment: a review. Water, Air, Soil Pollut 232:145.

Hamilton KA, Ahmed W, Rauh E, Rock C, McLain J, Muenich RL, 2020. Comparing microbial risks from multiple sustainable waste streams applied for agricultural use: biosolids, manure, and diverted urine. Curr Opin Environ Sci Health 14:37-50.

Hammann A, Ybañez LM, Isla MI, Hilal MB, 2019. Potential agricultural use of a sub product (olive cake) from olive oil industries composting with soil. J Pharm Pharmacogn Res 8:43-52.

Hernando-Amado S, Coque TM, Baquero F, Martínez JL, 2019. Defining and combating antibiotic resistance from One Health and Global Health perspectives. Nat Microbiol 4:1432-42.

Heres L, Hoogenboom RLAP, Herbes R, Traag W, Urlings B, 2010. Tracing and analytical results of the dioxin contamination incident in 2008 originating from the Republic of Ireland. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1733-44.

Hoogenboom LA, Van Eijkeren JCH, Zeilmaker MJ, Mengelers MJ, Herbes R, Immerzeel J, Traag WA, 2007. A novel source for dioxins present in recycled fat from gelatin production. Chemosphere 68:814-23.

https://openknowledge.fao.org/server/api/core/bitstreams/e37a57ec-26fe-4c0e a7e7-4cdc691d5360/content/safe-food-for-everyone-2023/food-production consumption-technology.html

Islam M, Morgan J, Doyle MP, Phatak SC, Millner P, Jiang X, 2004. Fate of Salmonella enterica serovar Typhimurium on carrots and radishes grown in fields treated with contaminated manure composts or irrigation water. Appl Environ Microbiol 70:2497-502.

Jansen LJ, Bolck YJ, Rademaker J, Zuidema T, Berendsen BJ, 2017. The analysis of tetracyclines, quinolones, macrolides, lincosamides, pleuromutilins, and sulfonamides in chicken feathers using UHPLC-MS/MS in order to monitor antibiotic use in the poultry sector. Anal Bioanal Chem 409:4927-41.

Johnson CJ, Phillips KE, Schramm PT, McKenzie D, Aiken JM, Pedersen JA, 2006. Prions adhere to soil minerals and remain infectious. PLoS Pathog 2:e32.

Johnson CJ, Pedersen JA, Chappell RJ, McKenzie D, Aiken JM, 2007. Oral transmissibility of prion disease is enhanced by binding to soil particles. PLoS Pathog 3:e93.

Klase G, Lee S, Liang S, Kim J, Zo YG, Lee J, 2019. The microbiome and antibiotic resistance in integrated fishfarm water: Implications of environmental public health. Sci Total Environ 649:1491-501.

Kouba A, Lunda R, Hlaváč D, Kuklina I, Hamáčková J, Randák T, Buřič M, 2018. Vermicomposting of sludge from recirculating aquaculture system using Eisenia andrei: technological feasibility and quality assessment of end-products. J Clean Prod 177:665-73.

Lange L, Meyer AS, 2019. Potentials and possible safety issues of using biorefinery products in food value chains. Trends Food Sci Technol 84:7-11.

Lee JI, Cho EJ, Lyonga FN, Lee CH, Hwang SY, Kim DH, Lee CG, Park SJ, 2021. Thermo-chemical treatment for carcass disposal and the application of treated carcass as compost. Appl Sci 11:431.

Lemunier M, Francou C, Rousseaux S, Houot S, Dantigny P, Piveteau P, Guzzo J, 2005. Long-term survival of pathogenic and sanitation indicator bacteria in experimental biowaste composts. Appl Environ Microbiol 71:5779-86.

Liu H, Whitehouse CA, Li B, 2018. Presence and persistence of Salmonella in water: the impact on microbial quality of water and food safety. Front Public Health 6:159.

Lopez Cabo M, Romalde J, Simal-Gandara J, Gago Martínez A, Giráldez Fernández J, Bernárdez Costas M, del Hierro SP, Ortega AP, Manaia CM, Silva JA, Rodríguez Herrera J, 2020. Identification of emerging hazards in mussels by the Galician emerging food safety risks network (RISEGAL). A first approach. Foods 9:1641.

Lu D, Wang L, Yan B, Ou Y, Guan J, Bian Y, Zhang Y, 2014. Speciation of Cu and Zn during composting of pig manure amended with rock phosphate. Waste Manag 34:1529-36.

Ma W, Kahn RE, Richt JA, 2009. The pig as a mixing vessel for influenza viruses: human and veterinary implications. J Mol Genet Med 3:158-66.

Mancini S, Fratini F, Tuccinardi T, Degl’Innocenti C, Paci G, 2020. Tenebrio molitor reared on different substrates: is it gluten free? Food Control 110:107014.

Marsh K, Bugusu B, 2007. Food packaging—roles, materials, and environmental issues. J Food Sci 72:R39-55.

Mason PE, Higgins L, Climent Barba F, Cunliffe A, Cheffins N, Robinson D, Jones JM, 2020. An assessment of contaminants in UK road-verge biomass and the implications for use as anaerobic digestion feedstock. Waste Biomass Valorization 11:1971-81.

Mastanjevic K, Lukinac J, Jukić M, Šarkanj B, Krstanović V, Mastanjević K, 2019. Multi-(myco) toxins in malting and brewing by-products. Toxins 11:30.

McBride MB, Shayler HA, Russell-Anelli JM, Spliethoff HM, Marquez-Bravo LG, 2015. Arsenic and lead uptake by vegetable crops grown on an old orchard site amended with compost. Water Air Soil Pollut 226:265

Meyer AM, Meijer N, Hoek-Van den Hil EF, Van der Fels-Klerx HJ, 2021. Chemical food safety hazards of insects reared for food and feed. J Insects Food Feed 7:823-31.

Milanović V, Roncolini A, Cardinali F, Garofalo C, Aquilanti L, Riolo P, Osimani A, 2021. Occurrence of antibiotic resistance genes in Hermetia illucens larvae fed coffee silverskin enriched with Schizochytrium limacinum or Isochrysis galbana microalgae. Genes, 12:213.

Miller A, Russell C, 2017. Food crops irrigated with cyanobacteria-contaminated water: an emerging public health issue in Canada. Environ Health Rev 60:58-63.

Millner P, Reynolds S, Nou X, Krizek D, 2009. High tunnel and organic horticulture: compost, food safety, and crop quality. HortScience 44:242-5.

Morais T, Inácio A, Coutinho T, Ministro M, Cotas J, Pereira L, Bahcevandziev K, 2020. Seaweed potential in the animal feed: a review. J Mar Sci Eng 8:559.

Mulder AC, Franz E, de Rijk S, Versluis MA, Coipan C, Buij R, Mughini-Gras L, 2020. Tracing the animal sources of surface water contamination with Campylobacter jejuni and Campylobacter coli. Water Res 187:116421.

Navarro S, Vela N, 2009. Fate of pesticide residues during brewing. In: Preedy VR, eds. Beer in health and disease prevention. Academic Press, Cambridge, MA, USA.

Nilsen‐Nygaard J, Fernández EN, Radusin T, Rotabakk BT, Sarfraz J, Sharmin N, Sone I, Pettersen MK, 2021. Current status of biobased and biodegradable food packaging materials: Impact on food quality and effect of innovative processing technologies. Compr Rev Food Sci Food Saf 20:1333-80.

Nomeda S, Valdas P, Chen SY, Lin JG, 2008. Variations of metal distribution in sewage sludge composting. Waste Manag 28:1637-44.

Nordentoft S, Cederberg TL, Fischer CH, Bjerrum L, 2014. Accumulation of dioxins and PCB in house fly larvae (musca domestica) reared in poultry manure and used in feed for organic laying hens. Available from: https://backend.orbit.dtu.dk/ws/portalfiles/portal/103601076/Dioxin2014_Dioxins_in_fly_larvae.pdf.

Ominski K, McAllister T, Stanford K, Mengistu G, Kebebe EG, Omonijo F, Wittenberg K, 2021. Utilization of by-products and food waste in livestock production systems: a Canadian perspective. Anim Front 11:55-63.

Osimani A, Ferrocino I, Corvaglia MR, Roncolini A, Milanović V, Garofalo C, Clementi F, 2021. Microbial dynamics in rearing trials of Hermetia illucens larvae fed coffee silverskin and microalgae. Food Res Int 140:110028.

Parlavecchia M, Carnimeo C, Loffredo E, 2020. Soil amendment with biochar, hydrochar and compost mitigates the accumulation of emerging pollutants in rocket salad plants. Water, Air, Soil Pollut 231:554.

Parfitt J, Barthel M, Macnaughton S, 2010. Food waste within food supply chains: quantification and potential for change to 2050. Philos Trans R Soc 365:3065-81.

Parodi A, Gerrits WJ, Van Loon JJ, De Boer IJ, Aarnink AJ, Van Zanten HH, 2021. Black soldier fly reared on pig manure: bioconversion efficiencies, nutrients in the residual material, greenhouse gas and ammonia emissions. Waste Manag 126:674-83.

Peters RJ, Groeneveld I, Sanchez PL, Gebbink W, Gersen A, de Nijs M, van Leeuwen SP, 2019. Review of analytical approaches for the identification of non-intentionally added substances in paper and board food contact materials. Trends Food Sci Technol 85:44-54.

Pivnenko K, Laner D, Astrup TF, 2016. Material cycles and chemicals: dynamic material flow analysis of contaminants in paper recycling. Environ Sci Technol 50:12302-11.

Pritzkow S, Morales R, Moda F, Khan U, Telling GC, Hoover E, Soto C, 2015. Grass plants bind, retain, uptake, and transport infectious prions. Cell Rep 11:1168-75.

Reemtsma T, Berger U, Arp HPH, Gallard H, Knepper TP, Neumann M, Quintana JB, Voogt PD, 2016. Mind the Gap: Persistent and Mobile Organic Compounds Water Contaminants That Slip Through. Environ Sci Technol 50:10308-15.

Salemdeeb R, Zu Ermgassen EK, Kim MH, Balmford A, Al-Tabbaa A, 2017. Environmental and health impacts of using food waste as animal feed: a comparative analysis of food waste management options. J Clean Prod 140:871-80.

Sterk A, Schijven J, de Nijs T, de Roda Husman AM, 2013. Direct and indirect effects of climate change on the risk of infection by water-transmitted pathogens. Environ Sci Technol 47:12648-60.

Sun Y, Guo Y, Shi M, Qiu T, Gao M, Tian S, Wang X, 2021. Effect of antibiotic type and vegetable species on antibiotic accumulation in soil-vegetable system, soil microbiota, and resistance genes. Chemosphere 263:128099.

Suplicy FM, 2020. A review of the multiple benefits of mussel farming. Rev Aquacult 12:204-23.

Tedesco DE, Conti C, Lovarelli D, Biazzi E, Bacenetti J, 2019. Bioconversion of fruit and vegetable waste into earthworms as a new protein source: the environmental impact of earthworm meal production. Sci Total Environ 683:690-8.

Terry LA, Howells L, Bishop K, Baker CA, Everest S, Thorne L, Gough KC, 2011. Detection of prions in the faeces of sheep naturally infected with classical scrapie. Vet Res 42:1-7.

Thakali A, MacRae JD, 2021. A review of chemical and microbial contamination in food: what are the threats to a circular food system?. Environ Res 194:110635.

Thévenot A, Rivera JL, Wilfart A, Maillard F, Hassouna M, Senga-Kiesse T, Aubin J, 2018. Mealworm meal for animal feed: environmental assessment and sensitivity analysis to guide future prospects. J Clean Prod 170:1260-7.

Tozzoli R, Di Bartolo I, Gigliucci F, Brambilla G, Monini M, Vignolo E, Caprioli A, Morabito S, 2017. Pathogenic Escherichia coli and enteric viruses in biosolids and related top soil improvers in Italy. J Appl Microbiol 122:239-47.

Truzzi C, Annibaldi A, Girolametti F, Giovannini L, Riolo P, Ruschioni S, Illuminati S, 2020. A chemically safe way to produce insect biomass for possible application in feed and food production. Int J Environ Res Public Health 17:2121.

Truzzi C, Illuminati S, Girolametti F, Antonucci M, Scarponi G, Ruschioni S, Annibaldi A, 2019. Influence of feeding substrates on the presence of toxic metals (Cd, Pb, Ni, As, Hg) in larvae of Tenebrio molitor: risk assessment for human consumption. Int J Environ Res Public Health 16:4815.

Tschirner M, Simon A, 2015. Influence of different growing substrates and processing on the nutrient composition of black soldier fly larvae destined for animal feed. J Insects Food Feed 1:249-59.

UNEP, 2021. Reducing consumer food waste using green and digital technologies. Available from: https://unepccc.org/wp-content/uploads/2021/11/reducing-consumer-food-waste-using-green-and-digital-technologies.pdf.

Van der Berg JP, Kleter GA, Battaglia E, Bouwman LM, Kok EJ, 2020. Application of the safe-by-design concept in crop breeding innovation. Int J Environ Res Public Health 17:6420.

Van der Fels-Klerx HJ, Bouzembrak Y, 2016. Modelling approach to limit aflatoxin B1 contamination in dairy cattle compound feed. World Mycotoxin J 9:55-64.

Van der Fels‐Klerx HJ, Camenzuli L, Belluco S, Meijer N, Ricci A, 2018. Food safety issues related to uses of insects for feeds and foods. Compr Rev Food Sci Food Saf 17:1172-83.

van der Fels-Klerx HJ, van Asselt ED, Adamse P, Nijkamp MN, van Leeuwen SPJ, Pikkemaat M, de Nijs M, Mol H, van Raamsdonk L, Hoogenboom R, de Jong J, 2019. Chemische en fysische gevaren in de Nederlandse diervoederketen. Available from: https://research.wur.nl/en/publications/chemische-en-fysische-gevaren-in-de-nederlandse-diervoederketen.

Van der Heide ME, Stødkilde L, Værum Nørgaard J, Studnitz M, 2021. The potential of locally-sourced european protein sources for organic monogastric production: a review of forage crop extracts, seaweed, starfish, mussel, and insects. Sustainability 13:2303.

Van Raamsdonk LWD, Van der Fels-Klerx HJ, De Jong J, 2017. New feed ingredients: the insect opportunity. Food Addit Contam Part A 34:1384-97.

Van Rijn J, 2013. Waste treatment in recirculating aquaculture systems. Aquacult Eng 53:49-56.

Van Zanten HH, Herrero M, Van Hal O, Röös E, Muller A, Garnett T, Gerber PJ, Schader C, De Boer IJ, 2018. Defining a land boundary for sustainable livestock consumption. Glob Chang Biol 24:4185-94.

Varotto Boccazzi I, Ottoboni M, Martin E, Comandatore F, Vallone L, Spranghers T, Epis, S, 2017. A survey of the mycobiota associated with larvae of the black soldier fly (Hermetia illucens) reared for feed production. PloS One 12:e0182533.

Veldkamp T, van Rozen K, Elissen H, van Wikselaar P, van der Weide R, 2021. Bioconversion of digestate, pig manure and vegetal residue-based waste operated by black soldier fly larvae, Hermetia illucens L.(Diptera: Stratiomyidae). Animals 11:3082.

Wang Y, Li L, Xiong R, Guo X, Liu J, 2019. Effects of aeration on microbes and intestinal bacteria in bioaerosols from the BRT of an indoor wastewater treatment facility. Sci Total Environ 648:1453-61.

WHO, 2021. The state of food security and nutrition in the world 2021: transforming food systems for food security, improved nutrition and affordable healthy diets for all. Available from: https://openknowledge.fao.org/server/api/core/bitstreams/1c38676f-f5f7-47cf-81b3-f4c9794eba8a/content.

Wirza R, Nazir S, 2021. Urban aquaponics farming and cities-a systematic literature review. Rev Environ Health 36:47-61.

Wynants E, Crauwels S, Verreth C, Gianotten N, Lievens B, Claes J, Van Campenhout L, 2018. Microbial dynamics during production of lesser mealworms (Alphitobius diaperinus) for human consumption at industrial scale. Food Microbiol 70:181-91.

Xu S, Reuter T, Gilroyed BH, Dudas S, Graham C, Neumann NF, Balachandran A, Czub S, Belosevic M, Leonard JJ, McAllister TA, 2013. Biodegradation of specified risk material and fate of scrapie prions in compost. J Environ Sci Health A Tox Hazard Subst Environ Eng 48:26-36.

Yildirim S, Yildirim DÇ, 2020. Achieving sustainable development through a green economy approach. In Advanced integrated approaches to environmental economics and policy: Eemerging research and opportunities. IGI Global, Hershey, PA, USA.

Zhelyazkov G, Yankovska-Stefanova T, Mineva E, Stratev D, Vashin I, Dospatliev L, Valkova E, Popova T, 2018. Risk assessment of some heavy metals in mussels (Mytilus galloprovincialis) and veined rapa whelks (Rapana venosa) for human health. Mar Pollut Bull 128:197-201.

Zhen H, Jia L, Huang C, Qiao Y, Li J, Li H, Chen Q, Wan Y, 2020. Long-term effects of intensive application of manure on heavy metal pollution risk in protected-field vegetable production. Environ Pollut 263:114552.

Zhou H, Yang WT, Zhou X, Liu L, Gu JF, Wang WL, Liao BH, 2016. Accumulation of heavy metals in vegetable species planted in contaminated soils and the health risk assessment. Int J Environ Res Public Health13:289.