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125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio1, Giuseppina Poppa1, Giuseppe Cammarata2, Sandra D’Ascenzo1, Vincenza Dolo1, Simona Taverna2, Ilaria Giusti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.
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094 | 2-octyl-2h-isothiazol-3-one and its role in zebrafish larvae neurogenesis and neuronal function Vanessa D’Altilia1, Ludovica Sulcanese1, Valentina Iezzi2, Silvana Zugaro2, Annamaria Iannetta1, Tommaso Silvestrini1|3, Elisabetta Benedetti2, Monia Perugini1. | 1Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy; 2Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy; 3University of Camerino, International School of Advanced Studies, Camerino, Italy.
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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024 | In vitro analysis of molecular chaperone involvement in the radiological response of triple-negative breast cancer models Giusi Alberti1, Giuseppe Vergilio1, Domiziana Picone1, Denise Amico1, Rosario Barone1, Francesca Rappa1, Marco Calvaruso3, Gaia Pucci3, Luigi Minafra3, Antonella Marino Gammazza2 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic BIND, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 3Institute of Bioimaging and Complex Biological Systems-National Reasearch Council IBSBC-CNR, Cefalù-Palermo, Italy.
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112 | Environmental isolation and genetic characterization of first Italian Candida blankii strains: an emerging pathogen Gabriele Parrino1, Alessia Billè1, Lucilla Lo Re1, Bianca Bauso1, Francesco Mediati1, Kyrylo Oleksandrovych Hnezdilov1, Domenico Davide Anania1, Gabriele Rigano2|3, Letterio Giuffrè1, Giuseppe Criseo1, Orazio Romeo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; 3PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.
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PERINATAL EXPOSURE TO BISPHENOL A AND BISPHENOL B CAN ALTER THE SEXUAL BEHAVIOUR AND REPRODUCTIVE SYSTEM OF OFFSPRING Elena RICCI1,2, Marilena MARRAUDINO1,2, Noemi CADORIN1, Iva SABOVIC3, Alberto FERLIN3, Stefano GOTTI1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Torino, Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy; 3Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy
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057 | Bioactive metabolites from antarctic sponge-associated bacteria: bioactivity and cytotoxic assessment Claudia Gravagno1|2, Stefano Putaggio2, Teresa Romeo2|3, Annamaria Russo2, Carmen Rizzo2|4, Ester Tellone2, Angelina Lo Giudice4 | 1Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; 2University of Messina, Italy; 3National Institute for Environmental Protection and Research, Milazzo [ME], Italy; 4National Research Council, Institute of Polar Sciences, Messina, Italy.
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110 | Integrative ultrastructural and molecular evidence of ferroptosis in lead-exposed zebrafish liver Ilaria Olivito, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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098 | Gill damage in zebrafish exposed to environmentally relevant concentrations of the UV filter avobenzone Antonio Paolo Maria Graziani, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Rachele Macirella, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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058 | Interaction between cyclic peptides and lipids: spectroscopic, calorimetric and structural analysis Anna Laura La Monaca, Gabriele Cavalieri, Erik Laurini, Sabrina Pricl | Molecular Biology and Nanotechnology Laboratory MolBNL@UniTs, Department of Engineerig and Architecture DEA, University of Trieste, Italy.
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163 | SIX-2G as a novel compound to attenuate airway inflammation in cystic fibrosis through modulation of molecular chaperones Giuseppa D’Amico1, Federica Scalia2, Maria Antonella Augello1, Giusi Alberti1, Roberta Bivacqua3, Marilia Barreca3, Rosario Barone1, Francesco Cappello1, Paola Barraja3, Alessandra Montalbano3, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy; 3Department of Biological, Chemical, Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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106 | Health effects of noise pollution on juvenile crustaceans: behavioral and molecular responses in Procambarus clarkii Maria Ceraulo1|2, Giuseppa Buscaino1, Clarissa De Vita1, Aiti Vizzini2|3|*, Mirella Vazzana2|3, Elena Papale1, Vincenzo Arizza2|3, Francesco Longo3, Francesco Paolo Faraone3, Manuela Mauro2|3 | 1Institute for the Study of Anthropogenic impacts and Sustainability in the marine environment, National Research Council of Italy, Torretta Granitola, Campobello di Mazara [TP], Italy; 2NBFC, National Biodiversity Future Center, Palermo, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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131 | First evidence of karyotype diversity and evolution in endemic Scincinae (squamata: scincinae) from madagascar Barbara Cirimele1, Elvira Brunelli1, Gaetano Odierna2, Fabio M. Guarino2, Valentina Basile1, Marcello Mezzasalma1 | 1Department of Biology, Ecology and Earth Science, University of Calabria Rende, Cosenza, Italy; 2Department of Biology, University of Naples Federico II, Naples, Italy.
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POLY-LACTIC ACID NANOPLASTICS BIOCCUMULATE IN DEVELOPING ZEBRAFISH AND INDUCE EPIGENETIC CHANGES Massimo VENDITTI1, Marta Anna SZYCHLINSKA2, Valentina LOPARDO3, Federica SCALIA4, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Francesco CAPPELLO5, Rosaria MECCARIELLO6 | 1Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Palermo, Italy; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy; 4Department of Medicine and Surgery, “Kore” University of Enna, Enna, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 6Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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187 | Beyond marker genes: mitochondrial genomics as a high-resolution tool for Sporothrix schenckii molecular epidemiology Laura Taca1, Andrea Bonomo2, Gabriele Rigano3|4, Letterio Giuffrè1, Orazio Romeo1, Domenico Giosa1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Mathematics, University of Pavia, Italy; 3Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; 4PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.
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006 | Iron-mediated mitochondrial dynamics shape ferroptosis and drug resistance in ovarian cancer cells Anna Martina Battaglia1, Emanuele Giorgio1, Lavinia Petriaggi1, Giuseppe Natali1, Cristiana Galeano1, Sebastiano Vaccarella2, Giorgia Federico3, Sandra Mota4, Paulo Jorge Oliveira4, Flavia Biamonte1 | 1Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Italy; 2Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy; 4CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
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070 | Role of bioactive extracts obtained from marine sources and agri-food industry by-products in ETosis modulation Federica Bellistrì1, Giulia Abruscato1, Manuela Perlotti1, Alessia Lo Muzzo1, Claudio Gargano1, Francesco Longo1, Manuela Mauro1, Roberto Chiarelli1, Vincenzo Arizza1|3, Claudio Luparello1|3, Gianluca Sarà2|3, Mirella Vazzana1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Earth and Marine Sciences, Palermo, Italy; 3National Biodiversity Future Center, Palermo, Italy.
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IDENTIFICATION OF D. MELANOGASTER ENZYMES POTENTIALLY INVOLVED IN PENTACHLOROPHENOL DEGRADATION M. CASTALDO1,2, D.M. MONTI2, A. TESTA3, J. VONTAS4,5, D. TSAKIRELLI4,5, M.M. MONTI1, P.A. PEDATA1 | 1Institute for Sustainable Plant Protection (CNR-IPSP), Portici (NA), Italy; 2Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy; 3Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 4Pesticide Science Lab, Agricultural University of Athens, Athens, Greece; 5Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
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032 | Natural exposure to Lactococcus garvieae in rainbow trout: evidence of susceptibility and clinical outcomes Annalisa Cotugno1, Sara Glorio Patrucco1, Giorgia Zicarelli1, Silvia Colussi1|2, Martina Gini1, Pier Luigi Acutis1, Giulia Milanese1, Giulia Stilo1, Caterina Faggio3|4, Giuseppe Esposito1, Paolo Pastorino1, Marino Prearo1 | 1Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy; 2Department of Animal, Nutritional and Food Sciences, Università Cattolica del Sacro Cuore, Piacenza, Italy; 3Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 4Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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117 | Modulation of DNA methylation patterns and heat shock proteins following exercise and probiotic supplementation A. Boatta1|2, G. Messina1, A. Pagliaro3, A. Alioto3, C. Rossi3, L. Paladino4, F. Rappa6, F. Naselli5, F. Cappello6, R. Barone6, P. Proia3 | 1Department of Human Sciences and Promotion of Quality of Life, San Raffaele Roma Open University, Roma, Italy; 2Institute for Biomedical Research and Innovation, CNR, Palermo, Italy; 3Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy; 4Department of Theoretical and Applied Sciences DiSTA, eCampus University, Novedrate, Italy; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy; 6Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Palermo, Italy.
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178 | Food-borne and environmental pathogens in wild ungulates from Sicily: implications for public health at the wildlife–livestock–human interface Elisa Maria Petta1, Valeria Vaglica1, Ilenia Giacchino1, Paola Galluzzo1, Sergio Migliore1, Federico Cangialosi1, Silvia Scibetta1, Elena Lo Bue1, Martina Imburgia1, Giuseppina Chiarenza1, Ettore Napoli2, Annalisa Guercio1, Francesca Grippi1, Valeria Blanda1 | 1Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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158 | Tick-borne pathogens in wild ungulates from Sicily (southern Italy): molecular detection and characterization Valeria Blanda1, Valeria Vaglica1, Sergio Migliore1, Ilenia Giacchino1, Elisa Maria Petta1, Federico Cangialosi1, Rosario Adragna1, Santina Di Bella1, Francesca Gucciardi1, Silvia Scibetta1, Francesca Grippi1, Annalisa Guercio1, Ettore Napoli2, Paola Galluzzo1 | 1Istituto Zooprofilattico Sperimentale della Sicilia, Palermo, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan1, Alessandra Maria Vitale1, Federica Scalia1|2, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy.
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056 | Thidiazuron exposure reprograms metabolic networks with lasting effects on growth and photosynthetic efficiency in Arabidopsis thaliana Manuela Giraldo-Acosta1, Giulia Giovanna Salerno2, Marino B. Arnao1, Cinzia Margherita Bertea3, Ada Ricci2, Giuseppe Mannino3 | 1Department of Plant Biology Plant Physiology, University of Murci, Spain; 2Department of Chemical, Life and Environmental Sustainability Sciences, University of Parma, Italy; 3Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy.
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054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana1, Chiara Agliassa2, Francesco Caldo1, Moez Maghrebi1, Valeria Contartese2, Giuseppe Mannino1, Gianpiero Vigani1 | 1Department of Life Sciences and Systems Biology, University of Turin, Italy; 2Green Has Italia SpA, Canale [AT], Italy.
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EFFECTS OF POLYLACTIC ACID-NANOPLASTICS ON THE INTESTINAL BARRIER: IN VITRO ANALYSIS ON HUMAN EPITHELIAL CELLS Maria Gerarda LULLO1, Raffaella D’AURIA1, Marianna MARINO1, Martina LOMBARDI1, Giovanna DELLA PORTA1,2, Erwin Pavel LAMPARELLI1, Rosaria MECCARIELLO3, Andrea VIGGIANO1,2, Antonietta SANTORO1,2 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Fisciano, Salerno, Italy; 2Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 3Department of Medical, Motor and Wellness Sciences, University of Naples Parthenope, Naples, Italy
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NANOPLASTICS AND IMMUNITY: INVESTIGATING THE EXTRACELLULAR MATRIX’S INFLUENCE ON MACROPHAGE INTERACTION WITH POLYSTYRENE NANOPARTICLES Marianna ROCA1, Naym BLAL1, Zeynep RENKLER2, Vincenzo GUARINO2, Antonia DI MOLA1, Antonio MASSA1, Ilaria DE MARTINO3, Velia SICILIANO3, Daniela GUARNIERI1 | 1Department of Chemistry and Biology, “Adolfo Zambelli”, University of Salerno; 2Institute of Polymers, Composites and Biomaterials, National Research Council of Italy; 3Synthetic and Systems Biology for Biomedicine Lab, Istituto Italiano di Tecnologia, Naples, Italy
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160 | Short-term mild caloric restriction induces early adaptive metabolic and mitochondrial responses in the liver of healthy rats Martina Coletta1, Vincenzo Migliaccio1, Giuliana Panico2, Ilaria Di Gregorio1, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology "A Zambelli", University of Salerno, Italy; 2Dept Biology, University of Naples Federico II, Naples, Italy.
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185 | From mycelium to medicine: cytotoxic effects of Ganoderma adspersum extracts in renal cancer cells Maria Noemi Sgobba1, Nikola Schlosserova1|2, Biagia Musio3, Federica Mastropirro1, Antonio Radesco4, Maria Favia5, Simona Marianna Sanzani4, Stefano Todisco3, Mariateresa Volpicella1, Anna De Grassi1, Vito Gallo3, Elena Ciani1, Ciro Leonardo Pierri6, Jakub Treml7, Lorenzo Guerra1 | 1Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 2Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Czech Republic; 3Department of Civil, Environmental, Land, Building Engineering and Chemistry DICATECh, Polytechnic University of Bari, Italy; 4Department of Soil, Plant and Food Sciences, University of Bari, Italy; 5Department of Translational Biomedicine and Neurosciences DiBraiN, University of Bari, Italy; 6Department of Pharmacy – Pharmaceutical Sciences, University of Bari, Italy; 7Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
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181 | Exploring boron neutron capture therapy effects on healthy skin: from cells to tissues Stefania Ricci1|2|3, Silva Bortolussi3|4, Ricardo Luis Ramos3|4, Ian Postuma3, Daniele Dondi3|5, Cinzia Ferrari3|7, Laura Cansolino3|7, Tea Maverna2, Federica Riva2|3 | 1Dept of Internal Medicine and Medical Therapy, University of Pavia, Italy; 2Dept of Experimental Medicine, Histology and Embryology Unit, University of Pavia, Italy; 3National Institute of Nuclear Physics INFN, Unit of Pavia, Italy; 4Dept of Physics, University of Pavia, Italy; 5Dept of Chemistry, University of Pavia, Italy; 6Dept of Molecular Medicine, Human Physiology Unit, University of Pavia, Italy; 7Laboratory of Experimental Surgery, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Italy.
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123 | Characterization of extracellular vesicles from the insect Hermetia illucens, a potential source of bioactive molecules Sharon Catrin Raimondi1, Kristian Riolo1, Domenico Savastano2, Sabrina Oliva1, Jessica Maria Abbate1, Antonio Leonardi1, Alessia Irrera3, Annalisa Pinsino4, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Progetto Hermetia, Gioia Tauro, Reggio Calabria, Italy; 3CNR IMM sede di Messina, Messina, Italy; 4Institute of Translational Pharmacology IFT National Research Council CNR, Palermo, Italy.
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UNTARGETED METABOLOMICS REVEALS GONADAL METABOLIC DISRUPTION IN MYTILUS GALLOPROVINCIALIS EXPOSED TO CADMIUM AND MICROPLASTICS Vera ABENANTE1,2, Andrea INGENITO1,2, Alessio TROTTA1,2, Giulio SANTANIELLO3, Gennaro LETTIERI3 , Marina PISCOPO3, Jacopo TROISI1,2,4 | 1Theoreo S.r.l., University of Salerno; 2European Institute of Metabolomics - Fondazione EIM, Baronissi (SA); 3Department of Biology, University of Naples Federico II, Naples; 4Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy
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096 | Hidden threats: trojan horse effects of microplastics enhance the toxicity of tire-wear chemicals in marine ecosystems Federica Davì, Roberta Fusco, Davide Di Paola | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti1, Gabriele La Monica2, Federica Alamia2, Alessia Bono2, Antonino Lauria2, Annamaria Martorana2, Antonella D’Anneo1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy.
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