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085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan1, Alessandra Maria Vitale1, Federica Scalia1|2, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy.
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054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana1, Chiara Agliassa2, Francesco Caldo1, Moez Maghrebi1, Valeria Contartese2, Giuseppe Mannino1, Gianpiero Vigani1 | 1Department of Life Sciences and Systems Biology, University of Turin, Italy; 2Green Has Italia SpA, Canale [AT], Italy.
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086 | Kir4.1 channels at the crossroads of oxidative stress and presbycusis: redox imbalance, electrophysiological failure and quercetin-mediated rescue Sara Spinelli1, Alessia Remigante2, Angela Marino1, Rossana Morabito1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Italy.
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078 | Stress-driven Dhurrin accumulation in sorghum revealed by physiological and biochemical markers Alessio Giannilivigni1, Manuela Giraldo-Acosta2, Flavia Girolami3, Stefano Giantin4, Luca Carisio4, Carlo Nebbia3, Marino Bañón Arnao2, Alberico Franzin4, Giuseppe Mannino1. | 1Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy; 2Department of Plant Biology Plant Physiology, University of Murcia, Spain; 3Department of Veterinary Sciences, University of Turin, Grugliasco [TO], Italy; 4Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta IZSPLV, Turin, Italy; 5Green Has Italia Spa, Plant Physiology Unit, Canale [CN], Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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072 | A standardized onion peel-derived bioactive ingredient attenuates palmitate-induced steatosis and oxidative stress in HepG2 cells Ilaria Di Gregorio1|2, Vincenzo Migliaccio2, Maria D’Elia1|3|4, Rita Celano1|3, Anna Lisa Piccinelli1|3, Luca Rastrelli1|3, Lillà Lionetti2|3 | 1Dept Pharmacy, University of Salerno, Salerno, Italy; 2Dept Chemistry and Biology “A Zambelli”, University of Salerno, Italy; 3National Biodiversity Future Center NBFC, Palermo, Italy; 4Dept Earth and Marine Sciences, University of Palermo, Italy.
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082 | Supplementation with Lactobacillus fermentum reversed fiber atrophy in a myopathy model by modulating IL-6, TNFα, and hsp60 levels, thereby enhancing muscle regeneration Martina Sausa1, Letizia Paladino2, Federica Scalia3, Francesco Paolo Zummo1, Giuseppe Vergilio1, Francesca Rappa1, Francesco Cappello1, Melania Ionelia Gratie1, Patrizia Proia4, Valentina Di Felice1, Antonella Marino Gammazza,5, Filippo Macaluso1, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO]; 3Department of Medicine and Surgery, Kore University of Enna; 4Department of Psychology, Educational Science and Human Movement, University of Palermo; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.
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114 | Mechanisms of antimony-induced intestinal injury under chronic low-dose exposure: evidence from Caco‑2 cells and protective role of cyanidin-3-o-glucoside Federica Lina Salamone1|2, Maria Sofia Molonia1, Santi Trischitta1, Antonella Saija1, Francesco Cimino1, Antonio Speciale1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 2Imbesi Foundation, Messina, Italy.
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044 | Thyroid response to stress in illness Caretta caretta: a preliminary study Chiara Lomonaco1, Paola Galluzzo2|3, Giorgia Schirò1|3, Angelo Costanza2|3, Rosario Adragna3, Vincenzo Monteverde2|3, Claudia Giannetto1, Salvatore Dara2|3, Rosaria Disclafani2|4 | 1Dipartimento di Scienze Veterinarie, Polo Universitario dell’Annunziata, University of Messina, Italy; 2Centro Referenza Nazionale per il Benessere, Monitoraggio e Diagnostica delle malattie delle Tartarughe Marine CReTaM; 3Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; 4Centro di Sostenibilità e Transizione Ecologica, University of Palermo, Italy.
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043 | Hemocyte motility integrated into a multimarker ecophysiological approach for thermal stress assessment in native and invasive bivalve species Gayatri Udayan, Claudio Calabrese1, Daniele Arduini; Antonella Giacovelli1, Maria Elena Giordano1, Adriana Giangrande1|2, Maria Giulia Lionetto1|2 | 1Dept Biological and Environmental Sciences and Technologies DiSTeBA, University of Salento; 2NBFC, National Biodiversity Future Center, Palermo, Italy.
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157 | A preliminary study on the interplay between serum neurotransmitter levels and the behavioral phenotype of Canis familiaris Federica Arrigo1, Raffaella Cocco2, Claudia Giannetto1, Giuseppe Piccione1, Alberto Cesarani3|4, Giuseppe Pulina3, Sara Sechi2, Francesca Arfuso1 | 1Department of Veterinary Sciences, University of Messina, Messina, Italy; 2Department of Veterinary Medicine, University of Sassari, Italy; 3Department of Agriculture, University of Sassari, Italy; 4Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
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POLYSTYRENE NANOPARTICLES IN ZEBRAFISH: THEIR ROLE IN OCULAR STRESS AND LIPID METABOLIC IMBALANCE V. IEZZI1, F. PERRELLA2, S. ZUGARO1, R. M. FERRI1, A. IANNETTA3, L. SULCANESE3, T. SILVESTRINI3,4, M. PERUGINI3, E. BENEDETTI1, C. FERRANTE5 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila; 2Department of Physical and Chemical Sciences University of L’Aquila; 3Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo; 4Advanced Study “Theoretical and Applied Neuroscience” Preclinical, clinical and Translational neuroscience, University of Camerino, Italy; 5CNR-SPIN, c/o Department of Physical and Chemical Sciences University of L’Aquila, Italy
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066 | Modulation of oxidative stress and mitochondrial alteration in IL1β-stimulated human astrocytes: effects of extracts from leaves and rhizomes of Posidonia oceanica (L) Delile Giulia Abruscato1, Lucia Sileo2, Giulia Scanavino2, Manuela Mauro1, Francesco Longo1, Vincenzo Arizza1|3, Mirella Vazzana1|3, Claudio Luparello1|3, Ada Maria Tata2 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STeBICeF, University of Palermo, Italy; 2Department of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center NBFC, Palermo, Italy.
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08 | NEURAL AND INTESTINAL IMPACT OF BIODEGRADABLE POLYLACTIC ACID NANOPLASTICS: RESULTS FROM THE PLASTAMINATION PROJECT Antonietta Santoro | Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy; Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy
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100 | Tracking polystyrene nanoplastics by raman microscopy reveals intestinal and retinal toxicity Valentina Iezzi1, Roberta Maria Ferri1, Annamaria Iannetta2, Ludovica Sulcanese2, Tommaso Silvestrini2, Vanessa D’Altilia2, Giovanni Angelozzi2, Federico Perrella3, Carino Ferrante4, Giulia Fioravanti3, Monia Perugini2, Elisabetta Benedetti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy; 3Department of Physical and Chemical Sciences University of L’Aquila, Italy; 4CNR-SPIN, c/o department of Physical and Chemical Sciences University of L’Aquila, Italy.
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107 | Protective effects of hydroxytyrosol against dichlorodiphenilethylene-induced oxidative injury in liver cells Vincenzo Migliaccio1, Ilaria Di Gregorio1, Martina Coletta1, Giuliana Panico2, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology “Adolfo Zambelli”, University of Salerno, Italy; 2Dept Biology, University Federico II, Napoli, Italy.
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023 | Chaperone-associated macrophage polarization and extracellular matrix remodelling in human glioblastoma Leila Noori1|2, Rosario Barone1, Giuseppe Vergilio1|2, Maria Antonella Augello1, Giuseppa D’Amico1, Federica Scalia3, Pierlorenzo Veiceschi2, Giovanni Tringali2, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics [BiND], University of Palermo, Italy; 2Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Italy.
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.
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088 | Investigating the role of Hsp60 in the pathophysiology of celiac disease Giusy Vultaggio1, Giuseppe Vergilio1|2, Letizia Paladino3, Rosario Barone1, Francesca Rappa1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy; 3Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy.
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154 | Metabolomic reprogramming and ferroptosis protection by the indole-based compound 20 against Aβ (25–35) in SH-SY5Y cells Mariapia Vietri1, Enza Napolitano1, Carmen Marino1, Tania Ciaglia1, Rodolfo Maria Abbate1, Pietro Campiglia1, Alessia Bertamino1, Michele Manfra2, Anna Maria D’Ursi1, Ornella Moltedo1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy; 2Department of Health Science, University of Basilicata, Potenza, Italy.
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121 | Probiotics effect on brain-gut axis mediated by nanovescicles Alessandro Lo Giudice1, Giuseppa D’Amico1, Melania Ionelia Gratie1, Letizia Paladino2, Giusy Vultaggio1, Adelaide Carista1, Francesco Cappello1, Vita Di Stefano3, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy; 3Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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D-ASPARTATE ALLEVIATES THE TESTICULAR DAMAGE INDUCED BY POLYSTYRENE MICROPLASTICS Sara FALVO1, Giulia GRILLO1, Gabriella CHIEFFI BACCARI1, Alessandra SANTILLO1, Imed MESSAOUDI2, Maria Maddalena DI FIORE1, Alessandra BIASI3, Maria Rosaria AMBRUOSI3, Massimo VENDITTI3 | 1Dept. of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; 2LR11ES41: Génétique, Biodiversité et Valorisation des Bioresources, Institut Supérieur de Biotechnologie, Université de Monastir, Monastir, Tunisia; 3Dept of Experimental Medicine, University of Campania ‘Luigi Vanvitelli’, Napoli, Italy
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081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti1, Gabriele La Monica2, Federica Alamia2, Alessia Bono2, Antonino Lauria2, Annamaria Martorana2, Antonella D’Anneo1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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090 | Activation of Sirtuin-1 by Cipollotto Nocerino leaf extract protects HepG2 cells from lipotoxicity Vincenzo Vestuto1, Maria Rosaria Miranda1, Giovanna Aquino2, Tania Ciaglia1, Rodolfo Maria Abbate1, Giuseppina Amodio3, Manuela Giovanna Basilicata4, Mario Felice Tecce1, Luca Rastrelli1, Pietro Campiglia1, Michele Manfra5, Giacomo Pepe1 | 1Department of Pharmacy, University of Salerno, Italy; 2AREA Science Park, Laboratorio di Multi-omica Area Sud LAAS, Baronissi [SA], Italy; 3Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi [SA], Italy; 4Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; 5Department of Science, University of Basilicata, Potenza, Italy.
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068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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101 | Physiological and cellular responses of the Mediterranean mussel to antifouling biocides 2-n-octyl-4-isothiazolin-3-one and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, alone and in mixture Federica Impellitteri1, Maria Giovanna Rizzo1, Giuseppe Piccione2, Paolo Pastorino3, Cristiana Roberta Multisanti2, Caterina Faggio1|4 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; 4Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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