Contents

The Journal of Biological Research – Bollettino della Società Italiana di Biologia Sperimentale is one of the oldest journals in Biology. Founded in 1925 the journal is available in Medline until 2001 and Scopus since 2014. The Journal of Biological Research – Bollettino della Società Italiana di Biologia Sperimentale is an online-only peer-reviewed journal which welcomes papers dealing with any aspect of experimental biology. Papers concerning clinical topics can be accepted only if they include experimental laboratory data. Original communications, review articles or short communications may be submitted.

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• CELL SPECIFIC METABOLOMIC AND FLUXOMIC RESPONSES TO POLYLACTIC ACID NANOPLASTICS EXPOSURE IN HUMAN INTESTINAL CELLS Martina LOMBARDI^1,2,3, Raffaella D’AURIA¹, Marianna MARINO¹, Mariagerarda LULLO¹, Erwin Pavel LAMPARELLI¹, Federica MONTELLA¹, Giovanna DELLA PORTA^1,4, Andrea VIGGIANO¹, Jacopo TROISI^1,2,3,5, Antonietta SANTORO^1,4 | ¹Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno; ²Theoreo Srl, Montecorvino Pugliano (SA); ³European Institute of Metabolomics - Fondazione EIM, Baronissi (SA); ⁴Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno; ⁵Department of Chemistry and Biology, “A. Zambelli”, University of Salerno, Fisciano (SA), Italy

  https://doi.org/10.4081/jbr.2025.14559

  278

• BIOPLASTICS IN SPORTS: OPPORTUNITIES AND CHALLENGES FOR A SUSTAINABLE FUTURE Filomena MAZZEO, Mario RUGGIERO | Università degli Studi di Napoli Parthenope, Italy

  https://doi.org/10.4081/jbr.2025.14579

  269

• DEVELOPMENT OF A NOVEL PROTOCOL FOR THE EXTRACTION OF SMALL MICROPLASTICS (1-5 µm) FROM BIOLOGICAL TISSUES Mary Carolin KURISINGAL CLEETUS¹, Ludovico PONTONI², Luigi ROSATI³, Massimiliano FABBRICINO², Annamaria LOCASCIO¹ | ¹Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy; ²Department of Civil, Architectural and Environmental Engineering, University of Naples Federico II, Naples, Italy; ³Department of Biology, University of Naples Federico II, Monte Sant’Angelo, Naples, Italy

  https://doi.org/10.4081/jbr.2025.14540

  268

• TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO¹, Martina LOMBARDI^1-3, Raffaella D’AURIA¹, Erwin Pavel LAMPARELLI¹, Giovanna DELLA PORTA^1,4, Marta Anna SZYCHLINSKA⁵, Federica SCALIA⁶, Francesco CAPPELLO^6,7, Rosaria MECCARIELLO⁸, Andrea VIGGIANO^1,4, Antonietta SANTORO^1,4 | ¹Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; ²Theoreo Srl, Montecorvino Pugliano, SA, Italy; ³European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; ⁴Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; ⁵Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; ⁶Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ⁷Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; ⁸Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy

  https://doi.org/10.4081/jbr.2025.14569

  252

• Growing patterns of multi-drug resistance in wound infections: a retrospective cross-sectional study from northern Iraq

  Khanda A. Anwar, Sharaza Q. Omer, Ayman M. Mustafa, Rawezh Q. Salih, Hidayat A. Yaseen, Hawnaz S. Abdullah, Wafa A. Hamaameen, Berun A. Abdalla, Shnya H. Ahmed, Dlsoz M. Hussein, Dahat A. Hussein, Awara K. Hama Rashid, Sasan M. Ahmed, Fahmi Kakamad

  https://doi.org/10.4081/jbr.2025.13807

  517

  Downloads: 464

• Impact of subclinical hypothyroidism on clinical, hormonal, and metabolic parameters in women with polycystic ovary syndrome: the role of levothyroxine therapy

  Zana Sabri Qasim, Suzan Omer Rasool

  https://doi.org/10.4081/jbr.2025.13712

  688

  Downloads: 385

• Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet

  Fatma A. Eissa, Taha A. Kumosani, Elie K. Barbour, Soonham S. Yaghmoor, Khalid M. El-Say, May M.M. Tadros, Said S. Moselhy

  https://doi.org/10.4081/jbr.2025.13730

  385

  Downloads: 245

• Sexual dysfunction in women with newly diagnosed thyroid dysfunction: a novel report from Basrah, Iraq

  Samih Abed Odhaib, Mahmood Thamer Altemimi, Abbas Ali Mansour

  https://doi.org/10.4081/jbr.2025.13578

  627

  Downloads: 563

• Clinical and biological significance of estrogen receptor-positive/progesterone receptor-negative in invasive breast cancer: bioinformatic analysis

  Maryam Althobiti, Raef Albugami, Mohammed Alnamnakani, Samir Alharbi, Michael Toss, Rajender Kumar, Fahad Alkhureeb

  https://doi.org/10.4081/jbr.2025.13361

  1123

  Downloads: 588

• Anti-inflammatory peptides and proteins from venomous snakes: a short review

  Fernando Lazcano-Pérez, Adrián Marcelo Franco-Vásquez, Ayetza Mathob Rodríguez-García, Roberto Arreguin-Espinosa

  https://doi.org/10.4081/jbr.2025.12996

  905

  Downloads: 516

• Cytotoxic activity of the crude extract and derived fractions from the sea anemone Telmatactis panamensis against cancer cell lines

  María Ivonne Garcia-Quezada, Fernando Lazcano-Pérez, Judith Sánchez-Rodríguez

  https://doi.org/10.4081/jbr.2025.12720

  796

  Downloads: 420

• Correlation of N-telopeptide of type 1 collagen and C-telopeptide of type 1 collagen in Iraqi women with breast cancer

  Zainab A. Salman, Rasha Abbas Azeez, Heba Kazhaal Mahmood

  https://doi.org/10.4081/jbr.2025.12728

  865

  Downloads: 302

• Antioxidant and antibacterial potential of Chromolaena odorata (L.) medicinal plant extracts

  Naruemon Bunkaew, Pattarapong Saensena, Penpicha Boonpeng, Pattarawadee Sumranmak, Thunjira Hanpipatsatian, Wanida Pan-utai

  https://doi.org/10.4081/jbr.2025.12500

  2359

  Downloads: 1352

• 97th National Congress of the Italian Society for Experimental Biology | Palermo, Italy, 10-13 April 2025

  The Editors

  https://doi.org/10.4081/jbr.2025.13875

  1516

  Downloads: 967

• Reduced folate carrier 1 (RFC1) gene polymorphisms among acute lymphoblastic leukemia patients

  Mashaer Taha Edris, Maye Mohammad Merghani, Shaza Salih Gafar, Ahmed Mohamed Asmeli, Elrashed B. Yasin, Raed Alserihi, Haitham M.H. Qutob, Aymen Yasin, Elshazali Ali

  https://doi.org/10.4081/jbr.2025.13105

  1138

  Downloads: 451

• Advanced glycation end products and human diseases

  Hamad Abu Zahra

  https://doi.org/10.4081/jbr.2025.12656

  2134

  Downloads: 949

• Evaluation of the activity of geraniol isolated from lemongrass (Cymbopogon commutatus Stapf.) on ochratoxin A-induced nephrotoxicity: role of the pPI3K/AKT-Nrf2 signaling pathway

  Rebai Ben Ammar, Shouq Nafea Al Mutairi, Peramaiyan Rajendran, Gamal M. Bekhet, Maged Elsayed Mohamed, Rashid Ismael Hag Ibrahim, Hamad Abu Zahra, Sarah Abdulaziz Alamer , Mohammed Salem Moqbel, Riadh Ksouri

  https://doi.org/10.4081/jbr.2025.13166

  1666

  Downloads: 438

• Estimation of lipid profile and some inflammatory biomarkers in patients with diabetes mellitus type 2 linked to hypertension

  Raed Madhi, Nidhal A. Hashim, Zainab A.J.R. Al-Ali , Noor Thair Tahir

  https://doi.org/10.4081/jbr.2024.12484

  1005

  Downloads: 447

• Implication of depleted uranium in human carcinogenesis with a glance to implementation of novel and reliable experimental models

  Stefano Burgio, Valerio Gennaro, Olga Maria Manna, Domiziana Picone, Adelaide Carista, Francesco Cappello

  https://doi.org/10.4081/jbr.2024.12663

  8059

  Downloads: 1945

• Genetic variation in GSTP1 and TBXA2R genes: influence of Badoush cement factory pollutant

  Dema Mohammed Sabah, Mohammad Ibrahim Khalil

  https://doi.org/10.4081/jbr.2024.12892

  805

  Downloads: 423

• The hemolysis index as a tool for monitoring mild hemolysis in biochemical assays at the emergency laboratory

  Sofiane Bouazza, Amine Bouarfa, Ali Khalfa, Slimane Brikhou, Abbassia Demmouche

  https://doi.org/10.4081/jbr.2024.12469

  1390

  Downloads: 1504

• Abnormal proteolytic activity profile in plasma of blood donors according to anti-SARS-CoV-2 IgG titer

  Tetiana Halenova, Antonina Rachkovska , Daryna Krenytska , Oleksandra Kostiuk, Vitalii Karbovskyy, Tetiana Vovk, Nataliia Raksha, Olexii Savchuk, Liudmyla Ostapchenko

  https://doi.org/10.4081/jbr.2024.12567

  868

  Downloads: 413

• Optimization attributes of fig (Ficus carica L.) salad dressing enrichment by Mentha pulegium L. extract and carboxymethyl cellulose

  Marjan Nouri, Farida Tromideh

  https://doi.org/10.4081/jbr.2024.12672

  908

  Downloads: 485

• Cytological analysis of interspecific hybrids of cotton

  Gulnoza Toshpulatova, Sayfulla Boboyev, Mirvakhob Mirakhmedov, Navruzbek Khusanov, Ulug‘bek Abdukarimov

  https://doi.org/10.4081/jbr.2024.12056

  1256

  Downloads: 450

• Contribution to knowledge of the true bugs species (Hemiptera: Heteroptera) in the habitats of the Berati area in Albania

  Eltjon Halimi, Xhuliana Qirinxhi, Anila Paparisto, Gerta Subashaj

  https://doi.org/10.4081/jbr.2024.12479

  2257

  Downloads: 712

• On probiotic integration in the management of inflammation and the maintenance of the intestinal epithelial barrier’s integrity

  Giovanna Traina

  https://doi.org/10.4081/jbr.2024.12362

  1242

  Downloads: 566

• Sudden cardiac death in the young. From gross to molecular autopsy

  Gaetano Thiene, Cristina Basso, Monica De Gaspari, Stefania Rizzo

  https://doi.org/10.4081/jbr.2024.12184

  1605

  Downloads: 405