Original Articles
Vol. 98 No. 2 (2025)
https://doi.org/10.4081/jbr.2025.13730
Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 13 February 2025
Accepted: 20 July 2025
Published: 11 September 2025
Accepted: 20 July 2025
Published: 11 September 2025
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Niacin is one of the B-complex vitamins that play an important role in metabolic pathways, while ubiquinone (Coenz-Q) is a component of the electron transport chain required for energy production. This study evaluated the role of niacin combined with ubiquinone in the inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on a High-Fat Diet (HFD). To achieve this purpose, sixty male albino rats (100– 150 g) were used in this study and divided into six groups (10 each). Group I (control): rats fed on a normal diet. Group II: Rats fed on HFD. Group III: Rats fed HFD and were given Niacin at 10 mg/kg body weight (b.w)/day orally by stomach tube. Group IV: Rats fed HFD and were given Coenz-Q (10 mg /kg b.w/day) orally. Group V: Rats fed HFD were given Niacin (10 mg/kg b.w/day) and Coenz- Q (10 mg /kg b.w/day). Group VI: Rats were given a hypocholesterolemic agent (cholerose) orally (10 mg/kg b.w/day) as positive control. The obtained results showed that treatment with Niacin or Coenz-Q or combined increased the activity of lipoprotein lipase (p < 0.001) and reduced the atherogenic effect and obesity index (p<0.001). The combined treatment is more effective than individual one or cholerose. In conclusion, Niacin combined with Coenz- Q increased lipid clearance and prevented its accumulation in blood. This combination is promising as antiatherogenic agent. Further investigation is required to identify the pathways regulated by these supplements that help in weight management.
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How to Cite
Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet. (2025). Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 98(2). https://doi.org/10.4081/jbr.2025.13730
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