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125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio1, Giuseppina Poppa1, Giuseppe Cammarata2, Sandra D’Ascenzo1, Vincenza Dolo1, Simona Taverna2, Ilaria Giusti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.
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048 | Metagenome-assembled genomes reveal spatial and seasonal variability of coastal microbial communities along the Calabrian coast Carmen Rizzo1|2, Rosario Calogero1|3, Erika Arcadi1, Francesco Fabiano1|4|6, Vittoria Dias1|5, Angelina Lo Giudice2, Teresa Romeo6|7|8, Silvestro Greco3|9 | 1Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; 2National Research Council, Institute of Polar Sciences, Messina, Italy; 3Calabrian Research Centre and Advanced Marine Infrastructures, CRIMAC; 4University of Palermo, Palermo, Italy; 5University of Milano Bicocca, Milano, Italy; 6National Biodiversity Future Centre NBFC, Italy; 7Zoologica Anton Dohrn, Sicily Marine Centre, Milazzo, Italy; 8National Institute for Environmental Protection and Research, Milazzo, Italy; 9Università delle Scienze Gastronomiche di Pollenzo UNISG, Cuneo, Italy.
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162 | Functional and health-promoting properties of EVOO from Sicilian olive cultivars: focus on oxidative stress and inflammation Mariateresa Cristani1, Ali Mert Yetisgin2, Giovanni Bartolomeo3, Nicola Cicero3|4, Rosaria Costa3, Nicola Micale1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2İnönü University, Faculty of Pharmacy, Kampüs, Battalgazi/Malatya, Türkiye; 3Department of Biomedical, Dental, Morphological and Functional Images Sciences BIOMORF, University of Messina, Messina, Italy; 4Science4Life srl, start-up of the University of Messina, Messina, Italy.
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155 | Mitochondrial dynamics and therapeutic insights in spinal muscular atrophy: effects of MFN2 boosting in motoneurons and human fibroblasts Francesco Paolo Zummo1, Serena Stanga1, Letizia Paladino2, Maria Beltran3, Francesco Fedeli4, Maria Rosa Soler3, Fabio Bucchieri5, Marina Boido1 | 1Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy; 2E-Campus University, Palermo, Italy; 3Neuronal Signaling Unit, Experimental Medicine Department, University of Lleida-IRBLleida, Lleida, Spain; 4University of Pavia, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.
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IDENTIFICATION OF D. MELANOGASTER ENZYMES POTENTIALLY INVOLVED IN PENTACHLOROPHENOL DEGRADATION M. CASTALDO1,2, D.M. MONTI2, A. TESTA3, J. VONTAS4,5, D. TSAKIRELLI4,5, M.M. MONTI1, P.A. PEDATA1 | 1Institute for Sustainable Plant Protection (CNR-IPSP), Portici (NA), Italy; 2Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy; 3Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 4Pesticide Science Lab, Agricultural University of Athens, Athens, Greece; 5Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
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182 | Preliminary data on clinical assessment, blood biochemistry analysis, and infrared thermography in dairy cows affected by foot diseases Maria Rizzo1, Nicolò Parisi1, Andrea Spadaro1, Esterina Fazio1, Enrico Fiore2, Giorgia Taio2, Giuseppe Piccione1, Francesca Arfuso1, Filippo Spadola1 | 1Department of Veterinary Sciences, University of Messina, Polo University Annunziata, Messina, Italy; 2Department of Animal Medicine, Productions and Health MAPS, University of Padua, Legnaro, Italy;.
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117 | Modulation of DNA methylation patterns and heat shock proteins following exercise and probiotic supplementation A. Boatta1|2, G. Messina1, A. Pagliaro3, A. Alioto3, C. Rossi3, L. Paladino4, F. Rappa6, F. Naselli5, F. Cappello6, R. Barone6, P. Proia3 | 1Department of Human Sciences and Promotion of Quality of Life, San Raffaele Roma Open University, Roma, Italy; 2Institute for Biomedical Research and Innovation, CNR, Palermo, Italy; 3Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy; 4Department of Theoretical and Applied Sciences DiSTA, eCampus University, Novedrate, Italy; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy; 6Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Palermo, Italy.
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187 | Beyond marker genes: mitochondrial genomics as a high-resolution tool for Sporothrix schenckii molecular epidemiology Laura Taca1, Andrea Bonomo2, Gabriele Rigano3|4, Letterio Giuffrè1, Orazio Romeo1, Domenico Giosa1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Mathematics, University of Pavia, Italy; 3Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; 4PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.
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049 | CMIT as an emerging contaminant: physiological and biochemical effects in Mytilus galloprovincialis Giuseppe Stracuzzi1, Federica Impellitteri1, Maria Giovanna Rizzo1, Monia Perugini2, Marika Cordaro3, Kateryna Yunko4, Oksana Stoliar4, Caterina Faggio1|5 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Feed and Food Scienxes, Teramo Univesity, Teramo, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Messina, Italy; 4Ternopil Volodymyr Hnatiuk National Pedagogical University, Ternopil, Ukraine; 5Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy.
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151 | Dysregulation of the lung-brain axis induced by CMIT/MIT: oxidative stress and junctional protein impairment lead to α-synuclein accumulation and dopaminergic neurotoxicity Nicla Tranchida1, Rosanna Di Paola2, Marika Cordaro3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Italy.
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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099 | Mechanistic insights into the ecotoxicity of bisphenol analogues and their mixtures in marine mussels: oxidative stress and neuro-immune responses Antonella Iaconis1, Marika Cordaro2, Davide Di Paola1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina,, Italy.
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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056 | Thidiazuron exposure reprograms metabolic networks with lasting effects on growth and photosynthetic efficiency in Arabidopsis thaliana Manuela Giraldo-Acosta1, Giulia Giovanna Salerno2, Marino B. Arnao1, Cinzia Margherita Bertea3, Ada Ricci2, Giuseppe Mannino3 | 1Department of Plant Biology Plant Physiology, University of Murci, Spain; 2Department of Chemical, Life and Environmental Sustainability Sciences, University of Parma, Italy; 3Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy.
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147 | Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease Cristina Giuffré1, Miriana Scordino1, Giulia Urone1, Miriam Buttacavoli1, Alessandra Montalbano2, Marilia Barreca2, Roberta Bivacqua2, Paola Barraja2, Virginia Spano’2, Giuseppa Mudo’1, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
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084 | Modulation of the autophagic process by S1P under hypoxia: dissecting the contribution of S1P1 and S1P5 receptors Beatrice Pranzo1, Marco Greco1, Luisa Rosato1, Rita Paroni2, Maria Rosaria Coscia3, Paola Italiani4, Giacomo Strapazzon5, Sara Ottolenghi2, Federico Maria Rubino2, Alessia Ametrano3, Michele Samaja2, Giulia Maria Lionetto6, Michele Maffia1 | 1Department of Experimental Medicine, University of Salento, Lecce, Italy; 2Department of Health Sciences, University of Milano, Italy; 3Institute of Biochemistry and Cell Biology, National Research Council of Italy, Naples, Italy; 4Institute for Biomedical Research and Innovation, National Research Council of Italy, Palermo, Italy; 5Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy; 6Department of Biological and Environmental Sciences and Technologies, Lecce, Italy.
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140 | The “invisible” plastic in our seafood chain: how a simple box can Sabrina Pricl1|2|3 | 1Molecular Biology and Nanotechnology Laboratory MolBNL@UniTS, Department of Engineering and Architecture DEA, University of Trieste, Italy; 2Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland; 3Delegate for Friuli Venezia-Giulia Region, WWF Italia, Rome, Italy;.
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159 | Innovative and sustainable strategies to recover bioactive molecules from pruning waste Giovanna Cafeo1, Marina Russo1, Alessia Arena2, Mariosimone Zoccali3, Paola Dugo1|2, Luigi Mondello1|2 | 1Messina Institute of Technology, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 3Department of Mathematical and Computer Science, Physical Sciences and Earth Sciences, University of Messina, Italy.
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134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan1, Paolo Bonivento2 | 1Nanocoatings Research, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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EFFECTS OF POLYLACTIC ACID-NANOPLASTICS ON THE INTESTINAL BARRIER: IN VITRO ANALYSIS ON HUMAN EPITHELIAL CELLS Maria Gerarda LULLO1, Raffaella D’AURIA1, Marianna MARINO1, Martina LOMBARDI1, Giovanna DELLA PORTA1,2, Erwin Pavel LAMPARELLI1, Rosaria MECCARIELLO3, Andrea VIGGIANO1,2, Antonietta SANTORO1,2 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Fisciano, Salerno, Italy; 2Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 3Department of Medical, Motor and Wellness Sciences, University of Naples Parthenope, Naples, Italy
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108 | Emerging models for emerging contaminants Camilla Mossotto1|2, Alice Gabetti1, Alessandra Maganza1|2, Alessia Merialdi1, Antonia Concetta Elia2, Monia Renzi3, Giuseppe Esposito1, Marino Prearo1, Caterina Faggio4, Paolo Pastorino1 | 1Istituto Zooprofilattico del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; 2Università di Perugia, Italy; 3Università degli Studi di Trieste, Italy; 4Università degli Studi di Messina, Italy.
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