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084 | Modulation of the autophagic process by S1P under hypoxia: dissecting the contribution of S1P1 and S1P5 receptors Beatrice Pranzo1, Marco Greco1, Luisa Rosato1, Rita Paroni2, Maria Rosaria Coscia3, Paola Italiani4, Giacomo Strapazzon5, Sara Ottolenghi2, Federico Maria Rubino2, Alessia Ametrano3, Michele Samaja2, Giulia Maria Lionetto6, Michele Maffia1 | 1Department of Experimental Medicine, University of Salento, Lecce, Italy; 2Department of Health Sciences, University of Milano, Italy; 3Institute of Biochemistry and Cell Biology, National Research Council of Italy, Naples, Italy; 4Institute for Biomedical Research and Innovation, National Research Council of Italy, Palermo, Italy; 5Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy; 6Department of Biological and Environmental Sciences and Technologies, Lecce, Italy.
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135 | Genotype-dependent modulation of drought-induced responses in durum wheat through wheat–clover intercropping Noemi Gatti1, Moez Maghrebi1, Matteo Spada2, Giuseppe Mannino1, Stefania Astolfi2, Gianpiero Vigani1 | 1University of Turin, Department of Life Sciences and Systems Biology, Turin, Italy; 2University of Tuscia, Department of Agriculture and Forest Sciences, Viterbo, Italy.
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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04 | MICRO AND NANO-PLASTICS A NEW CONCERN FOR PUBLIC HEALTH? Margherita Ferrante, Eloise Pulvirenti | Department of Medical Sciences, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy
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009 | Metabolic adaptation to hypoxia via lipid droplet accumulation in a 3D hepatocellular carcinoma model Giorgia Cannatà1, Caterina Faggio1|2, Maria Giovanna Rizzo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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151 | Dysregulation of the lung-brain axis induced by CMIT/MIT: oxidative stress and junctional protein impairment lead to α-synuclein accumulation and dopaminergic neurotoxicity Nicla Tranchida1, Rosanna Di Paola2, Marika Cordaro3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Italy.
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EVALUATION OF TRANS-EPITHELIAL PENETRATION AND MICROPLASTIC-INDUCED TISSUE DAMAGE IN A 3D MODEL OF HUMAN RESPIRATORY MUCOSA Adelaide CARISTA1, Domiziana PICONE1, Giulia Maria Giorgia LO PIANO1, Olga Maria MANNA2,3, Stefano BURGIO3,4, Giuseppa D’AMICO1, Margherita FERRANTE5, Gea OLIVERI CONTE5, Francesca RAPPA1, Rosario BARONE1, Fabio BUCCHIERI1, Alessandro PITRUZZELLA1, Alberto FUCARINO6 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy; 2Pathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 5Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Igiene e Sanità Pubblica; 6Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Italy
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099 | Mechanistic insights into the ecotoxicity of bisphenol analogues and their mixtures in marine mussels: oxidative stress and neuro-immune responses Antonella Iaconis1, Marika Cordaro2, Davide Di Paola1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina,, Italy.
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116 | Exosomes and miRNA content engagement in inflammatory processes let's take stock in the veterinary field Francesca Arfuso1, Jessica M. Abbate2, Claudia Giannetto1, Marilena Briglia3, Elisabetta Giudice1, Giovanni Lanteri2, Giuseppe Piccione1 | 1Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Messina, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Universitario Papardo, Messina, Italy; 3Department of Medicine and Surgery “Kore”, University of Enna, Italy.
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02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy
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098 | Gill damage in zebrafish exposed to environmentally relevant concentrations of the UV filter avobenzone Antonio Paolo Maria Graziani, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Rachele Macirella, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato1, Nicolò Ricciardi1, Valentina Di Liberto1, Miriana Scordino1, Giulia Urone1, Danila Di Majo1, Giuseppe Giglia1|4, Pierangelo Sardo1, Giuseppe Ferraro1, Riccardo Alessandro1|2|3, Stefania Raimondo1|2, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; 2Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; 3Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; 4Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.
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01 | INTEGRATED STRATEGIES FOR PLASTIC MANAGEMENT: MONITORING, BIOLOGICAL IMPACT, AND CIRCULAR PERSPECTIVES ROUND TABLE REPORT Giorgia Görner Enrile1|2, Antonietta Santoro3, Federica Scalia4, Stefania D’Angelo5, Annamaria Visco6, Andrea Pace7, Michele Torregrossa8, Dario Scalia9, Alessandro Aglialoro10, Salvatore Campanella10 | 1Siciliamedica.it; 2Ilsicilia.it; 3PI, Plastamination Project, University of Salerno, Italy; 4Human Anatomy, University Kore, Enna, Italy; 5Biochemistry, University Parthenope of Naples, Italy; 6Life Restart Project, University of Messina, Italy; 7Research and Technology Transfer, University of Palermo, Italy; 8Engineering, University of Palermo, Italy; 9Plastic Free Onlus Sicily, Italy; 10Regional Environmental Protection Agency of Sicily, Italy
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106 | Health effects of noise pollution on juvenile crustaceans: behavioral and molecular responses in Procambarus clarkii Maria Ceraulo1|2, Giuseppa Buscaino1, Clarissa De Vita1, Aiti Vizzini2|3|*, Mirella Vazzana2|3, Elena Papale1, Vincenzo Arizza2|3, Francesco Longo3, Francesco Paolo Faraone3, Manuela Mauro2|3 | 1Institute for the Study of Anthropogenic impacts and Sustainability in the marine environment, National Research Council of Italy, Torretta Granitola, Campobello di Mazara [TP], Italy; 2NBFC, National Biodiversity Future Center, Palermo, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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162 | Functional and health-promoting properties of EVOO from Sicilian olive cultivars: focus on oxidative stress and inflammation Mariateresa Cristani1, Ali Mert Yetisgin2, Giovanni Bartolomeo3, Nicola Cicero3|4, Rosaria Costa3, Nicola Micale1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2İnönü University, Faculty of Pharmacy, Kampüs, Battalgazi/Malatya, Türkiye; 3Department of Biomedical, Dental, Morphological and Functional Images Sciences BIOMORF, University of Messina, Messina, Italy; 4Science4Life srl, start-up of the University of Messina, Messina, Italy.
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EVALUATING ENDOCRINE AND OXIDATIVE EFFECTS OF POLYLACTIC ACID NANOPLASTICS (PLA-NPs) ON BREAST CELL MODELS Maria Denise AMICO1, Antonietta SANTORO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Magdalena GORSKA-PONIKOWSKA3,4,5, Francesca RAPPA1,5, Fabio BUCCHIERI1, Francesco CAPPELLO1,5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medical Chemistry, Medical University of Gdansk, Poland; 4Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Germany; 5Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
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071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia1, Alice Foti1, Fabio Allia1, Rosalia Battaglia1, Giuseppe Piccione2, Alessandro Attanzio3, Caterina Faggio4, Roberta Malaguarnera1, Adriana Carol Eleonora Graziano1 | 1Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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145 | Synergistic effects of APP and Tau on neuronal miRNA regulation Laura M. De Plano1, Alessandra Saitta1, Antonella Caccamo1, Emanuele L. Sciuto1, Sabrina Conoci2, Salvatore Oddo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Dipartimento di Chimica "Giacomo Ciamician", University of Bologna, Italy.
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PRELIMINARY RESULTS ON MICROPLASTIC AND NANOPLASTIC IMPACT IN VIRUS AND BACTERIAL REPLICATION Nicoletta CAPUANO1,2, Alessia GIANNATTASIO3, Noemi CAFA’1,2, Anna BARBATO1,2, Mariarosa SCOGNAMIGLIO4, Vincenzo BELGIORNO5, Luca RINALDI6, Veronica FOLLIERO1,2, Antonio BUONERBA3, Gianluigi FRANCI1,2 | 1Dipartimento di Medicina, Chirurgia e Odontoiatria, Scuola Medica Salernitana, Università degli Studi di Salerno, Baronissi (SA), Italia; 2UOS di Microbiologia e Virologia, AOU San Giovanni di Dio e Ruggi D’Aragona, Salerno, Italia; 3Dipartimento di Chimica e Biologia, Università degli Studi di Salerno, Fisciano (SA), Italia; 4Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Fisciano (SA), Italia; 5Dipartimento di Ingegneria Civile, Università degli Studi di Salerno, Fisciano (SA), Italia; 6Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise, Italy
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10 | EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON RAT SPERM PARAMETERS Maria Zelinda Romano1, Martina Lombardi2, Massimo Venditti1, Mariagerarda Lullo2, Marianna Marino2, Erwin Pawel Lamparelli2, Giovanna Della Porta2, Antonino Testa3, Andrea Viggiano2, Antonietta Santoro2, Rosara Meccariello4 | 1Department of Experimental Medicine, University of Campania “L Vanvitelli”, Naples Italy; 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy; 3Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy; 4Department of Medical, Human Movement and Well-being Sciences, University of Naples Parthenope, Naples, Italy
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO1, Martina LOMBARDI1-3, Raffaella D’AURIA1, Erwin Pavel LAMPARELLI1, Giovanna DELLA PORTA1,4, Marta Anna SZYCHLINSKA5, Federica SCALIA6, Francesco CAPPELLO6,7, Rosaria MECCARIELLO8, Andrea VIGGIANO1,4, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, SA, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 6Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 7Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy
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113 | Ecotoxicological effects of bromuconazole in Oryzias latipes from embryos to adult endpoints Tania Russo1|2, Ilaria Olivito1, Iolanda Carratù2, Chiara Barone2, Ivan Conte2, Anna Di Cosmo2, Gianluca Polese2, Elvira Brunelli1 | 1Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende [CS], Italy; 2Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.
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MICRO- AND NANO-PLASTICS: HEALTH, DENTAL PRACTICE, AND ENVIRONMENT Giuseppina DE BENEDETTO1, Veronica FOLLIERO1, Maria Pia DI PALO1, Leonardo AULISIO1, Luca RINALDI2, Gianluigi FRANCI1, Federica DI SPIRITO1 | 1Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; 2Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
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09 | POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTINATION): ORGAN INJURIES AND UNDERLINING MOLECULAR MECHANISMS: EVIDENCE FROM IN VIVO ZEBRAFISH MODEL Marta A. Szychlinska1, Federica Scalia2, Martina Di Marco3, Giusy Vultaggio3, Maria Denise Amico3, Fabiano Capparucci4, Carmelo Iaria4, Marianna Marino5, Erwin Pavel Lamparelli5, Giovanna Della Porta5, Francesca Rappa3, Antonella Marino Gammazza3, Rosario Barone3, Antonino Testa6, Rosaria Meccariello7, Antonietta Santoro5, Francesco Cappello3 | 1Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 2Department of Medicine and Surgery - Kore University of Enna, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 4Department of Chemical, Biological, Pharmacological and Environmental Sciences, University of Messina, Italy; 5Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 6Department of Biological and Pharmaceutical Environmental Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 7Department of Movement and Wellness Sciences, Parthenope University of Naples, Italy
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080 | Monocytes succumb to protect head and neck cancer cells from plasma-treated water solutions cytotoxicity Giuseppe Natali1, Anna Martina Battaglia2, Emanuele Giorgio2, Lavinia Petriaggi2, Alessandro Antonelli3, Cristiana Galeano2, Amerigo Giudice3, Eloisa Sardella4, Vittoria Perrotti5, Flavia Biamonte2 | 1Department of Health Sciences, Magna Graecia University of Catanzaro, Italy; 2Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy; 3Department of Health Science, School of Dentistry, Magna Graecia University of Catanzaro, Italy; 4CNR-Istituto di Nanotecnologia CNR-NANOTEC UoS Bari, c/o Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, Italy; 5Department of Innovative Technologies in Medicine & Dentistry, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy.
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110 | Integrative ultrastructural and molecular evidence of ferroptosis in lead-exposed zebrafish liver Ilaria Olivito, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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184 | Phytochemicals in pruning waste and food industry by-products: biodiversity and circular economy Marina Russo1, Giovanna Cafeo1, Luigi Mondello1|2, Paola Dugo1|2 | 1Messina Institute of Technology c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy; 2Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy.
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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