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174 | Mummified lung tissue as a microbiological archive: an integrated approach to investigate past pulmonary microbial communities in 18th-19th century Europe Angela Mollica Nardo1, David Harasser2, Dario Piombino-Mascali3|4 | 1Life Sciences Center, Vilnius University, Vilnius, Lithuania; 2Institute for Mummy Studies, EURAC Research, Bolzano, Italy; 3Department of Anatomy, Histology, and Anthropology, Vilnius University, Vilnius, Lithuania; 4Department of Cultural Heritage, University of Salento, Lecce, Italy.
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061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino1, Giovanni Perconti1, Alessia Giannetto2, Andi Alijagic3 | 1Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 3Man-Technology-Environment Research Center MTM, Orebro University, Sweden.
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EXPLORING THE NEUROTOXIC POTENTIAL OF LDPE MICROPLASTICS: EVIDENCE IN VITRO AND IN VIVO ASSESSMENT Marilena MARRAUDINO1,2, Elena RICCI1,2, Silvia CHASSEUR1,2, Daniela RASA'1, Riccardo ROLANDO1, Stefano GOTTI1,2, Marina BOIDO1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy
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149 | Behavioral markers of epileptogenesis and pharmacoresistance in a longitudinal pilocarpine model of temporal lobe epilepsy Nicolò Ricciardi1, Miriana Scordino1, Giulia Urone1, Miriam Buttacavoli1, Giuseppa Mudò1, Pierangelo Sardo1, Giuseppe Giglia1|2, Valentina Di Liberto1, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Euro Mediterranean Institute of Science and Technology - IEMEST, Palermo, Italy.
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081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti1, Gabriele La Monica2, Federica Alamia2, Alessia Bono2, Antonino Lauria2, Annamaria Martorana2, Antonella D’Anneo1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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136 | Community structure of ixodid ticks in Mediterranean protected areas: a comparative study of four Sicilian woodlands Paola Galluzzo1, Ettore Napoli2, Sergio Migliore2, Federico Cangialosi1, Elisa Maria Petta1, Valeria Vaglica1, Rosario Adragna1, Davide Pepe1, Francesca Gucciardi1, Vincenza Cannella1, Caterina Elen Culoma2, Annalisa Guercio1, Valeria Blanda1 | 1Istituto Zooprofilattico Sperimentale della Sicilia “A Mirri”, Palermo, Italy; 2University of Messina, Department of Veterinary Sciences, Messina, Italy.
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067 | Redefining amphibian innate immunity: first in vitro and in vivo evidence of phagocytic function in blood cells Valbona Aliko1, Erion Sukaj2, Cristiana Roberta Multisanti3, Federica Impelliteri4, Caterina Faggio4 | 1University of Tirana, Faculty of Natural Sciences, Department of Biology, Tirana, Albania; 2Western Balkans University, Faculty of Medicine and Technical Medical Sciences, Tirana, Albania; 3Department of Veterinary Sciences, University of Messina, Italy; 4University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.
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030 | The Piroscafo Torino shipwreck as a biodiversity hotspot in a sandy-bottom habitat (Ionian sea) Valentina Basile1, Marcello Mezzasalma1, Alessandra Ghelli2, Mauro F. La Russa1, Elvira Brunelli1 | 1Department of Biology, Ecology and Earth Science, University of Calabria, Rende [CS], Italy; 2Ministry of Culture – Regional Secretariat of the Ministry of Culture for Calabria MiC, Roccelletta di Borgia [CZ], Italy.
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051 | Optimization of a combined spectral and imaging flow cytometry protocol integrated with AI for rapid human microbiota screening Arianna Aquilini-Mummolo1|2, Francesca D’Ascanio1|2|3, Giulia Colasante1|2, Domenico De Bellis1|2, Pasquale Simeone4, Sabino Porro1|2, Tamer Esmail1|2, Ayesha Younas1|2, Luana D’Onofrio1|2, Isabel Vallejo Bermúdez5|6, Camilla Cichella2, Mariagiulia Filoso1|2, Chiara Porro4, Paola Lanuti1|2. | 1Department of Medicine and Aging Sciences, University “G d’Annunzio”, Chieti-Pescara, Chieti; 2Center for Advanced Studies and Technology CAST, University “G d’Annunzio”, Chieti-Pescara; 3Department of Humanities, Law and Economics, “Leonardo da Vinci” University, Torrevecchia Teatina, Italy; 4Department of Clinical and Experimental Medicine, University of Foggia, Italy; 5Molecular Immunology Group CTS208, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; 6Immunology and Allergy Group GC01, Maimonides Biomedical Research Institute of Cordoba IMIBIC, University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.
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017 | Targeting lipogenesis promotes the synergistic effect of the selective HDAC inhibitor ITF3756 with bortezomib in colon cancer cells Marzia Franzò1, Giovanni Pratelli1, Federica Affranchi2, Antonietta Notaro2, Michela Giuliano2, Sonia Emanuele1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, Biochemistry Building, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.
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129 | Ochratoxin and green coffee: certified analyses to prevent the presence of toxic alien microorganisms transported by logistic carriers Lorenzo Cergol1, Elena Ramalli1, Paolo Bonivento2 | 1New Eco srl, Trieste, Italy; 2Istituto di Studi Europei “A De Gasperi”, Roma, Italy.
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182 | Preliminary data on clinical assessment, blood biochemistry analysis, and infrared thermography in dairy cows affected by foot diseases Maria Rizzo1, Nicolò Parisi1, Andrea Spadaro1, Esterina Fazio1, Enrico Fiore2, Giorgia Taio2, Giuseppe Piccione1, Francesca Arfuso1, Filippo Spadola1 | 1Department of Veterinary Sciences, University of Messina, Polo University Annunziata, Messina, Italy; 2Department of Animal Medicine, Productions and Health MAPS, University of Padua, Legnaro, Italy;.
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010 | Combining a gemcitabine-derived prodrug, GEM-C18, with nanoparticles to counteract acidic ph-dependent chemoresistance of pancreatic adenocarcinoma Francesca Fracasso, Marilena Ardone, Tiago Miguel Amaral Carvalho1|2, Barbara Rolando3, Silvia Arpicco3, Valeria Bincoletto3, Francesca Bianco4, Alessandra Fiorio Pla4, Daniela Isabel Abbrescia5, Ylenia Antonacci5, Chrysovalentinos Pousis5, Sharon Natasha Cox1, Flaviana Marzano5, Graziano Pesole1, Apollonia Tullo5, Stephan Joel Reshikn1, Rosa Angela Cardone1 | 1Dept of Biosciences, Biotechnology and Environment, University of Bari, ltaly; 2CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, Covilhã, Portugal; 3Dept. of Drug Science and Technology, University of Turin, ltaly; 4Dept of Life Sciences and Systems Biology, University of Turin, Italy 5Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies – IBIOM - CNR, Bari, Italy.
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167 | The importance of personalized oxygen-ozone dosing in systemic therapy: algorithmic solutions for regenerative medicine Antonio Galoforo1, Paolo Bonivento2 | 1Tavolo Tecnico “Salute ed Ambiente”, Intergruppo parlamentare “One Health”, Camera dei Deputati, Roma, Italy; 2RING - ODR Research Innovation Networking Generation, Organismo di Ricerca, Milano, Italy.
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135 | Genotype-dependent modulation of drought-induced responses in durum wheat through wheat–clover intercropping Noemi Gatti1, Moez Maghrebi1, Matteo Spada2, Giuseppe Mannino1, Stefania Astolfi2, Gianpiero Vigani1 | 1University of Turin, Department of Life Sciences and Systems Biology, Turin, Italy; 2University of Tuscia, Department of Agriculture and Forest Sciences, Viterbo, Italy.
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154 | Metabolomic reprogramming and ferroptosis protection by the indole-based compound 20 against Aβ (25–35) in SH-SY5Y cells Mariapia Vietri1, Enza Napolitano1, Carmen Marino1, Tania Ciaglia1, Rodolfo Maria Abbate1, Pietro Campiglia1, Alessia Bertamino1, Michele Manfra2, Anna Maria D’Ursi1, Ornella Moltedo1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy; 2Department of Health Science, University of Basilicata, Potenza, Italy.
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NANOPLASTICS AND IMMUNITY: INVESTIGATING THE EXTRACELLULAR MATRIX’S INFLUENCE ON MACROPHAGE INTERACTION WITH POLYSTYRENE NANOPARTICLES Marianna ROCA1, Naym BLAL1, Zeynep RENKLER2, Vincenzo GUARINO2, Antonia DI MOLA1, Antonio MASSA1, Ilaria DE MARTINO3, Velia SICILIANO3, Daniela GUARNIERI1 | 1Department of Chemistry and Biology, “Adolfo Zambelli”, University of Salerno; 2Institute of Polymers, Composites and Biomaterials, National Research Council of Italy; 3Synthetic and Systems Biology for Biomedicine Lab, Istituto Italiano di Tecnologia, Naples, Italy
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073 | Modulation of NLRP3 inflammasome and macrophage polarization by quantum molecular resonance in THP-1 cells Maria Giulia Di Battista1, Osama Elsallabi1, Benedetta Rizza1, Tiziano Lupi1, Alessandro Pozzato2, Paola Lanuti1, Antonia Patruno1 | 1Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; 2Telea Electronic Engineering Srl, Sandrigo [VI], Italy.
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160 | Short-term mild caloric restriction induces early adaptive metabolic and mitochondrial responses in the liver of healthy rats Martina Coletta1, Vincenzo Migliaccio1, Giuliana Panico2, Ilaria Di Gregorio1, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology "A Zambelli", University of Salerno, Italy; 2Dept Biology, University of Naples Federico II, Naples, Italy.
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056 | Thidiazuron exposure reprograms metabolic networks with lasting effects on growth and photosynthetic efficiency in Arabidopsis thaliana Manuela Giraldo-Acosta1, Giulia Giovanna Salerno2, Marino B. Arnao1, Cinzia Margherita Bertea3, Ada Ricci2, Giuseppe Mannino3 | 1Department of Plant Biology Plant Physiology, University of Murci, Spain; 2Department of Chemical, Life and Environmental Sustainability Sciences, University of Parma, Italy; 3Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy.
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PLASTAMINATION, HUMAN HEALTH, AND COUNTRIES’ CULTURAL ORIENTATION: AN EXPLORATORY STUDY IN PREVENTING THE NEGATIVE EFFECTS ADOPTING ORGANIZATIONAL POLICIES AND PRACTICES Giuseppe PERNA1, Rosaria MECCARIELLO2, Luisa VARRIALE3 | 1Pegaso University; 2Parthenope University DiSMMeB; 3Parthenope University DiSEGIM, Naples, Italy
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147 | Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease Cristina Giuffré1, Miriana Scordino1, Giulia Urone1, Miriam Buttacavoli1, Alessandra Montalbano2, Marilia Barreca2, Roberta Bivacqua2, Paola Barraja2, Virginia Spano’2, Giuseppa Mudo’1, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
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115 | Thyroid-active endocrine disruptors shape distinct neurobehavioral signatures in zebrafish larvae Tommaso Sivestrini1|2, Annamaria Iannetta1, Ludovica Sulcanese1, Giovanni Angelozzi1, Vanessa D’Altilia1, Monica Ceci1, Monia Perugini1 | 1Advanced Study “Theoretical and Applied Neuroscience”, Preclinical clinical and Translational Neuroscience, University of Camerino, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy.
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009 | Metabolic adaptation to hypoxia via lipid droplet accumulation in a 3D hepatocellular carcinoma model Giorgia Cannatà1, Caterina Faggio1|2, Maria Giovanna Rizzo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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166 | Attenuation of Pseudomonas aeruginosa virulence by engineered phage Domenico Franco1, Salvatore Papasergi2, Francesco Mediati1, Salvatore P.P. Guglielmino1, Laura Maria De Plano1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 2Institute of Translational Pharmacology of the National Research Council; 3Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’Compensation Authority INAIL, Italy.
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134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan1, Paolo Bonivento2 | 1Nanocoatings Research, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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153 | α-synuclein regulation in brain and bone marrow is releted to the differential expression of GATA1 transcription factor Viola Velardi1, Francesca Arciprete1, Claudia Caturano,1Rosa Alba Rana1, Romina Mancinelli2, Maria Zingariello1, Giorgio Vivacqua1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy.
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086 | Kir4.1 channels at the crossroads of oxidative stress and presbycusis: redox imbalance, electrophysiological failure and quercetin-mediated rescue Sara Spinelli1, Alessia Remigante2, Angela Marino1, Rossana Morabito1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Italy.
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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140 | The “invisible” plastic in our seafood chain: how a simple box can Sabrina Pricl1|2|3 | 1Molecular Biology and Nanotechnology Laboratory MolBNL@UniTS, Department of Engineering and Architecture DEA, University of Trieste, Italy; 2Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland; 3Delegate for Friuli Venezia-Giulia Region, WWF Italia, Rome, Italy;.
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107 | Protective effects of hydroxytyrosol against dichlorodiphenilethylene-induced oxidative injury in liver cells Vincenzo Migliaccio1, Ilaria Di Gregorio1, Martina Coletta1, Giuliana Panico2, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology “Adolfo Zambelli”, University of Salerno, Italy; 2Dept Biology, University Federico II, Napoli, Italy.
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021 | Novel para-phenylenediamine-based derivatives as receptor tyrosine kinase-like orphan receptor 1 inhibitors: an in vitro preliminary characterization Maria Rosaria Miranda1, Gerardina Smaldone1, Francesca Di Matteo1, Valeria Napolitano1, Michela Aliberti1, Simona Musella1, Veronica Di Sarno1, Gianluigi Lauro1, Giuseppe Bifulco1, Giacomo Pepe1, Giovanna Aquino1, Mario Felice Tecce1, Isabel Maria Gomez-Monterrey2, Pietro Campiglia1, Carmine Ostacolo1, Alessia Bertamino1, Tania Ciaglia1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Italy; 2Department of Pharmacy, University of Naples Federico II, Naples, Italy.
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114 | Mechanisms of antimony-induced intestinal injury under chronic low-dose exposure: evidence from Caco‑2 cells and protective role of cyanidin-3-o-glucoside Federica Lina Salamone1|2, Maria Sofia Molonia1, Santi Trischitta1, Antonella Saija1, Francesco Cimino1, Antonio Speciale1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 2Imbesi Foundation, Messina, Italy.
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041 | Longitudinal characterization of the gut microbiota of Caretta caretta under controlled in-care conditions Martina Maria Imburgia1, Fanny Claire Capri, Vincenzo Monteverde, Giorgia Schirò, Rosaria Disclafani, Angelo Costanza, Rosa Alduina, Salvatore Dara, Paola Galluzzo | 1Centro di Referenza Nazionale sul benessere, monitoraggio, diagnostica delle malattie delle Tartarughe Marine CRetaM, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; 2Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Università degli Studi di Palermo, Italy.
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008 | A 3D bioprinted microfluidic Breast Cancer-on-Chip model for studying drug transport and resistance Simona Campora1, Kimia Abedi2, Alessandra Lo Cicero1, Gabriele Lo Buglio1, Francesco La Monica1, Giulia Palazzo1, Riccardo Barrile2, Giulio Ghersi1|4 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States; 3Center for Stem Cells and Organoid Medicine CuSTOM, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; 4Abiel Srl, Palermo, Italy.
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THE RISING THREAT: NANO AND MICROPLASTICS INFILTRATION IN URINARY AND REPRODUCTIVE SYSTEMS Luigi MONTANO | Andrology Unit and Service of Lifestyle Medicine in UroAndrology, “S. Francesco d’Assisi” Hospital, Local Health Authority (ASL) Salerno, EcoFoodFertility Project Coordi-nation Unit, Italian Network for Environmental and Reproductive Health, Oliveto Citra, Italy
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085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan1, Alessandra Maria Vitale1, Federica Scalia1|2, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy.
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.
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08 | NEURAL AND INTESTINAL IMPACT OF BIODEGRADABLE POLYLACTIC ACID NANOPLASTICS: RESULTS FROM THE PLASTAMINATION PROJECT Antonietta Santoro | Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy; Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy
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139 | Municipal and agricultural waste is increasingly complex and impacts local biodiversity electronics integrated with ai systems can help Matteo Mottica1, Paolo Bonivento2 | 1MQuadro srl, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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POLYLACTIC ACID (PLA) PRODUCED FROM BREWER'S SPENT GRAIN (BSG): SUSTAINABLE PRODUCTION AND BIOMEDICAL APPLICATIONS Mario RUGGIERO, Filomena MAZZEO | Università degli Studi di Napoli Parthenope, Italy
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054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana1, Chiara Agliassa2, Francesco Caldo1, Moez Maghrebi1, Valeria Contartese2, Giuseppe Mannino1, Gianpiero Vigani1 | 1Department of Life Sciences and Systems Biology, University of Turin, Italy; 2Green Has Italia SpA, Canale [AT], Italy.
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