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MATERNAL EXPOSURE TO ENDOCRINE DISRUPTORS AND INFANT DEVELOPMENT: FINDINGS FROM THE LIFE MILCH COHORT STUDY Silvia PATERLINI1, Maria Maddalena BRAMBILLA1, Francesca ALBERGHI2, Alessia ARDENGHI3, Mariateresa BELLANTONI1, Marta FONTANA2, Laura FILONZI3, Francesco NONNIS MARZANO3, Francesca NUTI4, Annalisa PELOSI1, Serafina PERRONE1, Silvia PETZA5, Roberta PINTUS5, Feliciana REAL-FERNANDEZ4, Vassilios FANOS5, Anna Maria PAPINI4, Maria E. STREET1,2, Paola PALANZA1 | 1Department of Medicine and Surgery, University of Parma (IT); 2Department of Obstetrics, Gynecology and Pediatrics, Azienda USL-IRCCS, Reggio Emilia (IT); 3Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma (IT); 4Department of Chemistry “Ugo Schiff”, University of Florence; 5Department of Surgical Sciences, University of Cagliari, Italy
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01 | INTEGRATED STRATEGIES FOR PLASTIC MANAGEMENT: MONITORING, BIOLOGICAL IMPACT, AND CIRCULAR PERSPECTIVES ROUND TABLE REPORT Giorgia Görner Enrile1|2, Antonietta Santoro3, Federica Scalia4, Stefania D’Angelo5, Annamaria Visco6, Andrea Pace7, Michele Torregrossa8, Dario Scalia9, Alessandro Aglialoro10, Salvatore Campanella10 | 1Siciliamedica.it; 2Ilsicilia.it; 3PI, Plastamination Project, University of Salerno, Italy; 4Human Anatomy, University Kore, Enna, Italy; 5Biochemistry, University Parthenope of Naples, Italy; 6Life Restart Project, University of Messina, Italy; 7Research and Technology Transfer, University of Palermo, Italy; 8Engineering, University of Palermo, Italy; 9Plastic Free Onlus Sicily, Italy; 10Regional Environmental Protection Agency of Sicily, Italy
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180 | Shared pathways in experimental projects: research, territory, and scientific communities compared the example of the initiatives of the Regional Agency for Rural Development – Ersa (Friuli Venezia Giulia, Italy) Simona Rainis | Regional Agency for the Rural Development ERSA, Gorizia, Italy.
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128 | Human biodiversity (anthropological, agricultural, and urban) is closely connected to experimental biology studies to understand the present and pave the way for the future Paolo Bonivento | Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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056 | Thidiazuron exposure reprograms metabolic networks with lasting effects on growth and photosynthetic efficiency in Arabidopsis thaliana Manuela Giraldo-Acosta1, Giulia Giovanna Salerno2, Marino B. Arnao1, Cinzia Margherita Bertea3, Ada Ricci2, Giuseppe Mannino3 | 1Department of Plant Biology Plant Physiology, University of Murci, Spain; 2Department of Chemical, Life and Environmental Sustainability Sciences, University of Parma, Italy; 3Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy.
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028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale1, Giuseppa D’Amico1, Martina Di Marco1, Giuseppina Poppa2, Pierlorenzo Maria Veiceschi3, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Paola Limoncelli2, Ilaria Giusti2, Vincenza Dolo2, Claudia Campanella1, Francesca Rappa1, Rosario Barone1, Giovanni Tringali3, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; 3Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.
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EXPOSITION TO PLASTIC AND ASSOCIATED-CHEMICALS IN NEURODEVELPMENTAL DISORDER: AN OVERVIEW Grazia Maria Giovanna PASTORINO, Francesca Felicia OPERTO | Department of Science of Health School of Medicine, University Magna Greacia of Catanzaro, Italy
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021 | Novel para-phenylenediamine-based derivatives as receptor tyrosine kinase-like orphan receptor 1 inhibitors: an in vitro preliminary characterization Maria Rosaria Miranda1, Gerardina Smaldone1, Francesca Di Matteo1, Valeria Napolitano1, Michela Aliberti1, Simona Musella1, Veronica Di Sarno1, Gianluigi Lauro1, Giuseppe Bifulco1, Giacomo Pepe1, Giovanna Aquino1, Mario Felice Tecce1, Isabel Maria Gomez-Monterrey2, Pietro Campiglia1, Carmine Ostacolo1, Alessia Bertamino1, Tania Ciaglia1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Italy; 2Department of Pharmacy, University of Naples Federico II, Naples, Italy.
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POLY-LACTIC ACID NANOPLASTICS BIOCCUMULATE IN DEVELOPING ZEBRAFISH AND INDUCE EPIGENETIC CHANGES Massimo VENDITTI1, Marta Anna SZYCHLINSKA2, Valentina LOPARDO3, Federica SCALIA4, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Francesco CAPPELLO5, Rosaria MECCARIELLO6 | 1Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Palermo, Italy; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy; 4Department of Medicine and Surgery, “Kore” University of Enna, Enna, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 6Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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094 | 2-octyl-2h-isothiazol-3-one and its role in zebrafish larvae neurogenesis and neuronal function Vanessa D’Altilia1, Ludovica Sulcanese1, Valentina Iezzi2, Silvana Zugaro2, Annamaria Iannetta1, Tommaso Silvestrini1|3, Elisabetta Benedetti2, Monia Perugini1. | 1Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy; 2Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy; 3University of Camerino, International School of Advanced Studies, Camerino, Italy.
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Adipokines in obesity and metabolic diseases
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COMMERCIALLY-DERIVED MICROPLASTICS AFFECT EARLY LIFE STAGES IN PARACENTROTUS LIVIDUS SEA URCHIN Amalia AMATO1,2,3, Ermelinda PRATO4, Mariacristina COCCA5, Francesca BIANDOLINO4, Immacolata LIOTTA5,6, Simone GIOIA1,2,3, Roberta ESPOSITO1, Davide CARAMIELLO7, Loredana MANFRA1,8, Giovanni LIBRALATO1,2, Valerio ZUPO3, Maria COSTANTINI1 | 1Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy; 2Department of Biology, University of Naples Federico II, Napoli, Italy; 3Stazione Zoologica Anton Dohrn, Department of Ecosustainable Marine Biotechnology, Ischia Marine Centre, Ischia, Italy; 4National Research Council, Water Research Institute (IRSA-CNR), Taranto, Italy; 5Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Pozzuoli, Napoli, Italy; 6Department of Chemical, Materials and Production Engineering, University of Naples “Federico II”, Napoli, Italy; 7Stazione Zoologica Anton Dohrn, Department of Marine Animal Conservation and Public Engagement, Naples, Italy; 8Institute for Environmental Protection and Research (ISPRA), Rome, Italy
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054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana1, Chiara Agliassa2, Francesco Caldo1, Moez Maghrebi1, Valeria Contartese2, Giuseppe Mannino1, Gianpiero Vigani1 | 1Department of Life Sciences and Systems Biology, University of Turin, Italy; 2Green Has Italia SpA, Canale [AT], Italy.
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100 | Tracking polystyrene nanoplastics by raman microscopy reveals intestinal and retinal toxicity Valentina Iezzi1, Roberta Maria Ferri1, Annamaria Iannetta2, Ludovica Sulcanese2, Tommaso Silvestrini2, Vanessa D’Altilia2, Giovanni Angelozzi2, Federico Perrella3, Carino Ferrante4, Giulia Fioravanti3, Monia Perugini2, Elisabetta Benedetti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy; 3Department of Physical and Chemical Sciences University of L’Aquila, Italy; 4CNR-SPIN, c/o department of Physical and Chemical Sciences University of L’Aquila, Italy.
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189 | Fluorescent analysis by confocal microscopy of lipid droplets as a marker of oocyte quality in Sarda sheep under different seasonal conditions Silvia Zaccardi1, Domenica Cocciolone1, Guido Macchiarelli1, Sara Succu2, Giovanni Giuseppe Leoni3, Maria Grazia Palmerini1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Department of Veterinary Medicine, University of Sassari, Italy; 3Department of Biomedical Sciences, University of Sassari, Italy.
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053 | Collagen-based biomaterials for biologically relevant 3D in vitro vascular models Elena Delgrosso1, Franca Scocozza1, Michele Conti1|2 | 1Department of Civil Engineering and Architecture, University of Pavia, Italy; 23D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, San Donato Milanese [MI], Italy.
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134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan1, Paolo Bonivento2 | 1Nanocoatings Research, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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044 | Thyroid response to stress in illness Caretta caretta: a preliminary study Chiara Lomonaco1, Paola Galluzzo2|3, Giorgia Schirò1|3, Angelo Costanza2|3, Rosario Adragna3, Vincenzo Monteverde2|3, Claudia Giannetto1, Salvatore Dara2|3, Rosaria Disclafani2|4 | 1Dipartimento di Scienze Veterinarie, Polo Universitario dell’Annunziata, University of Messina, Italy; 2Centro Referenza Nazionale per il Benessere, Monitoraggio e Diagnostica delle malattie delle Tartarughe Marine CReTaM; 3Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; 4Centro di Sostenibilità e Transizione Ecologica, University of Palermo, Italy.
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BIODEGRADABLE NANOPLASTIC: A TOOL FOR DRUG DELIVERY AND ENVIRONMENTAL CHALLENGE Enza TORINO1,2,3, Anna MENALE1, Samuele FIORENZA1,2, Simona SILVESTRI1,3 | 1University of Naples Federico II - Department of Chemical, Materials Engineering and Industrial Production; 2Interdepartmental Research Center on Biomaterial (CRIB); 3Fondazione Istituto Italiano di Tecnologia – Center for Advanced Biomaterials for Healthcare
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POLYSTYRENE NANOPARTICLES IN ZEBRAFISH: THEIR ROLE IN OCULAR STRESS AND LIPID METABOLIC IMBALANCE V. IEZZI1, F. PERRELLA2, S. ZUGARO1, R. M. FERRI1, A. IANNETTA3, L. SULCANESE3, T. SILVESTRINI3,4, M. PERUGINI3, E. BENEDETTI1, C. FERRANTE5 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila; 2Department of Physical and Chemical Sciences University of L’Aquila; 3Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo; 4Advanced Study “Theoretical and Applied Neuroscience” Preclinical, clinical and Translational neuroscience, University of Camerino, Italy; 5CNR-SPIN, c/o Department of Physical and Chemical Sciences University of L’Aquila, Italy
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061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino1, Giovanni Perconti1, Alessia Giannetto2, Andi Alijagic3 | 1Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 3Man-Technology-Environment Research Center MTM, Orebro University, Sweden.
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COMPARISON OF THE POTENTIAL CHRONIC TOXICITY OF POLYPROPYLENE AND POLYLACTIC ACID TO THE AMPHIPOD GAMMARUS AEQUICAUDA Francesca BIANDOLINO1, Ermelinda PRATO1, Amalia AMATO1,2, Loredana MANFRA2,5, Giovanni LIBRALATO2,3, Luisa ALBARANO3, Valerio ZUPO6, Maria COSTANTINI2 | 1National Research Council, Water Research Institute (IRSA-CNR), Taranto, Italy; 2Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy; 3Department of Biology, University of Naples Federico II, Naples, Italy; 4Stazione Zoologica Anton Dohrn, Department of Marine Animal Conservation and Public Engagement, Naples, Italy; 5Institute for Environmental Protection and Research (ISPRA), Rome, Italy; 6Stazione Zoologica Anton Dohrn, Department of Ecosustainable Marine Biotechnology, Ischia, Italy
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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PERINATAL EXPOSURE TO BISPHENOL A AND BISPHENOL B CAN ALTER THE SEXUAL BEHAVIOUR AND REPRODUCTIVE SYSTEM OF OFFSPRING Elena RICCI1,2, Marilena MARRAUDINO1,2, Noemi CADORIN1, Iva SABOVIC3, Alberto FERLIN3, Stefano GOTTI1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Torino, Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy; 3Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy
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113 | Ecotoxicological effects of bromuconazole in Oryzias latipes from embryos to adult endpoints Tania Russo1|2, Ilaria Olivito1, Iolanda Carratù2, Chiara Barone2, Ivan Conte2, Anna Di Cosmo2, Gianluca Polese2, Elvira Brunelli1 | 1Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende [CS], Italy; 2Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.
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Gambling: spreading among students in Palermo
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COMBINED EFFECTS OF POLYSTYRENE MICROPLASTICS, NANOPLASTICS, AND MERCURY ON THE GILL STRUCTURE AND FUNCTION OF MYTILUS GALLOPROVINCIALIS Rossana ROMANO1,2, Maria D. BORDALO3, Hugo C. VIEIRA3, Sílvia FS. PIRES3, Federica DI FRANCO1, Chiara M. MOTTA4, Palma SIMONIELLO1,2 | 1Department of Science and Technology, University Parthenope, Napoli, Italy; 2International PhD Programme, UNESCO Chair “Environment, Resources and Sustainable Development”, Department of Science and Technology, Parthenope University of Naples, Naples, Italy; 3CESAM—Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Aveiro, Portugal; 4Department of Biology, University of Naples Federico II, Napoli, Italy
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010 | Combining a gemcitabine-derived prodrug, GEM-C18, with nanoparticles to counteract acidic ph-dependent chemoresistance of pancreatic adenocarcinoma Francesca Fracasso, Marilena Ardone, Tiago Miguel Amaral Carvalho1|2, Barbara Rolando3, Silvia Arpicco3, Valeria Bincoletto3, Francesca Bianco4, Alessandra Fiorio Pla4, Daniela Isabel Abbrescia5, Ylenia Antonacci5, Chrysovalentinos Pousis5, Sharon Natasha Cox1, Flaviana Marzano5, Graziano Pesole1, Apollonia Tullo5, Stephan Joel Reshikn1, Rosa Angela Cardone1 | 1Dept of Biosciences, Biotechnology and Environment, University of Bari, ltaly; 2CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, Covilhã, Portugal; 3Dept. of Drug Science and Technology, University of Turin, ltaly; 4Dept of Life Sciences and Systems Biology, University of Turin, Italy 5Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies – IBIOM - CNR, Bari, Italy.
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161 | Anle 138b inclusion complex with methyl-β-cylodextrin: a novel liquid formulation for administration in Parkinson disease Giuditta Colangelo1, Adriana Trapani2, Giuseppe Fracchiolla2, Rosa Angela Cardone3, Anna Patrizia De Nichilo2, Stefano Castellani4, Michele Maffia5, Massimo Conese1, Rosanna Mallamaci3 | 1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 2Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, Bari, Italy; 4Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J, University of Bari “Aldo Moro”, Bari, Italy; 5Department of Biological and Environmental Science and Technologies DiSTeBA, University of Salento, Lecce, Italy.
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093 | Beyond biodegradability: assessing the toxicological footprint of polylactic acid nanoplastics on zebrafish gastrointestinal tract development Francesca Chiara Cecala1, Giusy Vultaggio1, Martina Di Marco1, Alessandra Maria Vitale1, Rosario Barone1, Francesca Rappa1, Maria Denise Amico1, Erwin Pavel Lamparelli2, Giovanna Della Porta2, Antonietta Santoro2, Francesco Cappello1|4, Federica Scalia3, Marta Anna Szychlinska5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medicine and Surgery - Kore University of Enna, Italy; 4Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care MePreCC, University of Palermo, Italy.
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184 | Phytochemicals in pruning waste and food industry by-products: biodiversity and circular economy Marina Russo1, Giovanna Cafeo1, Luigi Mondello1|2, Paola Dugo1|2 | 1Messina Institute of Technology c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy; 2Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy.
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