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085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan1, Alessandra Maria Vitale1, Federica Scalia1|2, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy.
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086 | Kir4.1 channels at the crossroads of oxidative stress and presbycusis: redox imbalance, electrophysiological failure and quercetin-mediated rescue Sara Spinelli1, Alessia Remigante2, Angela Marino1, Rossana Morabito1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Italy.
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054 | Biostimulant-mediated mitigation of hypoxic stress and recovery in lettuce under flooding conditions Chiara Dellapiana1, Chiara Agliassa2, Francesco Caldo1, Moez Maghrebi1, Valeria Contartese2, Giuseppe Mannino1, Gianpiero Vigani1 | 1Department of Life Sciences and Systems Biology, University of Turin, Italy; 2Green Has Italia SpA, Canale [AT], Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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072 | A standardized onion peel-derived bioactive ingredient attenuates palmitate-induced steatosis and oxidative stress in HepG2 cells Ilaria Di Gregorio1|2, Vincenzo Migliaccio2, Maria D’Elia1|3|4, Rita Celano1|3, Anna Lisa Piccinelli1|3, Luca Rastrelli1|3, Lillà Lionetti2|3 | 1Dept Pharmacy, University of Salerno, Salerno, Italy; 2Dept Chemistry and Biology “A Zambelli”, University of Salerno, Italy; 3National Biodiversity Future Center NBFC, Palermo, Italy; 4Dept Earth and Marine Sciences, University of Palermo, Italy.
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082 | Supplementation with Lactobacillus fermentum reversed fiber atrophy in a myopathy model by modulating IL-6, TNFα, and hsp60 levels, thereby enhancing muscle regeneration Martina Sausa1, Letizia Paladino2, Federica Scalia3, Francesco Paolo Zummo1, Giuseppe Vergilio1, Francesca Rappa1, Francesco Cappello1, Melania Ionelia Gratie1, Patrizia Proia4, Valentina Di Felice1, Antonella Marino Gammazza,5, Filippo Macaluso1, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO]; 3Department of Medicine and Surgery, Kore University of Enna; 4Department of Psychology, Educational Science and Human Movement, University of Palermo; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.
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114 | Mechanisms of antimony-induced intestinal injury under chronic low-dose exposure: evidence from Caco‑2 cells and protective role of cyanidin-3-o-glucoside Federica Lina Salamone1|2, Maria Sofia Molonia1, Santi Trischitta1, Antonella Saija1, Francesco Cimino1, Antonio Speciale1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 2Imbesi Foundation, Messina, Italy.
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078 | Stress-driven Dhurrin accumulation in sorghum revealed by physiological and biochemical markers Alessio Giannilivigni1, Manuela Giraldo-Acosta2, Flavia Girolami3, Stefano Giantin4, Luca Carisio4, Carlo Nebbia3, Marino Bañón Arnao2, Alberico Franzin4, Giuseppe Mannino1. | 1Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin, Italy; 2Department of Plant Biology Plant Physiology, University of Murcia, Spain; 3Department of Veterinary Sciences, University of Turin, Grugliasco [TO], Italy; 4Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta IZSPLV, Turin, Italy; 5Green Has Italia Spa, Plant Physiology Unit, Canale [CN], Italy.
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POLYSTYRENE NANOPARTICLES IN ZEBRAFISH: THEIR ROLE IN OCULAR STRESS AND LIPID METABOLIC IMBALANCE V. IEZZI1, F. PERRELLA2, S. ZUGARO1, R. M. FERRI1, A. IANNETTA3, L. SULCANESE3, T. SILVESTRINI3,4, M. PERUGINI3, E. BENEDETTI1, C. FERRANTE5 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila; 2Department of Physical and Chemical Sciences University of L’Aquila; 3Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo; 4Advanced Study “Theoretical and Applied Neuroscience” Preclinical, clinical and Translational neuroscience, University of Camerino, Italy; 5CNR-SPIN, c/o Department of Physical and Chemical Sciences University of L’Aquila, Italy
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107 | Protective effects of hydroxytyrosol against dichlorodiphenilethylene-induced oxidative injury in liver cells Vincenzo Migliaccio1, Ilaria Di Gregorio1, Martina Coletta1, Giuliana Panico2, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology “Adolfo Zambelli”, University of Salerno, Italy; 2Dept Biology, University Federico II, Napoli, Italy.
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066 | Modulation of oxidative stress and mitochondrial alteration in IL1β-stimulated human astrocytes: effects of extracts from leaves and rhizomes of Posidonia oceanica (L) Delile Giulia Abruscato1, Lucia Sileo2, Giulia Scanavino2, Manuela Mauro1, Francesco Longo1, Vincenzo Arizza1|3, Mirella Vazzana1|3, Claudio Luparello1|3, Ada Maria Tata2 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STeBICeF, University of Palermo, Italy; 2Department of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center NBFC, Palermo, Italy.
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100 | Tracking polystyrene nanoplastics by raman microscopy reveals intestinal and retinal toxicity Valentina Iezzi1, Roberta Maria Ferri1, Annamaria Iannetta2, Ludovica Sulcanese2, Tommaso Silvestrini2, Vanessa D’Altilia2, Giovanni Angelozzi2, Federico Perrella3, Carino Ferrante4, Giulia Fioravanti3, Monia Perugini2, Elisabetta Benedetti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy; 3Department of Physical and Chemical Sciences University of L’Aquila, Italy; 4CNR-SPIN, c/o department of Physical and Chemical Sciences University of L’Aquila, Italy.
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.
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D-ASPARTATE ALLEVIATES THE TESTICULAR DAMAGE INDUCED BY POLYSTYRENE MICROPLASTICS Sara FALVO1, Giulia GRILLO1, Gabriella CHIEFFI BACCARI1, Alessandra SANTILLO1, Imed MESSAOUDI2, Maria Maddalena DI FIORE1, Alessandra BIASI3, Maria Rosaria AMBRUOSI3, Massimo VENDITTI3 | 1Dept. of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; 2LR11ES41: Génétique, Biodiversité et Valorisation des Bioresources, Institut Supérieur de Biotechnologie, Université de Monastir, Monastir, Tunisia; 3Dept of Experimental Medicine, University of Campania ‘Luigi Vanvitelli’, Napoli, Italy
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EVALUATING ENDOCRINE AND OXIDATIVE EFFECTS OF POLYLACTIC ACID NANOPLASTICS (PLA-NPs) ON BREAST CELL MODELS Maria Denise AMICO1, Antonietta SANTORO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Magdalena GORSKA-PONIKOWSKA3,4,5, Francesca RAPPA1,5, Fabio BUCCHIERI1, Francesco CAPPELLO1,5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medical Chemistry, Medical University of Gdansk, Poland; 4Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Germany; 5Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
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081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti1, Gabriele La Monica2, Federica Alamia2, Alessia Bono2, Antonino Lauria2, Annamaria Martorana2, Antonella D’Anneo1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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090 | Activation of Sirtuin-1 by Cipollotto Nocerino leaf extract protects HepG2 cells from lipotoxicity Vincenzo Vestuto1, Maria Rosaria Miranda1, Giovanna Aquino2, Tania Ciaglia1, Rodolfo Maria Abbate1, Giuseppina Amodio3, Manuela Giovanna Basilicata4, Mario Felice Tecce1, Luca Rastrelli1, Pietro Campiglia1, Michele Manfra5, Giacomo Pepe1 | 1Department of Pharmacy, University of Salerno, Italy; 2AREA Science Park, Laboratorio di Multi-omica Area Sud LAAS, Baronissi [SA], Italy; 3Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi [SA], Italy; 4Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; 5Department of Science, University of Basilicata, Potenza, Italy.
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069 | Comparative analysis of inflammatory and redox responses in human and rat macrophages exposed to calcium-doped mesoporous silica nanoparticles Styliani Axypolitou1, Antonietta Ligas2, Ioannis Tsamesidis1, Georgia K. Pouroutzidou1, Pier Luigi Fiori2, Antonella Pantaleo2, Eleana Kontonasaki1 | 1Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.
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097 | Pharmaceutical pollution in aquatic environments: effects of valsartan on Mytilus galloprovincialis Giorgia Giurlanda1, Alessia Caferro1, Mariacristina Filice1, Maria Assunta Iovine1, Alfonsina Gattuso1, Federica Impellitteri2, Caterina Faggio3, Maria Carmela Cerra1, Sandra Imbrogno1 | 1Department of Biology, Ecology, and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy; 2Department of Veterinary Sciences, University of Messina, Italy; 3Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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101 | Physiological and cellular responses of the Mediterranean mussel to antifouling biocides 2-n-octyl-4-isothiazolin-3-one and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, alone and in mixture Federica Impellitteri1, Maria Giovanna Rizzo1, Giuseppe Piccione2, Paolo Pastorino3, Cristiana Roberta Multisanti2, Caterina Faggio1|4 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; 4Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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154 | Metabolomic reprogramming and ferroptosis protection by the indole-based compound 20 against Aβ (25–35) in SH-SY5Y cells Mariapia Vietri1, Enza Napolitano1, Carmen Marino1, Tania Ciaglia1, Rodolfo Maria Abbate1, Pietro Campiglia1, Alessia Bertamino1, Michele Manfra2, Anna Maria D’Ursi1, Ornella Moltedo1, Vincenzo Vestuto1 | 1Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy; 2Department of Health Science, University of Basilicata, Potenza, Italy.
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009 | Metabolic adaptation to hypoxia via lipid droplet accumulation in a 3D hepatocellular carcinoma model Giorgia Cannatà1, Caterina Faggio1|2, Maria Giovanna Rizzo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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151 | Dysregulation of the lung-brain axis induced by CMIT/MIT: oxidative stress and junctional protein impairment lead to α-synuclein accumulation and dopaminergic neurotoxicity Nicla Tranchida1, Rosanna Di Paola2, Marika Cordaro3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Italy.
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099 | Mechanistic insights into the ecotoxicity of bisphenol analogues and their mixtures in marine mussels: oxidative stress and neuro-immune responses Antonella Iaconis1, Marika Cordaro2, Davide Di Paola1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 2Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina,, Italy.
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098 | Gill damage in zebrafish exposed to environmentally relevant concentrations of the UV filter avobenzone Antonio Paolo Maria Graziani, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Rachele Macirella, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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105 | The invasive crab Callinectes sapidus as a model for assessing sub-lethal effects of polyvinyl alcohol Alessandra Maganza1|2, Alice Gabetti1, Camilla Mossotto1|2, Alessia Merialdi1, Monia Renzi3, Francesca Provenza4, Serena Anselmi4, Antonia Concetta Elia2, Giorgia Zicarelli1, Annalisa Cotugno1, Giuseppe Esposito1, Caterina Faggio5|6, Marino Prearo1, Paolo Pastorino1 | 1The Veterinary Medical Research Institute for Piemonte, Liguria and Valle d’Aosta, Torino, Italy; 2Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy; 3Bioscience Research Center, Orbetello, Italy; 4Department of Life Sciences, University of Trieste, Trieste, Italy; 5Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 6Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.
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162 | Functional and health-promoting properties of EVOO from Sicilian olive cultivars: focus on oxidative stress and inflammation Mariateresa Cristani1, Ali Mert Yetisgin2, Giovanni Bartolomeo3, Nicola Cicero3|4, Rosaria Costa3, Nicola Micale1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2İnönü University, Faculty of Pharmacy, Kampüs, Battalgazi/Malatya, Türkiye; 3Department of Biomedical, Dental, Morphological and Functional Images Sciences BIOMORF, University of Messina, Messina, Italy; 4Science4Life srl, start-up of the University of Messina, Messina, Italy.
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031 | Hypoxia exposure influences the oxidative status of Mytilus galloprovincialis in a time-dependent manner Alessia Caferro1, Mariacristina Filice1, Giorgia Giurlanda1, Maria Assunta Iovine1, Alfonsina Gattuso1, Federica Impellitteri2, Caterina Faggio3, Maria Carmela Cerra1, Sandra Imbrogno1 | 1 Department of Biology, Ecology, and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy; 2 Department of Veterinary Sciences, University of Messina, Italy; 3 Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.
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106 | Health effects of noise pollution on juvenile crustaceans: behavioral and molecular responses in Procambarus clarkii Maria Ceraulo1|2, Giuseppa Buscaino1, Clarissa De Vita1, Aiti Vizzini2|3|*, Mirella Vazzana2|3, Elena Papale1, Vincenzo Arizza2|3, Francesco Longo3, Francesco Paolo Faraone3, Manuela Mauro2|3 | 1Institute for the Study of Anthropogenic impacts and Sustainability in the marine environment, National Research Council of Italy, Torretta Granitola, Campobello di Mazara [TP], Italy; 2NBFC, National Biodiversity Future Center, Palermo, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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116 | Exosomes and miRNA content engagement in inflammatory processes let's take stock in the veterinary field Francesca Arfuso1, Jessica M. Abbate2, Claudia Giannetto1, Marilena Briglia3, Elisabetta Giudice1, Giovanni Lanteri2, Giuseppe Piccione1 | 1Department of Veterinary Sciences, University of Messina, Polo Universitario Annunziata, Messina, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Polo Universitario Papardo, Messina, Italy; 3Department of Medicine and Surgery “Kore”, University of Enna, Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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FROM PRISTINE TO LABORATORY-WEATHERED MICRO- AND NANOPLASTICS: INTERACTION WITH ENVIRONMENTAL CONTAMINANTS AND BIOLOGICAL EFFECTS Astrid SARACENI1, Barbara MOGNETTI1, Erika COTTONE1, Andrey Ethan RUBIN2, Maria Pia GALLO1, Yoav GOTHILF3, Ines ZUCKER2,4, Federica DAL BELLO5, Patrizia BOVOLIN1 | 1Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy; 2Porter School of Earth and Environmental Studies, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; 3Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel; 4School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; 5Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
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COMBINED EFFECTS OF POLYSTYRENE MICROPLASTICS, NANOPLASTICS, AND MERCURY ON THE GILL STRUCTURE AND FUNCTION OF MYTILUS GALLOPROVINCIALIS Rossana ROMANO1,2, Maria D. BORDALO3, Hugo C. VIEIRA3, Sílvia FS. PIRES3, Federica DI FRANCO1, Chiara M. MOTTA4, Palma SIMONIELLO1,2 | 1Department of Science and Technology, University Parthenope, Napoli, Italy; 2International PhD Programme, UNESCO Chair “Environment, Resources and Sustainable Development”, Department of Science and Technology, Parthenope University of Naples, Naples, Italy; 3CESAM—Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Aveiro, Portugal; 4Department of Biology, University of Naples Federico II, Napoli, Italy
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MARINE POLLUTION: MYTILUS GALLOPROVINCIALIS AS A MODEL ORGANISM TO ASSESS MICRO- AND NANOPLASTIC IMPACT Palma SIMONIELLO1, Rossana ROMANO1, Vincenzo MIGLIACCIO2, Gaetana NAPOLITANO1, Lilla LIONETTI2, Luigi ROSATI3, Chiara M. MOTTA3 | 1Department of Science and Technology, Parthenope University of Naples; 2Department of Chemistry and Biology “Adolfo Zambelli”, University of Salerno; 3Department of Biology, University of Naples Federico II, Italy
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167 | The importance of personalized oxygen-ozone dosing in systemic therapy: algorithmic solutions for regenerative medicine Antonio Galoforo1, Paolo Bonivento2 | 1Tavolo Tecnico “Salute ed Ambiente”, Intergruppo parlamentare “One Health”, Camera dei Deputati, Roma, Italy; 2RING - ODR Research Innovation Networking Generation, Organismo di Ricerca, Milano, Italy.
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