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151 | Dysregulation of the lung-brain axis induced by CMIT/MIT: oxidative stress and junctional protein impairment lead to α-synuclein accumulation and dopaminergic neurotoxicity Nicla Tranchida1, Rosanna Di Paola2, Marika Cordaro3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Italy.
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121 | Probiotics effect on brain-gut axis mediated by nanovescicles Alessandro Lo Giudice1, Giuseppa D’Amico1, Melania Ionelia Gratie1, Letizia Paladino2, Giusy Vultaggio1, Adelaide Carista1, Francesco Cappello1, Vita Di Stefano3, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy; 3Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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040 | Comparative neurotoxicity of glyphosate and its metabolite aminomethylphosphonic acid: evidence from Cyprinus carpio Serafina Ferrara1, Jana Blahova2, Premysl Mikula2, Petr Marsalek2, Caterina Faggio1|3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Animal Protection and Welfare and Veterinary Public Health, University of Veterinary Sciences Brno, Brno, Czech Republic; 3Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato1, Nicolò Ricciardi1, Valentina Di Liberto1, Miriana Scordino1, Giulia Urone1, Danila Di Majo1, Giuseppe Giglia1|4, Pierangelo Sardo1, Giuseppe Ferraro1, Riccardo Alessandro1|2|3, Stefania Raimondo1|2, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; 2Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; 3Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; 4Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.
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094 | 2-octyl-2h-isothiazol-3-one and its role in zebrafish larvae neurogenesis and neuronal function Vanessa D’Altilia1, Ludovica Sulcanese1, Valentina Iezzi2, Silvana Zugaro2, Annamaria Iannetta1, Tommaso Silvestrini1|3, Elisabetta Benedetti2, Monia Perugini1. | 1Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy; 2Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy; 3University of Camerino, International School of Advanced Studies, Camerino, Italy.
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153 | α-synuclein regulation in brain and bone marrow is releted to the differential expression of GATA1 transcription factor Viola Velardi1, Francesca Arciprete1, Claudia Caturano,1Rosa Alba Rana1, Romina Mancinelli2, Maria Zingariello1, Giorgio Vivacqua1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy.
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ENVIRONMENTAL NANOPLASTIC ACCUMULATION AND NEURODEGENERATIVE DISEASE IN ANIMAL MODELS Beatrice ZARRILLI1,2, Nicola B. MERCURI2,3, Rosaria MECCARIELLO1, Ezia GUATTEO1,2 | 1University of Naples ‘Parthenope’, Department of Medical, Human Movement and Well-being Sciences, Naples, Italy; 2Experimental Neurology Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy; 3University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy
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EXPLORING THE NEUROTOXIC POTENTIAL OF LDPE MICROPLASTICS: EVIDENCE IN VITRO AND IN VIVO ASSESSMENT Marilena MARRAUDINO1,2, Elena RICCI1,2, Silvia CHASSEUR1,2, Daniela RASA'1, Riccardo ROLANDO1, Stefano GOTTI1,2, Marina BOIDO1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy
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113 | Ecotoxicological effects of bromuconazole in Oryzias latipes from embryos to adult endpoints Tania Russo1|2, Ilaria Olivito1, Iolanda Carratù2, Chiara Barone2, Ivan Conte2, Anna Di Cosmo2, Gianluca Polese2, Elvira Brunelli1 | 1Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende [CS], Italy; 2Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy.
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007 | Dysregulation of the trans-sulfuration-sphingosine-1-phosphate signaling axis in glioblastoma: preclinical evidence Elsa Calcaterra1, Michela Campolo1, Melania Correale2, Rossella Basilotta1, Maria Caffo3, Roberta D’Emmanuele Di Villa Bianca2, Emma Mitidieri2, Giovanna Casili1, Emanuela Esposito1 | 1Department of Chemical, Biological, Pharmaceutical, Environmental Sciences, University of Messina, Italy; 2Department of Pharmacy, School of Medicine and Surgery, University of Study of Naples - Federico II, Naples, Italy; 3Unit of Neurosurgery, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.
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150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France.
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028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale1, Giuseppa D’Amico1, Martina Di Marco1, Giuseppina Poppa2, Pierlorenzo Maria Veiceschi3, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Paola Limoncelli2, Ilaria Giusti2, Vincenza Dolo2, Claudia Campanella1, Francesca Rappa1, Rosario Barone1, Giovanni Tringali3, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; 3Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.
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01 | INTEGRATED STRATEGIES FOR PLASTIC MANAGEMENT: MONITORING, BIOLOGICAL IMPACT, AND CIRCULAR PERSPECTIVES ROUND TABLE REPORT Giorgia Görner Enrile1|2, Antonietta Santoro3, Federica Scalia4, Stefania D’Angelo5, Annamaria Visco6, Andrea Pace7, Michele Torregrossa8, Dario Scalia9, Alessandro Aglialoro10, Salvatore Campanella10 | 1Siciliamedica.it; 2Ilsicilia.it; 3PI, Plastamination Project, University of Salerno, Italy; 4Human Anatomy, University Kore, Enna, Italy; 5Biochemistry, University Parthenope of Naples, Italy; 6Life Restart Project, University of Messina, Italy; 7Research and Technology Transfer, University of Palermo, Italy; 8Engineering, University of Palermo, Italy; 9Plastic Free Onlus Sicily, Italy; 10Regional Environmental Protection Agency of Sicily, Italy
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PERINATAL EXPOSURE TO BISPHENOL A AND BISPHENOL B CAN ALTER THE SEXUAL BEHAVIOUR AND REPRODUCTIVE SYSTEM OF OFFSPRING Elena RICCI1,2, Marilena MARRAUDINO1,2, Noemi CADORIN1, Iva SABOVIC3, Alberto FERLIN3, Stefano GOTTI1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Torino, Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy; 3Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy
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016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes Alice Foti1, Fabio Allia1, Marilena Briglia1, Gianpiero Tamburrini2, Roberta Malaguarnera1, Francesco Cecconi2|3, Vittoria Pagliarini2|3, Veronica Marabitti4, Francesca Nazio4, Adriana C.E. Graziano1 | 1University of Enna “Kore”, Enna, Italy; 2Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4University of Rome Tor Vergata, Rome, Italy.
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09 | POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTINATION): ORGAN INJURIES AND UNDERLINING MOLECULAR MECHANISMS: EVIDENCE FROM IN VIVO ZEBRAFISH MODEL Marta A. Szychlinska1, Federica Scalia2, Martina Di Marco3, Giusy Vultaggio3, Maria Denise Amico3, Fabiano Capparucci4, Carmelo Iaria4, Marianna Marino5, Erwin Pavel Lamparelli5, Giovanna Della Porta5, Francesca Rappa3, Antonella Marino Gammazza3, Rosario Barone3, Antonino Testa6, Rosaria Meccariello7, Antonietta Santoro5, Francesco Cappello3 | 1Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 2Department of Medicine and Surgery - Kore University of Enna, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 4Department of Chemical, Biological, Pharmacological and Environmental Sciences, University of Messina, Italy; 5Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 6Department of Biological and Pharmaceutical Environmental Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 7Department of Movement and Wellness Sciences, Parthenope University of Naples, Italy
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093 | Beyond biodegradability: assessing the toxicological footprint of polylactic acid nanoplastics on zebrafish gastrointestinal tract development Francesca Chiara Cecala1, Giusy Vultaggio1, Martina Di Marco1, Alessandra Maria Vitale1, Rosario Barone1, Francesca Rappa1, Maria Denise Amico1, Erwin Pavel Lamparelli2, Giovanna Della Porta2, Antonietta Santoro2, Francesco Cappello1|4, Federica Scalia3, Marta Anna Szychlinska5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medicine and Surgery - Kore University of Enna, Italy; 4Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care MePreCC, University of Palermo, Italy.
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TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO1, Martina LOMBARDI1-3, Raffaella D’AURIA1, Erwin Pavel LAMPARELLI1, Giovanna DELLA PORTA1,4, Marta Anna SZYCHLINSKA5, Federica SCALIA6, Francesco CAPPELLO6,7, Rosaria MECCARIELLO8, Andrea VIGGIANO1,4, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, SA, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 6Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 7Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy
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143 | Anodal tDCS enhances decision precision during biological motion perception: a computational active inference perspective Antonio Cangelosi1, Umberto Quartetti1, Giulio Musotto2, Dimitri Ognibene3, Giuditta Gambino1, Giuseppe Giglia1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, Section of Human Physiology, University of Palermo, Italy; 2Bioengineering Unit, RiMED Foundation, Palermo, Italy; 3Department of Psychology, University of Milan-Bicocca, Milan, Italy.
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.
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161 | Anle 138b inclusion complex with methyl-β-cylodextrin: a novel liquid formulation for administration in Parkinson disease Giuditta Colangelo1, Adriana Trapani2, Giuseppe Fracchiolla2, Rosa Angela Cardone3, Anna Patrizia De Nichilo2, Stefano Castellani4, Michele Maffia5, Massimo Conese1, Rosanna Mallamaci3 | 1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 2Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Bari, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, Bari, Italy; 4Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J, University of Bari “Aldo Moro”, Bari, Italy; 5Department of Biological and Environmental Science and Technologies DiSTeBA, University of Salento, Lecce, Italy.
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130 | Behavioural taxonomy of the common octopus: a framework for understanding individual variation through complex task navigation Emanuela Cirillo1|2, Tania Russo3, Mariangela Norcia1, Valeria Maselli1, Salvatore Valiante1, Michael Kuba1, Marco Gamba4, Gianluca Polese1|2, Anna Di Cosmo1|2 | 1Dipartimento di Biologia, Università di Napoli Federico II, Napoli, Italy; 2MNESYS - PNRR partenariato esteso; 3Dipartimento di Biologia, Ecologia e Scienze della Terra, Università della Calabria, Rende (CS), Italy; 4Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Italy.
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083 | HSV-1 replication and chemokines activation in human monocytes are suppressed by Pistacia vera l. extracts Rosamaria Pennisi1, Marianna Costa1|2, Paola Trischitta1|2, Giuseppina Mandalari1, Maria Teresa Sciortino1. | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy.
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005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16 Maria Antonella Augello1, Giuseppa D’Amico1, Alessandra Maria Vitale1, Rosario Barone1, Simona Rapposelli3, Maciej Wnuk4, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2, Federica Scalia5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Pharmacy, University of Pisa, Italy; 4Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; 5Department of Medicine and Surgery, Kore University of Enna, Italy.
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152 | Genetic and morphological factors in cortical folding: studies on the rolandic fissure Sophie Martinet, Fabrizio Pizzagalli, Alessandro Vercelli | Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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117 | Modulation of DNA methylation patterns and heat shock proteins following exercise and probiotic supplementation A. Boatta1|2, G. Messina1, A. Pagliaro3, A. Alioto3, C. Rossi3, L. Paladino4, F. Rappa6, F. Naselli5, F. Cappello6, R. Barone6, P. Proia3 | 1Department of Human Sciences and Promotion of Quality of Life, San Raffaele Roma Open University, Roma, Italy; 2Institute for Biomedical Research and Innovation, CNR, Palermo, Italy; 3Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy; 4Department of Theoretical and Applied Sciences DiSTA, eCampus University, Novedrate, Italy; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy; 6Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Palermo, Italy.
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115 | Thyroid-active endocrine disruptors shape distinct neurobehavioral signatures in zebrafish larvae Tommaso Sivestrini1|2, Annamaria Iannetta1, Ludovica Sulcanese1, Giovanni Angelozzi1, Vanessa D’Altilia1, Monica Ceci1, Monia Perugini1 | 1Advanced Study “Theoretical and Applied Neuroscience”, Preclinical clinical and Translational Neuroscience, University of Camerino, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy.
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