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125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio1, Giuseppina Poppa1, Giuseppe Cammarata2, Sandra D’Ascenzo1, Vincenza Dolo1, Simona Taverna2, Ilaria Giusti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.
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108 | Emerging models for emerging contaminants Camilla Mossotto1|2, Alice Gabetti1, Alessandra Maganza1|2, Alessia Merialdi1, Antonia Concetta Elia2, Monia Renzi3, Giuseppe Esposito1, Marino Prearo1, Caterina Faggio4, Paolo Pastorino1 | 1Istituto Zooprofilattico del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; 2Università di Perugia, Italy; 3Università degli Studi di Trieste, Italy; 4Università degli Studi di Messina, Italy.
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TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO1, Martina LOMBARDI1-3, Raffaella D’AURIA1, Erwin Pavel LAMPARELLI1, Giovanna DELLA PORTA1,4, Marta Anna SZYCHLINSKA5, Federica SCALIA6, Francesco CAPPELLO6,7, Rosaria MECCARIELLO8, Andrea VIGGIANO1,4, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, SA, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 6Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 7Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy
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055 | Investigating microgravity’s dual impact through neuronal and cyanobacterial models: mechanistic insights into spirulina bioactivity and Parkinson’s disease pathology Mohammed Amine El Faqir1|2, Giuseppe Uras1, Alessia Manca2, Veronica Lentini2, Antonella Pantaleo2 | 1Department of Clinical Neuroscience, Institute of Neurology, University college London, UK; 2Department of Biomedical Science, University of Sassari, Italy.
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EVALUATING ENDOCRINE AND OXIDATIVE EFFECTS OF POLYLACTIC ACID NANOPLASTICS (PLA-NPs) ON BREAST CELL MODELS Maria Denise AMICO1, Antonietta SANTORO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Magdalena GORSKA-PONIKOWSKA3,4,5, Francesca RAPPA1,5, Fabio BUCCHIERI1, Francesco CAPPELLO1,5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medical Chemistry, Medical University of Gdansk, Poland; 4Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Germany; 5Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
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053 | Collagen-based biomaterials for biologically relevant 3D in vitro vascular models Elena Delgrosso1, Franca Scocozza1, Michele Conti1|2 | 1Department of Civil Engineering and Architecture, University of Pavia, Italy; 23D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, San Donato Milanese [MI], Italy.
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181 | Exploring boron neutron capture therapy effects on healthy skin: from cells to tissues Stefania Ricci1|2|3, Silva Bortolussi3|4, Ricardo Luis Ramos3|4, Ian Postuma3, Daniele Dondi3|5, Cinzia Ferrari3|7, Laura Cansolino3|7, Tea Maverna2, Federica Riva2|3 | 1Dept of Internal Medicine and Medical Therapy, University of Pavia, Italy; 2Dept of Experimental Medicine, Histology and Embryology Unit, University of Pavia, Italy; 3National Institute of Nuclear Physics INFN, Unit of Pavia, Italy; 4Dept of Physics, University of Pavia, Italy; 5Dept of Chemistry, University of Pavia, Italy; 6Dept of Molecular Medicine, Human Physiology Unit, University of Pavia, Italy; 7Laboratory of Experimental Surgery, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Italy.
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155 | Mitochondrial dynamics and therapeutic insights in spinal muscular atrophy: effects of MFN2 boosting in motoneurons and human fibroblasts Francesco Paolo Zummo1, Serena Stanga1, Letizia Paladino2, Maria Beltran3, Francesco Fedeli4, Maria Rosa Soler3, Fabio Bucchieri5, Marina Boido1 | 1Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy; 2E-Campus University, Palermo, Italy; 3Neuronal Signaling Unit, Experimental Medicine Department, University of Lleida-IRBLleida, Lleida, Spain; 4University of Pavia, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.
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027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy.
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FROM PRISTINE TO LABORATORY-WEATHERED MICRO- AND NANOPLASTICS: INTERACTION WITH ENVIRONMENTAL CONTAMINANTS AND BIOLOGICAL EFFECTS Astrid SARACENI1, Barbara MOGNETTI1, Erika COTTONE1, Andrey Ethan RUBIN2, Maria Pia GALLO1, Yoav GOTHILF3, Ines ZUCKER2,4, Federica DAL BELLO5, Patrizia BOVOLIN1 | 1Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy; 2Porter School of Earth and Environmental Studies, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; 3Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel; 4School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; 5Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
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ENVIRONMENTAL NANOPLASTIC ACCUMULATION AND NEURODEGENERATIVE DISEASE IN ANIMAL MODELS Beatrice ZARRILLI1,2, Nicola B. MERCURI2,3, Rosaria MECCARIELLO1, Ezia GUATTEO1,2 | 1University of Naples ‘Parthenope’, Department of Medical, Human Movement and Well-being Sciences, Naples, Italy; 2Experimental Neurology Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy; 3University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy
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POLYSTYRENE NANOPARTICLES IN ZEBRAFISH: THEIR ROLE IN OCULAR STRESS AND LIPID METABOLIC IMBALANCE V. IEZZI1, F. PERRELLA2, S. ZUGARO1, R. M. FERRI1, A. IANNETTA3, L. SULCANESE3, T. SILVESTRINI3,4, M. PERUGINI3, E. BENEDETTI1, C. FERRANTE5 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila; 2Department of Physical and Chemical Sciences University of L’Aquila; 3Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo; 4Advanced Study “Theoretical and Applied Neuroscience” Preclinical, clinical and Translational neuroscience, University of Camerino, Italy; 5CNR-SPIN, c/o Department of Physical and Chemical Sciences University of L’Aquila, Italy
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CELL SPECIFIC METABOLOMIC AND FLUXOMIC RESPONSES TO POLYLACTIC ACID NANOPLASTICS EXPOSURE IN HUMAN INTESTINAL CELLS Martina LOMBARDI1,2,3, Raffaella D’AURIA1, Marianna MARINO1, Mariagerarda LULLO1, Erwin Pavel LAMPARELLI1, Federica MONTELLA1, Giovanna DELLA PORTA1,4, Andrea VIGGIANO1, Jacopo TROISI1,2,3,5, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno; 2Theoreo Srl, Montecorvino Pugliano (SA); 3European Institute of Metabolomics - Fondazione EIM, Baronissi (SA); 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno; 5Department of Chemistry and Biology, “A. Zambelli”, University of Salerno, Fisciano (SA), Italy
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028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale1, Giuseppa D’Amico1, Martina Di Marco1, Giuseppina Poppa2, Pierlorenzo Maria Veiceschi3, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Paola Limoncelli2, Ilaria Giusti2, Vincenza Dolo2, Claudia Campanella1, Francesca Rappa1, Rosario Barone1, Giovanni Tringali3, Francesco Cappello1, Celeste Caruso Bavisotto1 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; 3Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.
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UNTARGETED METABOLOMICS REVEALS GONADAL METABOLIC DISRUPTION IN MYTILUS GALLOPROVINCIALIS EXPOSED TO CADMIUM AND MICROPLASTICS Vera ABENANTE1,2, Andrea INGENITO1,2, Alessio TROTTA1,2, Giulio SANTANIELLO3, Gennaro LETTIERI3 , Marina PISCOPO3, Jacopo TROISI1,2,4 | 1Theoreo S.r.l., University of Salerno; 2European Institute of Metabolomics - Fondazione EIM, Baronissi (SA); 3Department of Biology, University of Naples Federico II, Naples; 4Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy
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067 | Redefining amphibian innate immunity: first in vitro and in vivo evidence of phagocytic function in blood cells Valbona Aliko1, Erion Sukaj2, Cristiana Roberta Multisanti3, Federica Impelliteri4, Caterina Faggio4 | 1University of Tirana, Faculty of Natural Sciences, Department of Biology, Tirana, Albania; 2Western Balkans University, Faculty of Medicine and Technical Medical Sciences, Tirana, Albania; 3Department of Veterinary Sciences, University of Messina, Italy; 4University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.
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016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes Alice Foti1, Fabio Allia1, Marilena Briglia1, Gianpiero Tamburrini2, Roberta Malaguarnera1, Francesco Cecconi2|3, Vittoria Pagliarini2|3, Veronica Marabitti4, Francesca Nazio4, Adriana C.E. Graziano1 | 1University of Enna “Kore”, Enna, Italy; 2Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4University of Rome Tor Vergata, Rome, Italy.
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146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato1, Nicolò Ricciardi1, Valentina Di Liberto1, Miriana Scordino1, Giulia Urone1, Danila Di Majo1, Giuseppe Giglia1|4, Pierangelo Sardo1, Giuseppe Ferraro1, Riccardo Alessandro1|2|3, Stefania Raimondo1|2, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; 2Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; 3Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; 4Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.
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061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino1, Giovanni Perconti1, Alessia Giannetto2, Andi Alijagic3 | 1Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 3Man-Technology-Environment Research Center MTM, Orebro University, Sweden.
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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163 | SIX-2G as a novel compound to attenuate airway inflammation in cystic fibrosis through modulation of molecular chaperones Giuseppa D’Amico1, Federica Scalia2, Maria Antonella Augello1, Giusi Alberti1, Roberta Bivacqua3, Marilia Barreca3, Rosario Barone1, Francesco Cappello1, Paola Barraja3, Alessandra Montalbano3, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy; 3Department of Biological, Chemical, Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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EXPOSITION TO PLASTIC AND ASSOCIATED-CHEMICALS IN NEURODEVELPMENTAL DISORDER: AN OVERVIEW Grazia Maria Giovanna PASTORINO, Francesca Felicia OPERTO | Department of Science of Health School of Medicine, University Magna Greacia of Catanzaro, Italy
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D-ASPARTATE ALLEVIATES THE TESTICULAR DAMAGE INDUCED BY POLYSTYRENE MICROPLASTICS Sara FALVO1, Giulia GRILLO1, Gabriella CHIEFFI BACCARI1, Alessandra SANTILLO1, Imed MESSAOUDI2, Maria Maddalena DI FIORE1, Alessandra BIASI3, Maria Rosaria AMBRUOSI3, Massimo VENDITTI3 | 1Dept. of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; 2LR11ES41: Génétique, Biodiversité et Valorisation des Bioresources, Institut Supérieur de Biotechnologie, Université de Monastir, Monastir, Tunisia; 3Dept of Experimental Medicine, University of Campania ‘Luigi Vanvitelli’, Napoli, Italy
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069 | Comparative analysis of inflammatory and redox responses in human and rat macrophages exposed to calcium-doped mesoporous silica nanoparticles Styliani Axypolitou1, Antonietta Ligas2, Ioannis Tsamesidis1, Georgia K. Pouroutzidou1, Pier Luigi Fiori2, Antonella Pantaleo2, Eleana Kontonasaki1 | 1Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.
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POLY-LACTIC ACID NANOPLASTICS BIOCCUMULATE IN DEVELOPING ZEBRAFISH AND INDUCE EPIGENETIC CHANGES Massimo VENDITTI1, Marta Anna SZYCHLINSKA2, Valentina LOPARDO3, Federica SCALIA4, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Francesco CAPPELLO5, Rosaria MECCARIELLO6 | 1Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Palermo, Italy; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy; 4Department of Medicine and Surgery, “Kore” University of Enna, Enna, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 6Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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039 | Age and growth of the mesopelagic fish Electrona risso (myctophidae) from the Strait of Messina (central Mediterranean sea) Calogero Fontana1, Alice Vaccaro2, Francesco Longo1, Danilo Malara3, Emanuela Fanelli2|4, Pietro Battaglia1|4 | 1Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; 2Università Politecnica delle Marche UNIVPM, Dipartimento di Scienze della Vita e dell’Ambiente, Ancona, Italy; 3Northern Territory Government of Australia, Department of Agriculture and Fisheries, Fisheries Division, Berrimah, NT, Australia; 4National Biodiversity Future Center, Palermo, Italy.
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MATERNAL EXPOSURE TO ENDOCRINE DISRUPTORS AND INFANT DEVELOPMENT: FINDINGS FROM THE LIFE MILCH COHORT STUDY Silvia PATERLINI1, Maria Maddalena BRAMBILLA1, Francesca ALBERGHI2, Alessia ARDENGHI3, Mariateresa BELLANTONI1, Marta FONTANA2, Laura FILONZI3, Francesco NONNIS MARZANO3, Francesca NUTI4, Annalisa PELOSI1, Serafina PERRONE1, Silvia PETZA5, Roberta PINTUS5, Feliciana REAL-FERNANDEZ4, Vassilios FANOS5, Anna Maria PAPINI4, Maria E. STREET1,2, Paola PALANZA1 | 1Department of Medicine and Surgery, University of Parma (IT); 2Department of Obstetrics, Gynecology and Pediatrics, Azienda USL-IRCCS, Reggio Emilia (IT); 3Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma (IT); 4Department of Chemistry “Ugo Schiff”, University of Florence; 5Department of Surgical Sciences, University of Cagliari, Italy
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POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTAMINATION): SIZE-DEPENDENT EFFECTS OF PLA-DERIVED NANOPLASTICS ON EARLY ZEBRAFISH DEVELOPMENT Giusy VULTAGGIO1, Martina DI MARCO1, Antonietta SANTORO2, Marianna MARINO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Francesco CAPPELLO1,3, Federica SCALIA1,4, Marta Anna SZYCHLINSKA5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery - Kore University of Enna, Enna, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Italy
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068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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180 | Shared pathways in experimental projects: research, territory, and scientific communities compared the example of the initiatives of the Regional Agency for Rural Development – Ersa (Friuli Venezia Giulia, Italy) Simona Rainis | Regional Agency for the Rural Development ERSA, Gorizia, Italy.
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018 | BSA nanoparticles containing collagenases and doxorubicin to enhance therapeutic efficacy in 3D models of solid tumor Gabriele Lo Buglio1|2, Alessandra Lo Cicero1, Simona Campora1, Paolo Cinà3Samuel Lenton2, Vito Foderà2, Giulio Ghersi1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Pharmacy, University of Copenhagen, Denmark; 3Abiel srl, Palermo, Italy.
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102 | Polylactic acid nanoparticles as metabolically active entities: a metabolomics and fluxomics perspective Martina Lombardi1|2|3, Vera Abenante2|3, Alessio Trotta2|3, Erwin Pavel Lamparelli1, Federica Montella1, Giovanna Della Porta1, Andrea Viggiano1, Jacopo Troisi1|2|3|4, Antonietta Santoro1 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, Salerno, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, Salerno, Italy; 4Department of Chemistry and Biology, “A Zambelli”, University of Salerno, Fisciano [SA], Italy.
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EFFECTS OF CO-EXPOSURE TO MICROPLASTICS AND CADMIUM ON THE BINDING OF PROTAMINE-LIKE PROTEINS TO DNA IN MYTILUS GALLOPROVINCIALIS Gennaro LETTIERI, Giulio SANTANIELLO, Simona AMORE, Carmela MARINARO, Marina PISCOPO | Dipartimento di Biologia, Università degli Studi di Napoli Federico II
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EXPLORING THE NEUROTOXIC POTENTIAL OF LDPE MICROPLASTICS: EVIDENCE IN VITRO AND IN VIVO ASSESSMENT Marilena MARRAUDINO1,2, Elena RICCI1,2, Silvia CHASSEUR1,2, Daniela RASA'1, Riccardo ROLANDO1, Stefano GOTTI1,2, Marina BOIDO1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy
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150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France.
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