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107 | Protective effects of hydroxytyrosol against dichlorodiphenilethylene-induced oxidative injury in liver cells Vincenzo Migliaccio1, Ilaria Di Gregorio1, Martina Coletta1, Giuliana Panico2, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology “Adolfo Zambelli”, University of Salerno, Italy; 2Dept Biology, University Federico II, Napoli, Italy.
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163 | SIX-2G as a novel compound to attenuate airway inflammation in cystic fibrosis through modulation of molecular chaperones Giuseppa D’Amico1, Federica Scalia2, Maria Antonella Augello1, Giusi Alberti1, Roberta Bivacqua3, Marilia Barreca3, Rosario Barone1, Francesco Cappello1, Paola Barraja3, Alessandra Montalbano3, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy; 3Department of Biological, Chemical, Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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120 | Exploring CD36-dependent lipid uptake in melanoma–adipocyte communication mediated by extracellular vesicles Gaia Giannitti1, Kinga Kamińska2|3, Sara Marchesi1, Riccardo Garavaglia1, Ivan Preosto1, Małgorzata Grzesiak2, Fabrizio Fontana1 | 1Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Italy; 2Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland; 3Department of Animal Biotechnology, University of Agriculture in Krakow, Poland.
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147 | Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease Cristina Giuffré1, Miriana Scordino1, Giulia Urone1, Miriam Buttacavoli1, Alessandra Montalbano2, Marilia Barreca2, Roberta Bivacqua2, Paola Barraja2, Virginia Spano’2, Giuseppa Mudo’1, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
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076 | Iron-driven redox dysregulation fuels psoriatic signaling in CARD14 e138a mutant keratinocytes Cristiana Galeano1, Anna Martina Battaglia1, Emanuele Giorgio1, Lavinia Petriaggi1, Giuseppe Natali2, Flavia Biamonte1 | 1Laboratory of Biochemistry and Cell Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy; 2Department of Life Science, Magna Graecia University of Catanzaro, Italy.
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105 | The invasive crab Callinectes sapidus as a model for assessing sub-lethal effects of polyvinyl alcohol Alessandra Maganza1|2, Alice Gabetti1, Camilla Mossotto1|2, Alessia Merialdi1, Monia Renzi3, Francesca Provenza4, Serena Anselmi4, Antonia Concetta Elia2, Giorgia Zicarelli1, Annalisa Cotugno1, Giuseppe Esposito1, Caterina Faggio5|6, Marino Prearo1, Paolo Pastorino1 | 1The Veterinary Medical Research Institute for Piemonte, Liguria and Valle d’Aosta, Torino, Italy; 2Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy; 3Bioscience Research Center, Orbetello, Italy; 4Department of Life Sciences, University of Trieste, Trieste, Italy; 5Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 6Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.
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Adipokines in obesity and metabolic diseases
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SWIMMING IN PLASTAMINATION: POLY-LACTIC ACID NANOPLASTICS AND SPERM FUNCTIONS Alberto CONTRI1, Massimo VENDITTI2, Alessia GLORIA1, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Rosaria MECCARIELLO4 | 1Department of Veterinary Medicine, University of Teramo; 2Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi (SA); 4Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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013 | Innovative therapeutic approaches in solid tumors Alessia Dottore1, Rosalba Rossello2, Francesco Ferraù1 | 1UOC Oncologia Medica, Ospedale “San Vincenzo”, Taormina [ME], Italy; 2UOS Oncologia Medica, Ospedale “Cutroni Zodda”, Barcellona Pozzo di Gotto [ME], Italy.
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064 | Sustainable extraction and functional characterization of bioactive compounds from Spirulina platensis for nutraceutical and cosmetic applications Carmen Sica1, Chiara Copat1, Gea Oliveri Conti1, Sheima Inoubli2, Margherita Ferrante1 | 1Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy; 2Department of Chemical Engineering, Universidade de Vigo, Campus de Ourense, Spain.
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134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan1, Paolo Bonivento2 | 1Nanocoatings Research, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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057 | Bioactive metabolites from antarctic sponge-associated bacteria: bioactivity and cytotoxic assessment Claudia Gravagno1|2, Stefano Putaggio2, Teresa Romeo2|3, Annamaria Russo2, Carmen Rizzo2|4, Ester Tellone2, Angelina Lo Giudice4 | 1Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; 2University of Messina, Italy; 3National Institute for Environmental Protection and Research, Milazzo [ME], Italy; 4National Research Council, Institute of Polar Sciences, Messina, Italy.
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MICROFLUIDIC SYNTHESIS OF PLA NANOPARTICLES: COMPARISON OF DIFFERENT SYSTEMS TO ACHIEVE HIGH SCALABILITY AND BATCH-TO-BATCH REPRODUCIBILITY Federica MONTELLA , Erwin Pavel LAMPARELLI, Giovanna DELLA PORTA | Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy
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103 | Valorization of olive mill wastewaters for the recovery of polyphenols with reducing, radical scavenging and anti-inflammatory activities Francesco Longo1, Luisa Tesoriere1, Claudio Luparello1, Ignazio Restivo1, Federica Bellistrì1, Serena Indelicato1, David Bongiorno1, Rosi De Luca1, Giulia Abruscato1, Antonio Fabbrizio2, Salvatore Terrani3, Mirella Vazzana1, Vincenzo Arizza1, Manuela Mauro1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Theoretical and Applied Sciences DiSTA, University e Campus, Novedrate [CIO], Italy; 3The Wave Innovation Group, Verona, Italy.
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027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy.
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082 | Supplementation with Lactobacillus fermentum reversed fiber atrophy in a myopathy model by modulating IL-6, TNFα, and hsp60 levels, thereby enhancing muscle regeneration Martina Sausa1, Letizia Paladino2, Federica Scalia3, Francesco Paolo Zummo1, Giuseppe Vergilio1, Francesca Rappa1, Francesco Cappello1, Melania Ionelia Gratie1, Patrizia Proia4, Valentina Di Felice1, Antonella Marino Gammazza,5, Filippo Macaluso1, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO]; 3Department of Medicine and Surgery, Kore University of Enna; 4Department of Psychology, Educational Science and Human Movement, University of Palermo; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.
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188 | Frontal sinus osteomas in the mummy of a poor clare nun from Fara in Sabina (17th-18th century) Luca Ventura1, Federico Bruno2, Veronica Forte1, Nadia Gabriele1, Irene Faenza3, Enrico Petrella4, Gianandrea Pasquinelli5, Mirko Traversari5 | 1UOC di Anatomia Patologica, Ospedale San Salvatore, L’Aquila, Italy; 2UOC di Neuroradiologia e Radiologia Interventistica, Ospedale San Salvatore, L’Aquila, Italy; 3Dipartimento di Scienze Biomediche e Neuromotorie DIBINEM, Alma Mater Studiorum Università di Bologna, Italy; 4Dipartimento di Radiologia, AUSL Romagna, Ospedale Morgagni-Pierantoni, Forlì, Italy; 5Dipartimento di Scienze Mediche e Chirurgiche DIMEC, Alma Mater Studiorum Università di Bologna, Italy.
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153 | α-synuclein regulation in brain and bone marrow is releted to the differential expression of GATA1 transcription factor Viola Velardi1, Francesca Arciprete1, Claudia Caturano,1Rosa Alba Rana1, Romina Mancinelli2, Maria Zingariello1, Giorgio Vivacqua1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy.
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088 | Investigating the role of Hsp60 in the pathophysiology of celiac disease Giusy Vultaggio1, Giuseppe Vergilio1|2, Letizia Paladino3, Rosario Barone1, Francesca Rappa1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy; 3Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO], Italy.
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COMBINED EFFECTS OF POLYSTYRENE MICROPLASTICS, NANOPLASTICS, AND MERCURY ON THE GILL STRUCTURE AND FUNCTION OF MYTILUS GALLOPROVINCIALIS Rossana ROMANO1,2, Maria D. BORDALO3, Hugo C. VIEIRA3, Sílvia FS. PIRES3, Federica DI FRANCO1, Chiara M. MOTTA4, Palma SIMONIELLO1,2 | 1Department of Science and Technology, University Parthenope, Napoli, Italy; 2International PhD Programme, UNESCO Chair “Environment, Resources and Sustainable Development”, Department of Science and Technology, Parthenope University of Naples, Naples, Italy; 3CESAM—Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Aveiro, Portugal; 4Department of Biology, University of Naples Federico II, Napoli, Italy
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150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France.
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02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy
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053 | Collagen-based biomaterials for biologically relevant 3D in vitro vascular models Elena Delgrosso1, Franca Scocozza1, Michele Conti1|2 | 1Department of Civil Engineering and Architecture, University of Pavia, Italy; 23D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, San Donato Milanese [MI], Italy.
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016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes Alice Foti1, Fabio Allia1, Marilena Briglia1, Gianpiero Tamburrini2, Roberta Malaguarnera1, Francesco Cecconi2|3, Vittoria Pagliarini2|3, Veronica Marabitti4, Francesca Nazio4, Adriana C.E. Graziano1 | 1University of Enna “Kore”, Enna, Italy; 2Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4University of Rome Tor Vergata, Rome, Italy.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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098 | Gill damage in zebrafish exposed to environmentally relevant concentrations of the UV filter avobenzone Antonio Paolo Maria Graziani, Abdalmoiz I.m. Ahmed, Federica Talarico, Marcello Mezzasalma, Rachele Macirella, Elvira Brunelli | Department of Biology, Ecology and Earth Sciences DiBEST, University of Calabria, Rende [CS], Italy.
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148 | Lysosomal and synuclein pathology in IPSC-derived dopaminergic neurons from GBA1-mutant Parkinson’s disease patients Gaia Pinna1, Giuseppe Uras1|2, Veronica Lentini1, Luca Miuzzo1, Sara Del Pozo3, Federico Fierli3, Anthony Schapira3, Antonella Pantaleo1 | 1Department of Biomedical Science, University of Sassari, Italy; 2Department of Haematology, UCL, London, United Kingdom; 3Department of Clinical and Movement Neurosciences, UCL, London, UK.
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