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The protective effect of Matricaria pubescens extracts against alloxan-induced hyperglycemia in rats

Authors

Published
4 August 2022
Section
Original Articles
DOI
10.4081/jbr.2022.10441

Abstract

The purpose of this research is to look into the potential inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) of 61% and 75%, respectively, resulted in an 184% increase in blood glucose levels compared to controls. However, compared to untreated diabetic rats, treatment with the extract (Diab + EMMP) resulted in a significant decrease in pancreatic α-amylase activity in the pancreas (15%) and serum (28%). As a result, a significant reduction in blood sugar level has been observed, reaching 28%. When rats treated with EMMP were compared to untreated diabetics, the level of glycated hemoglobin (HbA1c) decreased by 28%. Furthermore, a significant increase in pancreatic serum lipase activity (59%) in untreated diabetic rats treated with EMMP resulted in a significant inhibition (21%). In diabetic rats treated with EMMP, β-cells were found to have a powerful protective effect. However, we observed body weight recovery in diabetic rats treated with EMMP.

Keywords

References

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