https://doi.org/10.4081/cdr.13.13423
Thoracic ganglioneuroma found incidentally on a flight physical: an atypical magnetic resonance imaging presentation
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Published: 1 April 2025
Ganglioneuromas are rare, benign neuroblastic tumors from neural crest cells, commonly found in the posterior mediastinum or retroperitoneum. They grow slowly and are often incidental findings. This report details a 28-year-old airman with a left apical pleural-based mass detected on a chest radiograph during a routine physical. A Computed Tomography (CT) revealed a posterior mediastinal mass with punctate calcifications, and Magnetic Resonance Imaging (MRI) showed varying signal intensities but no enhancement. A CT-guided biopsy confirmed ganglioneuroma. This case emphasizes the value of routine screenings and highlights the diagnostic challenges of ganglioneuromas due to their nonspecific and variable imaging findings.
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Goldberg JL, Tong J, McGrath LB, Jr. Spinal ganglioneuroma. World Neurosurg 2022;162:15-6. DOI: https://doi.org/10.1016/j.wneu.2022.03.046
Duffy S, Jhaveri M, Scudierre J, et al. MR imaging of a posterior mediastinal ganglioneuroma: fat as a useful diagnostic sign. AJNR Am J Neuroradiol 2005;26:2658-62.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics 2002;22:911-34. DOI: https://doi.org/10.1148/radiographics.22.4.g02jl15911
Wang K, Dai J. Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report. Oncol Lett 2015;10:3803-6. DOI: https://doi.org/10.3892/ol.2015.3815
Rodriguez EF, Jones R, Miller D, Rodriguez FJ. Neurogenic tumors of the mediastinum. Semin Diagn Pathol 2020;37:179-86. DOI: https://doi.org/10.1053/j.semdp.2020.04.004
Ncheye MS, Mrimba PM, Dekker M, et al. Spinal ganglioneuroma with extension to the brachial plexus. The challenges for total surgical excision, a case report. Int J Surg Case Rep 2024;119:109756. DOI: https://doi.org/10.1016/j.ijscr.2024.109756
Pacella G, Brunese MC, Donnarumma F, et al. Imaging of ganglioneuroma: a literature review and a rare case of cystic presentation in an adolescent girl. Diagnostics 2023;13:2190. DOI: https://doi.org/10.3390/diagnostics13132190
Li S, Mao S, Ma Y, et al. Scoliosis: an unusual clinical presentation of paraspinal ganglioneuroma. Spine Deformity 2022;10:1185-95. DOI: https://doi.org/10.1007/s43390-022-00511-x
Prabaharan H, Chandrasekaran S, Shetty N, Nayak KP. Benign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome. BMJ Case Rep 2024;17:e256846. DOI: https://doi.org/10.1136/bcr-2023-256846
Armstrong EA, Harwood-Nash DC, Ritz CR, et al. CT of neuroblastomas and ganglioneuromas in children. AJR Am J Roentgenol 1982;139:571-6. DOI: https://doi.org/10.2214/ajr.139.3.571
Cai J, Zeng Y, Zheng H, et al. Retroperitoneal ganglioneuroma in children: CT and MRI features with histologic correlation. Eur J Radiol 2010;75:315-20. DOI: https://doi.org/10.1016/j.ejrad.2010.05.040
Das A, Bhalla AS, Sharma R, et al. Diffusion-weighted imaging in extracranial head and neck schwannomas: A distinctive appearance. Indian J Radiol Imaging 2016;26:231-6. DOI: https://doi.org/10.4103/0971-3026.184418
Rathi NK, Senthil Kumar AC, Vishnu S, Ashraf M. L1 nerve root ganglioneuroma: surgical tip on excising this well-differentiated and rarely appreciated tumor. J Orthop Case Rep 2022;12:27-9. DOI: https://doi.org/10.13107/jocr.2022.v12.i07.2902
Goldberg JL, Hussain I, Carnevale JA, et al. Clinical outcomes following resection of paraspinal ganglioneuromas: a case series of 15 patients. J Neurosurg Spine 2022;37:130-6. DOI: https://doi.org/10.3171/2021.11.SPINE211114
Benson Ham P, 3rd, Twist CJ, Rothstein DH. Retroperitoneoscopic resection of a T11-L2 right-sided ganglioneuroma. J Pediatr Surg 2019;54:1719-21. DOI: https://doi.org/10.1016/j.jpedsurg.2019.02.054
Radiopaedia. Contrast enhancement. 2023. Available from: https://radiopaedia.org/articles/contrast-enhancement
Kakkar C, Shetty CM, Koteshwara P, Bajpai S. Telltale signs of peripheral neurogenic tumors on magnetic resonance imaging. Indian J Radiol Imaging 2015;25:453-8. DOI: https://doi.org/10.4103/0971-3026.169447
Pavlus JD, Carter BW, Tolley MD, et al. Imaging of thoracic neurogenic tumors. AJR Am J Roentgenol 2016;207:552-61. DOI: https://doi.org/10.2214/AJR.16.16018
Guan YB, Zhang WD, Zeng QS, et al. CT and MRI findings of thoracic ganglioneuroma. Br J Radiol 2012;85:e365-72. DOI: https://doi.org/10.1259/bjr/53395088
Cox JE, Keesling CA, Johnson CE. The utility of screening chest radiographs for flight physicals. Mil Med 2000;165:667-9. DOI: https://doi.org/10.1093/milmed/165.9.667
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