https://doi.org/10.4081/cdr.13.12743
A case report of co-infection with two atypical pathogens: a particular case report
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Published: 16 January 2025
This case report describes a young asthmatic patient who contracted a dual infection with Chlamydia pneumoniae and Mycoplasma pneumoniae. The co-infection exacerbated the asthmatic symptoms, leading to significant complications. A literature review highlights how such atypical infections can aggravate respiratory conditions in patients with pre-existing asthma. Clinical patient management, including antibiotic therapy and respiratory support, led to a progressive resolution of the clinical picture. This case underscores the importance of considering atypical infections in the differential diagnosis of asthmatic patients with acute symptom worsening.
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Orders M. Antibacterial drugs for community-acquired pneumonia. Med Lett Drugs Ther 2021;63:10-5.
Blasi F, Tarsia P, Aliberti S, et al. Chlamydia pneumoniae and Mycoplasma pneumoniae. Semin Respir Crit Care Med 2005;26:617-24. DOI: https://doi.org/10.1055/s-2005-925525
De Francesco MA, Poiesi C, Gargiulo F, et al. Co-infection of Chlamydia pneumoniae and Mycoplasma pneumoniae with SARS-CoV-2 is associated with more severe features. J Infect 2021;82:e4-7. DOI: https://doi.org/10.1016/j.jinf.2021.01.009
Cunha BA. The atypical pneumonias: clinical diagnosis and importance. Clin Microbiol Infect 2006;12:12-24. DOI: https://doi.org/10.1111/j.1469-0691.2006.01393.x
Esposito S, Blasi F, Arosio C, et al. Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing. Eur Respir J 2000;16:1142-6. DOI: https://doi.org/10.1034/j.1399-3003.2000.16f21.x
Garin N, Marti C, Skali Lami A, Prendki V. Atypical pathogens in adult community-acquired pneumonia and implications for empiric antibiotic treatment: a narrative review. Microorganisms 2022;10:2326. DOI: https://doi.org/10.3390/microorganisms10122326
Iramain R, De Jesús R, Spitters C, et al. Chlamydia pneumoniae and Mycoplasma pneumoniae: are they related to severe asthma in childhood? J Asthma 2016;53:618-21. DOI: https://doi.org/10.3109/02770903.2015.1116085
Mandell LA. Community-acquired pneumonia: an overview. Postgrad Med 2015;127:607-15. DOI: https://doi.org/10.1080/00325481.2015.1074030
Meyer Sauteur PM, Beeton ML, European Society of Clinical Microbiology and Infectious Diseases (ESCMID) et al. Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions. Lancet Microbe 2024;5:e100-1.
Meyer Sauteur PM, Beeton ML, Uldum SA, et al. Mycoplasma pneumoniae detections before and during the COVID-19 pandemic: results of a global survey, 2017 to 2021. Euro Surveill 2022;27:2100746. DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.19.2100746
Oliva A, Siccardi G, Migliarini A, et al. Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae: a case series and review of the literature. Infection 2020;48:871-7. DOI: https://doi.org/10.1007/s15010-020-01483-8
Pittet LF, Bertelli C, Scherz V, et al. Chlamydia pneumoniae and Mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity. Pathog Dis 2021;79:ftaa074. DOI: https://doi.org/10.1093/femspd/ftaa074
Principi N, Esposito S. Mycoplasma pneumoniae and Chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients. Curr Opin Infect Dis 2002;15:295-300. DOI: https://doi.org/10.1097/00001432-200206000-00013
Sidal M, Kilic A, Unuvar E, et al. Frequency of Chlamydia pneumoniae and Mycoplasma pneumoniae infections in children. J Trop Pediatr 2007;53:225-31. DOI: https://doi.org/10.1093/tropej/fmm003
Tsai MK, Lai CH, Tsai C, Chen GL. Mycoplasma pneumoniae and Chlamydia pneumoniae coinfection with acute respiratory distress syndrome: a case report. Diagnostics (Basel) 2021;12:48. DOI: https://doi.org/10.3390/diagnostics12010048
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