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• 28 | Impairment of skeletal muscle force and mitochondrial respiratory capacity precedes muscle mass loss in an aged murine model of diet-induced obesity Clara Sciorati¹, R. De Lorenzo^1|2, A. Avola¹, M. Giovarelli³, C. De Palma³, E. Clementi³, C. Lanzani¹, P. Rovere-Querini^1|2 | ¹IRCCS San Raffaele Hospital Scientific Institute, Milan, Italy; ²Vita-Salute San Raffaele University, Milan, Italy; ³Department of Biomedical and Clinical Science, University of Milan, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15476

  88

• 41 | SRT2104 improves muscle and cognitive outcomes and has the potential to enhance μDys gene therapy in Duchenne muscular dystrophy Laura Lociuro¹, A. Arcari², O. Gjana¹, G. Scolari¹, S.R. Casati^1|2, S. Zecchini², M. Giovarelli², C. Perrotta², C. De Palma¹ | ¹Department of Medical Biotechnology and Translational Medicine (BioMeTra), Università degli Studi di Milano, Segrate (MI), Italy; ²Department of Biomedical and Clinical Sciences "Luigi Sacco" (DIBIC), Università degli Studi di Milano, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15489

  83

• 08 | Combination therapy targeting HDAC8 and SIRT1 improves muscle integrity in a Duchenne muscular dystrophy zebrafish model Sabrina Carbone¹, A. Brix¹, L. Lociuro¹, O. Gjana¹, L. Belleri², M. Schiavone³, A. Marozzi¹, F. Del Bene², C. De Palma¹, A. Pezzotta¹, A. Pistocchi¹ | ¹Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy; ²Sorbonne Université, INSERM U968, CNRS UMR 7210, Institut de la Vision, Paris, France; ³Department of Molecular and translational medicine, Università degli Studi di Brescia, Brescia, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15456

  98

• 21 | Transcriptional and metabolic analyses of cardiac mononucleated cells in dystrophic mdx mice upon treatment with a specific monoamino oxidase B inhibitor Francesca Fontana^1|2, F.C. Venegas^3|4, E. Baldisseri^3|4, R. Sánchez-Rodríguez^3|4, A. Reggio⁵, A. Palma⁶, M. Canton^3|4, L. Vitiello¹ | ¹Department of Biology, University of Padova, Italy; ²Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Italy; ³Fondazione Istituto di Ricerca Pediatrica Città della Speranza, IRP, Italy; ⁴Department of Biomedical Sciences, University of Padova, Italy; ⁵Saint Camillus International University of Health Sciences, Italy; ⁶Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Italy.

  Interuniversity Institute of Myology

  03-04-2026

  https://doi.org/10.4081/ejtm.2026.15469

  97