Report and Abstracts of the 20th Meeting of IIM, the Interuniversity Institute of Myology: Assisi, October 12-15, 2023

Published: 22 April 2024
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The 2023 represented a milestone for the Interuniversity Institute of Myology (IIM) since it marked twenty years of IIM activity joined with the 20th annual meeting organized by the association. The 20th IIM meeting took place in the fascinating town of Assisi, in the heart of central Italy, from 12 to 15 October. The commemorative 20th edition of the meeting represented a success in terms of participation and contributions as it brought together 160 myologists, clinicians, pharmaceutical companies, and patient organization representatives from Italy, several European countries (especially France), the United Kingdom, Brazil, and the USA. Four main scientific sessions hosted 36 oral communications and 54 always-on-display posters reporting original and unpublished results. Four main lectures from internationally renowned invited speakers and talks from delegates of the Societé Française de Myologie gave particular interest and emphasis to the scientific discussion. In line with the traditional policy of the IIM to encourage the participation of young researchers, about 50% of the attendees were under 35 years old. Moreover, the 20th IIM meeting was part of the high-training course in “Advanced Myology Update 2023”, reserved to young trainees and managed by the University of Perugia (Italy) in collaboration with the IIM. In addition to the meeting scientific sessions, the 29 attendees to the course had a dedicated round table and dedicated lessons with the IIM invited speakers as teachers. Awards for the best talk, best poster blitz, and best poster have been conferred to young attendees, who became part of the IIM Young Committee, involved in the scientific organization of the IIM meetings. To celebrate the 20th IIM anniversary, a special free-access educational convention on “Causes and mechanisms of muscle atrophy. From terrestrial disuse to Space flights” has been organized, in which IIM experts in the field have illustrated the current knowledge about the muscle atrophy process in several atrophying conditions, and the former Italian astronaut, Paolo Nespoli shared his incredible experience in Space fascinating the large audience attending both in presence and online live stream. The meeting was characterized by a vibrant, friendly, and inclusive atmosphere, and stimulated discussion on emerging areas of muscle research, fostering international collaborations, and confirming the IIM meeting as an ideal venue to discuss around muscle development, function, and diseases pointing to the development of efficacious therapeutic strategies. Here, the abstracts of the meeting illustrate the most recent results on basic, translational, and clinical research in the myology field. Some abstracts are missing as per authors’ decision due to the patentability of the results.

Zaidan L, Geara P, Borok MJ, et al. Unfractionated bulk culture of mouse skeletal muscle to recapitulate niche and stem cell quiescence. J Vis Exp 2023;196:65433. DOI:

Machado L, Geara P, Camps J, et al. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 2021;28:1125-35.e7. DOI:

Flamini V, Ghadiali RS, Antczak P, et al. The satellite cell niche regulates the balance between myoblast differentiation and self-renewal via p53. Stem Cell Reports 2018;10:970-83. DOI:

Pisconti A, Banks GB, Babaeijandaghi F, et al. Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration. Skelet Muscle 2016;6:34. DOI:

Evano B, Sarde L, Tajbakhsh S. Temporal static and dynamic imaging of skeletal muscle in vivo. Exp Cell Res 2023;424:113484. DOI:

Grimaldi A, Comai G, Mella S, Tajbakhsh S. Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse. Elife 2022;11:e70235. DOI:

Choi S, Ferrari G, Moyle LA, et al. Assessing and enhancing migration of human myogenic progenitors using directed iPS cell differentiation and advanced tissue modelling. EMBO Mol Med 2022;14:e14526. DOI:

Pinton L, Khedr M, Lionello VM, et al. 3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling. Nat Protoc 2023;18:1337-76. DOI:

Romanello V, Sandri M. The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass. Cell Mol Life Sci 2021;78:1305-28. DOI:

Garcia-Castillo L, Rubini G, Costelli P. Pharmacotherapeutic options for cancer cachexia: emerging drugs and recent approvals. Expert Opin Pharmacother 2023;24:1053-65. DOI:

Traoré M, Gentil C, Benedetto C, et al. An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. Sci Transl Med 2019;11:eaaw1131. DOI:

Di Filippo ES, Chiappalupi S, Balsamo M, et al. Preparation of human muscle precursor cells for the MyoGravity project’s study of cell cultures in experiment units for space flight purposes. Appl Sci 2022;12:7013. DOI:

Supporting Agencies

A and C M-C Foundation for Translational Myology, Padova, Italy, PAGEpress

Riuzzi, F., & Mocciaro, E. (2024). Report and Abstracts of the 20th Meeting of IIM, the Interuniversity Institute of Myology: Assisi, October 12-15, 2023. European Journal of Translational Myology.


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