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• 028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Martina Di Marco¹, Giuseppina Poppa², Pierlorenzo Maria Veiceschi³, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Paola Limoncelli², Ilaria Giusti², Vincenza Dolo², Claudia Campanella¹, Francesca Rappa¹, Rosario Barone¹, Giovanni Tringali³, Francesco Cappello¹, Celeste Caruso Bavisotto¹ | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; ³Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15280

  37

• 014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco¹, Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Francesco Cappello^1|2, Celeste Caruso Bavisotto^1|2 | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15266

  60

• 05 | ENGINEERED PARTICLES IN DRUG DELIVERY AND TISSUE ENGINEERING: IMPLICATIONS FOR PUBLIC HEALTH Anna Barbara Di Stefano¹, Simona Di Leo¹, Mara Franza^2|3, Francesca Toia^1|2|3 | ¹BIOPLAST-Laboratory of BIOlogy and Regenerative Medicine-PLASTic Surgery, Plastic and Reconstructive Surgery Section, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Italy; ²Plastic and Reconstructive Surgery Section, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Italy; ³Section of Plastic and Reconstructive Surgery, Department of DAI chirurgico, Azienda Policlinico Paolo Giaccone, Palermo, Italy

  Società Italiana di Biologia Sperimentale

  20-04-2026

  https://doi.org/10.4081/jbr.2026.15574

  102

  Downloads: 17

• An overview of glioblastoma multiforme in vitro experimental models

  Alessandra Maria Vitale, Giuseppa D’Amico, Radha Santonocito, Gioacchino Spinnato, Martina Di Marco, Federica Scalia, Claudia Campanella, Giovanni Tringali, Ilaria Giusti, Vincenza Dolo, Francesco Cappello, Celeste Caruso Bavisotto

  15-02-2024

  https://doi.org/10.4081/jbr.2024.11920

  1850

  Downloads: 869

• 027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma Fabiola Vaglica¹, Laura Tomasello¹, Mattia Biondo², Giuseppe Siragusa², Giorgio Arnaldi¹, Giuseppe Pizzolanti^1|3, Valentina Guarnotta¹ | ¹Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; ²Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; ³ATeN Center, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15279

  60

• 022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15274

  60

• 018 | BSA nanoparticles containing collagenases and doxorubicin to enhance therapeutic efficacy in 3D models of solid tumor Gabriele Lo Buglio^1|2, Alessandra Lo Cicero¹, Simona Campora¹, Paolo Cinà³Samuel Lenton², Vito Foderà², Giulio Ghersi^1|3 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; ²Department of Pharmacy, University of Copenhagen, Denmark; ³Abiel srl, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15270

  43

• 02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy

  Società Italiana di Biologia Sperimentale

  20-04-2026

  https://doi.org/10.4081/jbr.2026.15571

  123

  Downloads: 23

• 125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio¹, Giuseppina Poppa¹, Giuseppe Cammarata², Sandra D’Ascenzo¹, Vincenza Dolo¹, Simona Taverna², Ilaria Giusti¹ | ¹Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; ²Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15377

  58

• 020 | A three-dimensional vascularized cancer model mimicking the tumor microenvironment for drug resistance studies Alessandra Lo Cicero¹, Gabriele Lo Buglio¹, Francesco La Monica¹, Simona Campora¹, Margot Lo Pinto², Simone Dario Scilabra², Giulio Ghersi^1|3 | ¹Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Palermo, Italy; ²Proteomics Group of RiMED Foundation, Research Department IRCCS ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy; ³Abiel srl, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15272

  46