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131 | First evidence of karyotype diversity and evolution in endemic Scincinae (squamata: scincinae) from madagascar Barbara Cirimele1, Elvira Brunelli1, Gaetano Odierna2, Fabio M. Guarino2, Valentina Basile1, Marcello Mezzasalma1 | 1Department of Biology, Ecology and Earth Science, University of Calabria Rende, Cosenza, Italy; 2Department of Biology, University of Naples Federico II, Naples, Italy.
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TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO1, Martina LOMBARDI1-3, Raffaella D’AURIA1, Erwin Pavel LAMPARELLI1, Giovanna DELLA PORTA1,4, Marta Anna SZYCHLINSKA5, Federica SCALIA6, Francesco CAPPELLO6,7, Rosaria MECCARIELLO8, Andrea VIGGIANO1,4, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, SA, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 6Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 7Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy
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146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato1, Nicolò Ricciardi1, Valentina Di Liberto1, Miriana Scordino1, Giulia Urone1, Danila Di Majo1, Giuseppe Giglia1|4, Pierangelo Sardo1, Giuseppe Ferraro1, Riccardo Alessandro1|2|3, Stefania Raimondo1|2, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; 2Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; 3Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; 4Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.
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010 | Combining a gemcitabine-derived prodrug, GEM-C18, with nanoparticles to counteract acidic ph-dependent chemoresistance of pancreatic adenocarcinoma Francesca Fracasso, Marilena Ardone, Tiago Miguel Amaral Carvalho1|2, Barbara Rolando3, Silvia Arpicco3, Valeria Bincoletto3, Francesca Bianco4, Alessandra Fiorio Pla4, Daniela Isabel Abbrescia5, Ylenia Antonacci5, Chrysovalentinos Pousis5, Sharon Natasha Cox1, Flaviana Marzano5, Graziano Pesole1, Apollonia Tullo5, Stephan Joel Reshikn1, Rosa Angela Cardone1 | 1Dept of Biosciences, Biotechnology and Environment, University of Bari, ltaly; 2CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, Covilhã, Portugal; 3Dept. of Drug Science and Technology, University of Turin, ltaly; 4Dept of Life Sciences and Systems Biology, University of Turin, Italy 5Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies – IBIOM - CNR, Bari, Italy.
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IDENTIFICATION OF D. MELANOGASTER ENZYMES POTENTIALLY INVOLVED IN PENTACHLOROPHENOL DEGRADATION M. CASTALDO1,2, D.M. MONTI2, A. TESTA3, J. VONTAS4,5, D. TSAKIRELLI4,5, M.M. MONTI1, P.A. PEDATA1 | 1Institute for Sustainable Plant Protection (CNR-IPSP), Portici (NA), Italy; 2Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy; 3Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 4Pesticide Science Lab, Agricultural University of Athens, Athens, Greece; 5Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
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112 | Environmental isolation and genetic characterization of first Italian Candida blankii strains: an emerging pathogen Gabriele Parrino1, Alessia Billè1, Lucilla Lo Re1, Bianca Bauso1, Francesco Mediati1, Kyrylo Oleksandrovych Hnezdilov1, Domenico Davide Anania1, Gabriele Rigano2|3, Letterio Giuffrè1, Giuseppe Criseo1, Orazio Romeo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; 3PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.
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187 | Beyond marker genes: mitochondrial genomics as a high-resolution tool for Sporothrix schenckii molecular epidemiology Laura Taca1, Andrea Bonomo2, Gabriele Rigano3|4, Letterio Giuffrè1, Orazio Romeo1, Domenico Giosa1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Mathematics, University of Pavia, Italy; 3Department of Biology, University of Rome “Tor Vergata”, Rome, Italy; 4PhD programme in Space Science and Technology, Department of Physics, University of Trento, Italy.
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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093 | Beyond biodegradability: assessing the toxicological footprint of polylactic acid nanoplastics on zebrafish gastrointestinal tract development Francesca Chiara Cecala1, Giusy Vultaggio1, Martina Di Marco1, Alessandra Maria Vitale1, Rosario Barone1, Francesca Rappa1, Maria Denise Amico1, Erwin Pavel Lamparelli2, Giovanna Della Porta2, Antonietta Santoro2, Francesco Cappello1|4, Federica Scalia3, Marta Anna Szychlinska5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medicine and Surgery - Kore University of Enna, Italy; 4Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care MePreCC, University of Palermo, Italy.
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16 Maria Antonella Augello1, Giuseppa D’Amico1, Alessandra Maria Vitale1, Rosario Barone1, Simona Rapposelli3, Maciej Wnuk4, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2, Federica Scalia5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Pharmacy, University of Pisa, Italy; 4Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; 5Department of Medicine and Surgery, Kore University of Enna, Italy.
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ENVIRONMENTAL NANOPLASTIC ACCUMULATION AND NEURODEGENERATIVE DISEASE IN ANIMAL MODELS Beatrice ZARRILLI1,2, Nicola B. MERCURI2,3, Rosaria MECCARIELLO1, Ezia GUATTEO1,2 | 1University of Naples ‘Parthenope’, Department of Medical, Human Movement and Well-being Sciences, Naples, Italy; 2Experimental Neurology Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy; 3University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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MARINE POLLUTION: MYTILUS GALLOPROVINCIALIS AS A MODEL ORGANISM TO ASSESS MICRO- AND NANOPLASTIC IMPACT Palma SIMONIELLO1, Rossana ROMANO1, Vincenzo MIGLIACCIO2, Gaetana NAPOLITANO1, Lilla LIONETTI2, Luigi ROSATI3, Chiara M. MOTTA3 | 1Department of Science and Technology, Parthenope University of Naples; 2Department of Chemistry and Biology “Adolfo Zambelli”, University of Salerno; 3Department of Biology, University of Naples Federico II, Italy
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055 | Investigating microgravity’s dual impact through neuronal and cyanobacterial models: mechanistic insights into spirulina bioactivity and Parkinson’s disease pathology Mohammed Amine El Faqir1|2, Giuseppe Uras1, Alessia Manca2, Veronica Lentini2, Antonella Pantaleo2 | 1Department of Clinical Neuroscience, Institute of Neurology, University college London, UK; 2Department of Biomedical Science, University of Sassari, Italy.
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