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125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio1, Giuseppina Poppa1, Giuseppe Cammarata2, Sandra D’Ascenzo1, Vincenza Dolo1, Simona Taverna2, Ilaria Giusti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.
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053 | Collagen-based biomaterials for biologically relevant 3D in vitro vascular models Elena Delgrosso1, Franca Scocozza1, Michele Conti1|2 | 1Department of Civil Engineering and Architecture, University of Pavia, Italy; 23D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, San Donato Milanese [MI], Italy.
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TOXIC EFFECTS OF POLYLACTIC ACID NANOPLASTICS ON IN VITRO MODELS OF ASTROCYTES AND NEURONS Marianna MARINO1, Martina LOMBARDI1-3, Raffaella D’AURIA1, Erwin Pavel LAMPARELLI1, Giovanna DELLA PORTA1,4, Marta Anna SZYCHLINSKA5, Federica SCALIA6, Francesco CAPPELLO6,7, Rosaria MECCARIELLO8, Andrea VIGGIANO1,4, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, SA, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, SA, Italy; 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 6Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 7Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Physical Sciences and Wellness, University of Naples Parthenope, Italy
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067 | Redefining amphibian innate immunity: first in vitro and in vivo evidence of phagocytic function in blood cells Valbona Aliko1, Erion Sukaj2, Cristiana Roberta Multisanti3, Federica Impelliteri4, Caterina Faggio4 | 1University of Tirana, Faculty of Natural Sciences, Department of Biology, Tirana, Albania; 2Western Balkans University, Faculty of Medicine and Technical Medical Sciences, Tirana, Albania; 3Department of Veterinary Sciences, University of Messina, Italy; 4University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy.
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EVALUATING ENDOCRINE AND OXIDATIVE EFFECTS OF POLYLACTIC ACID NANOPLASTICS (PLA-NPs) ON BREAST CELL MODELS Maria Denise AMICO1, Antonietta SANTORO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Magdalena GORSKA-PONIKOWSKA3,4,5, Francesca RAPPA1,5, Fabio BUCCHIERI1, Francesco CAPPELLO1,5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Department of Medical Chemistry, Medical University of Gdansk, Poland; 4Department of Biophysics, Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Germany; 5Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
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08 | NEURAL AND INTESTINAL IMPACT OF BIODEGRADABLE POLYLACTIC ACID NANOPLASTICS: RESULTS FROM THE PLASTAMINATION PROJECT Antonietta Santoro | Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, Salerno, Italy; Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy
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FROM PRISTINE TO LABORATORY-WEATHERED MICRO- AND NANOPLASTICS: INTERACTION WITH ENVIRONMENTAL CONTAMINANTS AND BIOLOGICAL EFFECTS Astrid SARACENI1, Barbara MOGNETTI1, Erika COTTONE1, Andrey Ethan RUBIN2, Maria Pia GALLO1, Yoav GOTHILF3, Ines ZUCKER2,4, Federica DAL BELLO5, Patrizia BOVOLIN1 | 1Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy; 2Porter School of Earth and Environmental Studies, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; 3Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel; 4School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; 5Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
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181 | Exploring boron neutron capture therapy effects on healthy skin: from cells to tissues Stefania Ricci1|2|3, Silva Bortolussi3|4, Ricardo Luis Ramos3|4, Ian Postuma3, Daniele Dondi3|5, Cinzia Ferrari3|7, Laura Cansolino3|7, Tea Maverna2, Federica Riva2|3 | 1Dept of Internal Medicine and Medical Therapy, University of Pavia, Italy; 2Dept of Experimental Medicine, Histology and Embryology Unit, University of Pavia, Italy; 3National Institute of Nuclear Physics INFN, Unit of Pavia, Italy; 4Dept of Physics, University of Pavia, Italy; 5Dept of Chemistry, University of Pavia, Italy; 6Dept of Molecular Medicine, Human Physiology Unit, University of Pavia, Italy; 7Laboratory of Experimental Surgery, Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Italy.
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02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy
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EXPLORING THE NEUROTOXIC POTENTIAL OF LDPE MICROPLASTICS: EVIDENCE IN VITRO AND IN VIVO ASSESSMENT Marilena MARRAUDINO1,2, Elena RICCI1,2, Silvia CHASSEUR1,2, Daniela RASA'1, Riccardo ROLANDO1, Stefano GOTTI1,2, Marina BOIDO1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy
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EFFECTS OF POLYLACTIC ACID-NANOPLASTICS ON THE INTESTINAL BARRIER: IN VITRO ANALYSIS ON HUMAN EPITHELIAL CELLS Maria Gerarda LULLO1, Raffaella D’AURIA1, Marianna MARINO1, Martina LOMBARDI1, Giovanna DELLA PORTA1,2, Erwin Pavel LAMPARELLI1, Rosaria MECCARIELLO3, Andrea VIGGIANO1,2, Antonietta SANTORO1,2 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Fisciano, Salerno, Italy; 2Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 3Department of Medical, Motor and Wellness Sciences, University of Naples Parthenope, Naples, Italy
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015 | A flavonoid-rich extract of bergamot juice modulates redox homeostasis and apoptosis in colorectal cancer experimental models Martina Farina1, Alessandro Maugeri2, Michele Navarra1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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09 | POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTINATION): ORGAN INJURIES AND UNDERLINING MOLECULAR MECHANISMS: EVIDENCE FROM IN VIVO ZEBRAFISH MODEL Marta A. Szychlinska1, Federica Scalia2, Martina Di Marco3, Giusy Vultaggio3, Maria Denise Amico3, Fabiano Capparucci4, Carmelo Iaria4, Marianna Marino5, Erwin Pavel Lamparelli5, Giovanna Della Porta5, Francesca Rappa3, Antonella Marino Gammazza3, Rosario Barone3, Antonino Testa6, Rosaria Meccariello7, Antonietta Santoro5, Francesco Cappello3 | 1Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Italy; 2Department of Medicine and Surgery - Kore University of Enna, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 4Department of Chemical, Biological, Pharmacological and Environmental Sciences, University of Messina, Italy; 5Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 6Department of Biological and Pharmaceutical Environmental Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy; 7Department of Movement and Wellness Sciences, Parthenope University of Naples, Italy
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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022 | Physiologic remodelling in 3D hepatocellular carcinoma models: temporal evolution from day 0 to day 9 Serena Munaò, Alessandra Armeli, Desirèe Bonfiglio, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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061 | Immunosafe(r)-by-design invertebrate-based nanoparticles: from engineered to biogenic structures for translational nanomedicine Annalisa Pinsino1, Giovanni Perconti1, Alessia Giannetto2, Andi Alijagic3 | 1Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy; 2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy; 3Man-Technology-Environment Research Center MTM, Orebro University, Sweden.
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016 | Mechanisms underlying resistance to CDK4/6 inhibitors in aggressive medulloblastoma subtypes Alice Foti1, Fabio Allia1, Marilena Briglia1, Gianpiero Tamburrini2, Roberta Malaguarnera1, Francesco Cecconi2|3, Vittoria Pagliarini2|3, Veronica Marabitti4, Francesca Nazio4, Adriana C.E. Graziano1 | 1University of Enna “Kore”, Enna, Italy; 2Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Università Cattolica del Sacro Cuore, Rome, Italy; 4University of Rome Tor Vergata, Rome, Italy.
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176 | Preliminary observations on cannabinoid receptor activation in an in vitro steatosis model and in triple-negative breast cancer cells Roberta Oliveri1, Gianluca Lavanco2, Giovanni Pratelli1, Diana Di Liberto1, Fabiana Plescia3, Anna De Blasio3, Francesca Vaccaro2, Stella Cascioferro3, Flavia Zingales1, Marianna Lauricella1, Rosaria Maria Pipitone2, Stefania Grimaudo2, Fulvio Plescia2, Daniela Carlisi1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Health Promotion Sciences, Maternal and Child Care, Internal Medicine and Medical Specialties “Giuseppe D'Alessandro”, University of Palermo, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF - University of Palermo, Italy.
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THE RISING THREAT: NANO AND MICROPLASTICS INFILTRATION IN URINARY AND REPRODUCTIVE SYSTEMS Luigi MONTANO | Andrology Unit and Service of Lifestyle Medicine in UroAndrology, “S. Francesco d’Assisi” Hospital, Local Health Authority (ASL) Salerno, EcoFoodFertility Project Coordi-nation Unit, Italian Network for Environmental and Reproductive Health, Oliveto Citra, Italy
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102 | Polylactic acid nanoparticles as metabolically active entities: a metabolomics and fluxomics perspective Martina Lombardi1|2|3, Vera Abenante2|3, Alessio Trotta2|3, Erwin Pavel Lamparelli1, Federica Montella1, Giovanna Della Porta1, Andrea Viggiano1, Jacopo Troisi1|2|3|4, Antonietta Santoro1 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, Salerno, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, Salerno, Italy; 4Department of Chemistry and Biology, “A Zambelli”, University of Salerno, Fisciano [SA], Italy.
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142 | Drug repositioning reveals novel therapeutic candidates for spinal muscular atrophy Marina Boido1, Daniela Maria Rasà1, Serena Stanga1, Ersilia Nicorvo1, Pamela Santonicola2, Nadia Mazzarella3, Antonella Camera2, Roberto Iacomino2, Ilenia Matino2, Silvia Chasseur1, Giuseppina Zampi2, Piera Smeriglio4, Elia Di Schiavi2, Alessandro Vercelli1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy; 2Institute of Biosciences and BioResources IBBR, National Research Council CNR, Naples, Italy; 3Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" IGB-ABT, National Research Council CNR, Naples, Italy; 4Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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100 | Tracking polystyrene nanoplastics by raman microscopy reveals intestinal and retinal toxicity Valentina Iezzi1, Roberta Maria Ferri1, Annamaria Iannetta2, Ludovica Sulcanese2, Tommaso Silvestrini2, Vanessa D’Altilia2, Giovanni Angelozzi2, Federico Perrella3, Carino Ferrante4, Giulia Fioravanti3, Monia Perugini2, Elisabetta Benedetti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy; 3Department of Physical and Chemical Sciences University of L’Aquila, Italy; 4CNR-SPIN, c/o department of Physical and Chemical Sciences University of L’Aquila, Italy.
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068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTAMINATION): SIZE-DEPENDENT EFFECTS OF PLA-DERIVED NANOPLASTICS ON EARLY ZEBRAFISH DEVELOPMENT Giusy VULTAGGIO1, Martina DI MARCO1, Antonietta SANTORO2, Marianna MARINO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Francesco CAPPELLO1,3, Federica SCALIA1,4, Marta Anna SZYCHLINSKA5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery - Kore University of Enna, Enna, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Italy
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.
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024 | In vitro analysis of molecular chaperone involvement in the radiological response of triple-negative breast cancer models Giusi Alberti1, Giuseppe Vergilio1, Domiziana Picone1, Denise Amico1, Rosario Barone1, Francesca Rappa1, Marco Calvaruso3, Gaia Pucci3, Luigi Minafra3, Antonella Marino Gammazza2 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostic BIND, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 3Institute of Bioimaging and Complex Biological Systems-National Reasearch Council IBSBC-CNR, Cefalù-Palermo, Italy.
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MICROFLUIDIC SYNTHESIS OF PLA NANOPARTICLES: COMPARISON OF DIFFERENT SYSTEMS TO ACHIEVE HIGH SCALABILITY AND BATCH-TO-BATCH REPRODUCIBILITY Federica MONTELLA , Erwin Pavel LAMPARELLI, Giovanna DELLA PORTA | Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy
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150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France.
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071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia1, Alice Foti1, Fabio Allia1, Rosalia Battaglia1, Giuseppe Piccione2, Alessandro Attanzio3, Caterina Faggio4, Roberta Malaguarnera1, Adriana Carol Eleonora Graziano1 | 1Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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NANOPLASTICS AND IMMUNITY: INVESTIGATING THE EXTRACELLULAR MATRIX’S INFLUENCE ON MACROPHAGE INTERACTION WITH POLYSTYRENE NANOPARTICLES Marianna ROCA1, Naym BLAL1, Zeynep RENKLER2, Vincenzo GUARINO2, Antonia DI MOLA1, Antonio MASSA1, Ilaria DE MARTINO3, Velia SICILIANO3, Daniela GUARNIERI1 | 1Department of Chemistry and Biology, “Adolfo Zambelli”, University of Salerno; 2Institute of Polymers, Composites and Biomaterials, National Research Council of Italy; 3Synthetic and Systems Biology for Biomedicine Lab, Istituto Italiano di Tecnologia, Naples, Italy
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