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128 | Human biodiversity (anthropological, agricultural, and urban) is closely connected to experimental biology studies to understand the present and pave the way for the future Paolo Bonivento | Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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THE RISING THREAT: NANO AND MICROPLASTICS INFILTRATION IN URINARY AND REPRODUCTIVE SYSTEMS Luigi MONTANO | Andrology Unit and Service of Lifestyle Medicine in UroAndrology, “S. Francesco d’Assisi” Hospital, Local Health Authority (ASL) Salerno, EcoFoodFertility Project Coordi-nation Unit, Italian Network for Environmental and Reproductive Health, Oliveto Citra, Italy
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02 | MICROPLASTICS ENDOCRINE-DISRUPTING CHEMICALS AND HUMAN HEALTH: METABOLIC AND REPRODUCTIVE RISKS IN A ONE HEALTH PERSPECTIVE Oliana Carnevali | Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy
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EXPOSITION TO PLASTIC AND ASSOCIATED-CHEMICALS IN NEURODEVELPMENTAL DISORDER: AN OVERVIEW Grazia Maria Giovanna PASTORINO, Francesca Felicia OPERTO | Department of Science of Health School of Medicine, University Magna Greacia of Catanzaro, Italy
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01 | INTEGRATED STRATEGIES FOR PLASTIC MANAGEMENT: MONITORING, BIOLOGICAL IMPACT, AND CIRCULAR PERSPECTIVES ROUND TABLE REPORT Giorgia Görner Enrile1|2, Antonietta Santoro3, Federica Scalia4, Stefania D’Angelo5, Annamaria Visco6, Andrea Pace7, Michele Torregrossa8, Dario Scalia9, Alessandro Aglialoro10, Salvatore Campanella10 | 1Siciliamedica.it; 2Ilsicilia.it; 3PI, Plastamination Project, University of Salerno, Italy; 4Human Anatomy, University Kore, Enna, Italy; 5Biochemistry, University Parthenope of Naples, Italy; 6Life Restart Project, University of Messina, Italy; 7Research and Technology Transfer, University of Palermo, Italy; 8Engineering, University of Palermo, Italy; 9Plastic Free Onlus Sicily, Italy; 10Regional Environmental Protection Agency of Sicily, Italy
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MICROPLASTICS AND ENDOCRINE DISRUPTORS IN HUMAN HEALTH: FROM ENVIRONMENTAL EXPOSURE TO CELLULAR AND EPIGENETIC IMPACT Oliana CARNEVALI | Dipartimento di Scienze della vita e dell’ambiente, Università Politecnica delle Marche, Italy
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172 | Genetic diversity of Candida albicans in animal hosts Lucilla Lo Re1, Letterio Giuffrè1, Silvia Crotti2, Deborah Cruciani2, Alice Ranucci2, Orazio Romeo1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Experimental Zooprophylactic Institute of Umbria and Marche “Togo Rosati”, Perugia, Italy.
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EFFECTS OF POLYLACTIC ACID-NANOPLASTICS ON THE INTESTINAL BARRIER: IN VITRO ANALYSIS ON HUMAN EPITHELIAL CELLS Maria Gerarda LULLO1, Raffaella D’AURIA1, Marianna MARINO1, Martina LOMBARDI1, Giovanna DELLA PORTA1,2, Erwin Pavel LAMPARELLI1, Rosaria MECCARIELLO3, Andrea VIGGIANO1,2, Antonietta SANTORO1,2 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Fisciano, Salerno, Italy; 2Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno, Italy; 3Department of Medical, Motor and Wellness Sciences, University of Naples Parthenope, Naples, Italy
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168 | GLP‑1 receptor signaling directs adipogenic repression and thermogenic activation in human adipose-derived stem cells Carola Pia Giordano, Laura Tomasello, Luigi Di Rosa, Antonino Salvatore Fiore, Sonya Vasto, Sara Baldassano | Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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012 | Anticancer activity of Orobanche crenata leaf extract in human colorectal cancer cell lines Floriana D’Angeli1, Alfio Distefano2, Laura Orlando2, Elisa Gili3, Valentina Di Salvatore4, Simone Ronsisvalle4, Ivana Roberta Romano2, Giuliana Mannino2, Debora Lo Furno2, Giovanni Giurdanella1, Giovanni Li Volti2, Carlo Genovese1 | 1Department of Medicine and Surgery, School of Medicine and Surgery, University of Enna "Kore", Enna, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Department of Clinical and Experimental Medicine, "Regional Referral Center for Rare Lung Diseases", University, Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Italy; 4Department of Health and Drug Sciences, University of Catania, Italy.
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EVALUATION OF TRANS-EPITHELIAL PENETRATION AND MICROPLASTIC-INDUCED TISSUE DAMAGE IN A 3D MODEL OF HUMAN RESPIRATORY MUCOSA Adelaide CARISTA1, Domiziana PICONE1, Giulia Maria Giorgia LO PIANO1, Olga Maria MANNA2,3, Stefano BURGIO3,4, Giuseppa D’AMICO1, Margherita FERRANTE5, Gea OLIVERI CONTE5, Francesca RAPPA1, Rosario BARONE1, Fabio BUCCHIERI1, Alessandro PITRUZZELLA1, Alberto FUCARINO6 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy; 2Pathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 5Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Igiene e Sanità Pubblica; 6Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Italy
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124 | Immunomodulatory effects of extracellular vesicles from invertebrate species on human cells Kristian Riolo1, Francesco Di Pietro1, Sabrina Oliva1, Claudia Mosca1, Valeria Stefanizzi1, Giovanna Montana2, Annalisa Pinsino2, Alessia Giannetto1 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Institute of Translational Pharmacology IFT, National Research Council CNR, Palermo, Italy.
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MICRO- AND NANOPLASTIC CONTAMINATION IN HUMAN ATHEROSCLEROTIC PLAQUES AND ITS IMPACT ON CARDIOVASCULAR EVENTS Raffaele MARFELLA | Department of Advanced clinical and surgical sciences, University of Campania “L. Vanvitelli”, Naples, Italy
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155 | Mitochondrial dynamics and therapeutic insights in spinal muscular atrophy: effects of MFN2 boosting in motoneurons and human fibroblasts Francesco Paolo Zummo1, Serena Stanga1, Letizia Paladino2, Maria Beltran3, Francesco Fedeli4, Maria Rosa Soler3, Fabio Bucchieri5, Marina Boido1 | 1Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy; 2E-Campus University, Palermo, Italy; 3Neuronal Signaling Unit, Experimental Medicine Department, University of Lleida-IRBLleida, Lleida, Spain; 4University of Pavia, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy.
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04 | MICRO AND NANO-PLASTICS A NEW CONCERN FOR PUBLIC HEALTH? Margherita Ferrante, Eloise Pulvirenti | Department of Medical Sciences, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Italy
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095 | Nanoplastic as modulators of human immune responses: effect on natural killer and T cells Francesca D’Ascanio1|2|3, Isabel María Vallejo Bermúdez4|5, Domenico De Bellis1|2, Giulia Colasante,1|2, Arianna Aquilini1|2, Sabino Porro1|2, Tamer Shibl Ali Esmail1|2, Ayesha Younas1|2, Mariagiulia Filoso1|2, Luana D’Onofrio1|2, Piero Chiacchiaretta1|6, Melania Dovizio1|6, Patrizia Ballerini1|6, Piero Di Carlo1|6, Alejandra Pera4|5, Bruna Sinjiari6, Paola Lanuti1|2. | 1Center for Advanced Studies and Technology CAST, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 2Department of Medicine and Aging Sciences, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy; 3Department of Humanities, Law and Economics, “Leonardo da Vinci” University, Torrevecchia Teatina, Italy; 4Immunology and Allergy Group GC01, Instituto Maimónides de Investigación Biomédica IMIBIC, Córdoba, Spain; 5Molecular Immunology Group CTS208, Department of Cell Biology, Physiology and Immunology, University of Cordoba, , Spain; 6Department of Innovative Technologies in Medicine and Dentistry, University "G d'Annunzio" of Chieti-Pescara, Chieti, Italy.
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085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan1, Alessandra Maria Vitale1, Federica Scalia1|2, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy.
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184 | Phytochemicals in pruning waste and food industry by-products: biodiversity and circular economy Marina Russo1, Giovanna Cafeo1, Luigi Mondello1|2, Paola Dugo1|2 | 1Messina Institute of Technology c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy; 2Chromaleont srl, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, former Veterinary School, University of Messina, Italy.
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MICRO- AND NANO-PLASTICS: HEALTH, DENTAL PRACTICE, AND ENVIRONMENT Giuseppina DE BENEDETTO1, Veronica FOLLIERO1, Maria Pia DI PALO1, Leonardo AULISIO1, Luca RINALDI2, Gianluigi FRANCI1, Federica DI SPIRITO1 | 1Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; 2Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
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PLASTAMINATION, HUMAN HEALTH, AND COUNTRIES’ CULTURAL ORIENTATION: AN EXPLORATORY STUDY IN PREVENTING THE NEGATIVE EFFECTS ADOPTING ORGANIZATIONAL POLICIES AND PRACTICES Giuseppe PERNA1, Rosaria MECCARIELLO2, Luisa VARRIALE3 | 1Pegaso University; 2Parthenope University DiSMMeB; 3Parthenope University DiSEGIM, Naples, Italy
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183 | Pericyte-like adipose mesenchymal stem cells as a tool for blood-retinal barrier repair Ivana Roberta Romano1, Giuliana Mannino2, Alessio Canovai3, Rosario Amato3, Silvia Marracci3, Matteo Fallico4, Claudio Bucolo1, Rosario Giuffrida1, Maurizio Cammalleri3, Debora Lo Furno1 | 1Dept Biomedical and Biotechnological Sciences, Catania University, Catania, Italy; 2Faculty of Medicine and Surgery, Kore University, Enna, Italy; 3Department of Biology, Pisa University, Italy; 4Department of Ophthalmology, University of Catania, Italy.
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066 | Modulation of oxidative stress and mitochondrial alteration in IL1β-stimulated human astrocytes: effects of extracts from leaves and rhizomes of Posidonia oceanica (L) Delile Giulia Abruscato1, Lucia Sileo2, Giulia Scanavino2, Manuela Mauro1, Francesco Longo1, Vincenzo Arizza1|3, Mirella Vazzana1|3, Claudio Luparello1|3, Ada Maria Tata2 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STeBICeF, University of Palermo, Italy; 2Department of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center NBFC, Palermo, Italy.
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071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia1, Alice Foti1, Fabio Allia1, Rosalia Battaglia1, Giuseppe Piccione2, Alessandro Attanzio3, Caterina Faggio4, Roberta Malaguarnera1, Adriana Carol Eleonora Graziano1 | 1Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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134 | Living with mold: a growing problem for urban biodiversity Andrea Furlan1, Paolo Bonivento2 | 1Nanocoatings Research, Trieste, Italy; 2Istituto di Studi Europei “A. De Gasperi”, Roma, Italy.
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178 | Food-borne and environmental pathogens in wild ungulates from Sicily: implications for public health at the wildlife–livestock–human interface Elisa Maria Petta1, Valeria Vaglica1, Ilenia Giacchino1, Paola Galluzzo1, Sergio Migliore1, Federico Cangialosi1, Silvia Scibetta1, Elena Lo Bue1, Martina Imburgia1, Giuseppina Chiarenza1, Ettore Napoli2, Annalisa Guercio1, Francesca Grippi1, Valeria Blanda1 | 1Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Palermo, Italy; 2Department of Veterinary Sciences, University of Messina, Italy.
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CELL SPECIFIC METABOLOMIC AND FLUXOMIC RESPONSES TO POLYLACTIC ACID NANOPLASTICS EXPOSURE IN HUMAN INTESTINAL CELLS Martina LOMBARDI1,2,3, Raffaella D’AURIA1, Marianna MARINO1, Mariagerarda LULLO1, Erwin Pavel LAMPARELLI1, Federica MONTELLA1, Giovanna DELLA PORTA1,4, Andrea VIGGIANO1, Jacopo TROISI1,2,3,5, Antonietta SANTORO1,4 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno; 2Theoreo Srl, Montecorvino Pugliano (SA); 3European Institute of Metabolomics - Fondazione EIM, Baronissi (SA); 4Interdepartmental Observatory for Scientific Health Initiatives in Environmental Legislation and Disease Prevention, SHIELD, University of Salerno; 5Department of Chemistry and Biology, “A. Zambelli”, University of Salerno, Fisciano (SA), Italy
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MICROPLASTICS IN EDIBLE PLANTS: AN UNDERESTIMATED RISK IN THE HUMAN FOOD CHAIN Pasquale PERRONE, Stefania D’ANGELO | Department of Medical, Movement, and Wellbeing Sciences, Parthenope University of Naples, Naples, Italy
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171 | Development of a 3D ex vivo model of human intestinal organoids for the study of inflammatory bowel diseases Giulia Maria Giorgia Lo Piano1, Massimo Biondo1, Adelaide Carista1, Domiziana Picone1, Stefano Burgio2|3, Alberto Fucarino4, Francesca Rappa1, Alessandro Pitruzzella1, Fabio Bucchieri1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 4Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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185 | From mycelium to medicine: cytotoxic effects of Ganoderma adspersum extracts in renal cancer cells Maria Noemi Sgobba1, Nikola Schlosserova1|2, Biagia Musio3, Federica Mastropirro1, Antonio Radesco4, Maria Favia5, Simona Marianna Sanzani4, Stefano Todisco3, Mariateresa Volpicella1, Anna De Grassi1, Vito Gallo3, Elena Ciani1, Ciro Leonardo Pierri6, Jakub Treml7, Lorenzo Guerra1 | 1Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 2Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Czech Republic; 3Department of Civil, Environmental, Land, Building Engineering and Chemistry DICATECh, Polytechnic University of Bari, Italy; 4Department of Soil, Plant and Food Sciences, University of Bari, Italy; 5Department of Translational Biomedicine and Neurosciences DiBraiN, University of Bari, Italy; 6Department of Pharmacy – Pharmaceutical Sciences, University of Bari, Italy; 7Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
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117 | Modulation of DNA methylation patterns and heat shock proteins following exercise and probiotic supplementation A. Boatta1|2, G. Messina1, A. Pagliaro3, A. Alioto3, C. Rossi3, L. Paladino4, F. Rappa6, F. Naselli5, F. Cappello6, R. Barone6, P. Proia3 | 1Department of Human Sciences and Promotion of Quality of Life, San Raffaele Roma Open University, Roma, Italy; 2Institute for Biomedical Research and Innovation, CNR, Palermo, Italy; 3Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy; 4Department of Theoretical and Applied Sciences DiSTA, eCampus University, Novedrate, Italy; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy; 6Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Palermo, Italy.
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NANOPLASTICS AND IMMUNITY: INVESTIGATING THE EXTRACELLULAR MATRIX’S INFLUENCE ON MACROPHAGE INTERACTION WITH POLYSTYRENE NANOPARTICLES Marianna ROCA1, Naym BLAL1, Zeynep RENKLER2, Vincenzo GUARINO2, Antonia DI MOLA1, Antonio MASSA1, Ilaria DE MARTINO3, Velia SICILIANO3, Daniela GUARNIERI1 | 1Department of Chemistry and Biology, “Adolfo Zambelli”, University of Salerno; 2Institute of Polymers, Composites and Biomaterials, National Research Council of Italy; 3Synthetic and Systems Biology for Biomedicine Lab, Istituto Italiano di Tecnologia, Naples, Italy
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125 | Impact of 2D and 3D in vitro culture models on extracellular vesicles in human ovarian cancer Giulia Di Fazio1, Giuseppina Poppa1, Giuseppe Cammarata2, Sandra D’Ascenzo1, Vincenza Dolo1, Simona Taverna2, Ilaria Giusti1 | 1Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy; 2Institute of Translational Pharmacology IFT, National Research Council of Italy CNR, Palermo, Italy.
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049 | CMIT as an emerging contaminant: physiological and biochemical effects in Mytilus galloprovincialis Giuseppe Stracuzzi1, Federica Impellitteri1, Maria Giovanna Rizzo1, Monia Perugini2, Marika Cordaro3, Kateryna Yunko4, Oksana Stoliar4, Caterina Faggio1|5 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Feed and Food Scienxes, Teramo Univesity, Teramo, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Messina, Italy; 4Ternopil Volodymyr Hnatiuk National Pedagogical University, Ternopil, Ukraine; 5Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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102 | Polylactic acid nanoparticles as metabolically active entities: a metabolomics and fluxomics perspective Martina Lombardi1|2|3, Vera Abenante2|3, Alessio Trotta2|3, Erwin Pavel Lamparelli1, Federica Montella1, Giovanna Della Porta1, Andrea Viggiano1, Jacopo Troisi1|2|3|4, Antonietta Santoro1 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, Salerno, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, Salerno, Italy; 4Department of Chemistry and Biology, “A Zambelli”, University of Salerno, Fisciano [SA], Italy.
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069 | Comparative analysis of inflammatory and redox responses in human and rat macrophages exposed to calcium-doped mesoporous silica nanoparticles Styliani Axypolitou1, Antonietta Ligas2, Ioannis Tsamesidis1, Georgia K. Pouroutzidou1, Pier Luigi Fiori2, Antonella Pantaleo2, Eleana Kontonasaki1 | 1Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.
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