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142 | Drug repositioning reveals novel therapeutic candidates for spinal muscular atrophy Marina Boido1, Daniela Maria Rasà1, Serena Stanga1, Ersilia Nicorvo1, Pamela Santonicola2, Nadia Mazzarella3, Antonella Camera2, Roberto Iacomino2, Ilenia Matino2, Silvia Chasseur1, Giuseppina Zampi2, Piera Smeriglio4, Elia Di Schiavi2, Alessandro Vercelli1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy; 2Institute of Biosciences and BioResources IBBR, National Research Council CNR, Naples, Italy; 3Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" IGB-ABT, National Research Council CNR, Naples, Italy; 4Sorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
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060 | Interdomain interactions and pH modulate folding intermediates in MAGI1 PDZ4 Cosmin Marian Obreja1, Valeria Pennacchietti2, Dimitrios Marinidis1, Sara Di Matteo3, Rodolfo Ippoliti1, Stefano Gianni2, Francesca Malagrinò1 | 1University of L’Aquila, Italy; 2University “La Sapienza” of Rome, Italy; 3University of Chieti-Pescara, Italy.
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014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco1, Alessandra Maria Vitale1, Giuseppa D’Amico1, Alessandro Lo Giudice1, Francesca Chiara Cecala1, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2 | 1Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.
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EVALUATION OF TRANS-EPITHELIAL PENETRATION AND MICROPLASTIC-INDUCED TISSUE DAMAGE IN A 3D MODEL OF HUMAN RESPIRATORY MUCOSA Adelaide CARISTA1, Domiziana PICONE1, Giulia Maria Giorgia LO PIANO1, Olga Maria MANNA2,3, Stefano BURGIO3,4, Giuseppa D’AMICO1, Margherita FERRANTE5, Gea OLIVERI CONTE5, Francesca RAPPA1, Rosario BARONE1, Fabio BUCCHIERI1, Alessandro PITRUZZELLA1, Alberto FUCARINO6 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy; 2Pathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; 5Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Igiene e Sanità Pubblica; 6Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Italy
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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SWIMMING IN PLASTAMINATION: POLY-LACTIC ACID NANOPLASTICS AND SPERM FUNCTIONS Alberto CONTRI1, Massimo VENDITTI2, Alessia GLORIA1, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Rosaria MECCARIELLO4 | 1Department of Veterinary Medicine, University of Teramo; 2Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi (SA); 4Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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THE RISING THREAT: NANO AND MICROPLASTICS INFILTRATION IN URINARY AND REPRODUCTIVE SYSTEMS Luigi MONTANO | Andrology Unit and Service of Lifestyle Medicine in UroAndrology, “S. Francesco d’Assisi” Hospital, Local Health Authority (ASL) Salerno, EcoFoodFertility Project Coordi-nation Unit, Italian Network for Environmental and Reproductive Health, Oliveto Citra, Italy
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008 | A 3D bioprinted microfluidic Breast Cancer-on-Chip model for studying drug transport and resistance Simona Campora1, Kimia Abedi2, Alessandra Lo Cicero1, Gabriele Lo Buglio1, Francesco La Monica1, Giulia Palazzo1, Riccardo Barrile2, Giulio Ghersi1|4 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States; 3Center for Stem Cells and Organoid Medicine CuSTOM, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; 4Abiel Srl, Palermo, Italy.
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PERINATAL EXPOSURE TO BISPHENOL A AND BISPHENOL B CAN ALTER THE SEXUAL BEHAVIOUR AND REPRODUCTIVE SYSTEM OF OFFSPRING Elena RICCI1,2, Marilena MARRAUDINO1,2, Noemi CADORIN1, Iva SABOVIC3, Alberto FERLIN3, Stefano GOTTI1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Torino, Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy; 3Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy
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082 | Supplementation with Lactobacillus fermentum reversed fiber atrophy in a myopathy model by modulating IL-6, TNFα, and hsp60 levels, thereby enhancing muscle regeneration Martina Sausa1, Letizia Paladino2, Federica Scalia3, Francesco Paolo Zummo1, Giuseppe Vergilio1, Francesca Rappa1, Francesco Cappello1, Melania Ionelia Gratie1, Patrizia Proia4, Valentina Di Felice1, Antonella Marino Gammazza,5, Filippo Macaluso1, Rosario Barone1 | 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo; 2Department of Theoretical and Applied Sciences, eCampus University, Novedrate [CO]; 3Department of Medicine and Surgery, Kore University of Enna; 4Department of Psychology, Educational Science and Human Movement, University of Palermo; 5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy.
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071 | Decoding eryptosis: human red blood cells response to xenobiotic-induced stress Marilena Briglia1, Alice Foti1, Fabio Allia1, Rosalia Battaglia1, Giuseppe Piccione2, Alessandro Attanzio3, Caterina Faggio4, Roberta Malaguarnera1, Adriana Carol Eleonora Graziano1 | 1Department of Medicine and Surgery, University of Enna “Kore”, Enna, Italy; 2Department of Veterinary Sciences, University of Messina, Messina, Italy; 3Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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020 | A three-dimensional vascularized cancer model mimicking the tumor microenvironment for drug resistance studies Alessandra Lo Cicero1, Gabriele Lo Buglio1, Francesco La Monica1, Simona Campora1, Margot Lo Pinto2, Simone Dario Scilabra2, Giulio Ghersi1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Palermo, Italy; 2Proteomics Group of RiMED Foundation, Research Department IRCCS ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy; 3Abiel srl, Palermo, Italy.
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160 | Short-term mild caloric restriction induces early adaptive metabolic and mitochondrial responses in the liver of healthy rats Martina Coletta1, Vincenzo Migliaccio1, Giuliana Panico2, Ilaria Di Gregorio1, Assunta Lombardi2, Lillà Lionetti1 | 1Dept Chemistry and Biology "A Zambelli", University of Salerno, Italy; 2Dept Biology, University of Naples Federico II, Naples, Italy.
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069 | Comparative analysis of inflammatory and redox responses in human and rat macrophages exposed to calcium-doped mesoporous silica nanoparticles Styliani Axypolitou1, Antonietta Ligas2, Ioannis Tsamesidis1, Georgia K. Pouroutzidou1, Pier Luigi Fiori2, Antonella Pantaleo2, Eleana Kontonasaki1 | 1Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 2Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.
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019 | PDE5A promotes hypoxic hepatocellular carcinoma cell survival through ERK-dependent signalling Lara Lizzi, Alberto Massimi, Mara Massimi | Dept. of Life, Health and Environmental Sciences, University of L’Aquila, Italy.
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POLY-LACTIC ACID NANOPLASTICS BIOCCUMULATE IN DEVELOPING ZEBRAFISH AND INDUCE EPIGENETIC CHANGES Massimo VENDITTI1, Marta Anna SZYCHLINSKA2, Valentina LOPARDO3, Federica SCALIA4, Marianna MARINO3, Erwin Pavel LAMPARELLI3, Giovanna DELLA PORTA3, Antonietta SANTORO3, Francesco CAPPELLO5, Rosaria MECCARIELLO6 | 1Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy; 2Department of Precision Medicine in Medical, Surgical and Critical Care (MEPRECC), University of Palermo, Palermo, Italy; 3Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy; 4Department of Medicine and Surgery, “Kore” University of Enna, Enna, Italy; 5Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy; 6Department of Medical, Human Movement and Well-being Sciences, Parthenope University of Naples, Italy
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039 | Age and growth of the mesopelagic fish Electrona risso (myctophidae) from the Strait of Messina (central Mediterranean sea) Calogero Fontana1, Alice Vaccaro2, Francesco Longo1, Danilo Malara3, Emanuela Fanelli2|4, Pietro Battaglia1|4 | 1Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Messina, Italy; 2Università Politecnica delle Marche UNIVPM, Dipartimento di Scienze della Vita e dell’Ambiente, Ancona, Italy; 3Northern Territory Government of Australia, Department of Agriculture and Fisheries, Fisheries Division, Berrimah, NT, Australia; 4National Biodiversity Future Center, Palermo, Italy.
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MATERNAL EXPOSURE TO ENDOCRINE DISRUPTORS AND INFANT DEVELOPMENT: FINDINGS FROM THE LIFE MILCH COHORT STUDY Silvia PATERLINI1, Maria Maddalena BRAMBILLA1, Francesca ALBERGHI2, Alessia ARDENGHI3, Mariateresa BELLANTONI1, Marta FONTANA2, Laura FILONZI3, Francesco NONNIS MARZANO3, Francesca NUTI4, Annalisa PELOSI1, Serafina PERRONE1, Silvia PETZA5, Roberta PINTUS5, Feliciana REAL-FERNANDEZ4, Vassilios FANOS5, Anna Maria PAPINI4, Maria E. STREET1,2, Paola PALANZA1 | 1Department of Medicine and Surgery, University of Parma (IT); 2Department of Obstetrics, Gynecology and Pediatrics, Azienda USL-IRCCS, Reggio Emilia (IT); 3Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma (IT); 4Department of Chemistry “Ugo Schiff”, University of Florence; 5Department of Surgical Sciences, University of Cagliari, Italy
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POLY(LACTIC ACID) PLASTICS CONTAMINATION (PLASTAMINATION): SIZE-DEPENDENT EFFECTS OF PLA-DERIVED NANOPLASTICS ON EARLY ZEBRAFISH DEVELOPMENT Giusy VULTAGGIO1, Martina DI MARCO1, Antonietta SANTORO2, Marianna MARINO2, Erwin Pavel LAMPARELLI2, Giovanna DELLA PORTA2, Francesco CAPPELLO1,3, Federica SCALIA1,4, Marta Anna SZYCHLINSKA5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Italy; 2Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 3Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 4Department of Medicine and Surgery - Kore University of Enna, Enna, Italy; 5Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Italy
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068 | In vitro modulation of inflammatory mediators by eggplant peel extracts from two cultivar Alessandra Armeli, Desirèe Bonfiglio, Serena Munaò, Giovanna Calabrese | Department of Chemical, Biological, Pharmaceutical and Environmental Sciences ChiBioFarAm, University of Messina, Italy.
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180 | Shared pathways in experimental projects: research, territory, and scientific communities compared the example of the initiatives of the Regional Agency for Rural Development – Ersa (Friuli Venezia Giulia, Italy) Simona Rainis | Regional Agency for the Rural Development ERSA, Gorizia, Italy.
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018 | BSA nanoparticles containing collagenases and doxorubicin to enhance therapeutic efficacy in 3D models of solid tumor Gabriele Lo Buglio1|2, Alessandra Lo Cicero1, Simona Campora1, Paolo Cinà3Samuel Lenton2, Vito Foderà2, Giulio Ghersi1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2Department of Pharmacy, University of Copenhagen, Denmark; 3Abiel srl, Palermo, Italy.
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102 | Polylactic acid nanoparticles as metabolically active entities: a metabolomics and fluxomics perspective Martina Lombardi1|2|3, Vera Abenante2|3, Alessio Trotta2|3, Erwin Pavel Lamparelli1, Federica Montella1, Giovanna Della Porta1, Andrea Viggiano1, Jacopo Troisi1|2|3|4, Antonietta Santoro1 | 1Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; 2Theoreo Srl, Montecorvino Pugliano, Salerno, Italy; 3European Institute of Metabolomics - Fondazione EIM, Baronissi, Salerno, Italy; 4Department of Chemistry and Biology, “A Zambelli”, University of Salerno, Fisciano [SA], Italy.
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EFFECTS OF CO-EXPOSURE TO MICROPLASTICS AND CADMIUM ON THE BINDING OF PROTAMINE-LIKE PROTEINS TO DNA IN MYTILUS GALLOPROVINCIALIS Gennaro LETTIERI, Giulio SANTANIELLO, Simona AMORE, Carmela MARINARO, Marina PISCOPO | Dipartimento di Biologia, Università degli Studi di Napoli Federico II
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