Pharmacological manipulation of serotonin receptors during brain embryogenesis favours stress resiliency in female rats

  • Gianluca Lavanco Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.
  • Angela Cavallaro Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.
  • Emanuele Cannizzaro Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.
  • Marco Giammanco Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
  • Danila Di Majo Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
  • Anna Brancato | anna.brancato@unipa.it Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.

Abstract

Manipulations of the serotonin transmission during early development induce long-lasting changes in the serotonergic circuitry throughout the brain. However, little is known on the developmental consequences in the female progeny. Therefore, this study aimed at exploring the behavioural effects of pre- and postnatal stimulation of the serotonergic system by 5-methoxytryptamine in adolescent female rats on behavioural reactivity and anxiety- like phenotype. Our results show that perinatal 5- methoxythyptamine decreased total distance travelled and rearing frequency in the novel enviroment, and increased the preference for the centre of the arena in the open field test. Moreover, perinatal 5-methoxytryptamine increased the percentages of entries and time spent on the open arms of the elevated plus maze, with respect to perinatally vehicle-exposed rats. Thus, perinatal stimulation of serotonin receptors does not impair the functional response to the emotional challenges in female rats, favouring the occurrence of a stress-resilient phenotype.

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Published
2018-02-12
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Original Articles
Keywords:
5-methoxytryptamine, development, stress reactivity, female rats
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How to Cite
Lavanco, G., Cavallaro, A., Cannizzaro, E., Giammanco, M., Di Majo, D., & Brancato, A. (2018). Pharmacological manipulation of serotonin receptors during brain embryogenesis favours stress resiliency in female rats. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 90(2). https://doi.org/10.4081/jbr.2017.6782