Using high density EEG to assess TMS treatment in patients with schizophrenia

  • Sara Marcu Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland; Department of Information Engineering, University of Padova, Italy.
  • Elena Pegolo Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland; Department of Information Engineering, University of Padova, Italy.
  • Eysteinn Ívarsson Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.
  • Aron D. Jónasson Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.
  • Viktor D. Jónasson Psychiatric Department, National University Hospital of Iceland, Iceland.
  • Romain Aubonnet Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland.
  • Paolo Gargiulo Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik, Iceland.
  • Ovidiu Constantin Banea | ovidiubanea@gmail.com Reykjavik University, School of Science and Engineering, Biomedical Engineering, Reykjavik; Clinical Neurophysiology Unit, Neurology Department, National University Hospital of Iceland, Iceland.

Abstract

We present preliminary results from the ongoing study entitled “Icelandic AVH-TMS” which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory verbal hallucinations (AVH) using symptoms and psychometric scales and high-density EEG system (256 channels). The aim of the present work was to describe cortical topography of the auditory evoked responses like P50 and N100-P300 complex in healthy participants and patients with schizophrenia and to define a robust methodology of signal quantification using dense-array EEG. Preliminary data is shown for three healthy participants and three patients in baseline conditions and for two patients we show the results recorded before and after 10 days rTMS treatment. Our results show differences in sensory gating (P50 suppresion) and a stronger N100-P300 response to rare audio stimulus after the treatment. Moreover we show the value of assessing brain electrical activity from high-density EEG (256 channels) analyzing the results in different regions of interest. However, it is premature and hazardous to assume that rTMS treatment effectiveness in patients with AVH can be assessed using P50 suppression ratio.

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Published
2020-04-01
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Section
Focus on 30 Years of Translational Mobility Medicine - Communications
Keywords:
Transcranial magnetic stimulation, schizophrenia, high density EEG, P50, P300
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How to Cite
Marcu, S., Pegolo, E., Ívarsson, E., Jónasson, A. D., Jónasson, V. D., Aubonnet, R., Gargiulo, P., & Banea, O. (2020). Using high density EEG to assess TMS treatment in patients with schizophrenia. European Journal of Translational Myology, 30(1), 134-138. https://doi.org/10.4081/ejtm.2019.8903