The Arianna thread: the matching of S-100 family with the RyR’s muscle receptor

  • Stefania Fulle Department of Neuroscience, Imaging and Clinical Science, University “G. d’Annunzio” Chieti-Pescara; Interuniversity Institute of Miology (IIM), Italy.
  • Silvia Belia Interuniversity Institute of Miology (IIM); Department of Chemistry, Biology and Biothecnology, University of Perugia, Italy.
  • Giorgio Fano Illic | fanoillic@gmail.com Interuniversity Institute of Myology (IIM); Free University of Alcatraz, Santa Cristina of Gubbio, Perugia, Italy.

Abstract

The functional state of RyR depends on the intracellular calcium concentration and on the oxidation state of its protein components in some particular sites and of some sentinel amino acids. In addition to the regulation of the RyR channel by exogenous substances (caffeine, ryanodine), ions environmental situations (oxidative state), other components, such as some endogenous proteins present in the sarcoplasm and/or in muscle membranes that are able to determine changes in Ca2+ channel activity. Among these, calmodulin and S-100A could determine modifications in the status of RyR channel in the skeletal muscle. The currently available data can be justified the use of a simplified S-100/CaM and RyR interaction model for the regulation of Ca2+ release in skeletal muscle. Under resting conditions, the CaM/S100A1 binding domain on RyR1 is predominantly dependent on S100A1. Vice versa when the intracellular Ca2+ concentration becomes high as well as during repetitive (tetanus) stimulation, the Ca-CaM bond becomes dominant, shifting S100A1 from RyR1 and promoting channel inactivation. This may be one of the mechanism of muscle fatigue.

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Published
2020-04-01
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Section
Focus on 30 Years of Translational Mobility Medicine - Reviews
Keywords:
Ca2 release, RyR modulation, S-100 proteins, calmodulin
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How to Cite
Fulle, S., Belia, S., & Fano Illic, G. (2020). The Arianna thread: the matching of S-100 family with the RyR’s muscle receptor. European Journal of Translational Myology, 30(1), 48-52. https://doi.org/10.4081/ejtm.2019.8839