Synchronous multiple neuroendocrine primary lung cancer with endobronchial extension in a never smoker - An unusual manifestation
https://doi.org/10.4081/cdr.12.12297
Accepted: 24 January 2024
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Synchronous Lung Cancer primaries (SLC) are uncommon, with diverse underlying histology, constituting only a small proportion. The scarcity also poses a challenge in formulating a standardized diagnostic approach. Consequently, the diagnostic and staging challenges for SLC are heightened, particularly when the tumors are located on opposite sides of the chest. We report an exceptionally rare phenomenon in synchronous multiple primary lung cancers with simultaneous occurrence of two neuroendocrine tumors with endobronchial extension, small cell carcinoma and typical carcinoid tumor. Immunohistochemistry proved valuable in confirming the diagnosis. Given the poor prognosis associated with such cases, an accurate diagnosis is crucial for determining appropriate treatment options.
Froio E, D’Adda T, Fellegara G, et al. Three different synchronous primary lung tumours: a case report with extensive genetic analysis and review of the literature. Lung Cancer. 2008;59:395-402. DOI: https://doi.org/10.1016/j.lungcan.2007.07.007
Tie H, Luo J, Shi R, et al. Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence. Cancer Med. 2021;10:507-20. DOI: https://doi.org/10.1002/cam4.3614
Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975;70:606-12. DOI: https://doi.org/10.1016/S0022-5223(19)40289-4
Stirpe E, Bardaro F, Koehl J. Synchronous lung cancer presenting with small cell carcinoma and squamous cell lung carcinoma: a case report. Monaldi Arch Chest Disease. 2023;2748. DOI: https://doi.org/10.4081/monaldi.2023.2748
Shen KR, Meyers BF, Larner JM, Jones DR. Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132:290-305S. DOI: https://doi.org/10.1378/chest.07-1382
Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer: an increasing clinical occurrence requiring multidisciplinary management. J Thorac Cardiovasc Surg. 2007;133:1193-200. DOI: https://doi.org/10.1016/j.jtcvs.2007.01.012
Yoshino R, Yoshida N, Yasuda S, et al. Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma: A case report. World J Clin Cases. 2023;11:5919-25. DOI: https://doi.org/10.12998/wjcc.v11.i25.5919
Davis A, Jarrar S, Ciunci C. Synchronous Primary Lung Cancers Containing Discrete Driver Mutations in a Never-Smoker: Case Report. Case Rep Oncol. 2023;16:1384. DOI: https://doi.org/10.1159/000533892
Nie Y, Wang X, Yang F, et al. Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis. Clin Lung Cancer. 2021;22. DOI: https://doi.org/10.1016/j.cllc.2020.10.022
Chen C, Huang X, Peng M, et al. Multiple primary lung cancer: a rising challenge. J Thorac Dis. 2019;11:S523-36. DOI: https://doi.org/10.21037/jtd.2019.01.56
Dingemans AMC, Früh M, Ardizzoni A, et al. Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆. Annals of Oncology. 2021;32. DOI: https://doi.org/10.1016/j.annonc.2021.03.207
Jiang L, He J, Shi X, et al. Prognosis of synchronous and metachronous multiple primary lung cancers: systematic review and meta-analysis. Lung Cancer. 2015;87:303-10. DOI: https://doi.org/10.1016/j.lungcan.2014.12.013
Pezzuto A, Trabalza Marinucci B, Ricci A, et al. Predictors of respiratory failure after thoracic surgery: a retrospective cohort study with comparison between lobar and sub-lobar resection. Journal of International Medical Research. 2022;50. DOI: https://doi.org/10.1177/03000605221094531
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
