Letters to the Editor
Vol. 27 No. 1 (2017)
https://doi.org/10.4081/ejtm.2017.6483

Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains

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Received: 16 December 2016
Published: 27 March 2017
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BALB/c mice, Murine sub-strains, Inbred mouse strains, Running behavior, Endurance exercise
animal biology, sport and exercise, physiology

Authors

Dario Coletti
dario.coletti@uniroma1.it
http://orcid.org/0000-0001-7373-1953 (unauthenticated)
Sorbonne Universités, UPMC Univ Paris 06 (CNRS, UMR 8256, INSERM ERL U1164), Institut Biologie Paris-Seine, Paris, France; Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome; Interuniversity Institute of Myology, Italy.
Sergio Adamo
Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy.
Viviana Moresi
Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy.
Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents. The latter are prone to exercise in wheel-equipped cages even at advanced stages of cachexia. However, when we wanted to replicate the experimental model routinely used at the University of Rome in a different laboratory (i.e. at Paris 6 University), we had to struggle with puzzling results due to unpredicted mouse behavior. Here we report the experience and offer the explanation underlying these apparently irreproducible results. The original data are currently used for teaching purposes in undergraduate student classes of biological sciences.

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Supporting Agencies

ANR France, MIUR PRIN Italy, UPMC Emergence, Sapienza Ateneo

How to Cite



1.
Coletti D, Adamo S, Moresi V. Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains. Eur J Transl Myol [Internet]. 2017 Mar. 27 [cited 2026 Apr. 28];27(1). Available from: https://www.pagepressjournals.org/bam/article/view/6483

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