Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study

Submitted: 22 September 2023
Accepted: 2 October 2023
Published: 19 February 2024
Abstract Views: 577
PDF: 360
HTML: 6
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Neonatal respiratory distress syndrome (NRDS) is one of the major causes of pre-term mortality and morbidity among very-low-birth-weight infants (VLBWI) in low- and middle-income countries (LMIC). Some of the neonates pass away despite admission and care in intensive care units (ICUs). The present clinical trial seeks the application value of elevating oxygen saturation in the brain cells of pre-term neonates born with NRDS. Near-infrared spectroscopy (NIRS) was used to monitor the neonates’ microscopic cerebral oxygenation levels do determine hemoglobin concentration in brain tissues, whereas the pulse oximetry was used to measure oxygenation levels among the patients. In statistical analyses, the Analysis of Variance (ANOVA), and descriptive statistics was deployed in the Jupyter Notebook environment using Python language. High saturation of oxygen in the brain tissues result in important biological and physiological processes, including enhanced oxygen supply to cells, reduced severity of NRDS, and balancing oxygen demand and supply. The correlations of oxygen saturation with systemic saturation of oxygen, the saturation of oxygen in brain tissues, the association between brain-specific and systemic saturation, and the impact of these outcomes on clinical practices were deliberated. Also, the pH gas values, the saturation of oxygen in neonates’ brain tissues, metabolic acidosis, the effect of acid-base balance and cerebral oxygen supply, and the oxygenation of brain tissues and the pH values emerged as important variables of oxygenation of brain tissues in pre-term neonates. Oxygen saturation in brain cells influence vital physiological and biological processes. Balancing acid-base saturation or levels is needed despite the challenging achievement. Oxygenation of brain tissues improve the brain’s overall functioning.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Nogee LM, Ryan RM. Genetic Testing for Neonatal Respiratory Disease. Children (Basel). 2021 Mar 11;8(3):216. PMID: 33799761; PMCID: PMC8001923. DOI: https://doi.org/10.3390/children8030216
Yadav S, Lee B, Kamity R. Neonatal Respiratory Distress Syndrome. 2023 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32809614.
Marinonio ASS, Costa-Nobre DT, Miyoshi MH, Balda RCX, Areco KCN, Konstantyner T, Kawakami MD, Sanudo A, Bandiera-Paiva P, de Freitas RMV, Morais LCC, La Porte Teixeira M, Waldvogel BC, de Almeida MFB, Guinsburg R, Kiffer CRV. Clusters of preterm live births and respiratory distress syndrome-associated neonatal deaths: spatial distribution and cooccurrence patterns. BMC Public Health. 2022 Jun 20;22(1):1226. PMID: 35725459; PMCID: PMC9210662. DOI: https://doi.org/10.1186/s12889-022-13629-4
Ekhaguere OA, Okonkwo IR, Batra M, Hedstrom AB. Respiratory distress syndrome management in resource limited settings-Current evidence and opportunities in 2022. Front Pediatr. 2022 Jul 29;10:961509. PMID: 35967574; PMCID: PMC9372546. DOI: https://doi.org/10.3389/fped.2022.961509
Gitto E, Reiter RJ, Amodio A, Romeo C, Cuzzocrea E, Sabatino G, Buonocore G, Cordaro V, Trimarchi G, Barberi I. Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin. J Pineal Res. 2004 May;36(4):250-5. PMID: 15066049. DOI: https://doi.org/10.1111/j.1600-079X.2004.00124.x
Nalivaeva NN, Rybnikova EA. Editorial: Brain hypoxia and ischemia: New insights into neurodegeneration and neuroprotection, volume II. Front Neurosci. 2023 Jan 9;16:1125883. PMID: 36699512; PMCID: PMC9869268. DOI: https://doi.org/10.3389/fnins.2022.1125883
Mandolesi L, Polverino A, Montuori S, Foti F, Ferraioli G, Sorrentino P, Sorrentino G. Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits. Front Psychol. 2018 Apr 27;9:509. PMID: 29755380; PMCID: PMC5934999. DOI: https://doi.org/10.3389/fpsyg.2018.00509
Meybohm P, Müller MM, Zacharowski K. Präoperative Vorbereitung: Patient Blood Management – Was ist optimal? [Preoperative Preparation: Patient Blood Management - What is Optimal?]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2017 May;52(5):326-340. German. Epub 2017 May 22. PMID: 28561148. DOI: https://doi.org/10.1055/s-0042-108925
Saito-Benz M, Flanagan P, Berry MJ. Management of anaemia in pre-term infants. Br J Haematol. 2020 Feb;188(3):354-366. Epub 2019 Oct 6. PMID: 31588563. DOI: https://doi.org/10.1111/bjh.16233
Hafen BB, Sharma S. Oxygen Saturation. 2022 Nov 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30247849.
Hafen BB, Sharma S. Oxygen Saturation, Oxygen Saturation - StatPearls - NCBI Bookshelf (nih.gov), 2022. www.ncbi.nlm.nih.gov/books/NBK525974/
Pittman RN. Regulation of Tissue Oxygenation, Colloquium Series on Integrated Systems Physiology: From Molecule to Function, 2011;3:3, Colloquium Series on Integrated Systems Physiology: From Molecule to Function, DOI: https://doi.org/10.4199/C00029ED1V01Y201103ISP017
Ganesan G, Leu SY, Cerussi A, Tromberg B, Cooper DM, Galassetti P. Cerebral and Muscle Tissue Oxygenation During Incremental Cycling in Male Adolescents Measured by Time-Resolved Near-Infrared Spectroscopy. Pediatr Exerc Sci. 2016 May;28(2):275-85. Epub 2015 Oct 9. PMID: 26451845; PMCID: PMC4826640. DOI: https://doi.org/10.1123/pes.2015-0037
Vali P, Lakshminrusimha S. The Fetus Can Teach Us: Oxygen and the Pulmonary Vasculature. Children (Basel). 2017 Aug 3;4(8):67. PMID: 28771211; PMCID: PMC5575589. DOI: https://doi.org/10.3390/children4080067
Hillman NH, Kallapur SG, Jobe AH. Physiology of transition from intrauterine to extrauterine life. Clin Perinatol. 2012 Dec;39(4):769-83. PMID: 23164177; PMCID: PMC3504352. DOI: https://doi.org/10.1016/j.clp.2012.09.009
Morton SU, Brodsky D. Fetal Physiology and the Transition to Extrauterine Life. Clin Perinatol. 2016 Sep;43(3):395-407. Epub 2016 Jun 11. PMID: 27524443; PMCID: PMC4987541. DOI: https://doi.org/10.1016/j.clp.2016.04.001
Zhang K, Zhu L, Fan M. Oxygen, a Key Factor Regulating Cell Behavior during Neurogenesis and Cerebral Diseases. Front Mol Neurosci. 2011 Apr 4;4:5. PMID: 21503147; PMCID: PMC3073059. DOI: https://doi.org/10.3389/fnmol.2011.00005
Watts ME, Pocock R, Claudianos C. Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease. Front Mol Neurosci. 2018 Jun 22;11:216. PMID: 29988368; PMCID: PMC6023993. DOI: https://doi.org/10.3389/fnmol.2018.00216
Tin W, Gupta S. Optimum oxygen therapy in preterm babies. Arch Dis Child Fetal Neonatal Ed. 2007 Mar;92(2):F143-7. PMID: 17337663; PMCID: PMC2675464. DOI: https://doi.org/10.1136/adc.2005.092726
McCall EM, Alderdice F, Halliday HL, Vohra S, Johnston L. Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2018 Feb 12;2(2):CD004210. PMID: 29431872; PMCID: PMC6491068. DOI: https://doi.org/10.1002/14651858.CD004210.pub5
Langer T, Zadek F, Carbonara M, Caccioppola A, Brusatori S, Zoerle T, Bottazzini F, Ferraris Fusarini C, di Modugno A, Zanella A, Zanier ER, Fumagalli R, Pesenti A, Stocchetti N. Cerebrospinal Fluid and Arterial Acid-Base Equilibrium of Spontaneously Breathing Patients with Aneurismal Subarachnoid Hemorrhage. Neurocrit Care. 2022 Aug;37(1):102-110. Epub 2022 Feb 23. PMID: 35199305; PMCID: PMC9283163. DOI: https://doi.org/10.1007/s12028-022-01450-1
Farnam A. pH of soul: how does acid-base balance affect our cognition? Bioimpacts. 2014;4(2):53-4. Epub 2014 Jul 2. PMID: 25035847; PMCID: PMC4097972.
Clayton-Smith M, Sharma MP. Renal physiology: acid-base balance. Anaesthesia & Intensive Care Medicine, 2021;22(7):415–421. DOI: https://doi.org/10.1016/j.mpaic.2021.05.011
McTavish AD, Sharma MP. Renal physiology: acid–base balance, Anaesthesia and Intensive Care Medicine, 2018;19(5): 233-238. DOI: https://doi.org/10.1016/j.mpaic.2018.02.015

How to Cite

Cheng, K., Zhu, H., Zhou, Z., Chen, W., & Yang, A. (2024). Value of brain tissue oxygen saturation in neonatal respiratory distress syndrome: a clinical study. European Journal of Translational Myology, 34(1). https://doi.org/10.4081/ejtm.2024.11863