Is relaxation exercise therapy effective in the management of patients with severe arterial hypertension?


Published: 15 December 2021
Abstract Views: 881
PDF: 283
HTML: 2
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Olga. D. Lebedeva Federal State Budgetary Institution “National medical research center for rehabilitation and balneology”, Ministry of Health of Russia, Moscow, Russian Federation.
  • Abduahat A. Achilov Federal State Budgetary Institution “Skobelkin State Scientific Center of Laser Medicine Federal Medical and Biological Agency of Russia”, Moscow, Russian Federation.
  • Zilola F. Mavlyanova Samarkand state medical institution, Samarkand, Uzbekistan, Uzbekistan.
  • Alexey V. Baranov Federal State Budgetary Institution “Skobelkin State Scientific Center of Laser Medicine Federal Medical and Biological Agency of Russia”, Moscow, Russian Federation.
  • Shachnosa A. Achilova Federal State Budgetary Institution “Skobelkin State Scientific Center of Laser Medicine Federal Medical and Biological Agency of Russia”, Moscow, Russian Federation.
  • Natalia P. Sanina State Budgetary Healthcare Institution M. Vladimirsky Moscow Regional Research Clinical Institute, Russian Federation.
  • Anatoly D. Fesyun Federal State Budgetary Institution “National medical research center for rehabilitation and balneology”, Ministry of Health of Russia, Moscow, Russian Federation.
  • Andrey P. Rachin Federal State Budgetary Institution “National medical research center for rehabilitation and balneology”, Ministry of Health of Russia, Moscow, Russian Federation.
  • Maxim Yu. Yakovlev Federal State Budgetary Institution “National medical research center for rehabilitation and balneology”, Ministry of Health of Russia, Moscow, Russian Federation.
  • Kirill V. Terentev
  • Igor V. Reverchuk Federal State Autonomous Educational Institution of Higher Education FSAEI HE “Immanuel Kant Baltic Federal University”, Russian Federation.
  • Alie S. Velilyaeva Samarkand state medical institution, Samarkand, Uzbekistan.
  • Maria Chiara Maccarone Physical Medicine and Rehabilitation School, University of Padova, Padua, Italy.
  • Stefano Masiero Physical Medicine and Rehabilitation School, University of Padova, Padua, Italy; Rehabilitation Unit, Department of Neuroscience, University of Padova, Padua, Italy.

Arterial hypertension (AH) is a burning problem in the world. Antihypertensive pharmacological therapy combined by physical exercises is well-studied in patients with mild and moderate AH. However, studies that have investigated relaxation in patients with severe AH in addition to drug therapy are lacking. Optimization of a comprehensive treatment for patients with severe AH, by using a multicomponent rational antihypertensive pharmacotherapy (PT) with subsequent application of relaxation exercise therapy (RET). The study involved 32 male patients with severe AH. Initially, clinical-instrumental and laboratory examination, blood pressure registration and daily arterial blood pressure monitoring were carried out. Suitable PT was selected for all the patients. 3 months after starting PT the patients were divided in 2 groups. The patients of the 1st group were prescribed RET in addition to PT. The 2nd group of patients continued receiving PT alone. 3 months later, average daily blood pressure (ADBP)-syst and ADBP-diast were compared in both groups. Three months after PT both groups demonstrated a significant decrease in ADBP-syst and ADBP diast, but these indicators remained higher than normal and did not reach the target level. Three months after the inclusion of RET in the comprehensive treatment, the 1st group demonstrated a significant decrease in ADBP (systolic and diastolic), not only in comparison with the initial data, but also with the data observed three months after PT. After 6 months, ADBP-syst and ADBP-diast in the 1st group were significantly lower compared with those of patients in the 2nd group. The inclusion of RET in addition to a multicomponent antihypertensive PT is a promising treatment option for severe AH.


Xia N, Li H. The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol. 2017; 174 (20): 3425-3442. DOI: https://doi.org/10.1111/bph.13650

Ramalingam L, Menikdiwela K, LeMieux M, Dufour JM, Kaur G, Kalupahana N, Moustaid-Moussa N. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1106-1114. Epub 2016 Aug 4.. DOI: https://doi.org/10.1016/j.bbadis.2016.07.019

Aronov DM. History of cardiac rehabilitation in Russia. Kardiologiia. 2018;58(11S):14-21. (In Russ.). DOI: https://doi.org/10.18087/cardio.2604

Kontsevaya AV, Romanenko TS, Vygodin V, Fiitilev S.B. Pharmacoepidemiology and effectiveness of antihypertensive therapy in the specialized cardiological institution clinical practice. Rational pharmacotherapy in cardiology. 2015; 11(1):8-17. (In Russ.). DOI: https://doi.org/10.20996/1819-6446-2015-11-1-8-17

Aronov DM, Kozlova LV, Bubnova MG Current state and problems of cardiac rehabilitation in Russia. Cardiosomatics. 2017; 8 (3): 5–9. (In Russ.). DOI: https://doi.org/10.26442/CS45311

Bubnova MG, Aronov DM. Cardiac rehabilitation: stages, principles and international classification of functioning (ICF). Preventive medicine. 2020;23(5):40-49. DOI: https://doi.org/10.17116/profmed20202305140

Chazova IE, Aksenova AV, Oshchepkova EV. Features of the course of arterial hypertension in men and women (according to the national register of arterial hypertension). Therapeutic archive. 2019. Vol 91 No. 1. pp. 4-12. DOI: https://doi.org/10.26442/00403660.2019.01.000021

Cataldi M, di Geronimo O, Trio R, Scotti A, Memoli A, Capone D, Guida B. Utilization of antihypertensive drugs in obesity-related hypertension: a retrospective observational study in a cohort of patients from Southern Italy. BMC Pharmacol Toxicol. 2016; 17:9. DOI: https://doi.org/10.1186/s40360-016-0055-z

Jordan J. Pathophysiology of hypertension: what are our current concepts? Internist 2015; 56:219–223. DOI: https://doi.org/10.1007/s00108-014-3572-0

Kario K, Thijs L, Staessen JA. Blood Pressure Measurement and Treatment Decisions. Circ Res. 2019 Mar 29;124(7):990-1008. DOI: https://doi.org/10.1161/CIRCRESAHA.118.313219

Kobayashi K, Sato K, Hatori N, Miyakawa M. A questionnaire survey of general practitioners in Japan's Kanagawa Prefecture for the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014. ClinExpHypertens. 2017;39(8):705-710. DOI: https://doi.org/10.1080/10641963.2017.1313852

Tocci G. Cicero AF, Salvetti M, Musumeci MB, Ferrucci A, Borghi C, Volpe M. Attitudes and preferences for the clinical management of hypertension and hypertension-related cerebrovascular disease in the general practice: results of the Italian hypertension and brain survey. Clin Hypertens. 2017;23:10. DOI: https://doi.org/10.1186/s40885-017-0066-0

Wermelt JA, Schunkert H. Management der arteriellen Hypertonie [Management of arterial hypertension]. Herz, 2017; 42(5), 515–526. DOI: https://doi.org/10.1007/s00059-017-4574-1

Di Daniele N. Therapeutic approaches of uncomplicated arterial hypertension in patients with COPD. Pulm Pharmacol Ther. 2015; 35:1-7. DOI: https://doi.org/10.1016/j.pupt.2015.09.004

Mishina IE, Sarana A., Mikhailovskaya TV, Ivanova G. E. Principles of appointment of aerobic physical training during outpatient cardiac rehabilitation / Bulletin of rehabilitation medicine. 2020. No. 3 (97). pp. 83-95. (In Russ.). DOI: https://doi.org/10.38025/2078-1962-2020-97-3-83-95

Miroshnikov AB, Smolensky AV, Formenov AD. New possibilities of physical rehabilitation of athletes of power sports with essential hypertension: a randomized controlled study. Bulletin of rehabilitation Medicine. 2020. No. 3 (97). pp. 76-82 (In Russ.). DOI: https://doi.org/10.17116/kurort2020970615

Kulchitskaya DB, Kolbasova SN. Non-drug methods of treatment of patients with arterial hypertension / Bulletin of rehabilitation med. 2020. No. 3 (97). pp. 65-68 (In Russ). DOI: https://doi.org/10.38025/2078-1962-2020-97-3-65-68

Oganov RG, Shalnova SA, Maslennikova GYa. Epidemiology and prevention of cardiovascular diseases. Cardiology: national guidebook / edited by E. V. Shlyakhto. - 2nd edition, revised and enlarged - M.: GEOTAR-Media, 2019, pp. 173 -195. (In Russ.).

Boytsov SA, Balanova YuA, Shalnova SA, Deyev AD, Artamonova GV, Gatagonova TM, Duplyakov DV, Efanov AYu. Arterial hypertension among individuals of 25–64 years of age: prevalence, awareness, treatment and control. Adapted from the materials of ESSE. Cardiovascular therapy and prevention. 2014;4;4-14. (In Russ.).

Muromtseva GA, Kontsevaya A.V, Konstantinov, Artamonova GV Gatagonova TM, Duplyakov D V, Efanov A.Yu. The prevalence of non-infectious diseases risk factors in the Russian population in 2012-2013. the results of ESSE-RF. Cardiovascular therapy and prevention. 2014;13 (6): 4-11. (In Russ.)

Papathanasiou J, Troev T, Ferreira AS, Tsekoura D, Elkova H, Kyriopoulos E, Ilieva E. Advanced Role and Field of Competence of the Physical and Rehabilitation Medicine Specialist in Contemporary Cardiac Rehabilitation. Hellenic J Cardiol. 2016;57(1):16-22. DOI: https://doi.org/10.1016/S1109-9666(16)30013-6

Troev T, Papathanasiou J. Essentials of Physical and Rehabilitation Medicine for Undergraduate Medical Students. 1st edn. Lax Book. 2016; ISBN 978-619-189-041-5.

Papathanasiou JV, Ilieva EM, Nikolov FP. Exercise training modes in rehabilitation of patients with chronic heart failure. Folia Med (Plovdiv). 2012;54(4):22-28. DOI: https://doi.org/10.2478/v10153-012-0002-8

Achilov AA. Method of prevention, treatment and regression of hypertension, atherosclerosis, coronary heart disease, circulatory failure. Patent for the invention EN 2245700 C2, 10.02.2005. Application No. 2002123235/14 of 29.08.2002.

Achilov AA. Method for unloading the heart, increasing blood flow, restoring and preserving the reserve and general exchange surface of capillaries in various areas of the body at the level of regional hemodynamics. Eurasian patent No. 004621 of 24.06.2004.

Chazova IE, Zhernakova YuV. Clinical guidelines. Diagnosis and treatment of arterial hypertension. [Guidelines]. Systemic Hypertension. 2019; 16 (1): 6–31. (In Russ.). DOI: https://doi.org/10.26442/2075082X.2019.1.190179

Kobalava ZhD, Konradi AO, Nedogoda SV. Arterial hypertension in adults. Clinical guidelines 2020. Russian journal of cardiology. 2020; 25(3):149-218. (In Russ.).

Naci H, Salcher-Konrad M, Dias S, Blum MR, Sahoo SA, Nunan D, Ioannidis JPA. How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood pressure. Br J Sports Med. 2019 Jul;53(14):859-869. Epub 2018 Dec 18. DOI: https://doi.org/10.1136/bjsports-2018-099921

Saco-Ledo G, Valenzuela PL, Ruiz-Hurtado G, Ruilope LM, Lucia A. Exercise Reduces Ambulatory Blood Pressure in Patients With Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of the American Heart Association. 2020; 9(24), e018487. DOI: https://doi.org/10.1161/JAHA.120.018487

Boutcher YN, Boutcher SH. Exercise intensity and hypertension: what's new? Journal of human hypertension. 2017; 31(3), 157–164. DOI: https://doi.org/10.1038/jhh.2016.62

Ribeiro F. Resistance exercise for the management of arterial hypertension: An intervention that works!. Journal of clinical hypertension (Greenwich, Conn.), 2021; 23(5), 987–989. DOI: https://doi.org/10.1111/jch.14197

Polegato BF, Paiva SAR. Hypertension and Exercise: A Search for Mechanisms. Arq Bras Cardiol. 2018;111(2):180-181. DOI: https://doi.org/10.5935/abc.20180146

Maccarone MC, Magro G, Solimene U, Scanu A, Masiero S. From in vitro research to real life studies: an extensive narrative review of the effects of balneotherapy on human immune response. Sport Sci Health. 2021 May 20:1-19. Epub ahead of print. DOI: https://doi.org/10.1007/s11332-021-00778-z

Masiero S, Maccarone MC, Magro G. Balneotherapy and human immune function in the era of COVID-19. Int J Biometeorol. 2020; 64, 1433–1434. DOI: https://doi.org/10.1007/s00484-020-01914-z

Masiero S, Maccarone MC. Health resort therapy interventions in the COVID-19 pandemic era: what next?. Int J Biometeorol. 2021. DOI: https://doi.org/10.1007/s00484-021-02134-9

Gálvez I, Torres-Piles S, Ortega-Rincón E Balneotherapy, immune system, and stress response: a hormetic strategy? Int J Mol Sci. 2018; 19(6):1687. DOI: https://doi.org/10.3390/ijms19061687

Bhasin MK, Denninger JW, Huffman JC, Joseph MG, Niles H, Chad-Friedman E, Goldman R, Buczynski-Kelley B, Mahoney BA, Fricchione GL, Dusek JA, Benson H, Zusman RM, Libermann TA. Specific Transcriptome Changes Associated with Blood Pressure Reduction in Hypertensive Patients After Relaxation Response Training. J Altern Complement Med. 2018 May;24(5):486-504. Epub 2018 Apr 4. DOI: https://doi.org/10.1089/acm.2017.0053

Ramos RA, Guimarães FS, Dionyssiotis Y, Tsekoura D, Papathanasiou J, Ferreira AS. Development of a multivariate model of the six-minute walked distance to predict functional exercise capacity in hypertension. J Bodyw Mov Ther. 2019;23(1):32-38. DOI: https://doi.org/10.1016/j.jbmt.2018.01.010

Lebedeva, O. D., Achilov, A. A., Mavlyanova, Z. F., Baranov, A. V., Achilova, S. A., Sanina, N. P., Fesyun, A. D., Rachin, A. P., Yakovlev, M. Y., Terentev, K. V., Reverchuk, I. V., Velilyaeva, A. S. ., Maccarone, M. C., & Masiero, S. (2021). Is relaxation exercise therapy effective in the management of patients with severe arterial hypertension?. European Journal of Translational Myology, 31(4). https://doi.org/10.4081/ejtm.2021.10327

Downloads

Download data is not yet available.

Citations