Clinical characteristics of adult cases with urolithiasis from Turkey: A regional epidemiological study

Submitted: December 11, 2023
Accepted: December 25, 2023
Published: March 4, 2024
Abstract Views: 398
PDF: 176
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Objective: To evaluate the metabolic and clinical characteristics of adult cases with stone disease from a regional part of Turkey.
Methods: The study included 2348 adult patients with sonography and/or computed tomography-proven urinary stones. All cases were given a questionnaire about the epidemiological features of urolithiasis. Aside from the type and severity of stoneforming risk factors, both patient (age, gender, BMI, associated comorbidities, first onset of stone disease, positive family history, educational level) and stone-related (size, number, location, chemical composition, previous stone attacks) factors have been thoroughly assessed. The data were evaluated in multiple aspects to outline the epidemiological features.
Results: The overall mean age value of the cases was 43.3 years, and the M/F ratio was 1.34. The first onset of the disease was found to vary between 15-57 years, with a mean value of 32.4 years. While most of the stones were located in kidney and ureter, calcium-containing stones constituted the most common type (CaOx 69%, CaOxPO4 7%). More than 42% of the cases suffered from multiple stone attacks; positive family history was present in 31.6%. Among the associated comorbidities, hypertension was the most common pathology (45.8%), and the BMI index value was >30 in 31.3% of the cases. 57.7% of the patients had just one stone attack, and 42.2% had recurrent stone formation.
Conclusions: Our findings clearly show that important implications may be extracted from epidemiologic data acquired from local scale research to implement an effective preventative program and closely monitor the patients.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Sorokin I, Mamoulakis C, Miyazawa K, et al. Epidemiology of stone disease across the world. World J Urol 2017;35:1301-20. DOI: https://doi.org/10.1007/s00345-017-2008-6
Stamatelou K, Goldfarb DS. Epidemiology of Kidney Stones. Healthcare 2023; 11:424. DOI: https://doi.org/10.3390/healthcare11030424
Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med 2010;363:954-63. DOI: https://doi.org/10.1056/NEJMcp1001011
Huang WY, Chen YF, Carter S, et al. Epidemiology of upper urinary tract stone disease in a Taiwanese population: a nationwide, population based study. J Urol 2013;189:2158-63. DOI: https://doi.org/10.1016/j.juro.2012.12.105
Marya RK, Dadoo RC, Sharma NK. Genetic predisposition to renal stone disease in the first-degree relatives of stone-formers. Urol Int 1981;36:245-7. DOI: https://doi.org/10.1159/000280767
Trinchieri A. Epidemiological trends in urolithiasis: impact on our health care systems. Urol Res 2006; 34:151-6. DOI: https://doi.org/10.1007/s00240-005-0029-x
Soligo M, Morlacco A, Zattoni F, et al. Metabolic syndrome and stone disease. Panminerva Med 2022; 64:344-58. DOI: https://doi.org/10.23736/S0031-0808.21.04517-1
Chandrajith R, Wijewardana G, Dissanayake CB, Abeygunasekara A. Biomineralogy of human urinary calculi (kidney stones) from some geographic regions of Sri Lanka. Environ Geochem Health 2006;28:393-9. DOI: https://doi.org/10.1007/s10653-006-9048-y
Yasui T, Iguchi M, Suzuki S, Kohri K. Prevalence and epidemiological characteristics of urolithiasis in Japan: national trends between 1965 and 2005. Urology 2008;71:209-13. DOI: https://doi.org/10.1016/j.urology.2007.09.034
Trinchieri A. Diet and renal stone formation. Minerva Med 2013;104:41-54. DOI: https://doi.org/10.1007/s00240-012-0522-y
Nasir SJ. The mineralogy and chemistry of urinary stones from the United Arab Emirates. Qatar Univ Sci J 1999;18:189-202.
Muslumanoglu AY, Binbay M, Yuruk E, et al. Updated epidemiologic study of urolithiasis in Turkey. I: Changing characteristics of urolithiasis. Urol Res 2011;39:309-14. DOI: https://doi.org/10.1007/s00240-010-0346-6
Lee YH, Huang WC, Tsai JY, et al. Epidemiological studies on the prevalence of upper urinary calculi in Taiwan. Urol Int. 2002;68:172-7. DOI: https://doi.org/10.1159/000048445
Scales Jr. CD, Curtis LH, Norris RD, et al. Changing gender prevalence of stone disease. J Urol 2007;177:979-82. DOI: https://doi.org/10.1016/j.juro.2006.10.069
Strope SA, Wolf Jr. JS, Hollenbeck BK. Changes in gender distribution of urinary stone disease. Urology 2010; 75:543-6, 546.e1. DOI: https://doi.org/10.1016/j.urology.2009.08.007
Sierakowski R, Finlayson B, Landes RR, et al. The frequency of urolithiasis in hospital discharge diagnoses in the United States. Invest Urol 1978; 15:438-41.
Silva GR, Maciel LC. Epidemiology of urolithiasis consultations in the Paraíba Valley. Rev Col Bras Cir 2016;43:410-5. DOI: https://doi.org/10.1590/0100-69912016006001
Shastri S, Patel J, Sambandam KK, Lederer ED. Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023. Am J Kidney Dis 2023;82:617-634. DOI: https://doi.org/10.1053/j.ajkd.2023.03.017
Yitgin Y, Asrak H, Tefik T. Role, importance and assessment of dietary habits in urolithiasis patient. World J Urol 2023;41:1229-33. DOI: https://doi.org/10.1007/s00345-023-04277-3
Basiri A, Shakhssalim N, Khoshdel AR, et al. The demographic profile of urolithiasis in Iran: a nationwide epidemiologic study. Int Urol Nephrol 2010;42:119-26. DOI: https://doi.org/10.1007/s11255-009-9588-z
Abomelha MS, al-Khader AA, Arnold J. Urolithiasis in Saudi Arabia. Urology 1990;35:31-4. DOI: https://doi.org/10.1016/0090-4295(90)80008-B

How to Cite

Ezer, M., Güzel, R., Uslu, M., Güven S., & Sarica, K. (2024). Clinical characteristics of adult cases with urolithiasis from Turkey: A regional epidemiological study. Archivio Italiano Di Urologia E Andrologia, 96(1). https://doi.org/10.4081/aiua.2024.12181