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FROM PRISTINE TO LABORATORY-WEATHERED MICRO- AND NANOPLASTICS: INTERACTION WITH ENVIRONMENTAL CONTAMINANTS AND BIOLOGICAL EFFECTS Astrid SARACENI1, Barbara MOGNETTI1, Erika COTTONE1, Andrey Ethan RUBIN2, Maria Pia GALLO1, Yoav GOTHILF3, Ines ZUCKER2,4, Federica DAL BELLO5, Patrizia BOVOLIN1 | 1Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy; 2Porter School of Earth and Environmental Studies, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; 3Department of Neurobiology, The George S. Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel; 4School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; 5Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
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075 | Cytotoxic effects of grape seed oils on cancer cells Daniela Ganci1, Giulia Abruscato1, Roberto Chiarelli1, Manuela Mauro1|2, Vincenzo Arizza1|2, Mirella Vazzana1|2, Claudio Luparello1|2 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy; 2NFBC, National Biodiversity Future Center, Palermo, Italy.
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012 | Anticancer activity of Orobanche crenata leaf extract in human colorectal cancer cell lines Floriana D’Angeli1, Alfio Distefano2, Laura Orlando2, Elisa Gili3, Valentina Di Salvatore4, Simone Ronsisvalle4, Ivana Roberta Romano2, Giuliana Mannino2, Debora Lo Furno2, Giovanni Giurdanella1, Giovanni Li Volti2, Carlo Genovese1 | 1Department of Medicine and Surgery, School of Medicine and Surgery, University of Enna "Kore", Enna, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Department of Clinical and Experimental Medicine, "Regional Referral Center for Rare Lung Diseases", University, Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Italy; 4Department of Health and Drug Sciences, University of Catania, Italy.
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077 | Activation of the Keap1–Nrf2 axis underlies the antioxidant astrocytes protective effects of Boswellia sacra ethanolic extract: in vitro evidences supported by in silico analysis Graziella Serio1, Alessia Bono1, Roberto Chiarelli1, Marta Amato1, Mariangela Geraci1, Adriano Trapani1, Alessia Vermiglio1, Lorenza La Rosa1, Andrea Occhipinti2, Gabriella Schiera1, Antonino Lauria1, Carla Gentile1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Abel Nutraceuticals SRL, Turin, Italy.
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049 | CMIT as an emerging contaminant: physiological and biochemical effects in Mytilus galloprovincialis Giuseppe Stracuzzi1, Federica Impellitteri1, Maria Giovanna Rizzo1, Monia Perugini2, Marika Cordaro3, Kateryna Yunko4, Oksana Stoliar4, Caterina Faggio1|5 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2Department of Feed and Food Scienxes, Teramo Univesity, Teramo, Italy; 3Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Messina, Italy; 4Ternopil Volodymyr Hnatiuk National Pedagogical University, Ternopil, Ukraine; 5Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy.
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092 | Cellular and physiological responses of Mytilus galloprovincialis to the biocide octylisothiazolinone Emanuela Castronovo1, Cristiana Roberta Multisanti2, Benedetta Napoli1, Annalisa Cotugno3, Paolo Pastorino3, Caterina Faggio1|4 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina; 2Department of Veterinary Sciences, University of Messina; 3Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy; 4Department of Eco-sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Napoli, Italy.
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PRELIMINARY RESULTS ON MICROPLASTIC AND NANOPLASTIC IMPACT IN VIRUS AND BACTERIAL REPLICATION Nicoletta CAPUANO1,2, Alessia GIANNATTASIO3, Noemi CAFA’1,2, Anna BARBATO1,2, Mariarosa SCOGNAMIGLIO4, Vincenzo BELGIORNO5, Luca RINALDI6, Veronica FOLLIERO1,2, Antonio BUONERBA3, Gianluigi FRANCI1,2 | 1Dipartimento di Medicina, Chirurgia e Odontoiatria, Scuola Medica Salernitana, Università degli Studi di Salerno, Baronissi (SA), Italia; 2UOS di Microbiologia e Virologia, AOU San Giovanni di Dio e Ruggi D’Aragona, Salerno, Italia; 3Dipartimento di Chimica e Biologia, Università degli Studi di Salerno, Fisciano (SA), Italia; 4Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Fisciano (SA), Italia; 5Dipartimento di Ingegneria Civile, Università degli Studi di Salerno, Fisciano (SA), Italia; 6Dipartimento di Medicina e Scienze della Salute, Università degli Studi del Molise, Italy
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087 | Synergistic collapse of redox homeostasis in human hepatic and renal cells: perfluorooctane sulfonate as a priming factor for oxidative pathophysiology Graziano Vinci1, Marika Cordaro2, Rosanna Di Paola3 | 1Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Italy; 2Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy; 3Department of Veterinary Sciences, University of Messina, Italy.
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081 | Redox imbalance and ER stress mediate the anti-cancer effects of quinoline-based derivatives in triple-negative breast cancer cells Chiara Occhipinti1, Gabriele La Monica2, Federica Alamia2, Alessia Bono2, Antonino Lauria2, Annamaria Martorana2, Antonella D’Anneo1 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, Laboratory of Biochemistry, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16 Maria Antonella Augello1, Giuseppa D’Amico1, Alessandra Maria Vitale1, Rosario Barone1, Simona Rapposelli3, Maciej Wnuk4, Francesco Cappello1|2, Celeste Caruso Bavisotto1|2, Federica Scalia5 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; 3Department of Pharmacy, University of Pisa, Italy; 4Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; 5Department of Medicine and Surgery, Kore University of Enna, Italy.
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185 | From mycelium to medicine: cytotoxic effects of Ganoderma adspersum extracts in renal cancer cells Maria Noemi Sgobba1, Nikola Schlosserova1|2, Biagia Musio3, Federica Mastropirro1, Antonio Radesco4, Maria Favia5, Simona Marianna Sanzani4, Stefano Todisco3, Mariateresa Volpicella1, Anna De Grassi1, Vito Gallo3, Elena Ciani1, Ciro Leonardo Pierri6, Jakub Treml7, Lorenzo Guerra1 | 1Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 2Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Czech Republic; 3Department of Civil, Environmental, Land, Building Engineering and Chemistry DICATECh, Polytechnic University of Bari, Italy; 4Department of Soil, Plant and Food Sciences, University of Bari, Italy; 5Department of Translational Biomedicine and Neurosciences DiBraiN, University of Bari, Italy; 6Department of Pharmacy – Pharmaceutical Sciences, University of Bari, Italy; 7Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic.
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NANOPLASTICS AND IMMUNITY: INVESTIGATING THE EXTRACELLULAR MATRIX’S INFLUENCE ON MACROPHAGE INTERACTION WITH POLYSTYRENE NANOPARTICLES Marianna ROCA1, Naym BLAL1, Zeynep RENKLER2, Vincenzo GUARINO2, Antonia DI MOLA1, Antonio MASSA1, Ilaria DE MARTINO3, Velia SICILIANO3, Daniela GUARNIERI1 | 1Department of Chemistry and Biology, “Adolfo Zambelli”, University of Salerno; 2Institute of Polymers, Composites and Biomaterials, National Research Council of Italy; 3Synthetic and Systems Biology for Biomedicine Lab, Istituto Italiano di Tecnologia, Naples, Italy
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190 | Surface engineering of titanium implants with vanillin-chitosan and cerium doped-nanoparticle coatings for improved osteoimmune response Ioannis Tsamesidis1, Styliani Axypolitou1, Georgia K. Pouroutzidou1, Maria Bousnaki1, Dimitrios Bikiaris1, Evi Christodoulou1, Antonios D. Anastasiou2, Eleana Kontonasaki1 | 1Aristotle University of Thessaloniki, Greece 2University of Manchester, UK.
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163 | SIX-2G as a novel compound to attenuate airway inflammation in cystic fibrosis through modulation of molecular chaperones Giuseppa D’Amico1, Federica Scalia2, Maria Antonella Augello1, Giusi Alberti1, Roberta Bivacqua3, Marilia Barreca3, Rosario Barone1, Francesco Cappello1, Paola Barraja3, Alessandra Montalbano3, Celeste Caruso Bavisotto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; 2Department of Medicine and Surgery, Kore University of Enna, Italy; 3Department of Biological, Chemical, Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo, Italy.
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