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• 150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator Miriana Scordino¹, Giulia Urone¹, Monica Frinchi¹, Lucia Seidita¹, Alessandra Montalbano², Marilia Barreca², Paola Barraja², Maria Valeria Raimondi², Roberta Bivacqua², Fanny Malhaire³, Cyril Goudet³, Giuseppa Mudò¹, Virginia Spanò², Valentina Di Liberto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; ³IGF, Université de Montpellier, CNRS, INSERM, France.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15402

  45

• 149 | Behavioral markers of epileptogenesis and pharmacoresistance in a longitudinal pilocarpine model of temporal lobe epilepsy Nicolò Ricciardi¹, Miriana Scordino¹, Giulia Urone¹, Miriam Buttacavoli¹, Giuseppa Mudò¹, Pierangelo Sardo¹, Giuseppe Giglia^1|2, Valentina Di Liberto¹, Giuditta Gambino¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Euro Mediterranean Institute of Science and Technology - IEMEST, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15401

  43

• 147 | Screening of novel metabotropic glutamate receptor 4-oriented molecules in an in vitro model of Parkinson’s disease Cristina Giuffré¹, Miriana Scordino¹, Giulia Urone¹, Miriam Buttacavoli¹, Alessandra Montalbano², Marilia Barreca², Roberta Bivacqua², Paola Barraja², Virginia Spano’², Giuseppa Mudo’¹, Valentina Di Liberto¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Palermo, Italy; ²Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15399

  20

• 146 | Preventive effect of intranasal lemon-derived nanovesicles in a high-fat diet rat model of metabolic syndrome: modulation of anxiety-like behavior and survival signalling pathways Andrea Giubilato¹, Nicolò Ricciardi¹, Valentina Di Liberto¹, Miriana Scordino¹, Giulia Urone¹, Danila Di Majo¹, Giuseppe Giglia^1|4, Pierangelo Sardo¹, Giuseppe Ferraro¹, Riccardo Alessandro^1|2|3, Stefania Raimondo^1|2, Giuditta Gambino¹ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; ²Navhetec srl, Spinoff of the University of Palermo, Palermo, Italy; ³Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; ⁴Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15398

  93