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• 028 | Modelling glioblastoma multiforme microanatomical complexity with patient-derived 3D spheroids: a promising therapeutic tool for advancing precision medicine Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Martina Di Marco¹, Giuseppina Poppa², Pierlorenzo Maria Veiceschi³, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Paola Limoncelli², Ilaria Giusti², Vincenza Dolo², Claudia Campanella¹, Francesca Rappa¹, Rosario Barone¹, Giovanni Tringali³, Francesco Cappello¹, Celeste Caruso Bavisotto¹ | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; ²Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy; ³Department of Neurosurgery, National Relevance and High Specialization Hospital Trust ARNAS Civico, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15280

  28

• 005 | Targeting the CCT5–AURKA–CEP55 axis in glioblastoma and neuroblastoma cell lines: antitumor effects of SA16 Maria Antonella Augello¹, Giuseppa D’Amico¹, Alessandra Maria Vitale¹, Rosario Barone¹, Simona Rapposelli³, Maciej Wnuk⁴, Francesco Cappello^1|2, Celeste Caruso Bavisotto^1|2, Federica Scalia⁵ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; ³Department of Pharmacy, University of Pisa, Italy; ⁴Faculty of Biotechnology, Collegium Medicum, University of Rzeszow, Poland; ⁵Department of Medicine and Surgery, Kore University of Enna, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15257

  35

• 093 | Beyond biodegradability: assessing the toxicological footprint of polylactic acid nanoplastics on zebrafish gastrointestinal tract development Francesca Chiara Cecala¹, Giusy Vultaggio¹, Martina Di Marco¹, Alessandra Maria Vitale¹, Rosario Barone¹, Francesca Rappa¹, Maria Denise Amico¹, Erwin Pavel Lamparelli², Giovanna Della Porta², Antonietta Santoro², Francesco Cappello^1|4, Federica Scalia³, Marta Anna Szychlinska⁵ | ¹Department of Biomedicine, Neuroscience and Advanced Diagnostics BIND, University of Palermo, Italy; ²Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Italy; ³Department of Medicine and Surgery - Kore University of Enna, Italy; ⁴Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy; ⁵Department of Precision Medicine in Medical, Surgical and Critical Care MePreCC, University of Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15345

  32

• 014 | Development of a standardized and reproducible workflow for the generation and characterization of patient-derived glioblastoma spheroids Martina Di Marco¹, Alessandra Maria Vitale¹, Giuseppa D’Amico¹, Alessandro Lo Giudice¹, Francesca Chiara Cecala¹, Francesco Cappello^1|2, Celeste Caruso Bavisotto^1|2 | ¹Institute of Human Anatomy and Histology, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy; ²Euro-Mediterranean Institute of Science and Technology IEMEST, Palermo, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15266

  48

• 085 | Cytosolic and mitochondrial chaperonins (CCT/TRIC and HSPD1/HSP60) in human dermal fibroblasts cells under environmental stressors: heat, oxidative and cold paradigms Nima Shadan¹, Alessandra Maria Vitale¹, Federica Scalia^1|2, Rosario Barone¹ | ¹Department of Biomedicine, Neurosciences and Advanced Diagnostics BiND, University of Palermo, Italy; ²Department of Medicine and Surgery, Kore University of Enna, Italy.

  Società Italiana di Biologia Sperimentale

  31-03-2026

  https://doi.org/10.4081/jbr.2026.15337

  38