Original Articles Open access

Study on the leukocytes infiltration and association in diabetic foot ulceration patients

Authors

Published
9 June 2026
Issue
Early Access
Section
Original Articles
DOI
10.4081/jbr.2026.14830

Abstract

Diabetic foot ulcers are among the most common problems facing the people with diabetes. Leukocytes have been shown to penetrate the region of inflammation in order to regulate the infection. Thus, the current research was designed to study the infiltration of leukocytes in diabetic foot patients. Samples were taken from 50 healthy individuals and 100 diabetic foot ulcer patients. Levels of Fasting Blood Sugar (FBS), Hemoglobin A1C (HbA1c), cholesterol, triglycerides, urea, and creatinine were measured. Leukocytes infiltration was also evaluated in the diabetic foot patients. Levels of FBS and HbA1c were significantly increased (p≤ 0.05) in patients with diabetic foot ulceration. In addition, the levels of cholesterol, triglycerides and urea significantly increased (p≤ 0.05) in diabetic foot ulceration patients. However, the levels of creatinine greatly decreased in patients with diabetic foot ulceration. Infiltrated leukocytes were significantly increased in the ulcerated foot. Furthermore, the study found a strong association between leukocyte infiltration and HbA1c as follows: (y = 0.6864x + 0.9455: R² = 0.776). Thus, studying the mechanism of controlling leukocytes in diabetic foot ulcer could greatly participate in healing of diabetic foot ulcers.

Keywords

References

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Author Biographies

  • Marwah Majeed, Department of Biology, Collage of Science, University of Misan, Maysan

    N/A

  • Nidhal Abdullah Hashim, Southern Technical University, Amara Technical institute, Amara, Maysan

    N/A

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