https://doi.org/10.4081/jbr.2025.13533
Unveiling the muco-microbiotic layer: a three-component framework for mucosal health and disease
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 14 February 2025
We wish to bring attention to the critical role of the muco-microbiotic layer, a dynamic and integrated system located at mucosal surfaces. This layer represents a cornerstone of host-microbe interactions, composed of three key components: the mucus, the microbiota, and extracellular nanovesicles (commonly referred to as exosomes).
Downloads
Fucarino A, Burgio S, Paladino L, et al. The Microbiota is not an organ: Introducing the muco-microbiotic layer as a novel morphofunctional structure. Anatomia 2022;1:186-203. DOI: https://doi.org/10.3390/anatomia1020019
Cappello F, Saguto D, Burgio S, et al. Does intestine morphology still have secrets to reveal? A proposal about the “ghost” layer of the bowel. Appl Biosci 2022;1:95-100. DOI: https://doi.org/10.3390/applbiosci1010006
Paladino L, Rappa F, Barone R, et al. NF-kB regulation and the chaperone system mediate restorative effects of the probiotic Lactobacillus fermentum LF31 in the small intestine and cerebellum of mice with ethanol-induced damage. Biology (Basel) 2023;12:1394. DOI: https://doi.org/10.3390/biology12111394
Cappello F, Rappa F, Canepa F, et al. Probiotics can cure oral aphthous-like ulcers in inflammatory bowel disease patients: A review of the literature and a working hypothesis. Int J Mol Sci 2019;20:5026. DOI: https://doi.org/10.3390/ijms20205026
How to Cite

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.