Chemical compounds investigation and profiling of antimicrobial and antiviral constituents of Tephrosia purpurea subsp. apollinea
https://doi.org/10.4081/jbr.2024.12401
Accepted: April 3, 2024
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Tephrosia purpurea subsp. apollinea belongs to the family Fabaceae, and it is distributed in the delta region of Egypt. It has been used in traditional medicine for the management of various diseases. This study aimed to identify the phytochemicals utilizing LC/MS, and biological properties of a methanolic extract of Tephrosia purpurea subsp. apollinea. The analysis identified 31 compounds representing various phytochemical classes, including fatty acids, sterols, phenolic acids, polyphenols, terpenoids, and flavonoids. Among the major compounds detected, linoleic acid (13.2%) and campesterol (10.1%) were the most abundant. The extract displayed antibacterial, antifungal, and antiviral activities. The methanolic extract demonstrated varying degrees of antimicrobial activity against the tested microorganisms, with Bacillus subtilis showing the highest susceptibility. Significant antiviral activity was observed against herpes simplex and hepatitis C viruses. These findings highlight the potential of T. purpurea subsp. apollinea as a valuable source of natural bioactive compounds including antiviral agents. Additional investigation is required to explore the active principles responsible for the observed biological properties and their therapeutic applications in combating bacterial, fungal, and viral infections.
Jabborova D, Davranov K, Egamberdieva D. Antibacterial, antifungal, and antiviral properties of medical plants. In: Medically Important Plant Biomes: Source of Secondary Metabolites. Egamberieva D, Tiezzi A, eds.2019:51-65. DOI: https://doi.org/10.1007/978-981-13-9566-6_3
Di Petrillo A, Orrù G, Fais A, Fantini MC. Quercetin and its derivates as antiviral potentials: A comprehensive review. Phytother Res 2022:36:266-78. DOI: https://doi.org/10.1002/ptr.7309
Gao Z, Shao J, Sun H, et al. Evaluation of different kinds of organic acids and their antibacterial activity in Japanese apricot fruits. Afr J Agric Res 2012:7:4911-8.
Akram M, Tahir IM, Shah SMA, et al. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytother Res 2018:32:811-22. DOI: https://doi.org/10.1002/ptr.6024
Youssef AMM, Maaty DAM, Al-Saraireh YM. Phytochemical analysis and profiling of antioxidants and anticancer compounds from Tephrosia purpurea (L.) subsp. apollinea family Fabaceae. Molecules 2023:28:3939. DOI: https://doi.org/10.3390/molecules28093939
Masoko P, Gololo SS, Mokgotho MP, et al. Evaluation of the antioxidant, antibacterial, and antiproliferative activities of the acetone extract of the roots of Senna italica (Fabaceae). Afr J Tradit Complement Altern Med 2009:7:138-48. DOI: https://doi.org/10.4314/ajtcam.v7i2.50873
Chen Y, Yan T, Gao C, et al. Natural products from the genus Tephrosia. Molecules. 2014:19:1432-58. DOI: https://doi.org/10.3390/molecules19021432
Boulos L. Flora of Egypt. Cairo, Egypt: Al Hadara Publishing; 1999.
Dalwadi PP, Patel JL, Patani PV. Tephrosia purpurea Linn (Sharpunkha, Wild Indigo): a review on phytochemistry and pharmacological studies. Indian J Pharm Biol Res 2014:2:108. DOI: https://doi.org/10.30750/ijpbr.2.1.18
Youssef AM, Maaty DA, Al-Saraireh YM. Phytochemistry and anticancer effects of mangrove (Rhizophora mucronata Lam.) leaves and stems extract against different cancer cell lines. Pharmaceuticals 2023:16:4. DOI: https://doi.org/10.3390/ph16010004
Youssef AMM, EL-Swaify ZAS, Maaty DA, Youssef MM. Phytochemistry and antiviral properties of two Lotus species growing in Egypt. Vitae 2021:28. DOI: https://doi.org/10.17533/udea.vitae.v28n3a348069
Achika JI, Ayo RG, Habila JD, Oyewale AO. Terpenes with antimicrobial and antioxidant activities from Lannea humilis (Oliv.). Sci Afr 2020: 10:e00552. DOI: https://doi.org/10.1016/j.sciaf.2020.e00552
Huang CB, George B, Ebersole JL. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. Arch Oral Biol 2010: 55:555-60. DOI: https://doi.org/10.1016/j.archoralbio.2010.05.009
Lee H, Woo E-R, Lee DG. Apigenin induces cell shrinkage in Candida albicans by membrane perturbation. FEMS Yeast Res 2018:18:foy003. DOI: https://doi.org/10.1093/femsyr/foy003
Zhong X, Wang X, Chen L, et al. Synthesis and biological activity of myricetin derivatives containing 1, 3, 4-thiadiazole scaffold. Chem Cent J 2017:11:1-9. DOI: https://doi.org/10.1186/s13065-017-0336-7
Suzuki H, Asakawa A, Kawamura N, et al. Hesperidin potentiates ghrelin signaling. Recent Pat Food Nutr Agric 2014:6:60-3. DOI: https://doi.org/10.2174/2212798406666140825120623
Li ZJ, Guo X, Dawuti G, Aibai S. Antifungal activity of ellagic acid in vitro and in vivo. Phytother Res 2015:29:1019-25. DOI: https://doi.org/10.1002/ptr.5340
Johann S, Mendes BG, Missau FC, et al. Antifungal activity of five species of Polygala. Braz J Microbiol 2011:42:1065-75. DOI: https://doi.org/10.1590/S1517-83822011000300027
Quejada LF, de Almeida R, Vegi PF, et al. Rotenone enhances antifungal activity of novel pyrazoles against Candida spp. Eur J Med Chem 2022:5:100045. DOI: https://doi.org/10.1016/j.ejmcr.2022.100045
Lee CH, An DS, Lee SC, et al. A coating for use as an antimicrobial and antioxidative packaging material incorporating nisin and α-tocopherol. J Food Eng 2004:62:323-9. DOI: https://doi.org/10.1016/S0260-8774(03)00246-2
Palbag S, Dey BK, Singh NK. Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea. Chin J Nat Med 2014:12:1-7. DOI: https://doi.org/10.1016/S1875-5364(14)60001-7
Liao W, Liu X, Yang Q, et al. Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells. Antiviral Res 2020:174:104704. DOI: https://doi.org/10.1016/j.antiviral.2020.104704
Nukui M, O’Connor CM, Murphy EA. The natural flavonoid compound deguelin inhibits HCMV lytic replication within fibroblasts. Viruses 2018:10:614. DOI: https://doi.org/10.3390/v10110614
Salas MP, Céliz G, Geronazzo H, et al. Antifungal activity of natural and enzymatically-modified flavonoids isolated from citrus species. Food Chem 2011:124:1411-5. DOI: https://doi.org/10.1016/j.foodchem.2010.07.100
Sun ZC, Chen C, Xu FF, et al. Evaluation of the antiviral activity of naringenin, a major constituent of Typha angustifolia, against white spot syndrome virus in crayfish Procambarus clarkii. J Fish Dis 2021:44:1503-13. DOI: https://doi.org/10.1111/jfd.13472
Agus S, Achmadi SS, Mubarik NR. Antibacterial activity of naringenin-rich fraction of pigeon pea leaves toward Salmonella thypi. Asian Pac J Trop Biomed 2017:7:725-8. DOI: https://doi.org/10.1016/j.apjtb.2017.07.019
Grabarczyk M, Wińska K, Mączka W, et al. Loliolide-the most ubiquitous lactone. Acta Univ Lodz Folia Biol Oecol 2015:11:1-8. DOI: https://doi.org/10.1515/fobio-2015-0001
Chung C-Y, Liu C-H, Burnouf T, et al. Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry. Antiviral Res 2016:130:58-68. DOI: https://doi.org/10.1016/j.antiviral.2016.03.012
Chung ST, Huang YT, Hsiung HY, et al. Novel daidzein analogs and their in vitro anti‐influenza activities. Chem Biodivers 2015:12:685-96. DOI: https://doi.org/10.1002/cbdv.201400337
He Y, Huang M, Tang C, et al. Dietary daidzein inhibits hepatitis C virus replication by decreasing microRNA-122 levels. Virus Res 2021:298:198404. DOI: https://doi.org/10.1016/j.virusres.2021.198404
Argenta DF, Bidone J, Koester LS, et al. Topical delivery of coumestrol from lipid nanoemulsions thickened with hydroxyethylcellulose for antiherpes treatment. AAPS PharmSciTech 2018:19:192-200. DOI: https://doi.org/10.1208/s12249-017-0828-8
Gao Z, Shao J, Sun H, et al. Evaluation of different kinds of organic acids and their antibacterial activity in Japanese apricot fruits. Afr J Agric Res 2012:7:4911-8. DOI: https://doi.org/10.5897/AJAR12.1347
Ren J, Zhou J, Zhang W, et al. Antibacterial activity and mechanism of aureusidin against Staphylococcus aureus. Front Med Sci Res 2022:4:24-31. DOI: https://doi.org/10.25236/FMSR.2022.040806
Ogawa M, Shirasago Y, Tanida I, et al. Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus. J Infect Chemother 2021:27:397-400. DOI: https://doi.org/10.1016/j.jiac.2020.10.015
Bae J, Kim N, Shin Y, et al. Activity of catechins and their applications. BMC Dermatol 2020:4:1-10. DOI: https://doi.org/10.1186/s41702-020-0057-8
Rashed KNZ. Biological activities of isorhamnetin: A review. Plantae Sci 2020:3:78-81. DOI: https://doi.org/10.32439/ps.v3i5.78-81
Mahanty S, Rathinasamy K. The natural anthraquinone dye purpurin exerts antibacterial activity by perturbing the FtsZ assembly. Bioorg Med Chem 2021:50:116463. DOI: https://doi.org/10.1016/j.bmc.2021.116463
Khan NA. In vitro antimicrobial activity of triterpenoid saponin from Tephrosia purpurea seeds extract. Eur J Chem 2011:2:189-92. DOI: https://doi.org/10.5155/eurjchem.2.2.189-192.239
Jayaweera D. Medicinal plants used in Ceylon. National Science Council of Sri Lanka, Colombo 1982:5:201.
Venkatraman S, Krushnarajan D, Mannivannan R. Phytochemical evaluation and antimicrobial activity of Tephrosia purpurea. Imp J Pharm Cosmetol 2011:1:8-16.
Soni K, Kumar PS, Saraf M. Antioxidant activity of fraction of Tephrosia purpurea linn. Indian J Pharm Sci 2006:68:456-60. DOI: https://doi.org/10.4103/0250-474X.27817
Laishram A, Naik J, Reddy S, Jayasimha Rayalu D. Phytochemical analysis, TLC profiling and antimicrobial activity of Tephrosia purpurea. Int J Pharm Sci 2013:4:2375.
Nivedithadevi D, Manivannan P, Somasundaram R. Evaluation of antimicrobial and antihistamin activity of aerial parts of Tephrosia purpurea. International Res J Pharm 2012:3:147-9.
Singh V, Saxena R, Singh A. A flavonoid out of Tephrosia purpurea extract and its antimicrobial effect. Biomed Pharmacol J 2008:1:465.
Chinniah A, Mohapatra S, Goswami S, et al. On the potential of Tephrosia purpurea as anti-Helicobacter pylori agent. J Ethnopharmacol 2009:124:642-5. DOI: https://doi.org/10.1016/j.jep.2009.05.016
Ansari M, Jahan N. Tephrosia purpurea (L.) Pers.(Sarphuka, Wild Indigo): an important drug of Unani system of medicine. Discov Phytomed 2019:6:61-9. DOI: https://doi.org/10.15562/phytomedicine.2019.80
Parmar KA, Patel AN, Prajapati SN. Preliminary phytochemical screening and study of antiviral activity and antibacterial of Tephrosia purpurea flower. Life Sci Leaf 2010:1:7-13.
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