Simulated Microgravity Induces Apoptosis in Human Lymphocytes by a 5-Lipoxygenase-Mediated Mechanism
https://doi.org/10.4081/jbr.2003.10528
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Experiments performed during spaceflight clearly show that several cellular processes, such as oxidative metabolism, growth rates, signaling pathways and gene expression, are modified under conditions of weightlessness [1]. In particular, it has been suggested that reduced growth response in lymphocytes during spaceflight might be linked to apoptosis, based on morphological detection and cDNA microarray analysis [2] of space-flown human lymphoblastoid (Jurkat) cells. 5-Lipoxygenase (arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34; 5-LOX) plays a central role in interleukin-2 expression and activation of human lymphocytes, and is involved in the initiation of programmed death (apoptosis) triggered by unrelated stimuli in different human cells (reviewed in ref. 3). [...]
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
