In memory of Professor Gianni Losano. One year after his death
https://doi.org/10.4081/jbr.2021.9855
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Prof. Losano was born on July the 25th 1934, and he graduated in Medicine and Surgery on November 18th 1959. He started his university career in the early 60ties as “Assistente Volontario alla Cattedra di Fisiologia”. He was several times a Visiting Professor at the A.M. Dogliotti College of Medicine of the University of Liberia in Monrovia (Liberia), where he also served as Dean of the Medicine Faculty. In 1973 he was named full professor and he continued to work at Torino University until 2019 as Professor Emeritus.
Gattullo D, Losano G, Marsh NA, et al. Artificial respiration and survival time in anaesthetized rat after injection of gaboon viper (Bitis gabonica) venom. Boll Soc Ital Biol Sper 1986;62:143-9.
Alloatti G, Gattullo D, Losano G, et al. The mechanical effects of rhinoceros horned viper (Bitis nasicornis) venom on the isolated perfused guinea-pig heart. Exp Physiol 1991;76:611-4. DOI: https://doi.org/10.1113/expphysiol.1991.sp003529
Marsh N, Gattullo D, Pagliaro P, Losano G. The Gaboon viper, Bitis gabonica: hemorrhagic, metabolic, cardiovascular and clinical effects of the venom. Life Sci 1997;61:763-9. DOI: https://doi.org/10.1016/S0024-3205(97)00244-0
Gattullo D, Linden RJ, Losano G, et al. The effect of the coronary vascular wall on the changes in the coronary vascular resistance during a sudden reduction and recovery of the aortic blood pressure. Q J Exp Physiol 1986 71:657-74. DOI: https://doi.org/10.1113/expphysiol.1986.sp003025
Dambrosio M, Gattullo D, Linden RJ, et al. Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs. Exp Physiol 1990;75:725-8. DOI: https://doi.org/10.1113/expphysiol.1990.sp003453
Gattullo D, Linden RJ, Losano G, et al. Coronary flow and left ventricular pressure during diastole in the anaesthetized dog. Exp Physiol 1992;77:397-400. DOI: https://doi.org/10.1113/expphysiol.1992.sp003602
Gattullo D, Linden RJ, Losano G, et al. "Resistance" to left ventricular
outflow studied in anesthetized dogs. J Med 1993;24:369-83. DOI: https://doi.org/10.1093/labmed/24.6.369
Gattullo D, Linden RJ, Losano G, et al. Ventricular distension and
diastolic coronary blood flow in the anaesthetized dog. Basic Res Cardiol 1993;88:340-9.
Gattullo D, Dalla Valle R, Linden RJ, et al. Increases in coronary
intravascular pressure during maximal coronary vasodilatation in the anaesthetized dog. Cardiology 1994;84:89-98.
Gattullo D, Linden RJ, Losano G, Pagliaro P. Transient effects of quick changes in myocardial metabolism and perfusion pressure on coronary vasomotor responses. Basic Res Cardiol 1994;89:341-53. DOI: https://doi.org/10.1159/000176526
Gattullo D, Pagliaro P, Linden RJ, et al. The role of nitric oxide in the initiation
and in the duration of some vasodilator responses in the coronary circulation. Pflugers Arch 1995;430:96-104. DOI: https://doi.org/10.1007/BF00373844
Pagliaro P, Gattullo D, Linden RJ, et al. Systolic coronary flow impediment in the dog: role of ventricular pressure and contractility. Exp Physiol 1998;83:821-31. DOI: https://doi.org/10.1113/expphysiol.1998.sp004162
Gattullo D, Linden RJ, Losano G, et al. Ischaemic preconditioning changes the pattern of coronary reactive hyperaemia in the goat: role of adenosine and nitric oxide. Cardiovasc Res 1999;42:57-64. DOI: https://doi.org/10.1016/S0008-6363(98)00319-8
Di Lavore P, Gattullo D, Guiot C, et al. Effect of tachycardia and constriction of left circumflex artery on coronary flow and pressure in anaesthetized dogs. J Physiol 1988;406:469-81. DOI: https://doi.org/10.1113/jphysiol.1988.sp017391
Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6. DOI: https://doi.org/10.1038/288373a0
Penna C, Rastaldo R, Mancardi D, et al. Effect of endothelins on the cardiovascular system. J Cardiovasc Med (Hagerstown) 2006;7:645-52. DOI: https://doi.org/10.2459/01.JCM.0000242996.19077.ba
Penna C, Rastaldo R, Mancardi D, et al. Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K+ channel and protein kinase C activation. Basic Res Cardiol 2006;101:180-9. DOI: https://doi.org/10.1007/s00395-006-0584-5
Penna C, Cappello S, Mancardi D, et al. Post-conditioning reduces infarct size in the isolated rat heart: role of coronary flow and pressure and the nitric oxide/cGMP pathway. Basic Res Cardiol 2006;101:168-79. DOI: https://doi.org/10.1007/s00395-005-0543-6
Pagliaro P, Penna C, Rastaldo R, et al. Endothelial
cytochrome P450 contributes to the acetylcholine-induced cardiodepression in isolated rat hearts. Acta Physiol Scand 2004;182:11-20. DOI: https://doi.org/10.1111/j.1365-201X.2004.01339.x
Penna C, Pagliaro P, Rastaldo R, et al. F0F1 ATP synthase activity is differently modulated by coronary reactive hyperemia before and after ischemic preconditioning in the goat. Am J Physiol Heart Circ Physiol 2004;287:H2192-200. DOI: https://doi.org/10.1152/ajpheart.00327.2004
Folino A, Accomasso L, Giachino C, et al. Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src. Acta Physiol (Oxf) 2018;222. DOI: https://doi.org/10.1111/apha.12924
Losano G, Folino A, Rastaldo R. Role of three adipokines in metabolic syndrome. Pol Arch Med Wewn 2016;126:219-21. DOI: https://doi.org/10.20452/pamw.3386
Rastaldo R, Cappello S, Folino A, et al. Apelin-13 limits infarct size and improves cardiac postischemic mechanical recovery only if given after ischemia. Am J Physiol Heart Circ Physiol. 2011;300:H2308-15. DOI: https://doi.org/10.1152/ajpheart.01177.2010
Lionetti V. Cardioprotection gain with apelin-13: A matter of signalling. Acta Physiol (Oxf) 2018;222. DOI: https://doi.org/10.1111/apha.13005
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