Bioactive effects of citrus flavonoids and role in the prevention of atherosclerosis and cancer

Submitted: December 5, 2021
Accepted: January 8, 2022
Published: January 14, 2022
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  • Marco Giammanco Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.
  • Fulvio Plescia Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties “Giuseppe D’Alessandro”, University of Palermo, Italy.
  • Manfredi M. Giammanco Medical School, University of Palermo, Italy.
  • Gaetano Leto Laboratory of Experimental Pharmacology, Department of Health Sciences, University of Palermo, Palermo, Italy.
  • Carla Gentile University of Palermo, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Section of Cellular Biology, Palermo, Italy.

Citrus fruits are the main fruits of the Mediterranean diet and have been long recognized for their beneficial effects on human health. Observational studies have shown a significant association between dietary flavonoid intake and reduced risk of cardiovascular and malignant diseases. The beneficial effects of citrus fruits on human health appear to be due to their high content in vitamins, minerals and fibers. In particular, the antioxidant and anti-inflammatory activities have been indicated as some of the mechanisms through which citrus fruits may thwart the development of chronic degenerative diseases such as atherosclerosis and cancer. This review would critically examine the results from numerous experimental and clinical studies carried out in order assess the contribute of citrus flavonoids to the prevention of chronic pathological conditions including atherosclerosis and cancer.

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