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Analysis of correlation between estradiol and fracture of femur neck

Mohammad Davood Sharifi, Masoud Mohebbi, Mahmood Farrokhfar, Roohie Farzaneh, Hamideh Feiz Disfani, Amir Masoud Hashemian
  • Mohammad Davood Sharifi
    Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of | sharifimd@mums.ac.ir
  • Masoud Mohebbi
    Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of
  • Mahmood Farrokhfar
    Department of Emergency Medicine, Emergency Medicine Specialist, Hasheminejad Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of
  • Roohie Farzaneh
    Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of
  • Hamideh Feiz Disfani
    Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of
  • Amir Masoud Hashemian
    Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of

Abstract

Osteoporosis is a major public health challenge all over the world. Estrogen hormone was cited amongst other hormones to be an efficient hormone for the production and maintenance of bone density. This study was designed with the purpose of evaluating and analyzing the estradiol effect on fractures of femur neck in the Iranian society. This study evaluated men over 50 years of age suffering with mild trauma (falling off the same level height or lower) and with a fracture on their femur neck. Also, their serum level of estradiol was measured with an ELISA method. Using this procedure, the patients were assigned into groups with either normal estradiol serum level (10pg/ml and higher) or with lower than normal level (lower than 10 pg/ml). A control group including 50-year-old and older men without hip fracture, or its history, was chosen to access their estradiol serum level. Data collected from these two groups were statistically compared. A total of 120 patients were evaluated (60 in the control and 60 in the test group). The mean age of patients in the control and test groups were 67.9±10.22 and 69.5±8.84 years, respectively (p=0.376). Smoker patients’ percentages in the control and test groups were 35% and 31.7%, respectively (p=0.699). On the basis of the serum estradiol level, patients’ percentages with low estradiol level in control and test groups were 10% and 16.7%, respectively (p=0.283). The only significant factor in predicting serum estradiol level was smoking. In conclusion, in this study it was observed that fractures of the femoral neck following a mild trauma were not correlated to low level of serum estradiol.

Keywords

Estradiol, fracture, neck of femur, men, osteoporosis

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Submitted: 2018-02-25 11:34:55
Published: 2018-05-16 14:40:06
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Copyright (c) 2018 Mohammad Davood Sharifi, Masoud Mohebbi, Mahmood Farrokhfar, Roohie Farzaneh, Hamideh Feiz Disfani, Amir Masoud Hashemian

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