Endophytic to total tumour volume ratio: An added variable to patients with T1b/T2 renal tumours undergoing partial nephrectomy


Submitted: September 6, 2023
Accepted: September 28, 2023
Published: November 21, 2023
Abstract Views: 368
PDF: 150
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Authors

Introduction: Partial nephrectomy is the standard of care to patients with small renal masses. It is still encouraged to larger tumours whenever feasible. The aim of this study is to look for the endophytic to total tumour volume ratio as an added variable to study the complexity of partial nephrectomy to patients with T1b/ T2 renal tumours. Methods: Retrospective data collection of patients that had partial nephrectomy for T1b/T2 renal tumours by a single surgeon was done. Radiological re-assessment for the CT images to measure the endophytic to total tumour volume ratio was done. Results: The mean age of the patients was 63 years. The study included 25 males and 11 females. All cases were managed by open surgery using retroperitoneal transverse lateral lumbotomy and warm ischemia was used in all patients. The mean tumour volume was 74 cc, the mean endophytic tumour volume was 29 cc. The mean percentage of endophytic to total tumour volume was 42%. Conclusions: Partial nephrectomy is safe for most of the patients with good performance status, having large renal masses. More complex surgery can be predicted in patients with endophytic to total tumour volume greater than 42%.


Finelli A, Ismaila N, Bro B, et al. Management of Small Renal Masses: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2017; 35:668-680. DOI: https://doi.org/10.1200/JCO.2016.69.9645

Campbell SC, Clark PE, Chang SS, et al. Renal Mass and Localized Renal Cancer: Evaluation, Management, and Follow-Up: AUA Guideline: Part I. J Urol. 2021; 206:199-208. DOI: https://doi.org/10.1097/JU.0000000000001911

Richard PO, Violette PD, Bhindi B, et al. Canadian Urological Association guideline: Management of small renal masses - Full-text. Can Urol Assoc J. 2022; 16:E61-E75. DOI: https://doi.org/10.5489/cuaj.7763

Ljungberg B, Albiges L, Abu-Ghanem Y, et al. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update. Eur Urol. 2022; 82:399-410. DOI: https://doi.org/10.1016/j.eururo.2022.03.006

Nahar B, Gonzalgo ML. What is the current role of partial nephrectomy for T2 tumors? Can J Urol. 2017; 24:8698-8704.

Sharafeldeen M, Sameh W, Mehrnoush V, et al. Partial Nephrectomy for T1b/T2 Renal Mass: An Added Shift from Radical Nephrectomy. J Kidney Cancer VHL. 2022; 9:1-5. DOI: https://doi.org/10.15586/jkcvhl.v9i4.255

Kutikov A, Uzzo RG. The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009; 182:844-53. DOI: https://doi.org/10.1016/j.juro.2009.05.035

Kriegmair MC, Mandel P, Moses A, et al. Defining Renal Masses: Comprehensive Comparison of RENAL, PADUA, NePhRO, and CIndex Score. Clin Genitourin Cancer. 2017; 15:248-255.e1. DOI: https://doi.org/10.1016/j.clgc.2016.07.029

Ismail A, Oquendo F, Allard-Ihala E, et al. Transverse Lumbotomy for Open Partial/Radical Nephrectomy: How I Do It. Urol Int. 2020; 104:131-134. DOI: https://doi.org/10.1159/000504787

Sciorio C, Prontera PP, Scuzzarella S, et al. Predictors of surgical outcomes of retroperitoneal laparoscopic partial nephrectomy. Arch Ital Urol Androl. 2020; 92:165. DOI: https://doi.org/10.4081/aiua.2020.3.165

Tiwari RV, Ho CM, Huang HH, et al. Role of computed tomography- calculated intraparenchymal tumor volume in assessment of patients undergoing partial nephrectomy. Int J Urol. 2018; 25:436-441. DOI: https://doi.org/10.1111/iju.13531

Mohammadi A, Aghamir SMK. Partial nephrectomy of a huge solid-cystic renal mass with final pathology of renal cell carcinoma. J Surg Case Rep. 2022; 2022:rjab622. DOI: https://doi.org/10.1093/jscr/rjab622

Ismail, A., Mehrnoush, V., Alaref, A., Rozenberg, R., Elmansy, H., Shahrour, W., Burute, N., Shuster, A., Prowse, O., Zakaria, A., Shabana, W., & Kotb, A. (2023). Endophytic to total tumour volume ratio: An added variable to patients with T1b/T2 renal tumours undergoing partial nephrectomy. Archivio Italiano Di Urologia E Andrologia, 95(4). https://doi.org/10.4081/aiua.2023.11723

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