Hearing loss, why a bronchial tree may be involved?

Authors

  • Marisa Anelli Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan
  • Federico Raimondi Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo https://orcid.org/0000-0001-9599-6864
  • Luca Novelli Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo https://orcid.org/0000-0002-2705-248X
  • Chiara Allegri Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan
  • Simone Bonetti Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan
  • Carlo Catani Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan
  • Luca Malandrino Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan
  • Elisabetta Candiago Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo
  • Giuseppe Ciaravino Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo
  • Andrea Gianatti Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo
  • Fabiano Di Marco Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Department of Pathological Anatomy, ASST Papa Giovanni XXIII, Bergamo; Department of Health Sciences, University of Milan

DOI:

https://doi.org/10.4081/cdr.12.12298

Keywords:

endobronchial metastasis, anachronous metastasis, interventional pulmonology, melanoma, hearing loss

Abstract

A 62-years-old man former occasional smoker was hospitalized for progressive hearing loss and Magnetic Resonance Imaging (MRI) detected multiple round hyperdense lesions in each cerebral hemisphere. Total body Computed Tomography (CT) scan showed a lobulated consolidative lesion on the right lung lower lobe associated to conglomerate lymph nodes (11R) suspected for primary lung cancer. Endoscopy showed an endobronchial invasion and integrated endobronchial ultrasound did not demonstrate any accessible lymph node for sampling. Forceps biopsy report on the endobronchial specimen led to histopathological diagnosis of metastatic melanoma. Skin and ophthalmologic examinations were negative for suspicious pigmented lesions findings and patient had no history of familiarity for melanoma. Malignant melanoma is rarely observed to metastasize to endobronchial tissue and it is represented only in the 4.5% of cases. The vast majority of endobronchial metastases are metachronous, even after several years. Nevertheless, the anachronous manifestations are possible.

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References

Jung R. Pulmonary Lesions Associated with Extrapulmonary Malignancies. Sem Resp Crit Care M 1988;9:334-42. DOI: https://doi.org/10.1055/s-2007-1012721

Greelish JP, Friedberg JS. Secondary pulmonary malignancy. Surg Clin N Am 2000;80:633-57. DOI: https://doi.org/10.1016/S0039-6109(05)70204-8

Marchioni A, Lasagni A, Busca A, et al. Endobronchial metastasis: An epidemiologic and clinicopathologic study of 174 consecutive cases. Lung Cancer 2014;84:222-8. DOI: https://doi.org/10.1016/j.lungcan.2014.03.005

Sørensen JB. Endobronchial Metastases from Extrapulmonary Solid Tumors. Acta Oncol 2004;43:73-9. DOI: https://doi.org/10.1080/02841860310018053

Katz KA, Jonasch E, Hodi FS, et al. Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute. Melanoma Res 2005;15:77-82. DOI: https://doi.org/10.1097/00008390-200502000-00013

Wee E, Wolfe R, Mclean C, et al. Clinically amelanotic or hypomelanotic melanoma: Anatomic distribution, risk factors, and survival. JAMA Dermatol 2018;79:645-651.e4. DOI: https://doi.org/10.1016/j.jaad.2018.04.045

Bernal L, Restrepo J, Alarcón ML, et al. Primary braf mutant melanoma of the lung treated with immunotherapy and pulmonary bilobectomy: A case report. Am J Case Rep 2021;22:1-6. DOI: https://doi.org/10.12659/AJCR.927757

Yde SS, Sjoegren P, Heje M, Stolle LB. Mucosal Melanoma: a Literature Review. Curr Oncol Rep. 2018;20:28. DOI: https://doi.org/10.1007/s11912-018-0675-0

Filosso PL, Donati G, Ruffini E, et al. Primary malignant melanoma of the bronchus intermedius. J Thorac Cardiov Surg 2003;126:1215-7. DOI: https://doi.org/10.1016/S0022-5223(03)00691-3

Paliogiannis P, Fara AM, Pintus G, et al. Primary melanoma of the lung: A systematic review. Med;56:1-10. DOI: https://doi.org/10.3390/medicina56110576

Allen MS, Drash EC. Primary melanoma of the lung. Cancer 1968;21:154-9. DOI: https://doi.org/10.1002/1097-0142(196801)21:1<154::AID-CNCR2820210123>3.0.CO;2-K

Furney SJ, Turajlic S, Stamp G, et al. Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma. J Pathol 2013;230:261-9. DOI: https://doi.org/10.1002/path.4204

Chaussende A, Hermant C, Tazi-Mezalek R, et al. Endobronchial metastases from melanoma: a survival analysis. Clin Respir J 2017;11:1006-11. DOI: https://doi.org/10.1111/crj.12456

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Published

25-01-2024

Issue

Section

Case Reports

How to Cite

Hearing loss, why a bronchial tree may be involved?. (2024). Chest Disease Reports, 12(1). https://doi.org/10.4081/cdr.12.12298